Good afternoon,
There are 1059 citations in today’s scan. 471 were considered primary research or review literature.
Highlights today include:
CANADA
·
Dozois, D., explored how Canadians are managing with the COVID-19 outbreak and determine the impact of the pandemic on levels of anxiety and depression. The percentage
of respondents who indicated that their anxiety was high to extremely high quadrupled and the number of participants with high self-reported depression more than doubled. Although current anxiety levels are expected to remain the same, respondents predicted
that depression would worsen if physical distancing and self-isolation continue for another 2 months.
PUBLIC HEALTH INTERVENTION
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Steyn et al
model the testing, isolation and transmission of COVID-19 within quarantine facilities to estimate the risk of community outbreaks being seeded at the New Zealand border. The combination of 14-day quarantine with two tests reduces the risk of releasing
an infectious case to around 0.1% per infected arrival. Shorter quarantine periods, or reliance on testing only with no quarantine, substantially increases this risk.
·
Larremore et al. modeled surveillance effectiveness considering test sensitivities, frequency, and sample-to-answer reporting time. Results demonstrate
that effective surveillance depends largely on frequency of testing and the speed of reporting, and is only marginally improved by high test sensitivity. Auhors conclude that surveillance should prioritize accessibility, frequency, and sample-to-answer time;
analytical limits of detection should be secondary.
IPAC
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Colnago et al. proposed simple, easy to prepare, low-cost and efficient antiviral films, made with a widely available dishwashing detergent, which can be spread on hands
and inanimate surfaces and is expected to maintain virucidal activity for longer periods than the current sanitizers.
TRANSMISSION
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Lentz et al characterized associations between exposures within and outside the medical workplace with healthcare personnel (HCP) SARS-CoV-2 infection, including the effect of
various forms of respiratory protection. HCP infection was associated with non-aerosol-generating contact with COVID-19 patients and extra-occupational exposures including gatherings of ten or more, patronizing restaurants or bars, and public transportation.
Respirator use during aerosol-generating procedures (AGPs) was associated with lower odds of HCP infection as was exposure to intensive care and dedicated COVID units, negative pressure rooms, and personal protective equipment (PPE) observers.
EPIDEMIOLOGY
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van den Broek-Altenburg et al. report prevalence of COVID-19 in the general population of the Northest U.S.; and identifies
factors that affect exposure to the virus. We found a positivity rate of 2.2 percent, a hospitalization rate of 1.2 percent and an adjusted IFR of 0.55 percent. The number of contacts with adults and seniors increases the probability of becoming infected.
Occupation, living in apartment versus a house, and wearing a facial mask outside work increased probability of COVID-19 infection.
Ozer et al. We report a 39-week-gestational-age infant delivered to a 37-year-old mother diagnosed with SARS-CoV-2 infection at 37 weeks gestation. The placental examination showed
the morphological features of VUE. We showed immunohistochemically that macrophages and CD4-positive T cells predominated in the villous tissue, although elevated numbers of CD8-positive cells were also present. We hypothesize that VUE may represent a maternal
anti-viral immune response, in this case to SARS-CoV-2.
·
Yoon et al.
describe SARS-CoV-2 prevalence among individuals experiencing homelessness and staff servicing the homeless in Atlanta, Georgia. Testing was conducted at two different time points April and May 2020. Infection prevalence was 2.1% among individuals living
in shelters, 0.5% among individuals not living in shelters (i.e. unsheltered homeless persons), and 1.3% among tested staff during the initial phase of testing. A decrease in infection rates were noted at the second phase of testing (4 weeks later) due to
the implementation of effective infection prevention and control process in homeless shelters.
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Fouillet et al estimate excess all-cause mortality
during the first wave of the COVID-19 epidemic in France, as 25,030 excess deaths, or 16.6% above the baseline for the whole of France, from March 2 to May 31, 2020.
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Tadiri, et al.
found institutionalized gender inequality to be positively associated with the male:female ratio reported cases of coronavirus disease 2019 (COVID-19) among countries that report sex-disaggregated data; males accounted for more cases in countries with
higher gender inequality. Institutionalized gender and culturally entrenched roles and norms may influence who is most at risk of acquiring infection or who is able to receive a test.
·
Tu et al.
recruited pediatric medical workers (n = 325) in one hospital in Wuhan. They were divided into three groups depending on their level of contact with confirmed and/or suspected COVID-19 cases during the outbreak. Three different immunological detection
methods were used to measure SARS-CoV-2 serum antibodies. The overall positive rate for SARS-CoV-2 IgG and IgM antibodies was 43.08 and 5.85%, respectively. Results suggests the colloidal gold detection kit used in this research is not sensitive enough to
be useful in accurate antibody detection, whereas the DTFA and ELISA positive rate performed similarly.
CLINICAL DATA
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Prado-Vivar et al.
presented the first confirmed case of SARS-CoV-2 re-infection in Ecuador and South America. The first laboratory-confirmed infection presented with mild symptoms and full recovery, reaffirmed by a negative RT-PCR test result obtained two weeks after
symptoms onset. More severe COVID-19-like symptoms presented again four weeks after the first event, and a third RT-PCR test was performed, which was positive. Different SARS-CoV-2 variants were identified in each event. High levels of both SARS-CoV-2 specific
IgM and IgG were observed during the second event.
·
Wang, et al.
report the case of a patient with mild symptoms of COVID-19 who achieved clinical recovery but showed persistently positive SARS-CoV-2 nucleic acid test results until Day 92 after disease onset.
·
Wang, et al.
report a case of serious neurological damage and mental abnormalities in a patient who was finally confirmed to have COVID-19 based on IgM and IgG antibodies in the cerebrospinal fluid (CSF).
·
Ozer et al. We report a 39-week-gestational-age infant delivered to a 37-year-old mother diagnosed with
SARS-CoV-2 infection at 37 weeks gestation. The placental examination showed the morphological features of VUE. We showed immunohistochemically that macrophages and CD4-positive T cells predominated in the villous tissue, although elevated numbers of CD8-positive
cells were also present. We hypothesize that VUE may represent a maternal anti-viral immune response, in this case to SARS-CoV-2.
VACCINE RESEARCH
·
Vogel, et al.
report the 40 design, preclinical development, immunogenicity and anti-viral protective effect in rhesus 41 macaques of the BNT162b2 vaccine candidate. The BNT162b2 vaccine candidate fully 50 protected the lungs of immunised rhesus macaques from infectious
SARS-CoV-2 challenge. 51 BNT162b2 is currently being evaluated in a global, pivotal Phase 2/3 trial (NCT04368728).
CORONAVIROLOGY
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Latini et al. investigated the variability of genes coding for the proteins involved in the SARS-CoV-2 entry into the cells. They analyzed 131 COVID-19 patients by exome sequencing
and examined the genetic variants of TMPRSS2, PCSK3, DPP4, and BSG genes. In total they identified seventeen variants. Genetic variants in these genes could influence the entry of the SARS-CoV-2. These data also support the hypothesis that host genetic variability
may contribute to the variability in infection susceptibility and severity.
PUBLIC HEALTH RESPONSE
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Hammoudi et al.
propose a design of a mobile application for permitting everyone having a smartphone and being able to take a picture to verify that his/her protection mask is correctly positioned on his/her face. Experimental results show the potential of this
method in the validation of the correct mask wearing
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Mieth et al. In the direct questioning group 94.5 % of the participants claimed to practice proper hand hygiene; in the indirect questioning group a significantly
lower estimate of only 78.1 % was observed. These results indicate that estimates of the degree of commitment to measures designed to counter the spread of the disease may be significantly inflated by social desirability in direct questionings.
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Shiraly et al.
establish the frequency of face-touching behavior by the public after quarantine restrictions were lifted in Shiraz, Iran. 92% of people were observed touching their face at least once an hour and averaged 10 touches per hour. Nonmask wearers touched
their face significantly more often than mask wearers (11 vs 8 times per hour, P < .001). Nonmask wearers were also 1.5 times more likely to touch their mucosal zone than mask wearers.
·
Tomczyk, et al.
aim to identify causes and patterns of non-compliance in the German population to further optimize risk and health communication. With 25% of the sample reporting full compliance, and 51% differing in terms of public and personal compliance, these findings
challenge the sustainability of strict regulatory measures. Moreover, young males were most likely to express low compliance, stressing the need for selective health promotion efforts.
HEALTHCARE RESPONSE
·
Goodyear-Smith et al.
The aim of this study was to compare perceptions of primary care (PC) experts on PC system strength, pandemic preparedness, and response with COVID-19 mortality rates in countries globally. Countries perceived by expert participants as having a prepared
pandemic plan and a strong PC system did not necessarily experience lower COVID-19 mortality rates
ECONOMICS
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Khurshid et al. analyzed the impact of the COVID-19 shock on GDP, energy consumption, and climate change then forecasted the situation until 2032 using
the system dynamic modeling approach. The energy consumption and quarantine situation will improve the climate situation and drop the average temperature by 0.049 and 0.021 degrees C in 2020 and 2021. The decline in oil prices provides an opportunity to cut
fossil fuel subsidies and implement a carbon pricing mechanism
Regards,
Lisa Waddell, Tricia Corrin, Rukshanda Ahmad, Robyn Odell, Maribeth Mitri, Julie Theriault, Dobrila Todoric, Alejandra Dubois, Christina Bancej, Austyn Baumeister, Anam Khan, Musaab Younis, Lien Mi Tien, Dima Ayache, Angela Sloan, Kaitlin
Young, Chatura Prematunge, Ainsley Otten
Focus areas: Modelling/ prediction, Epidemiology, Transmission, Clinical data, Surveillance, Coronavirology, Diagnostics / Pathogen detection, Therapeutics,
Vaccine Research, Public health interventions, Public Health response, Public Health Priorities, IPAC, Health care response, immunology, economics, animal model, zoonoses, Review Literature, Commentary/Editorial, news
Domaines cibles: Modélisation/prédiction, Épidémiologie, Transmission, Données cliniques, Surveillance, Coronavirologie, Diagnostics
/ Détection d'agents pathogènes, Thérapeutique, Recherche sur les vaccins, Interventions de santé publique, Priorités de santé publique, PCI,
Réponse des soins de santé, immunologie, économie, modèle animal, zoonoses, Revue de littérature, Commentaire/Éditorial, journaux
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PUBLICATIONS |
AUTHORS / AUTEURS |
SOURCE |
FOCI / DOMAINE |
SUMMARY / SOMMAIRE |
Perceived public stress among Jordanians during the COVID-19 outbreak |
Abdel Jalil, MH, Alsous, et al |
Disaster Med Public Health Prep |
Public Health response| Interventions de santé publique |
This study aimed to determine the perceived stress level and factors associated with it in the Jordanian population
during the COVID-19 outbreak. The mean (standard deviation) of perceived stress score was 19.8 (6.7). Regression analysis reviled that stress was increased in females, young adults, usually being stressed more than others by a health problem, increased perceived
severity of the disease, increased overall worry score, and student's worry regarding their studies/graduation. While perceived stress was decreased if participants' self-rated health status score increased. |
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Agarwal, Anup, Mukherjee, et al |
medRxiv |
Clinical data| Données cliniques Therapeutics| Thérapeutique RCT |
Convalescent plasma (CP) as a passive source of neutralizing antibodies and immunomodulators is a century-old therapeutic option used for the management
of viral diseases. We investigated its effectiveness for the treatment of COVID-19 in an open-label, parallel-arm, phase II, multicentre, randomized controlled trial. Participants were randomized to either control (best standard of care (BSC)) or intervention
(CP + BSC) arm. Two doses of 200 mL CP was transfused 24 hours apart in the intervention arm. Main Outcome Measure: Composite of progression to severe disease (PaO2/FiO2<100) or all-cause mortality at 28 days post-enrolment. Between 22 nd April to 14 th July
2020, 464 participants were enrolled; 235 and 229 in intervention and control arm, respectively. Composite primary outcome was achieved in 44 (18.7%) participants in the intervention arm and 41 (17.9%) in the control arm aOR: 1.09 [95% CI: 0.67, 1.77]. Mortality
was documented in 34 (13.6%) and 31 (14.6%) participants in intervention and control arm, respectively aOR 1.06 [95% CI: -0.61 to 1.83]. |
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COVID-19 in Somalia: Adherence to Preventive Measures and Evolution of the Disease
Burden |
Ahmed, MAM, Siewe Fodjo, et al |
Pathogens |
Public Health response| Interventions de santé publique |
We assessed adherence to the government recommendations via two consecutive online cross-sectional surveys between April and July 2020. A five-point adherence
score was constructed based on self-reported observance of five preventive measures (physical distancing, face mask use, hand hygiene, mouth covering when coughing/sneezing, and avoidance of touching the face). 4124 and 4703 responses were analyzed during
the first and second survey, respectively. The mean adherence score decreased from 3.54 ± 1.5 in the first survey to 3.40 ± 1.6 during the second survey; p < 0.001. More participants experienced at least one flu-like symptom during the second survey (38.2%)
compared to the first (16.2%); however, the proportion of positive COVID-19 tests in the first (26.9%) and second survey (26.5%) was similar. The ordinal logistic regression model identified the following predictors for high adherence scores: female gender
(odds ratio (OR) = 1.715 (1.581-1.861), p < 0.001); being a healthcare worker/student (OR = 2.180 (2.000-2.377), p < 0.001); obtaining COVID-19 information from official sources (OR = 1.460 (1.341-1.589), p < 0.001); and having postgraduate education (OR =
1.679 (1.220-2.307), p < 0.001). Conversely, obtaining COVID-19 information from social media and residing in urban settings were associated with lower adherence. Targeted and context-specific adaptations of the COVID-19 response may be required in Somalia. |
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Aiello, P, Johnson, et al |
BMJ Case Rep |
Clinical data| Données cliniques |
A 73-year-old man with significant medical history including renal transplantation and chronic immunosuppression presented to the hospital with acute respiratory
failure. His initial treatment included steroids for concern for Pneumocystis jiroveci pneumonia, although this was later excluded as the diagnosis. The patient’s illness was consistent with COVID-19; however, he was not diagnosed with the virus until late
in his course. |
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Surgical tracheostomy in COVID-19 patients: Report of 5 cases |
Aissaoui, O, Nsiri, et al |
Pan African Medical Journal |
Clinical data| Données cliniques |
Severe acute respiratory distress syndrome (ARDS) related to SARS-COV-2 is resulting in increasing numbers of patients requiring mechanical ventilation.
Although tracheostomy may reduce the duration of mechanical ventilation in these patients, it is considered a highly aerosol generating procedure and controversies regarding its safety, time of realization and indications remain to date. We share our experience
about 5 cases of surgical tracheostomy in COVID-19 patients performed in our ICU. |
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Akhter, Javed, Pillai, et al |
bioRxiv |
Coronavirology| Coronavirologie |
We sought to determine whether BromAc has activity on the spike and envelope protein specific to SARS-CoV-2 virus.
Gel electrophoresis analysis was carried out on recombinant spike and envelope proteins that were treated with a range of concentrations of single agents and BromAc. For UV analysis of disulfide bonds reduction, both spike and envelope protein were treated
with Acetylcysteine with the determination of loss of disulfide bonds. Recombinant spike and envelope SARS-CoV-2 protein were fragmented by BromAc whilst single agents had minimal effect. Spike and envelope proteins disulphide bonds were reduced by Acetylcysteine.
BromAc disintegrates the spike and envelope protein from SARS-CoV-2 and may render it non-infective. In vitro tests on live virus have been encouraging and clinical testing through nasal administration in patients with early SARS-CoV-2 infection is imminent. |
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Al Helali, AA, Saeed, et al |
Radiol Case Rep |
Clinical data| Données cliniques |
This is a case report of a 55-year-old male, with COVID-19 pneumonia who has received convalescent plasma as part of
a treatment plan which showed significant radiological and clinical improvement post-treatment. |
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Ali, KF, Whitebridge, et al |
J Med Internet Res |
Public Health response| Interventions de santé publique |
The aim of this study was to rapidly obtain information on public perceptions, knowledge, and behaviors related to
COVID-19 in order to identify deficiencies in key areas of public education. A total of 5677 subjects completed the survey over the course of 1 week. "Fever or chills" (n=4973, 87.6%) and "shortness of breath" (n=4695, 82.7%) were identified as the main symptoms
of COVID-19. Washing and sanitizing hands (n=4990, 87.9%) and avoiding public places and crowds (n=4865, 85.7%) were identified as the protective measures most frequently used against COVID-19. Social media was the most utilized source for information on the
disease (n=4740, 83.5%), followed by the World Health Organization (n=2844, 50.1%). Subgroup analysis revealed that younger subjects (<35 years), males, and those working or studying in health care reported a higher perceived likelihood of acquiring COVID-19,
whereas older subjects, females, and those working or studying in non-health care areas reported a lower perceived likelihood of acquiring COVID-19. Similar trends were observed for vaccination against COVID-19, with older subjects, females, and those working
or studying in non-health care sectors reporting a lower likelihood of vaccinating against COVID-19. |
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Alkhowailed, M, Shariq, et al |
Informatics in Medicine Unlocked |
Epidemiology| Épidémiologie |
This study was undertaken to analyse the effect of meteorological parameters such as temperature, humidity, and wind
speed on the spread of ongoing COVID-19 in Saudi Arabia. Novel data revealed interesting facts on the spreading of COVID-19 in Saudi Arabia, the data showed that the number of COVID-19 positive cases increases due to the decrease of temperature or humidity,
whereas an average decrease in the wind speed was also found to be associated with an elevation of the number of positive cases. |
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The potential impact of Covid-19 on the Irish
housing sector |
Allen-Coghlan, M, McQuinn, et al |
International Journal of Housing Markets and Analysis |
Economics | Économie |
This paper aims to examine the implications for the Irish housing market of the economic slowdown due to the Covid-19
virus. The scenario analysis presented here indicates that Irish house prices are set to fall over the next 18 months as a result of the Covid-19 downturn. This contraction in prices is due to the decline in household disposable income and the sharp fall-off
in mortgage market activity, which will inevitably result from the administrative closedown implemented by the Irish authorities. |
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Impact of the COVID-19 lockdown on diabetes patients in Jeddah, Saudi Arabia |
Alshareef, R, Al Zahrani, et al |
Diabetes and Metabolic Syndrome: Clinical Research and Reviews |
Public Health response| Interventions de santé publique |
This study aimed to explore the impact of the coronavirus disease lockdown on diabetes patients living in Jeddah, Saudi
Arabia, in terms of their compliance with medication intake and lifestyle habits, and quality of life. In total, 394 patients participated. All of them had type 2 diabetes, and 37.6% had only one comorbidity. Antidiabetic monotherapy was used in 76.4% of the
patients, while combination therapy was used in 23.6%. The compliance score before the lockdown was significantly higher (18.49 ± 3.05) than that after it (17.40 ± 3.25) (p-value <0.001). The average psychological assessment score was 9.78 ± 4.14 (range 8–35).
Male participants and smokers had a significantly better psychological status than female participants (p-value = 0.002) and non-smokers (p value < 0.001), respectively. The patients’ levels of compliance with medications and healthy lifestyle habits were
significantly reduced after the lockdown. |
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Alteri, C, Cento, et al |
PLoS One |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Here we evaluated the performance of a ddPCR-based assay to quantify SARS-CoV-2 titer in 55 suspected COVID-19 cases
with negative rtPCR results thanks to in-house ddPCR assay (targeting RdRp and host RNaseP). Samples were collected at ASST-GOM Niguarda between February and May 2020 at hospital admission. In 15 of them (78.9%), chest CT showed a classical COVID-19 bilateral
interstitial pneumonia; 14 patients (73.7%) showed severe COVID-19 manifestations. ddPCR did not identify any trace of SARS-CoV-2 genome in the respiratory samples of the remaining 36 patients. The serological assay performed in a subgroup of 34 patients at
the later stage of illness (from 3 days to 90 days after) confirmed the presence of SARS-CoV-2 antibodies in all patients tested positive for SARS-CoV-2 in ddPCR (100%). Contrariwise, negative tests were observed in 95.0% ddPCR negative patients (P<0.001).
Thanks to a ddPCR-based assay, we achieved a rapid and accurate SARS-CoV-2 diagnosis in rtPCR-negative respiratory samples of individuals with COVID-19 suspect, allowing the rapid taking care and correct management of these patients. |
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Ammar, A, Chtourou, et al |
International Journal of Environmental Research and Public Health |
Public Health response| Interventions de santé publique |
An international online survey was launched in April 2020 to elucidate the behavioral and lifestyle consequences of
COVID-19 restrictions. This report presents the preliminary results from more than one thousand responders on social participation and life satisfaction. 1047 participations (54% women) from Asia (36%), Africa (40%), Europe (21%), and others (3%) were included
in the analysis. Findings revealed psychosocial strain during the enforced COVID-19 home confinement. Large decreases (p < 0.001) in the amount of social activity through family (−58%), friends/neighbors (−44.9%), or entertainment (−46.7%) were triggered by
the enforced confinement. These negative effects on social participation were also associated with lower life satisfaction (−30.5%) during the confinement period. Conversely, the social contact score through digital technologies significantly increased (p
< 0.001) during the confinement period with more individuals (+24.8%) being socially connected through digital technology. |
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Interaction of human ACE2 to membrane-bound SARS-CoV-1
and SARS-CoV-2 S glycoproteins |
Anand, Sai Priya, Chen, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Here, we investigated the degree of cooperativity of ACE2 within both the SARS-CoV-2 and the closely related SARS-CoV-1
membrane-bound S glycoproteins. We show that there exist differential inter-protomer conformational transitions between both Spike trimers. Interestingly, the SARS-CoV-2 spike exhibits a positive cooperativity for monomeric soluble ACE2 binding when compared
to the SARS-CoV-1 spike, which might have more structural restrains. Our findings can be of importance in the development of therapeutics that block the Spike/ACE2 interaction. |
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The impact of the COVID-19 lockdown on stock market performance: evidence from Vietnam |
Anh, DLT, Gan, et al |
Journal of Economic Studies |
Economics | Économie |
This study explores the effects of the COVID-19 outbreak and its following lockdown on daily stock returns in Vietnam,
a fast-growing emerging market that successfully revived after the pandemic lockdown. This study uses panel-data regression models to evaluate the influence of the daily increase in the number of COVID-19 confirmed cases during pre-lockdown and lockdown on
daily stock returns of 723 listed firms in Vietnam from 30 January to 30 May 2020. The study confirms the adverse impact of the daily increasing number of COVID-19 cases on stock returns in Vietnam. The study also discloses that the Vietnam stock market before
and during the nationwide lockdown performed in opposing ways. Though COVID-19 pre-lockdown had a significant, negative impact on Vietnam's stock returns, the lockdown period had a significant, positive influence on stock performance of the entire market and
the different business sectors in Vietnam. The financial sector was hardest hit on the Vietnam stock market during the COVID-19 outbreak. |
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The impact of COVID-19 lockdown on the air quality of Eastern Province, Saudi Arabia |
Anil, I, Alagha, et al |
Air Quality, Atmosphere and Health |
Public health interventions*| Interventions de santé publique |
In this work, the possible effects of the lockdown on the air quality were investigated using meteorological and air
quality datasets obtained from eight monitoring stations covering the Eastern Province of the KSA. The studied air pollutants include carbon monoxide (CO), sulfur dioxide (SO2), nitrogen dioxide (NO2), ozone (O3), and inhalable particulate matter (PM10). The
NO2 was found to be the marker pollutant responding best to the lockdown measures since its concentrations decreased at all sites during- and post-lockdown periods and ranged between 12–86% and 14–81%, respectively. Compared with pre-lockdown period, the Eastern
Province also experienced significant concentration reductions at varying rates for PM10 (21–70%), CO (5.8–55%), and SO2 (8.7–30%), while O3 concentrations showed increasing rates ranging between 6.3 and 45%. The consequences of these reductions were reflected
in easing the outdoor air quality, which might reduce the impact of COVID-19 pandemic, especially on elderly and sensitive groups. |
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Anser, MK, Yousaf, et al |
Frontiers in Public Health |
Economics | Économie |
The study focused on the following key variables: communicable diseases, healthcare expenditures, population density,
poverty, economic growth, and COVID-19 dummy variable in a panel of 76 selected countries from 2010 through 2019. The results show that the impact of communicable diseases on economic growth is positive because the infected countries get a reap of economic
benefits from other countries in the form of healthcare technologies, knowledge transfers, cash transfers, international loans, aid, etc., to get rid of the diseases. However, the case is different with COVID-19 as it has seized the whole world together in
a much shorter period of time and no other countries are able to help others in terms of funding loans, healthcare facilities, or technology transfers. Thus, the impact of COVID-19 in the given study is negatively impacting countries' economic growth that
converts into a global depression. The high incidence of poverty and social closeness increases more vulnerable conditions that spread coronavirus across countries. The momentous increase in healthcare expenditures put a burden on countries' national healthcare
bills that stretch the depression phase-out of the boundary. The forecasting relationship suggested the negative impact of the coronavirus pandemic on the global economy would last the next 10 years. Unified global healthcare policies, physical distancing,
smart lockdowns, and meeting food challenges are largely required to combat the coronavirus pandemic and escape from global depression. |
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Arana-Chicas, E |
Research Square prepub |
Public Health response| Interventions de santé publique |
The purpose of this study was to assess COVID-19 prevention practices and beliefs of Black Lives Matter protesters
in the USA. Twenty participants completed the study. Participants’ average age was 29 and most participants were female (80%) and black (75%). Most always or almost always properly wore their masks (50% and 25%, respectively) and washed their hands during
a protest 2-3 times or more than 3 times (35% and 50%, respectively). Although all believed that COVID-19 testing is important (90%), most had never been tested (85%) and most did not self-quarantine for 14 days after protesting (95%). Moreover, most participants
reported never or rarely following social distancing guidelines at a protest (25% and 30%, respectively) and most reported being Not at all or Slightly concerned about COVID-19 while at a protest (25% and 30%, respectively). Qualitative data highlighted the
following themes: 1) Fighting for social justice, 2) Protesting being more important than COVID-19, 3) Unable to keep 6 ft distance, 4) Masks worn most of the time, 5) Protests sparked global movement, and 6) Increasing awareness of injustices. |
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Age and gender distribution of COVID-19 infected cases in Italian population |
Arisi, I, M |
Research Square prepub |
Epidemiology| Épidémiologie |
Our analysis was devoted to the distribution of the infected cases in the Italian population stratified by age and
sex in order to define the differences in gender impact of COVID-19 in each age class. Data on infected cases were extracted from the Italian EpiCentro (ISS) web site from March 12 to May 20, 2020. Data were pooled in ten years’ groups. Odds ratio (OR) men
versus women was evaluated by the Fisher exact test. Logistic regression was used to investigate the combined effect of age and sex on infection incidence. Statistical analysis, performed by R-Bioconductor, highlights differences in age-dependent susceptibility
to infection between men and women. In elderly class (50+ ) generally man result more infected than women, with the exception of the oldest women (90+). In age classes <50 OR was about 1.0, while an intriguing exception is the age group 20-29 in which the
ratio was unbalanced in favour of men. This analysis supports a strong influence of biological sex and environmental factors related to age in COVID-19 infection by SARS-Cov-2. |
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Asai, N, Sakanashi, et al |
Journal of Microbiology, Immunology and Infection |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
For the purpose of identifying clinical manifestations and radiological findings of COVID-19 pneumonia, we reviewed
all cases of COVID-19 pneumonia which were published by the homepage of the Japanese Association for Infectious Diseases from Feb 5 2020 until April 30 2020, including our cases. A total of 92 patients were enrolled in this study. The median age was 66 years
(range 16–92 years). For all, 50 (54%) were males. The most common underlying disease was hypertension in 32 (36%). Any comorbidity was seen in 60 (67%). The mortality rate was 4 (6%). In terms of clinical symptoms on an initial visit, fever and cough were
confirmed in 66 (72%) and 37 (40%). Forty-three (47%) had no respiratory symptoms. As for radiological findings by chest CT scan, ground-glass opacities (GGO)s, peripheral distribution, bilateral lung involvements were seen in 88 (96%), 76 (83%) and 78 (85%),
respectively. |
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Azizi, A, Achak, et al |
Data in Brief |
Public Health response| Interventions de santé publique |
The EQ-5D instrument is a generic questionnaire developed by the Euroqol group for measuring the HRQoL by combining
five health dimensions (mobility, self-care, usual activities, pain/discomfort, and anxiety/depression) 7]. Herein, we used the EQ-5D-5L instrument to assess for the first time the impact of the home confinement on the HRQoL. Also, we evaluated the changes
in behaviors by asking some questions related to lifestyle before and during the home confinement. These data can help the Moroccan authorities and other countries to more understand the impact of this crisis on citizens and therefore to set up adequate protocols
for managing the post-confinement or possible future crisis. We provided two datasets: (1) data we collected before confinement from a sample of 484 individuals describing their HRQoL and (2) data we collected during the home confinement period from a sample
of 537 individuals describing their HRQoL and behavior-related lifestyle. |
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PMC7471580; Atrioventricular and Sinus Node Dysfunction in Stable COVID-19 Patients |
Babapoor-Farrokhran, S, Batnyam, et al |
SN Compr Clin Med |
Clinical data| Données cliniques |
We report two patients with no known history of cardiac conduction disease who presented with COVID-19 symptoms, positive
SARS-CoV-2 infection, and developed cardiac conduction abnormalities. Cardiac conduction system disease involving the sino-atrial (SA) node and atrioventricular (AV) node could be a manifestation of SARS-CoV-2 infection. |
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Babar, Z, Khan, et al |
J Biomol Struct Dyn |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This study targeted viral macrodomain-I by using drug similarity, virtual screening, docking and re-docking approaches.
A total of 64,043 compounds were screened, and potential hits were identified based on the docking score and interactions with the key residues. The top six hits were subjected to molecular dynamics simulation and Free energy calculations and repeated three
times each. The per-residue energy decomposition analysis reported that these compounds significantly interact with Asp22, Ala38, Asn40, Val44, Phe144, Gly46, Gly47, Leu127, Ser128, Gly130, Ile131, Phe132 and Ala155 which are the critical active site residues.
Here, we also used ADPr as a positive control to compare our results. Our results suggest that our identified hits by using such a complicated computational pipeline could inhibit the SARs-CoV-2 by targeting the macrodomain-1. We strongly recommend the experimental
testing of these compounds, which could rescue the host immune system and could help to contain the disease caused by SARs-CoV-2. |
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Baquero, H, Venegas, et al |
Biomedica |
Clinical data| Données cliniques |
We are reporting three cases of newborns who were attended in the course of the mitigation phase in the emergency service
of a maternal hospital in Barranquilla, Colombia, for high temperature and general compromised condition. During their clinical course, they developed gastrointestinal symptoms without showing any respiratory manifestations. They were not epidemiologically
linked to a contact suspected to be a COVID-19 case and their mothers had had no respiratory symptoms since the public health emergency in our country was declared 45 days before. The absence of clinical respiratory manifestations in this group of patients
with COVID-19 should draw clinicians' attention to the need to suspect SARS CoV-2 infection in febrile newborns. |
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A Romanian survey on the impact of sars-cov-2 pandemic on dystonia patients |
Barbu, MG, Thompson, et al |
Romanian Journal of Legal Medicine |
Healthcare Response | Réponse des soins de santé |
This study aimed to assess the impact of botulinum toxin (BoNT) injection therapy discontinuation on the physical status
and quality of life (QoL) of patients suffering from dystonia. A questionnaire was applied between April 1st and April 15th, 2020 to a group of 50 dystonia patients that met the inclusion criteria for this study. The majority of the respondents (92%) indicated
that their greatest issue during SARS-CoV-2 lockdown was the lack of access to regular BoNT injections. Over 50% of respondents stated that they experienced atypical physical pain, followed by the inability to perform usual activities, with further impact
on the QoL. Alteration of the physical status due to the inability to follow an in-clinic rehabilitation program was also reported by up to 25% of patients. In 10% of patients, dystonia became more severe, and led to further afflictions, with a great impact
on their QoL. Younger dystonia participants registered lower QoL scores than older participants. Furthermore, isolation and income reduction were found to cause a moderate impact on QoL in most patients and may be associated with mild to moderate forms of
depression. |
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Beck, MJ, Hensher, et al |
Journal of Transport Geography |
Public Health response| Interventions de santé publique |
In going from almost no commuting, except for essential workers, to a slow increase in travel activity with working
from home (WFH) continuing to be both popular and preferred, this paper draws on two surveys, one in late March at the height of restrictions and one in late May as restrictions are starting to be partially relaxed, to develop models for WFH and weekly one-way
commuting travel by car and public transport. We compare the findings as one way to inform us of the extent to which a sample of Australian residents have responded through changes in WFH and commuting. While it is early days to claim any sense of a new stable
pattern of commuting activity, this paper sets the context for ongoing monitoring of adjustments in travel activity and WFH, which can inform changes required in the revision of strategic metropolitan transport models as well as more general perspectives on
future transport and land use policy and planning. |
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Becq, A, Jais, et al |
Clinics and Research in Hepatology and Gastroenterology |
Healthcare Response | Réponse des soins de santé |
The objective of this study was to describe the observed number of acts during the 2020 mandatory period of home isolation,
compared to the values in prior years and the expected value for 2020. We performed a multicenter cohort study to investigate the practice of urgent endoscopy acts, outside regular working hours, in Paris and its surrounding suburbs, in the setting of the
COVID-19 pandemic. From March 17th to April 17th (during home isolation), the number of acts was respectively of 147 in 2018, 137 in 2019, and 79 in 2020, lower that the expected number of 142 (-44.0%). In 2020, the number of endoscopies for suspected gastrointestinal
bleeding (GIB), and findings of variceal and non-variceal bleeding decreased by 52.1%, 69.2% and 43.1% respectively, after a month of home isolation. In-hospital death rate were similar. |
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32557489; Impact of the COVID-19 pandemic on gastrointestinal endoscopy activity in France |
Belle, A, Barret, et al |
Endoscopy |
Healthcare Response | Réponse des soins de santé |
We sought to measure the impact of the COVID-19 pandemic on gastrointestinal (GI) endoscopy activity in France. We
performed a web-based survey, including 35 questions on the responders and their endoscopic practice, from 23 March to 27 March 2020, sent to the 3300 French gastroenterologists practicing endoscopy. 694 GI endoscopists (21%) provided analyzable data; of these,
29.4% (204/694) were involved in the management of COVID-19 patients outside the endoscopy department. During the study period, 98.7% (685/694) of endoscopists had had to cancel procedures. There were 89 gastroenterologists (12.8%) who reported symptoms compatible
with COVID-19 infection, and a positive PCR test was recorded in 12/197 (6.1%) vs. 3/497 (0.6%) endoscopists in the high vs. low prevalence areas, respectively (P<0.001). |
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Benito-Pascual, B, Gegúndez, et al |
Ocular immunology and inflammation |
Clinical data| Données cliniques |
A case of unilateral panuveitis and optic neuritis as initial presentation of COVID-19 is described. |
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32867123; Using all-atom potentials to refine rna structure predictions of sars-cov-2
stem loops |
Bergonzo, C, Szakal, et al |
International Journal of Molecular Sciences |
Coronavirology| Coronavirologie |
In this work, we assess the 3D structure of the 5′ untranslated region of its RNA, in the hopes that stable secondary
structures can be targeted, interrupted, or otherwise measured. To this end, we have combined molecular dynamics simulations with previous Nuclear Magnetic Resonance measurements for stem loop 2 of SARS-CoV-1 to refine 3D structure predictions of that stem
loop. We find that relatively short sampling times allow for loop rearrangement from predicted structures determined in absence of water or ions, to structures better aligned with experimental data. We then use molecular dynamics to predict the refined structure
of the transcription regulatory leader sequence (TRS-L) region which includes stem loop 3, and show that arrangement of the loop around exchangeable monovalent potassium can interpret the conformational equilibrium determined by in-cell dimethyl sulfate (DMS)
data. |
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Bernal-Monterde, V, Casas-Deza, et al |
Biomedicines |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We hypothesized that early altered liver biochemistries at admission might have different clinical relevance than subsequent
changes during hospitalization. A single-center retrospective study was conducted on 540 consecutive hospitalized patients, PCR-diagnosed with SARS-CoV-2. By the end of the follow-up period, 502 patients (94.5%) were discharged (109 (20.5%) died). A total
of 319 (64.3%) had at least one abnormal liver test result at admission. More prevalent were elevated AST (40.9%) and GGT (47.3%). Abnormalities were not associated with survival but with respiratory complications at admission. Conversely, LMM models adjusted
for age and sex showed that longitudinal increases during hospitalization in ferritin, GGT, and alkaline phosphatase (ALP), as well as a decreased albumin levels, were associated with reduced survival. This dual pattern of liver damage might reconcile previous
conflicting reports. GGT and ALP trajectories could be useful to determine who might need more surveillance and intensive care. |
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Bhattacharya, Debdutta, Dash, et al |
SSRN- Lancet prepublication |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
The study assessed the feasibility of pooled testing in the high throughput machine of Roche Cobas 6800 rapidly increasing
the testing number for containing the virus spread and management of cases. The Cobas 6800 was able to detect the SARS-COV virus in all the samples, however, the amplified RNA reached the threshold later as the number of negative samples increased in the pool.
We demonstrated strategies for pooling, which improve test efficiency and while maintaining high sensitivity in a high-throughput system. The comparison of 1410 samples tested individually and in pools of five samples/pool showed that test results were not
significantly affected. Implementing the five-sample Dorfman pooling to test 1410 samples, we identified 42 (2.9%) SARS-CoV-2 positive samples, achieving a 3-fold increase in throughput with one-third of the cost. |
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Bi, J, Lin, et al |
Journal of Infection |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aimed to examine the prevalence and clinical characteristics of asymptomatic COVID-19 in cancer patients versus
caregivers with a similar COVID-19 exposure history from the experience of the only cancer hospital in Wuhan, China. A total of 3261 consecutive individuals who visited Hubei Cancer Hospital from March 9, 2020 to April 7, 2020 (comprising 2094 cancer patients
and 1167 caregivers) were required to undergo chest computed tomography (CT) and routine bloodwork as well as viral serum antibodies against SARS-CoV-2 by the colloidal gold immunoassay. In our study, 82(2.5%) asymptomatic SARS-CoV-2 infections were detected
in 3261 individuals who visited Hubei Cancer Hospital, which is higher than the 1.2% asymptomatic COVID-19 cases from the report by the China CDC. |
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Biamonte, F, B |
Research Square prepub |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In the present study, we retrospectively evaluated and integrated laboratory parameters/variables of 45 elderly subjects
from a long-term care facility with Sars-CoV-2 outbreak and spread, to identify potential common patterns of systemic response able to better stratify patients’ clinical course and outcome. Of the 45 patients, 19 were male and 26 were female, with a median
age of 81 years. The overall mortality rate was 26.67%. By PCA and clustering approach we identified 3 laboratory patterns of response, renamed as low-risk, intermediate-risk, and high-risk, strongly associated with patients’ survival (p<0.01). D-dimer, iron
status, lymphocyte/monocyte count represented the main markers discriminating high- and low-risk groups. Furthermore, patients belonging to the high-risk group presented a significantly longer time to ferritin decrease (p:0.047). Iron-to-ferritin-ratio (IFR)
significantly segregated recovered and dead patients in the intermediate-risk group (p:0.012). |
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Middle cerebral artery ischemic stroke and COVID-19: a case report |
Bigliardi, G, Ciolli, et al |
J Neurovirol |
Clinical data| Données cliniques |
We present a clinical case of a patient with SARS-CoV-2 infection and respiratory symptoms, complicated with a pro-thrombotic
state involving multiple vascular territories and concomitant interleukin-6 increase. This case underlines the possibility to develop a COVID-19-related coagulopathy. |
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Bisag, A, Isabelli, et al |
Plasma Processes and Polymers |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) |
One of the major concerns in the COVID-19 pandemic is related to the possible transmission in poorly ventilated spaces
of SARS-CoV-2 through aerosol microdroplets, which can remain in the air for long periods of time and be transmitted to others over distances >1 m. Cold atmospheric pressure plasmas can represent a promising solution, thanks to their ability in producing a
blend of many reactive species, which can inactivate the airborne aerosolized microorganisms. In this study, a dielectric barrier discharge plasma source is used to directly inactivate suitably produced bioaerosols containing Staphylococcus epidermidis or
purified SARS-CoV-2 RNA flowing through it. Results show that for low residence times (<0.2 s) in the plasma region a 3.7 log R on bacterial bioaerosol and degradation of viral RNA can be achieved. © 2020 Wiley-VCH GmbH |
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Bolsover, G |
ArXiv |
Public Health response| Interventions de santé publique |
This project collected a sample of data from all trending topics within the US between 25 May and 31 May, 2020. This
period therefore captures the initial reaction, |
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Infectious diseases, market uncertainty and oil market volatility |
Bouri, E, Demirer, et al |
Energies |
Economics | Économie |
We examine the predictive power of a daily newspaper-based index of uncertainty associated with infectious diseases
(EMVID) for oil-market volatility. Using the heterogeneous autoregressive realized volatility (HAR-RV) model, we document a positive effect of the EMVID index on the realized volatility of crude oil prices at the highest level of statistical significance,
within-sample. Importantly, we show that incorporating EMVID into a forecasting setting significantly improves the forecast accuracy of oil realized volatility at short-, medium-, and long-run horizons. Our findings comprise important implications for investors
and risk managers during the unprecedented episode of high uncertainty resulting from the COVID-19 pandemic. © 2020 by the authors. |
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Oral lesions in patients with SARS-CoV-2 infection: could the oral cavity be a
target organ? |
Brandão, TB, Gueiros, et al |
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology |
Clinical data| Données cliniques |
Here, we report a series of 8 cases of COVID-19 infection, with oral necrotic ulcers and aphthous-like ulcerations
which developed early in the course of disease after the development of dysgeusia and affected the tongue, lips, palate, and oropharynx. A short review of the literature regarding the important role of ACE2 in SARS-CoV-2 cellular entry is also provided, bringing
new insights into oral keratinocytes and minor salivary glands as potential targets. |
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A coronavirus disease 2019 (COVID-19) patient with bilateral orchitis: A case report |
Bridwell, RE, Merrill, et al |
American Journal of Emergency Medicine |
Clinical data| Données cliniques |
We describe a novel case of SARS-CoV2 bilateral orchitis in a previously healthy 37-year-old male who presented for
testicular pain with constitutional symptoms. Additionally, there was no epididymitis associated with the bilateral orchitis. Based on both data in SARS-CoV2 infected males and previous data from prior SARS infections, spermatocyte function may be compromised
secondary to this infection. With the various symptoms associated with this virulent pathogen, we characterize the potential complications and importance of fertility follow up. |
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Brown, MEL, Crampton, et al |
Educ Prim Care |
Public Health response| Interventions de santé publique |
In 2019-20, the Hull York Medical School ran a pilot Longitudinal integrated clerkships (LIC) for 6 fourth-year medical
students. This work describes the longitudinal qualitative programme evaluation. LIC students participated in two focus groups, one after four months, and another at the end of the programme. In total, 16 faculty were also interviewed regarding their experiences
in developing, implementing and running the LIC. Students' GP supervisors were difficult to engage in detailed evaluation due to the COVID-19 pandemic, and so were briefly surveyed at the end of the LIC. |
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Buonsenso, D, Lazzareschi, et al |
J Clin Rheumatol |
Clinical data| Données cliniques |
This case report describes a 14-year old boy with Aicardi syndrome due to fever for 5 days. He was diagnosed with pediatric
multisystem inflammatory syndrome related to SARS-CoV-2. |
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Busani, S, Dall’Ara, et al |
Therapeutic Advances in Respiratory Disease |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
We here report five cases of critically ill COVID-19 patients undergoing exogenous surfactant instillation though the
airways. |
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C, S, S, et al |
J Biomol Struct Dyn |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The study aims to evaluate the potency of two hundred natural antiviral phytocompounds against the active site of the
SARS-CoV-2 Main-Protease (M(pro)) using AutoDock 4.2.6. The compounds theaflavin-3-3'-digallate, rutin, hypericin, robustaflavone, and (-)-solenolide A with respective binding energy of -12.41 (Ki = 794.96 pM); -11.33 (Ki = 4.98 nM); -11.17 (Ki = 6.54 nM);
-10.92 (Ki = 9.85 nM); and -10.82 kcal/mol (Ki = 11.88 nM) were ranked top as COVID-19 M(pro) inhibitors. The interacting amino acid residues were visualized using Discovery Studio 3.5 to elucidate the 2-dimensional and 3-dimensional interactions. The study
was validated by i) re-docking the N3-peptide inhibitor-M(pro) and superimposing them onto co-crystallized complex and ii) docking decoy ligands to M(pro). The ligands that showed low binding energy were further predicted for and pharmacokinetic properties
and Lipinski's rule of 5 and the results are tabulated and discussed. Molecular dynamics simulations were performed for 50 ns for those compounds using the Desmond package, Schrödinger to assess the conformational stability and fluctuations of protein-ligand
complexes during the simulation. |
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Camacho-Rivera, M, Islam, et al |
Health Equity |
Public Health response| Interventions de santé publique |
We utilized data from a sample of 2190 U.S. adults from the COVID-19 Impact Survey to examine associations between
the presence of underlying chronic health conditions and COVID-19-related preventive behaviors (e.g., use of face masks, hand washing, social distancing, etc.). Adults with cardiometabolic disease were more likely to report staying home because they felt unwell,
compared with individuals without cardiometabolic disease. Individuals with underlying respiratory conditions were more likely to work from home, compared with individuals without a respiratory condition. Adults with immune conditions were twice more likely
to report wearing a face mask when compared with individuals without immune conditions. |
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Social capital and perceived stress related to coronavirus disease in Colombia |
Campo-Arias, A, Perdomo-Rojas, et al |
J Epidemiol Community Health |
Public Health response| Interventions de santé publique |
An online cross-sectional study was carried out with the participation of adults residing in Colombia. A total of 700
adults answered the questionnaire, in ages between 18 and 76 years (mean =37.1, SD =12.7), 68% female, 52% without a permanent partner, 60% reside in low or medium socioeconomic status (Colombian classification of six status) and 90% with higher education
(college or more). Also, 24.0% (n=168) participants scored low social capital and 7.6% (n=53) reported high perceived stress related to COVID-19. Low social capital was associated with high perceived stress related to COVID-19, crude (OR 2.23, 95% CI 1.25
to 2.99) and adjusted for age, gender and working in the health sector (OR 1.99, 95% CI 1.10 to 3.61). |
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Cancello, R, Soranna, et al |
International Journal of Environmental Research and Public Health |
Public Health response| Interventions de santé publique |
We conducted a self-reported survey in northern Italy to observe the lockdown effects on lifestyle changes and to assess
their determinants. 490 adults (84% female) completed the survey: 13% and 43% reported improved and unchanged sleep quality, respectively, while 43% had insomnia symptoms. Among the 272 active subjects in pre-lockdown, 14% continued habitual exercising, 18%
increased it and 68% reduced it; 27% of sedentary subjects started physical exercise; 34% reported an improvement in diet quality; 42% increased food intake and 13% decreased it; and 38% of the smokers increased cigarette consumption. Age and the pre-lockdown
habit of regular physical exercising were the mainly determinants of lifestyle changes whereas BMI, gender, and the presence of chronic diseases did not. Living with other people increased the likelihood of increasing the food intake (p = 0.002). |
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Cañizares Fuentes, R, Aroca, et al |
Disaster Med Public Health Prep |
Epidemiology| Épidémiologie Surveillance |
This study aimed to evaluate the relevance of the COVID 19 positive case detection policy or model implemented by the
Ministry of Public Health (MPH) of Ecuador and to compare it with the experiences of other countries. The probability of detecting positive cases of COVID-19 in Ecuador was higher than Iceland and South Korea, since the diagnostic tests were aimed at symptomatic
patients, without identifying asymptomatic or mild symptomatic, who play an important role in the transmission of the disease. In addition, many symptomatic patients were examined but will remain undiagnosed due to the unavailability of tests and the low quality
of many of them. |
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Cao, J, Zheng, et al |
Theranostics |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We investigated whether myocardial injury occurred in COVID-19 patients and assessed the performance of serum high-sensitivity
cardiac Troponin I (hs-cTnI) levels in predicting disease severity and 30-day in-hospital fatality. We included 244 COVID-19 patients, who were admitted to Renmin Hospital of Wuhan University with no preexisting cardiovascular disease or renal dysfunction.
In this retrospective observational study, 11% of COVID-19 patients had increased hs-cTnI levels (>40 ng/L) on admission. Of note, serum hs-cTnI levels were positively associated with the severity of medical conditions (median interquartile range (IQR)]: 6.00
6.00-6.00] ng/L in 91 patients with moderate conditions, 6.00 6.00-18.00] ng/L in 107 patients with severe conditions, and 11.00 6.00-56.75] ng/L in 46 patients with critical conditions, P for trend=0.001). Besides empirical prognostic factors, serum hs-cTnI
levels upon admission provided independent prediction to both the severity of the medical condition and 30-day in-hospital fatality. These findings may shed important light on the clinical management of COVID-19. |
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32870738; Ocular Features and Associated Systemic Findings in SARS-CoV-2 Infection |
Cavalleri, M, Brambati, et al |
Ocular immunology and inflammation |
Clinical data| Données cliniques |
This study aimed to describe the prevalence of ocular features among COVID-19 patients and their relationship with
clinical data, inflammatory markers and respiratory support therapy (including CPAP); to investigate SARS-CoV-2 in ocular secretions of symptomatic patients. 172 COVID-19 patients were evaluated for presence of ocular manifestations. Forty-five patients (26.2%)
reported ocular manifestations. Patients treated with CPAP were more likely to have ocular abnormalities (p <.01). The presence of ocular symptoms was not associated with more significant alterations on blood tests. Conjunctival swabs from patients with suspect
conjunctivitis yielded negative results for SARS-CoV-2. |
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Cerulli Irelli, E, Orlando, et al |
Journal of the neurological sciences |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
This study aimed to investigate if enhanced hygienic measures, including the systematic use of personal protective
equipment (PPE), determined a decrease in hospital-acquired infections (HAI) during the recent COVID-19 outbreak in “COVID-free” neurological units. Patients hospitalized in neurology and stroke units of Policlinico Umberto I Hospital in Rome from March 8,
2020 and discharged prior to May 31, 2020 were included in the study and compared with patients hospitalized during the same period in 2019. A total of 319 patients were included in the study (n = 103 in 2020, n = 216 in 2019). Among patients hospitalized
in 2019, the incidence of HAIs was 31.5% (95% CI: 0.25–0.38), compared with 23.3% (95% CI: 0.15–0.32) in 2020 (p = 0.12). Multivariable logistic regression showed that hospitalization during 2020 was independently associated with a lower risk of HAIs (OR:
0.34, 95% CI:0.16–0.71, p = 0.004). Poisson regression models showed that hospitalization during 2020 was also independently associated with both a lower number of HAIs (relative risk RR]: 0.56, 95% CI:0.38–0.81, p = 0.01) and a lower number of prescribed
antibiotics per patient (RR: 0.66, 95% CI: 0.49–0.87, p = 0.02). |
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Chachkhiani, D, Soliman, et al |
Clinical neurology and neurosurgery |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We reviewed the electronic medical records (EMR) of patients hospitalized during the peak of the pandemic, March 1st
through March 31st, to document the type and frequency of neurological problems seen in patients with COVID-19 at presentation to the emergency room. A large proportion of our sample (80 %) was African American and had hypertension (79 %). Out of 250 patients,
56 (22 %) patients died, and 72 (29 %) patients required intubation. Thirty-four (14 %) had a neurological chief complaint at presentation; the most common neurological chief complaints in the entire sample were altered mental status (AMS) (8 %), headache
(2 %), and syncope (2 %). We used a competing risk model to determine whether neurological symptoms at presentation or during hospital stay were predictors of prolonged hospital stay and death. Age was the only significant demographic predictor of death and
hospital stay. Neurological complaints at presentation and during the hospital stay are associated with a higher risk of death, prolonged hospital stay, and intubation. More work is needed to determine whether the cause of the neurological complaints was direct
CNS involvement by the virus or the other systemic complications of the virus. |
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Chae, SY, Lee, et al |
Frontiers in Physics |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
We estimated the infection rate and the initial individuals infected with COVID-19 by using officially reported data
from the early stages of the epidemic for a model of susceptible (S), infectible (I), quarantined (Q), and officially confirmed recovered (Rk) populations (the so-called SIQRk model). In the officially reported data, we know the number of quarantined cases
and the officially reported number of recovered cases. We cannot know about recovered cases from asymptomatic patients. In the SIQRk model, we can estimate the parameters and the initial infections (confirmed cases + asymptomatic cases) from fitted values.
We obtained an infection rate in the range β = 0.233 ~ 0.462, a basic reproduction number of Ro = 1.8 ~ 3.5, and the initial number of infected individuals, I (0) = 10 ~ 8409, for selected countries. By using fitting parameters, we estimated that the maximum
time span of the infection was around 50 days in Germany when the government invoked the quarantine policy. The disease is expected to subside about 6 months after the first patients are found. |
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Silent hypoxia: a frequently overlooked clinical entity in patients with COVID-19 |
Chandra, A, Chakraborty, et al |
BMJ Case Rep |
Clinical data| Données cliniques |
We present a case of a 56-year-old man with COVID-19 who presented to the fever clinic of our institution with fever
and cough without any respiratory distress but low oxygen saturation. The patient deteriorated over the next 2 days but eventually recovered of his illness in due course of time. This case demonstrates 'silent hypoxia' as a possible presentation in COVID-19
and emphasises the importance of meticulous clinical examination including oxygen saturation measurements in suspected or confirmed patients. |
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Chandra, TB, Verma, et al |
Expert Systems with Applications |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
The study reveals that infected patients exhibit distinct radiographic visual characteristics along with fever, dry
cough, fatigue, dyspnea, etc. Chest X-Ray (CXR) is one of the important, non-invasive clinical adjuncts that play an essential role in the detection of such visual responses associated with SARS-COV-2 infection. In this study, we present an automatic COVID
screening (ACoS) system that uses radiomic texture descriptors extracted from CXR images to identify the normal, suspected, and nCOVID-19 infected patients. The proposed system uses two-phase classification approach (normal vs. abnormal and nCOVID-19 vs. pneumonia)
using majority vote based classifier ensemble of five benchmark supervised classification algorithms. The training-testing and validation of the ACoS system are performed using 2088 (696 normal, 696 pneumonia and 696 nCOVID-19) and 258 (86 images of each category)
CXR images, respectively. The obtained validation results for phase-I (accuracy (ACC) = 98.062%, area under curve (AUC) = 0.956) and phase-II (ACC = 91.329% and AUC = 0.831) show the promising performance of the proposed system. Further, the Friedman post-hoc
multiple comparisons and z-test statistics reveals that the results of ACoS system are statistically significant. |
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Liquid-liquid phase separation by SARS-CoV-2 nucleocapsid protein and RNA |
Chen, H, Cui, et al |
Cell Res |
Coronavirology| Coronavirologie |
The exact molecular mechanism by which N protein packs up the viral genome still remains elusive. We hypothesized that
N protein may also undergo LLPS with viral genome RNA and potentially facilitate viral assembly. To test this hypothesis, we directly mixed the Alexa-488-labeled recombinant full-length N protein (488-N) with 20-nt single strand RNA (ssRNA; A20). We revealed
that N protein and RNA underwent LLPS. The LLPS is dependent on the length and concentration of ssRNA. N protein forms typical sphere-like droplets with short ssRNAs, but solid-like structures with long ssRNAs. We further identified that the LLPS could be
enhanced by Zn2+. Our findings suggest that N protein/RNA LLPS may be essential for SARS-CoV-2 viral assembly, which may shed light on developing intervention strategies to prevent COVID-19 pandemic by disrupting the LLPS and viral assembly. |
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Chen, J, Ye, et al |
BioMed Research International |
Clinical data| Données cliniques |
We retrospectively analyzed the clinical characteristics of 62 patients who died from COVID-19 at the Central Hospital
of Wuhan between January 26 and February 17, 2020. Of the 62 patients with COVID-19, 41 (66%) patients were male, and 21 (34%) were female. The median age was 72 years (interquartile range (IQR), 54-88), and 45 (72.5%) patients had preexisting conditions.
The median time from symptom onset to the first visit at the clinic was three days, while the median time from symptom onset to death was 18.5 days. During disease progression, the amounts of arterial gases worsened, and liver, renal, and heart dysfunction
was observed. Due to the cytokine storm, infection-related biomarkers, including lactic acid, C-reactive protein, and interleukine-6, gradually worsened during hospitalization. |
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Chen, L, Feng, et al |
ESC Heart Fail |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aims to describe electrocardiographic (ECG) characteristics of COVID-19 patients and to identify ECG parameters
that are associated with cardiac involvement. The study included patients who were hospitalized with COVID-19 diagnosis and had cardiac biomarker assessments and simultaneous 12-lead surface ECGs. Sixty-three hospitalized patients (median 53 inter-quartile
range, 43-65] years, 76.2% male) were enrolled, including patients with (n = 23) and without (n = 40) cardiac injury. Patients with cardiac injury were older, had more pre-existing co-morbidities, and had higher mortality than those without cardiac injury.
They also had prolonged QTc intervals and more T wave changes. Logistic regression model identified that the number of abnormal T waves (OR), 2.36 95% CI, 1.38-4.04], P = 0.002) and QTc interval (OR, 1.31 95% CI, 1.03-1.66], P = 0.027) were independent indicators
for cardiac injury. The combination model of these two parameters along with age could well discriminate cardiac injury (area the under curve 0.881, P < 0.001) by receiver operating characteristic analysis. Cox regression model identified that the presence
of T wave changes was an independent predictor of mortality (hazard ratio, 3.57 1.40, 9.11], P = 0.008) after adjustment for age. |
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32867425; Typical case analysis of COVID-19 cluster epidemic in Shaanxi,
2020 |
Chen, S, Zhang, et al |
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi |
Epidemiology| Épidémiologie Transmission |
In this study, the transmission patterns of 4 out of the 51 COVID-19 cluster cases in Shaanxi province were analyzed
to provide evidences for the COVID-19 control and prevention. Transmission chain was drawn and the transmission process was analyzed. Cluster case 1 contained 13 cases and was caused by a family of 5 who traveled by car to Wuhan and returned to Shaanxi. Cluster
case 2 had 5 cases and caused by initial patient who participated family get-together right after back from Wuhan while under incubation period. Cluster case 3 contained 10 cases and could be defined as nosocomial infection. Cluster case 4 contained 4 cases
and occurred in work place. |
|
Chen, W, Yuan, et al |
Engineering |
Clinical data| Données cliniques |
In order to investigate the potential risk of SARS-CoV-2 vertical transmission, we explored ACE2 and TMPRSS2 (encoding
transmembrane protease serine 2) expression patterns in peri-implantation embryos and the maternal–fetal interface using previously published single-cell transcriptome data. The results showed that day 6 (D6) trophectoderm cells (TE) in peri-implantation embryos,
as well as syncytiotrophoblast (STB) at 8 weeks of gestation (STB_8W) and extravillous trophoblasts cells (EVT) at 24 weeks of gestation (EVT_24W) in the maternal–fetal interface, strongly co-expressed ACE2 and TMPRSS2, indicating a SARS-CoV-2 infection susceptibility.
The ACE2 positive-expressing cells in the three cell types mentioned above were found to share common characteristics, which were involved in autophagy and immune-related processes. ACE2 showed no gender bias in post-implantation embryos but showed a significant
gender difference in D6_TE, D6 primitive endoderm cells (PE), and ACE2 positive-expressing STBs. These findings suggest that there may be different SARS-CoV-2 infection susceptibilities of D6 embryos of different genders and during the gestation of different
genders. Our results reveal potential SARS-CoV-2 infection risks during embryo transfer, peri-implantation embryo development, and gestation. |
|
|
Cheng, X, Liu, et al |
Cell Metabolism |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this study, we retrospectively enrolled 15,451 confirmed COVID-19 cases that were admitted among 16 hospitals from
Hubei Province, China, among which 2,563 individuals had pre-existing type 2 diabetes (T2D), to investigate the relationship between in-hospital use of metformin and the clinical outcomes in those individuals with COVID-19 and pre-existing T2D. Our findings
indicate that metformin use is associated with increased incidence of acidosis, but not 28-day all-cause mortality, in individuals with COVID-19 and pre-existing T2D. Furthermore, metformin use was significantly associated with reduced heart failure as well
as an inflammatory response. |
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Chi, X, Becker, et al |
Frontiers in Psychiatry |
Public Health response| Interventions de santé publique |
This study aimed to investigate the prevalence and risk factors for poor mental health of Chinese university students
during the Corona Virus Disease 2019 (COVID-19) pandemic. Of 2,500 invited Chinese university students, 2,038 completed the survey. Prevalence of clinically-relevant PTSD, anxiety, and depressive symptoms, and post traumatic growth (PTG) was 30.8, 15.5, 23.3,
and 66.9% respectively. Older age, knowing people who had been isolated, more ACEs, higher level of anxious attachment, and lower level of resilience all predicted primary outcome (all p < 0.01). |
|
|
Choi, S, Ki, et al |
Epidemiol Health |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
This study aimed to estimate the reproductive numbers(R) for each epidemic stage to analyze the effects of the preventive
measures and to predict the COVID-19 transmission trends. We estimated the transmission rates for each epidemic stage by fitting a COVID-19 transmission model, based on a deterministic mathematical model, to the data on confirmed cases. The value of R was
3.53 from February-18 to February-28, and the mean R reduced to 0.45 from March-14 to April-30, but it significantly increased to 2.69 from April-30 to May-13 and it was maintained at 1.03 from May-14 to July-23. |
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Chong, WH, Saha, et al |
American Journal of the Medical Sciences |
Clinical data| Données cliniques |
Case report of a 37 year old male with COVID-19 associated with Rhabdomyolysis and Acute Kidney Injury |
|
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Experiential Education during the COVID-19 Pandemic: A Reflective Process |
Christian, DD, McCarty, et al |
Journal of Constructivist Psychology |
Public Health response| Interventions de santé publique |
This article describes experiential education and outlines how educators can use a model that integrates the adventure
wave and experiential learning cycle to guide online instruction. The proposed model is useful for enhancing the learning process and promoting wellbeing by providing students the needed time to construct new knowledge about course content within the context
of the pandemic. Case examples demonstrating the application of experiential education using the proposed model in a counseling theories course and basic skills course are included. Emphasis is placed on ensuring student welfare so that learning can continue
during the disruption of COVID-19. |
|
Online learning readiness among university students in Malaysia amidst Covid-19 |
Chung, E, Subramaniam, et al |
Asian Journal of University Education |
Public Health response| Interventions de santé publique |
This paper sets out to examine online learning readiness among university students who have been thrown in at the deep
end. It aims to investigate if demographic factors make any difference in their readiness to learn, online learning experiences and intention to continue using online learning. It also examines their preferred methods of online learning and challenges they
face. Data collected from 399 students in two different online learning courses in Malaysia showed that respondents are generally ready for online learning. However, females are found to be more ready than male, degree students are more ready than diploma
students while female students and degree students are more satisfied with online learning and have better learning experiences compared to male and diploma students. More than half of the respondents indicated that if given a choice, they do not want to continue
with online learning in the future. Most respondents preferred online learning via pre-recorded lectures uploaded to Google Classroom and YouTube. |
|
Cipolat, MM, Sprinz, et al |
Brazilian Journal of Infectious Diseases |
Clinical data| Données cliniques |
Case report of a 63 year old female with HIV and hospitalized due to COVID-19 |
|
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Clouser, K, Baer, et al |
Pediatr Infect Dis J |
Clinical data| Données cliniques |
Case report of an 11 year old female with COVID-19 and diagnosed with MIS-C |
|
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Collado, S, Arenas, et al |
Kidney Blood Press Res |
Clinical data| Données cliniques |
Here we present 7 patients with grade 4-5 CKD who developed symptomatic COVID-19. |
|
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Colnago, LA, Trevisol, et al |
Int J Environ Res Public Health |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) |
We are proposing simple, easy to prepare, low-cost and efficient antiviral films, made with a widely available dishwashing
detergent, which can be spread on hands and inanimate surfaces and is expected to maintain virucidal activity for longer periods than the current sanitizers. Avian coronavirus (ACoV) was used as model of the challenge to test the antivirus efficacy of the
proposed films. Polystyrene petri dishes were covered with a thin layer of detergent formula. After drying, the films were exposed to different virus doses for 10 min and virus infectivity was determined using embryonated chicken eggs, and RNA virus quantification
in allantoic fluids by RT-qPCR. The films inactivated the ACoV (ranging from 10(3.7) to 10(6.7) EID(50)), which is chemically and morphologically similar to SARS-CoV-2, and may constitute an excellent alternative to minimize the spread of COVID-19. |
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Cook, J, Newberger, et al |
Economics Letters |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique
Public Health response| Interventions de santé publique |
We analyze multiple datasets constructed from cellphone location data and find that social distancing is affected by
the policies of neighboring counties. People may infer that there is less risk in an area from the policies of neighboring counties or the actions of residents in neighboring counties. A stay-at-home order in a neighboring county reduces social distancing
by more than half as much as implementing an order in that county. This implies that, to increase social distancing in hard-hit counties, stay-at-home orders need to be implemented in a regionally or federally coordinated response. We also find that estimates
of the efficacy of stay-at-home orders that do not control for policies in neighboring counties overstate the effect of these orders by about 50%. |
|
|
Coppola, S, Ciabattoni, et al |
British journal of anaesthesia |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Herein, we report data from 53 COVID-19 patients admitted to the ICU and on mechanical ventilation in a single-centre
study with a median age of 57 (9) yr. Among these, 26 (49%) received empiric antibiotic therapy upon hospital admission. As recommended for patients with community-acquired pneumonia,7 empirical therapy comprised ceftriaxone plus a macrolide or levofloxacin
(in 17 patients, 32%), but also piperacillin-tazobactam, oxacillin, and linezolid (in nine patients, 16%). Moreover, 43 (81%) received steroids, 18 (34%) hydroxychloroquine, and three (6%) humanized monoclonal antibody against the interleukin-6 receptor. Routine
tracheal surveillance cultures were obtained after a median of 2 days from tracheal intubation. Among 53 tracheal aspirates, 16 (30%) were positive and 37 (70%) negative. The causative pathogens most commonly found were Staphylococcus aureus, Streptococcus
pneumoniae, and Haemophilus influenzae; in five cases, Pseudomonas aeruginosa and Acinetobacter baumannii were identified. |
|
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Athletes and adversities: athletic identity and emotional regulation in time of
COVID-19 |
Costa, S, Santi, et al |
Sport Sciences for Health |
Public Health response| Interventions de santé publique |
Objectives: The objectives of our investigation were to: (a) validate the athletic identity measurement scale (AIMS)
for use in Italian language; and (b) explore differences by gender, typology of sport (individual vs. team), and competitive level (elite vs. non-elite) in athletic identity and in cognitive emotion regulation during the Covid-19 lockdown period. Methods:
To achieve these objectives, the reliability and construct validity of the Italian version of the AIMS have been tested in Study 1. Multivariate and univariate analyses were run to evaluate differences between different groups of athletes in Study 2. Results:
Results from Study 1 suggest a 3-factor higher order model of athletic identity. Results from Study 2 highlight that, during this lockdown period, elite athletes and team sports athletes show higher athletic identity. Cognitive emotion regulation strategies
are different for gender and for competitive level. Finally, athletes with higher athletic identity tend to ruminate and catastrophize more. |
|
Costanzo, L, Failla, et al |
Acta Phlebologica |
Clinical data| Données cliniques |
Autoptic analysis in deaths fore severe COVID-19 disease revealed fibrin exudation in alveoli, blood vessel wall edema
and hyaline thrombi in small vessels in other organs and tissues. Heparin is an anticoagulant molecule that also showed anti-inflammatory properties and a potential antiviral effect. The use of low molecular weight heparin could prevent thromboembolic complications
in COVID-19 pneumopathy. However, the correct timing of prophylaxis according to the stage of COVID-19 disease and the appropriate therapeutic dosage to use in severe cases need further research. |
|
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Crone, MA, Priestman, et al |
Nat Commun |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Here, we present a reagent-agnostic automated SARS-CoV-2 testing platform that can be quickly deployed and scaled.
Using an in-house-generated, open-source, MS2-virus-like particle (VLP) SARS-CoV-2 standard, we validate RNA extraction and RT-qPCR workflows as well as two detection assays based on CRISPR-Cas13a and RT-loop-mediated isothermal amplification (RT-LAMP). In
collaboration with an NHS diagnostic testing lab, we report the performance of the overall workflow and detection of SARS-CoV-2 in patient samples using RT-qPCR, CRISPR-Cas13a, and RT-LAMP. The validated RNA extraction and RT-qPCR platform has been installed
in NHS diagnostic labs, increasing testing capacity by 1000 samples per day. |
|
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PMC7471856; A case of corticosteroid-responsive SARS-CoV-2 related massive rhabdomyolysis |
Cunha, M, Pinho, et al |
IDCases |
Clinical data| Données cliniques |
Case report of a 46 year old female with breast cancer and is positive for COVID-19 |
|
Cause for concerns: gender inequality in experiencing the COVID-19 lockdown
in Germany |
Czymara, CS, Langenkamp, et al |
European Societies |
Public Health response| Interventions de santé publique |
Using topic modeling on over 1,100 open reports from a survey fielded during the first four weeks of the lockdown in
Germany, we shed light on how personal experiences of the lockdown differ between women and men. Our results show that, in general, people were most concerned about social contacts and childcare. However, we find clear differences among genders: women worried
more about childcare while men were more concerned about paid work and the economy. We argue that the COVID-19 pandemic is affecting women more heavily than men not only at the physical level of work (e.g. women are reducing more paid work hours than men),
but also through increasing the division regarding the cognitive level of work (e.g. women are more worried about childcare work while men are about paid work). |
|
COVID-19 in a patient with advanced Merkel cell carcinoma receiving immunotherapy |
da Costa, CM, de Souza, et al |
Immunotherapy |
Clinical data| Données cliniques |
Case report of a 66 year old male with with a metastatic Merkel cell carcinoma and is positive for COVID-19 |
|
Spatial Bayesian Hierarchical Modelling with Integrated Nested Laplace Approximation |
D'Angelo, N, Abbruzzo, et al |
ArXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
We report the study of two spatial datasets, referring both to the continuous and discrete domain models, according
to the nature of data. The dataset analysed in this section refers to the number of people infected by the Covid-19 in the 47 Northern Italian provinces from February 24th to April 26th, 2020. The aim of this application is to investigate the incidence of
the cases. The results confirms that, while before the lock-down the spread of the Covid-19 could be attributable to the spatial displacement of provinces, the same conclusion does not hold after the lock-down, since from that time, the number of people moving
among provinces has largely |
|
Dansana, D, Kumar, et al |
Soft Computing |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
In this study, convolution neural networks method is used for binary classification pneumonia-based conversion of VGG-19,
Inception_V2 and decision tree model on X-ray and CT scan images dataset, which contains 360 images. It can infer that fine-tuned version VGG-19, Inception_V2 and decision tree model show highly satisfactory performance with a rate of increase in training
and validation accuracy (91%) other than Inception_V2 (78%) and decision tree (60%) models. |
|
|
Davido, B, Boussaid, et al |
International journal of antimicrobial agents |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
Methods: Single center, retrospective study in adults hospitalized in a medicine ward for COVID-19 from March 5th to
April 25th 2020. Patient characteristics were compared between two periods (before/after March 19th) considering French guidelines. The aim of the study was to evaluate how medical care impacted unfavorable outcome, namely admission to intensive care unit
(ICU) and/or death. Results: There was a significant decrease in ICU admission, from 43% to 12%, between the two periods. Delays until transfer to ICU were similar between periods. Pulmonary computerized tomography (CT)-scans were performed significantly more
often with time, and oxygen-dependency and prescription of AZI±HCQ were also greater over time. Multivariate analyses showed a reduction of unfavorable outcome in patients receiving AZI±HCQ |
|
|
de la Portilla de Juan, F, Reyes Díaz, et al |
Cirugia Espanola |
Healthcare Response | Réponse des soins de santé |
We conducted a survey in colorectal surgery units to assess the impact on colorectal cancer surgery waiting lists.
Method: All personnel in charge of colorectal surgery units nationwide received a survey (from February to April, 2020) with eight questions divided into three sections—cessation date of colorectal cancer surgeries, number of patients waiting for treatment,
and use of neoadjuvant therapy to postpone surgery. Results: Sixty-seven units participated in the study, with 79.1% of units ceasing some type of activity (32.8% total and 46.3% partial cessation) and 20.9% continuing all surgical activity. In addition, 65%
of units used or prolonged neoadjuvant therapy in rectal cancer patients and 40% of units performed at least five emergency colorectal cancer surgeries. It was estimated that at least one month of intense surgical activity will be required to catch up. |
|
|
de Lusignan, S, Joy, et al |
Journal of Infection |
Epidemiology| Épidémiologie |
We report the absolute excess risk (AER) of mortality and excess mortality rate (EMR) from a nationally representative
COVID-19 sentinel surveillance network including known COVID-19 risk factors in people aged 45 years and above. Methods: Pseudonymised, coded clinical data were uploaded from contributing primary care providers (N = 1,970,314, ≥45years). We calculated the
AER in mortality by comparing mortality for weeks 2 to 20 this year with mortality data from the Office for National Statistics (ONS) from 2018 for the same weeks. Results: The AER of mortality was 197.8/10,000 person years. The EMR for male gender, compared
with female, was 1.4 ; for our oldest age band (≥75 years) 10.09 compared to 45–64 year olds; Black ethnicity's EMR was 1.17, reference white; and for dwellings with ≥9 occupants 8.01. Presence of all included comorbidities significantly increased EMR. Ranked
from lowest to highest these were: hypertension, chronic kidney disease, chronic respiratory and heart disease, and cancer or immunocompromised. Conclusions: The absolute excess mortality was approximately 2 deaths per 100 person years in the first wave of
COVID-19. |
|
|
De Rossi, N, Scarpazza, et al |
EClinicalMedicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
Methods: A retrospective cohort study at the Montichiari Hospital, Brescia, Italy, was conducted. We included consecutive
patients with COVID-19 related pneumonia at the early stage of respiratory failure, all treated with a standard protocol (hydroxychloroquine 400 mg daily, lopinavir 800 mg plus ritonavir 200 mg per day). We compared survival rate and clinical status in a cohort
of patients who received additional treatment with tocilizumab once (either 400 mg intravenous or 324 mg subcutaneous) with a retrospective cohort of patients who did not receive tocilizumab (referred to as the standard treatment group). All outcomes were
assessed at the end of the follow-up, that correspond to death or complete recovery and discharge from the hospital. Findings: 158 patients were included, 90 of which received tocilizumab. 34 out of 68 (50%) patients in the standard treatment group and 7 out
of 90 (7.7%) in the tocilizumab group died. Tocilizumab significantly improved survival compared to standard care. No differences between the two administration routes of tocilizumab were observed. No tocilizumab-related infections and/or side effects were
observed. |
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|
de Ruijter, NS, Kramer, et al |
Multiple Sclerosis and Related Disorders |
Clinical data| Données cliniques |
Case report of a 15 year old male with COVID-19 presenting with subacute visual los. |
|
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32473193; Single cell RNA sequencing analysis did not predict hepatocyte infection
by SARS-CoV-2 |
De Smet, V, Verhulst, et al |
Journal of hepatology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We analyzed 3 publicly available human liver datasets published by Aizarani et al.,7 Macparland et al.8 and Ramachandran
et al.9 The latter includes cirrhotic livers from patients undergoing orthotopic liver transplantation, caused by non-alcoholic liver disease, alcohol-related liver disease and primary biliary cholangitis. Using these 3 datasets, we verified ACE2 and TMPRSS2
expression in healthy and diseased human livers, In conclusion, scRNAseq analyis does not point towards hepatocytes as a likely point of entry for SARS-CoV-2 infection. Cholangiocytes are among the highest expressors of ACE2 in all datasets, which is in line
with previous scRNAseq reports. The low expression of ACE2 seen in this data presumably represents technical limitations of the scRNAseq technique, rather than an absolute absence of ACE2 in these cells, leading to an underestimation of ACE2 expressing hepatocytes. |
|
Dell’Era, V, Dosdegani, et al |
Journal of International Medical Research |
Clinical data| Données cliniques |
We herein present the data of 30 patients with COVID-19 who developed spontaneous epistaxis while hospitalized at Eastern
Piedmont Hospital during March and April 2020. All patients received low-molecular-weight heparin during their hospital stay and required supplementary oxygen therapy either by a nasal cannula or continuous positive airway pressure. Both conditions can represent
risk factors for developing epistaxis. Prevention of crust formation in patients with rhinitis using a nasal lubricant should be recommended. |
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d'Ettorre, G, Recchia, et al |
Medicine (Baltimore) |
Clinical data| Données cliniques |
Case report of the 52 year old female with coinfection of COID-19 and HIV. |
|
|
Dhillon, MS, Kumar, et al |
Indian Journal of Orthopaedics |
Healthcare Response | Réponse des soins de santé |
To see if there was significant change in the pattern and management of trauma in our region, we evaluated data from
our centre for the lockdown period and compared it with data from the previous year, and also with some available international data. Methods: We collated data from our Tertiary care hospital for two periods, i.e. from 25th March 2020 to 3rd May 2020 signifying
strict lockdown and then from 4th May to 31st May during which some conditional relaxations were given. This was compared to data from similar periods in 2019. Results: Significant reductions in caseloads were noted; open injuries were less, road accidents
were infrequent, but cases due to falls, especially children and the elderly were still seen, although slightly reduced. |
|
|
Di Mauro, M, Migliaccio, et al |
Int Urol Nephrol |
Clinical data| Données cliniques |
Case report of an 81 year old female with COVID-19 who developed hypotension, oliguria and impaired renal function,
with the lower glomerular filtration rate |
|
|
Do-Umehara, H, Chen, et al |
Science advances |
Coronavirology| Coronavirologie Animal model | Modèle animal |
Here we show that mice with lung epithelial cell-specific loss of function of Miz1, which we identified as a negative
regulator of nuclear factor κB (NF-κB) signaling, spontaneously develop progressive age-related changes resembling COPD. Furthermore, loss of Miz1 up-regulates the expression of Ace2, the receptor for SARS-CoV-2. Our data suggest that Miz1 down-regulation-induced
sustained activation of NF-κB-dependent inflammation in the lung epithelium is sufficient to induce progressive lung and airway destruction that recapitulates features of COPD, with implications for COVID-19. |
|
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Impact of COVID-19 Pandemic on Colorectal Cancer Screening Program |
D'Ovidio, V, Lucidi, et al |
Clinical Colorectal Cancer |
Healthcare Response | Réponse des soins de santé |
We carried out a retrospective controlled cohort study in our “COVID-free” hospital to compare data of the CRCS colonoscopies
of the lockdown period (March 9 to May 4, 2020) with those of the same period of 2019 (control group). A pre/post endoscopic sanitary surveillance for COVID-19 infection was organized for patients and sanitary staff. Results: In the lockdown group, 60 of 137
invited patients underwent endoscopy, whereas in the control group, 238 CRCS colonoscopies (3.9-fold) were performed. In the lower number of examinations during the lockdown, we found more colorectal cancers. The “high-risk” adenomas detection rate was also
significantly higher in the “lockdown group” than in controls. |
|
Anxiety and Depression in Canada During the COVID-19 Pandemic: A National Survey |
Dozois, DJA, Mental Health Research, et al |
Canadian Psychology |
Public Health response| Interventions de santé publique |
The objective is this research was to explore how Canadians are managing with the COVID-19 outbreak and determine the
impact of the pandemic on levels of anxiety and depression. A nationally representative sample of 1,803 participants completed an online survey that was offered in both official languages. The percentage of respondents who indicated that their anxiety was
high to extremely high quadrupled (from 5% to 20%) and the number of participants with high self-reported depression more than doubled (from 4% to 10%) since the onset of COVID-19. Although current anxiety levels are expected to remain the same, respondents
predicted that depression would worsen if physical distancing and self-isolation continue for another 2 months. One-third of Canadians with anxiety and depression also report an increase in alcohol and cannabis use during the pandemic. |
|
Association of contact to small children with mild course of COVID-19 |
Dugas, M, Schrempf, et al |
Int J Infect Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
If a childhood-related infection would be protective against severe course of COVID-19, it would be expected that adults
with intensive and regular contact to small children also may have a mild course of COVID-19 more frequently. To test this hypothesis, a survey among 4,010 recovered COVID-19 patients was conducted in Germany. 1,186 complete answers were collected. 6.9% of
these patients reported frequent and regular job-related contact to children below 10 years of age and 23.2% had own small children, which is higher than expected. In the relatively small subgroup with intensive care treatment (n = 19), patients without contact
to small children were overrepresented. |
|
Dutescu, RM, Banasik, et al |
Cornea |
Clinical data| Données cliniques |
PURPOSE: This study was designed to detect CoV-RNA in the tears of PCR confirmed SARS-CoV-2 positive patients. METHODS:
We performed a prospective case-series study of hospitalized patients that have been confirmed SARS-CoV-2 positive by oropharyngeal swab within the previous 5 days. Tear samples obtained with a laboratory capillary and oropharyngeal swabs were analyzed by
RT-PCR using the Altona SARS-CoV-2-Assay or the Roche SARS-CoV-2 LightMix PCR, depending on availability. Patients history was documented, ophthalmoscopy was used to assess for ocular surface disease. RESULTS: Of all 18 patients recruited in April 2020, 5
suffered from respiratory failure and were submitted to an intensive care unit. None of our patients had signs of viral conjunctivitis although all patients in intensive care showed chemosis and conjunctival hyperemia due to third-spacing or fluid overload.
Presence of Coronavirus RNA was confirmed by PCR in 5 out of 18 patients (28%) in tears and 72% for oropharyngeal swabs. CONCLUSIONS: Using a tear fluid sampling technique similar to oropharyngeal lavage presents a higher percentage of SARS-CoV-2 positive
tears in contrast to earlier reports which used a conjunctival swab. This does not automatically indicate viral shedding in ocular tissue, or contagiousness of tear fluid. |
|
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Systemic inflammation as fuel for acute liver injury in COVID-19 |
Effenberger, M, Grander, et al |
Digestive and Liver Disease |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Aims: We explored a link between systemic IL-6, related acute phase proteins and liver injury in hospitalized COVID-19
patients. Methods: 655 patients with suspected COVID-19 were screened in the emergency department at the University Hospital of Innsbruck, Austria, between February and April 2020. 96 patients (∼15%)
were hospitalized with COVID-19. 15 patients required intensive-care treatment (ICT). Results: Of all hospitalized COVID-19 patients, 41 (42%) showed elevated aspartate aminotransferase (AST) concentration. COVID-19 patients with elevated AST exhibited significantly
higher IL-6, ferritin, LDH and CRP serum concentrations compared to patients with normal AST. Liver injury correlated with systemic IL-6, CRP, ferritin and LDH concentration. |
|
COVID-19-FAKES: A Twitter (Arabic/English) dataset for detecting misleading information
on COVID-19 |
Elhadad, MK, Li, et al |
|
Public Health response| Interventions de santé publique |
This paper aims to aid the ongoing research efforts for combating the Infodemic related to COVID-19. We provide an
automatically annotated, bilingual (Arabic/English) COVID-19 Twitter dataset (COVID-19-FAKES). This dataset has been continuously collected from February 04, 2020, to March 10, 2020. For annotating the collected dataset, we utilized the shared information
on the official websites and the official Twitter accounts of the WHO, UNICEF, and UN as a source of reliable information, and the collected COVID-19 pre-checked facts from different fact-checking websites to build a ground-truth database. This work will help
researchers in understanding the dynamics behind the COVID-19 outbreak on Twitter. |
|
An Ensemble Deep Learning Technique to Detect COVID-19 Misleading Information |
Elhadad, MK, Li, et al |
|
Public health interventions*| Interventions de santé publique Surveillance Public Health
response| Interventions de santé publique |
This paper aims to combat the Infodemic related to COVID-19. We propose an ensemble deep learning system for detecting
misleading information related to COVID-19. This system depends on the shared COVID-19-related information from the official websites and Twitter accounts of the WHO, UNICEF, and UN, as well as the COVID-19 pre-checked facts from different fact-checking websites,
as a source of reliable information to train the detection model. We use these collected data to build an ensemble system that uses several deep learning techniques to detect misleading information. To improve the performance of the proposed ensemble detection
system, we implement a data preparation and preprocessing step, along with a features engineering step. We deploy Word Embedding based on a pre-trained word embedding list in addition to the existing word impeding in the input layer of the employed techniques.
The experimental results are examined using fourteen performance measures (Accuracy, Error Rate, Loss, Precision, Recall, F1-Score, Area Under the Curve, Geometric-Mean, Specificity, Miss Rate, Fall-Out Rate, False-Discovery Rate, False-Omission Rate, and
the Total Training Time). The obtained results are promising and indicate the quality and validity of the trusted information collected, for building misleading-information detection systems. It is worth noting that, in this paper, we use the terms “misleading
information”, “misinformation”, and “fake news” interchangeably. © 2021, Springer Nature Switzerland AG. |
|
Esposito, AJ, Menon, et al |
Am J Respir Crit Care Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this letter, we present the results of a multicenter retrospective case-control study examining outcomes from COVID-19
in patients with pre-existing interstitial lung diseases (ILD) . |
|
|
Etemadifar, M, Salari, et al |
Neurol Sci |
Clinical data| Données cliniques |
Novel coronavirus (SARS-CoV-2) occurred in December 2019 in Wuhan, China, and has become a global health emergency.
Coronavirus primarily is a respiratory virus, but it has been detected in the brain and cerebrospinal fluid of infected individuals. The present report describes a case of fulminant encephalitis in a patient affected by COVID-19. |
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The impact of COVID-19 infection on hip fractures 30-day mortality |
Fadulelmola, A, Gregory, et al |
Trauma (United Kingdom) |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Introduction: A novel virus, SARS-CoV-2 has caused a fatal global pandemic which particularly affects the elderly and
those with co-morbidities. Hip fractures affect elderly populations, necessitate hospital admissions, and place this group at particular risk from COVID-19 infection. This study investigates the effect of COVID-19 infection on 30-day hip fracture mortality.
Method: Data related to seventy-five adult hip fractures admitted to two units during March and April 2020 was reviewed. The mean age was 83.5 years (range 65-98 years) and most (53, 70.7%) were females. The primary outcome measure was 30-day mortality associated
with COVID-19 infection. Results: The COVID-19 infection rate was 26.7% (20 patients), with a significant difference in the 30-day mortality rate in COVID-19 positive group (10/20, 50%) compared to COVID-19 negative group (4/55, 7.3%), with mean time to death
of 19.8 days (95% confidence interval 17.0-22.5). The mean time from admission to surgery was 43.1 hours and 38.3 hours, in COVID-19 positive and COVID-19 negative groups, respectively. All COVID-19 positive patients had shown symptoms of fever and cough,
and all ten cases who died were from hypoxia. Seven (35%) cases had radiological lung findings consistent with viral pneumonitis which resulted in mortality (70% of mortality). 30% (n = 6) contracted the COVID-19 infection in the community and 70% (n = 14)
developed symptoms after hospital admission. Conclusion: Hip fractures associated with COVID-19 infection have a high 30-day mortality. COVID-19 testing and chest x-ray for patients presenting with hip fractures, helps in early planning of high-risk surgeries
and allows counselling of the patients and family using realistic prognosis. © The Author(s) 2020. |
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Obese communities among the best predictors of COVID-19-related deaths |
Fakhry Abdelmassih, A, Ghaly, et al |
Cardiovascular Endocrinology and Metabolism |
Epidemiology| Épidémiologie |
Introduction Coronavirus disease 2019 (COVID-19) is the largest outbreak to strike the world since the Spanish flu
in 1918. Visual examination of the world map shows a wide variation of death tolls between countries. The main goal of our series is to determine the best predictors of such discrepancy. Methods This is a retrospective study in which the rate of COVID-19 deaths
was correlated with each of the following independent variables: total tests per 1 million population, gross domestic product (GDP), average temperatures per country, ultraviolet index, median age, average BMI per country, food supply, Bacille Calmette-Guerin
compulsory status, and passenger traffic. Results BMI per country proved to be the second best predictor of death rate with an R value of 0.43, and GDP being the best predictor with R = 0.65. Conclusion This article shows a tight correlation between average
BMI, food supply per country, and COVID-19-related deaths. Such predisposing factors might operate by upregulating the inflammation pathway in heavily struck countries, leading to easier triggering of the infamous cytokine storm syndrome. Obesity also increases
cardiovascular and respiratory morbidities, which are coupled to increased ICU demand and deaths among infected cases. Video abstract: http://links.lww.com/CAEN/A25. © 2020 BMJ Publishing Group. All rights reserved. |
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Fan, T, Hao, et al |
JMIR Med Inform |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
BACKGROUND: In late December 2019, a pneumonia caused by SARS-CoV-2 was first reported in Wuhan and spread worldwide
rapidly. Currently, no specific medicine is available to treat infection with COVID-19. OBJECTIVE: The aims of this study were to summarize the epidemiological and clinical characteristics of 175 patients with SARS-CoV-2 infection who were hospitalized in
Renmin Hospital of Wuhan University from January 1 to January 31, 2020, and to establish a tool to identify potential critical patients with COVID-19 and help clinical physicians prevent progression of this disease. METHODS: In this retrospective study, clinical
characteristics of 175 confirmed COVID-19 cases were collected and analyzed. Univariate analysis and least absolute shrinkage and selection operator (LASSO) regression were used to select variables. Multivariate analysis was applied to identify independent
risk factors in COVID-19 progression. We established a nomogram to evaluate the probability of progression of the condition of a patient with COVID-19 to severe within three weeks of disease onset. The nomogram was verified using calibration curves and receiver
operating characteristic curves. RESULTS: A total of 18 variables were considered to be risk factors after the univariate regression analysis of the laboratory parameters (P<.05), and LASSO regression analysis screened out 10 risk factors for further study.
The six independent risk factors revealed by multivariate Cox regression were age (OR 1.035, 95% CI 1.017-1.054; P<.001), CK level (OR 1.002, 95% CI 1.0003-1.0039; P=.02), CD4 count (OR 0.995, 95% CI 0.992-0.998; P=.002), CD8 % (OR 1.007, 95% CI 1.004-1.012,
P<.001), CD8 count (OR 0.881, 95% CI 0.835-0.931; P<.001), and C3 count (OR 6.93, 95% CI 1.945-24.691; P=.003). The areas under the curve of the prediction model for 0.5-week, 1-week, 2-week and 3-week nonsevere probability were 0.721, 0.742, 0.87, and 0.832,
respectively. The calibration curves showed that the model had good prediction ability within three weeks of disease onset. CONCLUSIONS: This study presents a predictive nomogram of critical patients with COVID-19 based on LASSO and Cox regression analysis.
Clinical use of the nomogram may enable timely detection of potential critical patients with COVID-19 and instruct clinicians to administer early intervention to these patients to prevent the disease from worsening. |
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Fan, Z, Zhan, et al |
International Journal of Environmental Research and Public Health |
Public health interventions*| Interventions de santé publique |
Due to the suspension of traffic mobility and industrial activities during the COVID-19, particulate matter (PM) pollution
has decreased in China. However, rarely have research studies discussed the spatiotemporal pattern of this change and related influencing factors at city-scale across the nation. In this research, the clustering patterns of the decline rates of PM2.5 and PM10
during the period from January 20 to April 8 in 2020, compared with the same period of 2019, were investigated using spatial autocorrelation analysis. Four meteorological factors and two socioeconomic factors, i.e., the decline of intra-city mobility intensity
(dIMI) representing the effect of traffic mobility and the decline rates of the secondary industrial output values (drSIOV), were adopted in the regression analysis. Then, multi-scale geographically weighted regression (MGWR), a model allowing the particular
processing scale for each independent variable, was applied for investigating the relationship between PM pollution reductions and influencing factors. For comparison, ordinary least square (OLS) regression and the classic geographically weighted regression
(GWR) were also performed. The research found that there were 16% and 20% reduction of PM2.5 and PM10 concentration across China and significant PM pollution mitigation in central, east, and south regions of China. As for the regression analysis results, MGWR
outperformed the other two models, with R2 of 0.711 and 0.732 for PM2.5 and PM10, respectively. The results of MGWR revealed that the two socioeconomic factors had more significant impacts than meteorological factors. It showed that the reduction of traffic
mobility caused more relative declines of PM2.5 in east China (e.g., cities in Jiangsu), while it caused more relative declines of PM10 in central China (e.g., cities in Henan). The reduction of industrial operation had a strong relationship with the PM10
drop in northeast China. The results are crucial for understanding how the decline pattern of PM pollution varied spatially during the COVID-19 outbreak, and it also provides a good reference for air pollution control in the future. © 2020, MDPI AG. All rights
reserved. |
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Faqihi, F, Alharthy, et al |
Respiratory Medicine Case Reports |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This is the first reported case, to our knowledge, of co-infection of Bordetella bronchiseptica and SARS-CoV-2 in a
young patient with underlying idiopathic bronchiectasis and vitamin D3 deficiency that was treated successfully with a combination therapeutic regime integrating doxycycline, empiric therapies for COVID-19, vitamin D supplementation, and supportive ICU care.
Large prospective studies are required to investigate further the role of co-infections in COVID-19 patients with bronchiectasis. Randomized control trials should examine the putative beneficial role of vitamin D supplementation in patients with COVID-19.
© 2020 The Author(s) |
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32798533; Medical features of COVID-19 and influenza infection: A comparative study
in Paris, France |
Faury, H, Courboulès, et al |
Journal of Infection |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This retrospective study included 200 inpatients from the Pitié-Salpêtrière University Hospital (Paris, France) with
SARS-CoV-2 (n = 100, ‘COVID-19 group’) or influenza (n = 100, ‘influenza group’) laboratory-confirmed infections on respiratory specimens between January 1st-March 25th, 2020. Comorbidities were present in the majority of patients (>89%) with diabetes, hypertension,
and overweight/obesity as most common comorbidities. However, influenza patients were more likely to have chronic pulmonary diseases (p = 0.01). Overweight/obesity rate (p = 0.02) and median BMI (p = 0.04) were significantly higher in COVID-19. At the time
of diagnosis, the most frequent symptoms were fever (p = 0.63) and cough (p = 1.00) in both groups. COVID-19 patients complained more significantly about fatigue, faintness, diarrhea, and anosmia/ageusia. |
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In severe COVID-19, SARS-CoV-2 induces a chronic,
TGF-β-dominated adaptive immune response |
Ferreira-Gomes, Marta, Kruglov, et al |
medRxiv |
Clinical data| Données cliniques Immunology | Immunologie |
Here we have analyzed the dynamics of the adaptive immune response triggered by SARS-CoV-2 in severely affected COVID-19
patients, as reflected by activated B cells egressing into the blood, at the single cell level. Early on, before seroconversion in response to SARS-CoV-2 spike protein, activated peripheral B cells displayed a type 1 interferon-induced gene expression signature.
After seroconversion, activated B cells lost this signature, expressed IL-21- and TGF-β-induced gene expression signatures, and mostly IgG1 and IgA1. In the sustained immune reaction of the COVID-19 patients, until day 59, activated peripheral B cells shifted
to expression of IgA2, reflecting instruction by TGF-β. Despite the continued generation of activated B cells, those cells were not found in the lungs of deceased COVID-19 patients, nor did the IgA2 bind to dominant antigens of SARS-CoV-2. In severe COVID-19,
SARS-CoV-2 thus triggers a chronic immune reaction distracted from itself and instructed by TGF-β. |
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Fiore, A, Piscitelli, et al |
Journal of cardiothoracic and vascular anesthesia |
Clinical data| Données cliniques |
Clinical manifestations of coronavirus disease 2019 in pregnant women, in contrast to previous outbreaks, seem to be
similar to those of nonpregnant women. During severe acute respiratory syndrome (SARS), SARS influenza A, and Middle East respiratory syndrome outbreaks, an increased severity of disease among pregnant women was observed. In some pregnant women, respiratory
failure can occur and progress quickly to acute respiratory distress syndrome requiring extracorporeal membrane oxygenation (ECMO) as a rescue therapy. Despite a lack of current guidelines on the use of ECMO in pregnant or postpartum women, this support therapy
is an effective salvage therapy for patients with cardiac and/or respiratory failure, and is associated with favorable maternal and fetal outcomes. Herein, the authors report a case of severe COVID-19 disease in a pregnant patient after urgent cesarean delivery,
who was treated successfully with ECMO during the postpartum. Extracorporeal membrane oxygenation should be considered early when conventional therapy is ineffective, and it is essential to refer to ECMO expert centers. © 2020 Elsevier Inc. |
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Flynn, D, Moloney, et al |
Health Policy and Technology |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique
Economics | Économie |
Objectives: To describe epidemiological data on cases of COVID-19 and the spread of Severe Acute Respiratory Syndrome
Coronavirus 2 in the United Kingdom (UK), and the subsequent policy and technological response to the pandemic, including impact on healthcare, business and the economy. Methods: Epidemiological, business and economic data were extracted from official government
sources covering the period 31st January to 13th August 2020; healthcare system data up to end of June 2019. Results: UK-wide COVID-19 cases and deaths were 313,798 and 46,706 respectively (472 cases and 70 deaths per 100,000 population) by 12th August. There
were regional variations in England, with London and North West (756 and 666 cases per 100,000 population respectively) disproportionately affected compared with other regions. As of 11th August, 13,618,470 tests had been conducted in the UK. Increased risk
of mortality was associated with age (≥60 years), gender (male) and BAME groups. Since onset of the pandemic, emergency department attendance, primary care utilisation and cancer referrals and inpatient/outpatient referrals have declined; emergency ambulance
and NHS111 calls increased. Business sectors most impacted are the arts, entertainment and recreation, followed by accommodation and food services. Government interventions aimed at curtailing the business and economic impact have been implemented, but applications
for state benefits have increased. Conclusions: The impact of COVID-19 on the UK population, health system and economy has been profound. More data are needed to implement the optimal policy and technological responses to preventing further spikes in COVID-19
cases, and to inform strategic planning to manage future pandemics. © 2020 Elsevier Ltd |
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Fouillet, A, Pontais, et al |
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin |
Epidemiology| Épidémiologie |
Through a weekly all-cause mortality surveillance system, we observed in France a major all-cause excess mortality
from March to May 2020, concomitant with the coronavirus disease (COVID-19) epidemic. The excess mortality was 25,030 deaths, mainly among elderly people. Five metropolitan regions were the most affected, particularly Île-de-France and the Grand-Est regions.
Assessing the excess mortality related to COVID-19 is complex because of the potential protective effect of the lockdown period on other causes of mortality. |
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|
Franco, N |
ArXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
We model the evolution of the covid-19 epidemic in Belgium with an age-structured extended SEIR-QD epidemic model with
separated consideration for nursery homes. All parameters of the model are estimated using a MCMC method, except integrated data on social contacts. The model is calibrated on hospitals' data, number of deaths, nursery homes' tests and serological tests. We
present the current situation on September 2020 as well as long-term scenarios-based forecasts with the possibility of a second wave in function of new transmissions from contacts at school. |
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Galindo-Vázquez, O, Ramírez-Orozco, et al |
Gaceta medica de Mexico |
Public Health response| Interventions de santé publique |
The objective of the study was to determine the levels of anxiety, depression and self-care symptoms during the COVID-19
pandemic in the general Mexican population. |
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Gallagher, MW, Zvolensky, et al |
Cognitive Therapy and Research |
Public Health response| Interventions de santé publique |
This study examined how experiences related to COVID-19 and associated stress impact, anxiety, depression, and functional
impairment in a convenience sample of American adults recruited through MTURK. |
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Gallè, F, Sabella, et al |
International journal of environmental research and public health |
Public Health response| Interventions de santé publique |
This study, carried out among Italian undergraduates, explored their sedentary and physical activities (PA) during
the lockdown with respect to their previous habits. |
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Gandhi, S, Bhatta, et al |
Indian Journal of Otolaryngology and Head and Neck Surgery |
Healthcare Response | Réponse des soins de santé |
To prepare safety protocols for performing videolaryngoscopy (VLS) during COVID-19 pandemic, that would be feasible
for patients, hospital and the health care providers. This was a prospective study performed from March 01, 2020 to June 30, 2020. It analyzed the precautions adapted for VLS initially and subsequently describes modifications with the time. The VLS was performed
with the personal protective equipment (PPE), including the face shield mask and head cover. The PPE was re-used after sterilization with ethylene oxide. For local anesthesia, the oropharynx was sprayed with 15% xylocaine and nose packed with 4% xylocaine
soaked pledget. Following the VLS, the scope was wiped three times with 80% alcohol and then immersed in 5.25% sodium hypochlorite and 0.55% ortho-phthalaldehyde for 10 min each. Each VLS was spaced by at least 15 min gap. The endoscopy suite maintained with
laminar air flow. It can be concluded that during the COVID-19 pandemic, the VLS must be performed using PPE with proper sterilization of the scope and the endoscopy suite after the procedure. |
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Gao, X, Zhang, et al |
|
Modelling/ prediction| Modélisation/prédiction Clinical data| Données cliniques |
Online case intelligent interaction system based on virtual reality technology under the background of the novel coronavirus
is designed and implemented in this paper. It provides more information for the application of virtual reality technology to realize the 3D animation system. In the process of the model itself, the 3D animation model usually retains the deformation process
of the object so that it can be observed. Besides, staff should use 3D scanners to scan objects and also store 3D data accurately, which requires technicians to use computers to operate very similar structures and to use 3D coordinates to enhance authenticity.
With this technology support, this paper integrates the VR for constructing the system. The experiment has proven the effectiveness which will be necessary. © 2020 IEEE. |
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Preliminary Exploration of the Cause of Liver Disorders During Early Stages in COVID-19
Patients |
Gao, Y, Li, et al |
Frontiers in Medicine |
Clinical data| Données cliniques |
Authors investigated the role played by these to determine the cause of liver abnormality in the early stages of COVID-19.
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Garduño-Soto, M, Choreño-Parra, et al |
Gaceta medica de Mexico |
Clinical data| Données cliniques |
The objective of this study was to determine the susceptibility of the skin to SARS-CoV-2 infection based on the expression
of viral entry factors ACE2 and TMPRSS2 in this organ. |
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Decrease of exercise endurance in critically ill COVID-19 survivors: 4
case reports |
Geng, Q, Y |
Research Square prepub |
Clinical data| Données cliniques |
Authors describe the pulmonary function test (PFT) and cardiopulmonary exercise test (CPET) of critically ill COVID-19
in four cases with severe acute respiratory distress syndrome (ARDS) after discharge. |
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Impact of the COVID-19 pandemic on sleep medicine in the Czech Republic and Slovakia |
Genzor, S, Sova, et al |
Ceska a Slovenska Neurologie a Neurochirurgie |
Public Health response| Interventions de santé publique |
The aim of this study was to assess the pandemics effect on sleep medicine in the Czech Republic (CZE) and Slovakia
(SVK). |
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Ghosh, S, Bhattacharya, et al |
Applied Soft Computing Journal |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this work, a probabilistic cellular automata based method has been employed to model the infection dynamics for
a significant number of different countries. |
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Gianotti, R, Coggi, et al |
Acta Dermato-Venereologica |
Clinical data| Données cliniques |
Authors examined the histological features of 30 skin biopsies from two groups of patients: Ten specimens of patients
tested positive for COVID-19 with an active systemic infection and associated dermatosis. |
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Giebel, C, Hanna, et al |
BMC Geriatr |
Healthcare Response | Réponse des soins de santé |
The aim of this study was to explore the decision-making processes of continued paid home care support for dementia
in the time of COVID-19 in the UK. |
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Giron, F, Rao, et al |
Respiratory Medicine Case Reports |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
Coronavirus disease 2019 (COVID-19) is the cause of the pandemic that has affected millions of people worldwide with
pulmonary manifestations ranging from mild pneumonia to ARDS and characterized by hypoxia. This has led to questions regarding the most efficacious and least harmful oxygen delivery strategies that minimize exposure to health care workers. In this case series,
we present the hospital course of 4 patients that were managed with a multi-component oxygen delivery method in a COVID-19 step down unit. © 2020 |
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Glibbery, N, Karamali, et al |
Journal of Laryngology and Otology |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
The objective of this study was to report feasibility, early outcomes and challenges of implementing a 14-day threshold
for undertaking surgical tracheostomy in the critically ill coronavirus disease 2019 patient. Performing a tracheostomy in coronavirus disease 2019 positive patients at 8-14 days following intubation is compatible with favourable outcomes. |
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Preventing epidemics by wearing masks: An application to COVID-19 |
Gondim, JAM |
ArXiv |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique |
The goal of this work is to consider widespread use of face masks as a non-pharmaceutical control strategy for the
Covid-19 pandemic. A SEIR model that divides the population into individuals that wear masks and those that do not is considered. After calculating the basic reproductive number by a next generation approach, a criterion for determining when an epidemic can
be prevented by the use of masks only and the critical percentage of mask users for disease prevention in the population are derived. The results are then applied to real world data from the United States, Brazil and Italy. |
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Goodyear-Smith, F, Kinder, et al |
BJGP Open |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
The aim of this study was to compare perceptions of primary care (PC) experts on PC system strength, pandemic preparedness,
and response with COVID-19 mortality rates in countries globally. Countries perceived by expert participants as having a prepared pandemic plan and a strong PC system did not necessarily experience lower COVID-19 mortality rates. |
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Kawasaki Disease Outbreak in Children During COVID-19 Pandemic |
Gowin, E, W |
Research Square prepub |
Clinical data| Données cliniques Public Health response| Interventions de santé publique |
Authors present a group of six patients hospitalized from March to May 2020 with an inflammatory disease similar to
Kawasaki disease (KD). |
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Potential role of subcutaneous tocilizumab injections in patients
with COVID-19 associated pneumonia |
Greco, G, Ripamonti, et al |
J Med Virol |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
Guaraldi et al. found a significant reduction in risk of invasive mechanical ventilation or death in patients with
severe COVID-19 pneumonia who were treated with either I.V. or S.C. tocilizumab and standard of care, compared with those treated with standard of care only. This article is protected by copyright. All rights reserved. |
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Gruber, AD, Osterrieder, et al |
Am J Respir Cell Mol Biol |
Animal model | Modèle animal |
In this letter to the editor, authors propose a catalog for the reporting of histopathology in SARS-CoV-2 infected
hamsters which is based on their previous observations and systematic comparisons with other reports on SARS-CoV-2 infected hamsters, macaques and lesions considered relevant in humans . |
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Gupta, S, Prasad, et al |
Medical Journal Armed Forces India |
Healthcare Response | Réponse des soins de santé |
A prospective study was conducted during the second phase of the COVID-19 pandemic in India to assess the prevalence
of anxiety and depressive symptoms among healthcare workers (HCWs) and factors that influence the outcome.
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Gurard-Levin, Z, Liu, et al |
Antiviral Res |
Therapeutics| Thérapeutique |
This study describes the evaluation of SARS-CoV-2 3CLpro inhibitors in a novel self-assembled monolayer desorption
ionization mass spectrometry (SAMDI-MS) enzymatic assay. |
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Hahn, M, Condori, et al |
Tidsskr Nor Laegeforen |
Clinical data| Données cliniques |
*Translated from Norwegian* Patient with severe covid-19 treated with recovery plasma. This is a case report of the
first COVID-19 patient treated with convalescent plasma in Norway. A SARS-CoV-2 test was not performed immediately before transfusion and the complexity of intensive care treatment makes it difficult to draw any conclusions on the potential effectiveness
of this treatment. |
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Hammoudi, K, Cabani, et al |
CMES - Computer Modeling in Engineering and Sciences |
Public Health response| Interventions de santé publique |
In this paper, authors propose a design of a mobile application for permitting everyone having a smartphone and being
able to take a picture to verify that his/her protection mask is correctly positioned on his/her face. Experimental results show the potential of this method in the validation of the correct mask wearing. |
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Han, BS, Park, et al |
International Journal of Environmental Research and Public Health |
Public health interventions*| Interventions de santé publique |
Fine particulate matter (PM2.5) and other air pollutants measured in Seoul over the two 30 day periods before and after
the start of social distancing are analyzed to assess the change in air quality during the period of social distancing. Results show that social distancing, a weaker forcing toward reduced human activity than a strict lockdown, can help lower pollutant emissions. |
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Han, H, Al-Ansi, et al |
Int J Environ Res Public Health |
Public Health response| Interventions de santé publique |
The major aim of this study is to develop a conceptual framework that clearly explains the US international tourists'
post-pandemic travel behaviors by expanding the theory of planned behavior (TPB). Overall, the findings of this study considerably enhanced our understanding of US overseas tourists' post-pandemic travel decision-making processes and behaviors. |
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32768451; Clinical and CT imaging features of SARS-CoV-2 patients presented with
diarrhea |
Han, J, Gong, et al |
Journal of Infection |
Clinical data| Données cliniques |
Here, we reported the clinical and compute tomography (CT) imaging features of SARS-CoV-2 patients presented with diarrhea
at admission, to familiarize clinicians with clinical features of pa- tients with this atypical symptom. |
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Havnen, A, Anyan, et al |
Int J Environ Res Public Health |
Public Health response| Interventions de santé publique |
This study investigated if resilience moderated the effect of stress on symptoms of depression and if anxiety symptoms
mediated the association with negative emotional outcome like depressive symptoms.. |
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Hawryluk, I, M |
ArXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Authors discuss model selection; a fundamental part of Bayesian statistical inference; a widely used tool in the field
of epidemiology. |
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The impact of COVID-19 on relative changes in aggregated mobility using mobile-phone data |
Heiler, G, H |
ArXiv |
Public Health response| Interventions de santé publique |
Evaluating relative changes leads to additional insights which would remain hidden when only evaluating absolute changes.
We analyze a dataset describing mobility of mobile phones in Austria before, during COVID-19 lock-down measures until recent. By applying compositional data analysis we show that formerly hidden information becomes available: we see that the elderly population
groups increase relative mobility and that the younger groups especially on weekends also do not decrease their mobility as much as the others. |
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PCR test for SARS-CoV-2 persistently positive. Virus detection is not always
COVID-19 |
Herrero Hernando, C, Álvarez Serra, et al |
Anales de Pediatria |
Clinical data| Données cliniques |
Article in Spanish. This case report describes a 4-year-old girl who, on March 31, 2020, was diagnosed with SARS-CoV-2
infection by PCR due to a fever of 5 days of evolution, with no other accompanying symptoms. |
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Herzog, M, Beule, et al |
Eur Arch Otorhinolaryngol |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
In the course of the COVID-19 pandemic, otorhinolaryngologists (ORL) are assumed to be at high risk due to close contact
with the mucosa of the upper airways. |
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Hoste, ACR, Venteo, et al |
Diagnostic microbiology and infectious disease |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Immunology
| Immunologie |
Two serological tools based on a double recognition assay enzyme-linked immunosorbent assay (DR-ELISA) and lateral
flow assay (DR-LFA)] to detect total antibodies to SARS-CoV-2 have been developed based on the recombinant nucleocapsid protein. A total of 1065 serum samples, including positive for COVID-19 and negative samples from healthy donors or infected with other
respiratory pathogens, were analyzed. The results showed values of sensitivity between 91.2% and 100%, and specificity of 100% and 98.2% for DR-LFA and DR-ELISA, respectively. |
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Predictive value of five early warning scores for critical novel coronavirus disease |
Hu, H, Yao, et al |
Disaster Med Public Health Prep |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
This study aimed to evaluate the predictive value of five early warning scores based on the admission data of critical
COVID-19 patients. |
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Dynamic modeling and analysis of COVID-19 in different transmission process and control strategies |
Hu, L, Nie, et al |
Mathematical Methods in the Applied Sciences |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
Based on the control measures at different stages of COVID-19 and its transmission characteristics, authors propose
a dynamical model to describe the transmission of this virus among wild animals, human population, and the environment, where the migration of humans, asymptomatic infected humans, and the self-protection awareness of susceptible humans are also introduced. |
|
Ilbeigi, M, Jagupilla, et al |
Sustainability (Switzerland) |
Epidemiology| Épidémiologie |
The objective of this study was to compare the associations between communities' socioeconomic characteristics and
exposure to dierent types of natural hazards in New York City (NYC) to examine whether commonly accepted indicators of social vulnerability are associated with similar levels of exposure across various natural hazards. The outcomes showed that the significance
and direction of the associations depend on the type of natural hazard. Particularly, the results indicated that zip codes with lower socioeconomic factors and greater percentage of minority ethnicities are exposed disproportionately to extreme heat and COVID-19.
On the other hand, zip codes with higher percentage of areas prone to flooding have relatively higher socioeconomic factors. Furthermore, the results did not show any statistically significant association between socioeconomic factors and exposure to coastal
storm inundations. The outcomes of this study will help decision makers design and implement better optimized and eective emergency preparedness plans by prioritizing their target areas based on socioeconomic factors in order to enhance social justice. |
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Ishiguro, T, Takano, et al |
Respiratory Medicine Case Reports |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Objective: To clarify what future problems must be resolved and how clinical findings of SARS-CoV-2 infection differ
from those of cHCoV infection. Methods: Patients and Methods Clinical characteristics of 14 patients with laboratory-confirmed Coronavirus disease 2019 (COVID-19) and 5 patients with cHCoV pneumonia admitted to our institution and treated up to March 8, 2020,
were retrospectively analyzed. Results: On admission, 10 patients had pneumonia, 5 of whom had pulmonary shadows detectable only via computed tomography (CT). During hospitalization, another patient with no pulmonary shadows on admission developed pneumonia.
In total, 11 (78.6%) of the 14 patients developed pneumonia, indicating its high prevalence in COVID-19. During hospitalization, the patients' symptoms spontaneously relapsed and resolved, and gastrointestinal symptoms were frequently found. C-reactive protein
values showed correlation with the patients’ clinical courses. Ritonavir/lopinavir were administered to 5 patients whose respiratory conditions worsened during admission, all of whom improved. However, the pneumonia in the 6 other patients improved without
antivirals. None of the 14 patients died, whereas 5 other patients with cHCoV pneumonia were in respiratory failure on admission, and one patient (20%) died. Conclusion: Both SARS-CoV-2 and cHCoV can cause severe pneumonia. Problems for future resolution include
whether antiviral agents administered in cases of mild or moderate severity can reduce the number of severe cases, and whether antivirals administered in severe cases can reduce mortality. © 2020 The Author(s) |
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Issa, M, Elaziz, et al |
Appl Soft Comput |
Coronavirology| Coronavirologie |
SARS-CoV-2 (COVID-19) virus is a havoc pandemic that infects millions of people over the world and thousands of infected
cases dead. So, it is vital to propose new intelligent data analysis tools and enhance the existed ones to aid scientists in analyzing the COVID-19 virus. Fragmented Local Aligner Technique (FLAT) is a data analysis tool that is used for detecting the longest
common consecutive subsequence (LCCS) between a pair of biological data sequences. FLAT is an aligner tool that can be used to find the LCCS between COVID-19 virus and other viruses to help in other biochemistry and biological operations. In this study, the
enhancement of FLAT based on modified Ions Motion Optimization (IMO) is developed to produce acceptable LCCS with efficient performance in a reasonable time. The proposed method was tested to find the LCCS between Orflab poly-protein and surface glycoprotein
of COVID-19 and other viruses. The experimental results demonstrate that the proposed model succeeded in producing the best LCCS against other algorithms using real LCCS measured by the SW algorithm as a reference. |
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32758438; Risk of COVID-19 in health-care workers in Denmark: an observational
cohort study |
Iversen, K, Bundgaard, et al |
The Lancet Infectious Diseases |
Epidemiology| Épidémiologie |
Background: Health-care workers are thought to be highly exposed to severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection. We aimed to investigate the prevalence of antibodies against SARS-CoV-2 in health-care workers and the proportion of seroconverted health-care workers with previous symptoms of COVID-19. Methods: In this observational cohort study,
screening was offered to health-care workers in the Capital Region of Denmark, including medical, nursing, and other students who were associated with hospitals in the region. Screening included point-of-care tests for IgM and IgG antibodies against SARS-CoV-2.
Test results and participant characteristics were recorded. Results were compared with findings in blood donors in the Capital Region in the study period. Findings: Between April 15 and April 23, 2020, we screened 29 295 health-care workers, of whom 28 792
(98·28%) provided their test results. We identified 1163 (4·04% 95% CI 3·82–4·27]) seropositive health-care workers. Seroprevalence was higher in health-care workers than in blood donors (142 3·04%] of 4672; risk ratio RR] 1·33 95% CI 1·12–1·58]; p<0·001).
Seroprevalence was higher in male health-care workers (331 5·45%] of 6077) than in female health-care workers (832 3·66%] of 22 715; RR 1·49 1·31–1·68]; p<0·001). Frontline health-care workers working in hospitals had a significantly higher seroprevalence
(779 4·55%] of 16 356) than health-care workers in other settings (384 3·29%] of 11 657; RR 1·38 1·22–1·56]; p<0·001). Health-care workers working on dedicated COVID-19 wards (95 7·19%] of 1321) had a significantly higher seroprevalence than other frontline
health-care workers working in hospitals (696 4·35%] of 15 983; RR 1·65 1·34–2·03]; p<0·001). 622 53·5%] of 1163 seropositive participants reported symptoms attributable to SARS-CoV-2. Loss of taste or smell was the symptom that was most strongly associated
with seropositivity (377 32·39%] of 1164 participants with this symptom were seropositive vs 786 2·84%] of 27 628 without this symptom; RR 11·38 10·22–12·68]). The study is registered at ClinicalTrials.gov, NCT04346186. Interpretation: The prevalence of health-care
workers with antibodies against SARS-CoV-2 was low but higher than in blood donors. The risk of SARS-CoV-2 infection in health-care workers was related to exposure to infected patients. More than half of seropositive health-care workers reported symptoms attributable
to COVID-19. Funding: Lundbeck Foundation. © 2020 Elsevier Ltd |
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Analysis of SARS-CoV-2 genomes from across Africa reveals
potentially clinically relevant mutations |
Iweriebor, BensonC, Egbule, et al |
bioRxiv |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
SARS-CoV-2 is a betacoronavirus, the etiologic agent of the novel Coronavirus disease 2019 (COVID-19). In December
2019, an outbreak of COVID-19 began in Wuhan province of the Hubei district in China and rapidly spread across the globe. On March 11th, 2020, the World Health Organization officially designated COVID-19 as a pandemic. Across the continents and specifically
in Africa, all index cases were travel related. Thus, it is crucial to compare COVID-19 genome sequences from the African continent with sequences from COVID-19 hotspots (including China, Brazil, Italy, United State of America and the United Kingdom). To identify
if there are distinguishing mutations in the African SARS-CoV-2 genomes compared to genomes from other countries, including disease hotspots, we conducted in silico analyses and comparisons. Complete African SARS-CoV-2 genomes deposited in GISAID and NCBI
databases as of June 2020 were downloaded and aligned with genomes from Wuhan, China and other SARS-CoV-2 hotspots. Using phylogenetic analysis and amino acid sequence alignments of the spike and replicase (NSP12) proteins, we searched for possible targets
for vaccine coverage or potential therapeutic agents. Our results showed a similarity between the African SARS-CoV-2 genomes and genomes in countries including China, Brazil, France, the United Kingdom, Italy, France and the United States of America. This
study shows for the first time, an in-depth analysis of the SARS-CoV-2 landscape across Africa and will potentially provide insights into specific mutations to relevant proteins in the SARS-CoV-2 genomes in African populations.Competing Interest StatementThe
authors have declared no competing interest. |
|
Jamshidi, M, Torabi, et al |
Journal of the Electrochemical Society |
Therapeutics| Thérapeutique |
Caucasian whortleberry (Vaccinium Arctostaphylos L.) is rich in anthocyanins, which possesses a wide range of biological
and pharmaceutical activities. Electrochemical behavior of V. Arctostaphylos extract of dried fruit was performed by cyclic voltammetry and differential pulse voltammetry in aqueous solution. The results show that the level of delphinidin 3-O-glucoside (D3-OG)
compound is higher than petunidin 3-O-glucoside (P3-OG) and malvidin 3-O-glucoside (M3-OG) level. This extract has a high solubility in water, and the potential-pH diagram indicates that the D3-OG capable oxidized to D3-OGOX with two electron/two proton process.
D3-OG compound has a high antioxidant power because of the oxidation peak potential is low. Furthermore, total antioxidant capacity (1.475 C g-1) was determined by charges under of first oxidation peak. The antioxidant activity of three anthocyanins against
Xanthine oxidase, Myeloperoxidase, NADPH oxidase, cytochrome P450 3A4 and 2B4 (ROS generation enzymes) has been performed through molecular docking studies. The results indicated that all the anthocyanins (D3-OG, P3-OG and M3-OG) bound exclusively to the binding
site of ROS generation enzymes and have a remarkable role in suppressing the destructive effects of oxidative stress in the biological system of the human body. Also, D3-OG as a major anthocyanin of Vaccinium Arctostaphylos L. extract has an inhibition effect
against the COVID-19 outbreak. Electrochemical approaches provided a simple, fast, low cost, green, and high sensitivity methods for investigation of electroactive compounds in plant extracts. © 2020 The Author(s). Published on behalf of The Electrochemical
Society by IOP Publishing Limited. |
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PMC7471593; Accounting for Global COVID-19 Diffusion Patterns, January-April 2020 |
Jinjarak, Y, Ahmed, et al |
Econ Disaster Clim Chang |
Epidemiology| Épidémiologie Public Health response| Interventions de santé publique |
Key factors in modeling a pandemic and guiding policy-making include mortality rates associated with infections; the
ability of government policies, medical systems, and society to adapt to the changing dynamics of a pandemic; and institutional and demographic characteristics affecting citizens' perceptions and behavioral responses to stringent policies. This paper traces
the cross-country associations between COVID-19 mortality, policy interventions aimed at limiting social contact, and their interactions with institutional and demographic characteristics. We document that, with a lag, more stringent pandemic policies were
associated with lower mortality growth rates. The association between stricter pandemic policies and lower future mortality growth is more pronounced in countries with a greater proportion of the elderly population and urban population, greater democratic
freedoms, and larger international travel flows. Countries with greater policy stringency in place prior to the first death realized lower peak mortality rates and exhibited lower durations to the first mortality peak. In contrast, countries with higher initial
mobility saw higher peak mortality rates in the first phase of the pandemic, and countries with a larger elderly population, a greater share of employees in vulnerable occupations, and a higher level of democracy took longer to reach their peak mortalities.
Our results suggest that policy interventions are effective at slowing the geometric pattern of mortality growth, reducing the peak mortality, and shortening the duration to the first peak. We also shed light on the importance of institutional and demographic
characteristics in guiding policy-making for future waves of the pandemic. |
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Joo, J, Shin, et al |
Service Business |
Public Health response| Interventions de santé publique |
Although contact tracing apps can be effective for controlling COVID-19, the app usage can be stressful for users.
This study identifies countermeasures for users’ stress while maximizing full utilization of the apps. This study presents the relationships among the stress factors, users’ appraisal, users’ emotion focus coping, and the infusion to exert the full potential
of the app through a structural equation model. The research model is validated by surveying Health Code app users. Given the results of the study, the contact tracing apps could become a valuable tool to control COVID-19 by removing app users’ privacy concerns.
© 2020, Springer-Verlag GmbH Germany, part of Springer Nature. |
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The landscape of host genetic factors involved in
immune response to common viral infections |
Kachuri, Linda, Francis, et al |
medRxiv |
Clinical data| Données cliniques Coronavirology| Coronavirologie Immunology | Immunologie |
Introduction: Humans and viruses have co-evolved for millennia resulting in a complex host genetic architecture. Understanding
the genetic mechanisms of immune response to viral infection provides insight into disease etiology and informs public health interventions. Methods: We conducted a comprehensive study including genome-wide and transcriptome-wide association analyses to identify
genetic loci associated with immunoglobulin G antibody response to 28 antigens for 16 viruses using serological data from 7924 European ancestry participants in the UK Biobank cohort. Results: Signals in human leukocyte antigen (HLA) class II region dominated
the landscape of viral antibody response, with 40 independent loci and 14 independent classical alleles, 7 of which exhibited pleiotropic effects across viral families. We identified specific amino acid (AA) residues that are associated with seroreactivity,
the strongest associations presented in a range of AA positions within DRβ1 at positions 11, 13, 71, and 74 for Epstein-Barr Virus (EBV), Varicella Zoster Virus (VZV), Human Herpes virus 7, (HHV7) and Merkel cell polyomavirus (MCV). Genome-wide association
analyses discovered 7 novel genetic loci associated with viral antibody response (P<5.0×10-8), including FUT2 (19q13.33) for human polyomavirus BK (BKV), STING1 (5q31.2) for MCV, as well as CXCR5 (11q23.3) and TBKBP1 (17q21.32) for human herpesvirus 7. Transcriptome-wide
association analyses identified 114 genes associated with response to viral infection, 12 outside of the HLA region, including ECSCR: P=5.0×10-15 (MCV), NTN5: P=1.1×10-9 (BKV), and P2RY13: P=1.1×10-8 (Epstein-Barr virus nuclear antigen). We also demonstrated
pleiotropy between viral response genes and complex diseases, such as C4A expression in varicella zoster virus and schizophrenia. Conclusions: Our study confirms the importance of the HLA region in host response to viral infection and elucidates novel genetic
determinants beyond the HLA that contribute to host-virus interaction. |
|
Karim, N, Ashraf, et al |
Int J Clin Pract |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Healthcare
Response | Réponse des soins de santé |
OBJECTIVES: The Coronavirus disease 2019 (COVID-19) pandemic is straining healthcare resources. Molecular testing turnaround
time precludes having results at the point-of-care (POC) thereby exposing COVID-19/Non-COVID-19 patients while awaiting diagnosis. We evaluated the utility of a triage strategy including FebriDx, a 10-minute POC fingerstick blood test that differentiates viral
from bacterial acute respiratory infection through detection of Myxovirus-resistance protein A (MxA) and C-reactive protein (CRP), to rapidly isolate viral cases requiring confirmatory testing. METHODS: This observational, prospective, single-center study
enrolled patients presenting to/within an acute care hospital in England with suspected COVID-19 between March-April 2020. Immunocompetent patients ≥16 years requiring hospitalization with pneumonia or acute respiratory distress syndrome or influenza-like
illness (fever and ≥1 respiratory symptom within 7 days of enrolment, or inpatients with new respiratory symptoms, fever of unknown cause or pre-existing respiratory condition worsening). The primary endpoint was diagnostic performance of FebriDx to identify
COVID-19 as a viral infection; secondary endpoint was SARS-CoV-2 molecular test diagnostic performance compared to the reference standard COVID-19 Case Definition (molecular or antibody detection of SARS-CoV-2). RESULTS: Valid results were available for 47
patients. By reference standard, 35 had viral infections (34/35 COVID-19; 1/35 non-COVID-19; overall FebriDx viral sensitivity 97.1% (95%CI 83.3-99.9)). Of the COVID-19 cases, 34/34 were FebriDx viral positive (sensitivity 100%; 95%CI 87.4-100); 29/34 had
an initial SARS-CoV-2 positive molecular test (sensitivity 85.3%; 95%CI 68.2-94.5). FebriDx was viral negative when the diagnosis was not COVID-19 and SARS-Cov-2 molecular test was negative (negative predictive value (NPV) 100% (13/13; 95%CI 71.7-100)) exceeding
initial SARS-CoV-2 molecular test NPV 72.2% (13/19; 95%CI 46.4-89.3). The diagnostic specificity of FebriDx and initial SARS-CoV-2 molecular test was 100% (13/13; 95%CI 70-100 and 13/13; 95%CI 85.4-100, respectively). CONCLUSIONS: FebriDx could be deployed
as part of a reliable triage strategy for identifying symptomatic cases as possible COVID-19 in the pandemic. |
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Karuc, J, Sorić, et al |
Sustainability (Switzerland) |
Public Health response| Interventions de santé publique |
This study aimed to investigate moderators of change in physical activity (PA) levels after 30 days (30-d) of restrictions
due to the COVID-19 pandemic in young adults. This research is an extension of the CRO-PALS study and analyses for this study were performed on young adults (20-21 y.o., n = 91). Moderate-to-vigorous physical activity (MVPA), sport participation, student and
socioeconomic status were assessed pre- and post-30-d restrictions. Differences in MVPA levels were examined using repeated-measures ANOVAs. After 30-d of restrictions, the drop in MVPA in females (-64.8 min/day, p = 0.006) and males was shown (-57.7 min/day,
p < 0.00). However, active participants decreased, while non-active peers increased their MVPA level (-100.7 min/day, p < 0.00, and +48.9 min/day, p = 0.051, respectively). Moreover, students and non-students decreased their MVPA level (-69.0 min/day, p <
0.00, and -35.0 min/day, p = 0.22, respectively) as well as sport participants and non-sport participants (-95.3 min/day, p < 0.001, and -53.9 min/day, p < 0.00, respectively). Our results suggest that 30-d of restrictions equally affect females and males
where the evident drop in MVPA is seen in both genders. However, active people decreased their PA level during lockdown and the opposite pattern was seen in non-active peers, where restrictions for them can represent an opportunity to change their behavior
in a positive direction in order to gain better health status. © 2020 by the authors. |
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ECMO support in SARS-CoV2 multisystem inflammatory syndrome in children in a child |
Kaushik, S, Ahluwalia, et al |
Perfusion |
Clinical data| Données cliniques |
In this report, we describe the case of a 5-year-old male with SARS-CoV-2 associated MIS-C with progressive respiratory
failure and vasoplegic shock requiring extracorporeal support. At presentation, reverse transcription-polymerase chain reaction (RT-PCR) testing for SARS-CoV-2 was negative, however, SARS-CoV2 antibody testing was positive. Multiple inflammatory markers and
cardiac biomarkers were elevated. Echocardiogram demonstrated mildly depressed left ventricular function and no coronary anomalies noted. The patient required mechanical ventilation, vasopressors, and eventually extracorporeal membrane oxygenation (ECMO) for
profound circulatory shock and progressive respiratory failure. During his clinical course, recovery of cardiac function was demonstrated however, a middle cerebral artery infarct and left frontal subarachnoid hemorrhage was suffered which ultimately the patient
succumbed to. To the best of our knowledge, this is the youngest previously healthy child who had multi-system hyperinflammatory syndrome requiring ECMO support and the first case of SARS-CoV-2 related pediatric stroke.Clinical Trial Registration: None. |
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Immune response against SARS-CoV-2 in pediatric patients including young infants |
Kawamura, Y, Higashimoto, et al |
J Med Virol |
Clinical data| Données cliniques Immunology | Immunologie |
Here, the clinical and virological characteristics of 4 children with COVID-19 including two young infants were investigated.
One- and 4-month-old boys with COVID-19 were both asymptomatic, and seroconversion was demonstrated. These findings suggest that even young infants can mount an immune response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), despite having
weaker immune defenses than adolescents and adults. |
|
Keane, M, Neal, et al |
Journal of Econometrics |
Public Health response| Interventions de santé publique |
We develop an econometric model of consumer panic (or panic buying) during the COVID-19 pandemic. Using Google search
data on relevant keywords, we construct a daily index of consumer panic for 54 countries from January 1st to April 30th 2020. We also assemble data on government policy announcements and daily COVID-19 cases for all countries. Our panic index reveals widespread
consumer panic in most countries, primarily during March, but with significant variation in the timing and severity of panic between countries. Our model implies that both domestic and world virus transmission contribute significantly to consumer panic. But
government policy is also important: Internal movement restrictions – whether announced by domestic or foreign governments – generate substantial short run panic that largely vanishes in a week to ten days. Internal movement restrictions announced early in
the pandemic generated more panic than those announced later. Stimulus announcements had smaller impacts, and travel restrictions do not appear to generate consumer panic. © 2020 Elsevier B.V. |
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Machine learning-based mortality rate prediction using optimized hyper-parameter |
Khan, YA, Abbas, et al |
Computer methods and programs in biomedicine |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Objective and background: The current scenario of the Pandemic of COVID-19 demands multi-channel investigations and
predictions. A variety of prediction models are available in the literature. The majority of these models are based on extrapolating by the parameters related to the diseases, which are history-oriented. Instead, the current research is designed to predict
the mortality rate of COVID-19 by Regression techniques in comparison to the models followed by five countries. Methods: The Regression method with an optimized hyper-parameter is used to develop these models under training data by Machine Learning Technique.
Results: The validity of the proposed model is endorsed by considering the case study on the data for Pakistan. Five distinct models for mortality rate prediction are built using Confirmed cases data as a predictor variable for France, Spain, Turkey, Sweden,
and Pakistan, respectively. The results evidenced that Sweden has a fewer death case over 20,000 confirmed cases without observing lockdown. Hence, by following the strategy adopted by Sweden, the chosen entity will control the death rate despite the increase
of the confirmed cases. Conclusion: The evaluated results notice the high mortality rate and low RMSE for Pakistan by the GPR method based Mortality model. Therefore, the morality rate based MRP model is selected for the COVID-19 death rate in Pakistan. Hence,
the best-fit is the Sweden model to control the mortality rate. © 2020 |
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How COVID-19 shock will drive the economy and climate? A data-driven approach to
model and forecast |
Khurshid, A, Khan, et al |
Environ Sci Pollut Res Int |
Economics | Économie |
The pandemic shock puts the world on quarantine and paused economic operations that affected energy consumption and
economic output. This study analyzed the impact of the COVID-19 shock on GDP, energy consumption, and climate change then forecasted the situation until 2032 using the system dynamic modeling approach. The outcomes reveal that the pandemic shock will decrease
the growth by 1.3% in 2020 and 1.32% in 2021. The current shortfall, low energy consumption, and delay in completion of energy-related projects can reduce the GDP by 5.2% in 2020. The effect will penetrate the system and will cause further losses in the upcoming
years. The energy consumption and quarantine situation will improve the climate situation and drop the average temperature by 0.049 and 0.021 (o)C in 2020 and 2021. The aggregate demand and supply side measures such as national spending, lowering the lending
rate, and cuts in income taxes can help in diffusing the situation. The government should start operations on ongoing energy projects, give relaxation to SME's with tight SOPs to secure jobs, and prevent possible GDP losses. The decline in oil prices provides
an opportunity to cut fossil fuel subsidies and implement a carbon pricing mechanism. |
|
Klein, EA, Li, et al |
J Urol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
BACKGROUND: TMPRSS2 is a host co-receptor for cell entry of SARS-CoV-2. One prior report suggested that use of androgen
deprivation therapy (ADT), which downregulates TMPRSS2, may protect men with prostate cancer from infection. PATIENTS AND METHODS: Cohort study of a prospective registry of all patients tested for SARS-CoV-2 between March 12 and June 10, 2020, with complete
follow-up until disease recovery or death. The main exposure examined was the use of ADT, and the outcome measures were the rate of SARS-CoV-2 positivity and disease severity as a function of ADT use. RESULTS: The study cohort consisted of 1,779 men with prostate
cancer from a total tested population of 74,787, of whom 4,885 (6.5%) were positive for SARS-CoV-2. Of those with prostate cancer, 102 (5.7%) were SARS-CoV-2 positive and 304 (17.1%) were on ADT. Among those on ADT, 5.6% were positive as compared to 5.8% not
on ADT. Men on ADT were slightly older (75.5 vs. 73.8 years, p=.009), more likely to have smoked (68.1% vs. 59.3%, p =.005), and more likely to report taking steroids (43.8% vs. 23.3%, p < .001). Other factors known to increase both risk of infection and disease
severity were equally distributed (asthma, diabetes mellitus, hypertension, coronary artery disease, heart failure, and immune suppressive disease). Multivariable analysis did not indicate a difference in infection risk for those with prostate cancer on ADT
(OR 0.93, 95% CI 0.54-1.61, p = 0.8). CONCLUSIONS: ADT does not appear to be protective against SARS-CoV-2 infection. |
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32872179; Health behavior changes during covid-19 pandemic and subsequent “stay-at-home”
orders |
Knell, G, Robertson, et al |
International Journal of Environmental Research and Public Health |
Public Health response| Interventions de santé publique |
The purpose of this study was to investigate how these health behaviors changed (increased/improved or decreased/worsened)
at the early stages of the pandemic, what participant characteristics were associated with health behavior changes, and why these behavioral changes may have occurred. A convenience sample of 1809 adults residing in the United States completed a 15-min self-report
questionnaire in April and May 2020. Participants were primarily female (67.4%), aged 35–49 years (39.8%), college graduates (83.3%), non-tobacco users (74.7%), and had previously used marijuana (48.6%). Overall, participants primarily reported a decrease
in physical activity, while sleep and all of the negative health behaviors remained the same. Changes in negative health behaviors were related (p < 0.05) to sex, age, parental status, educational status, job status, BMI, and depression scores. Changes in
positive health behaviors were related (p < 0.05) to sex, parental status, job status, and depression scores. |
|
Knolle, Franziska, Ronan, et al |
medRxiv |
Epidemiology| Épidémiologie Public Health response| Interventions de santé publique |
In this study, we compare the impact of the pandemic on two European countries: the UK and Germany, which reported
their first cases within a week. 241 residents of the UK and 541 residents of Germany filled in an online survey, including questions on COVID-19 exposure, impact on financial situation and work, substance and media consumption, self-reported mental and physical
health, as well as including two clinical questionnaires, the general mental health Symptom Check List-27 (SCL-27) and the Schizotypal Personality Questionnaire. Data collection was completed between 27/04/20-31/05/20. We found distinct differences between
the two countries. UK responders reported a stronger direct impact on their health, financial situation and their families. UK responders had higher clinical scores on the SCL-27, with a higher percentage being above cut-off. Interestingly, however, we found
that German responders were less hopeful for an end of the pandemic and more concerned about their life-stability. Generally, we found that a younger age, being female, lower education, poorer mental and physical health before the pandemic, as well as more
social media and substance consumption was associated with a higher clinical risk. |
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Koeppel, L, Gottschalk, et al |
F1000Research |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Since the first identified case of COVID-19 in Wuhan, China, the disease has developed into a pandemic, imposing a
major challenge for health authorities and hospitals worldwide. Mathematical transmission models can help hospitals to anticipate and prepare for an upcoming wave of patients by forecasting the time and severity of infections. Taking the city of Heidelberg
as an example, we predict the ongoing spread of the disease for the next months including hospital and ventilator capacity and consider the possible impact of currently imposed countermeasures. Copyright: © 2020 Koeppel L et al. |
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Binding mechanism of SARS-CoV-2 spike protein with human ACE2 receptor |
Koirala, RP, T |
Research Square prepub |
Coronavirology| Coronavirologie |
SARS-CoV-2 virus interacts via C-terminal domain of spike protein to human cell receptor protein hACE2. Amino acid
residues residing at the interface play vital role in binding of SARS-CoV-2 CTD to hACE2. The detailed atomic level inves- tigation of interactions at binding interface of SARS-CoV-2 CTD/hACE2 provides indispensable information on better understanding of location
for drug target. In the present work, we have studied the dynamical behaviour of the complex by ana- lyzing the molecular dynamics (MD) trajectories. The major interacting residues of SARS-CoV-2 CTD and hACE2 have been identified by analyzing the non-bonded
interactions such as hydrogen bondings, salt bridges, hydrophobic interactions, van der Waals interactions etc. Umbrella sampling method has been used to estimate the binding free energy for in-depth understanding of binding mechanism between virus protein
and host receptor. The binding free energy difference, key residues at the interface, important atomic interactions and contact surface areas have been compared with the molecular complex of SARS-CoV and hACE2. Relatively larger contact surface area, more non-bonded
interactions as well as greater binding free energy provide the evidence for favorable binding of SARS-CoV-2 with hACE2 receptor than SARS-CoV. |
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Forecasting
COVID-19 cases in Saudi Arabia using machine learning SEIR and LSTM |
Kola, S, Veena, et al |
Journal of Green Engineering |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
COVID-19 has spread out as an undescribable bug affecting civilizations. Economies of umpteen governments of the world
are strained. Virus is selfpostulating affecting many cultures of the world.Incarnated as a tumultuous pandemic changing many governments’walks and expectations. Cases in number uncountable and unaccountable resulted as burden on security and healthcare systems.
As data sets are tender and virus reflecting many behavioural qualities, predicting the loss and behaviour of the virus appears as biased. We have shown in this article information-driven methods of forecasting the numbers of COVID-19 cases in Saudi Arabia
60 days ahead and impacts of protective steps such as social isolations or lockout of COVID-19 in the future, using the different machine learning models such as Sigmoid fitting, SEIR model and LSTM. The affected states are analysed in the model as susceptible
(S), exposed (E), infected (I), and resistant (R) and a model is developed which is tested with intervention and without intervention. An SEIR model is a family of factor models for the purposes of time series analysis and forecasting. Usage of raw data by
separating an event from the preceding event to render the time series set. The estimation of different parameters achieved by the suggested method (number of positives, number of re-referred events, etc.) is accurate within a specified range and is a resource
for health authorities and officials to gain. © 2020 Alpha Publishers. All rights reserved. |
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Kolta, MF, Ghonimy, et al |
Egyptian Journal of Radiology and Nuclear Medicine |
Clinical data| Données cliniques |
The purpose is to investigate the wide spectrum of radiological pulmonary changes in COVID-19 patients and compare
them to the variable CT findings reported in MERS and SARS. From March 15 to May 12, 2020, 50 patients in Cairo, Egypt, who have positive RT-PCR tests, were included in our study. The most imminent radiological finding was patchy peripheral subpleural ground
glass opacity found in 42 patients (84% of cases), followed by consolidation found in 30 patients (60% of cases) and ground glass and consolidation together found in 22 patients (44% of cases). Unlike SARS, where initial chest imaging abnormalities are more
frequently unilateral, COVID-19 is more likely to involve both lungs on initial imaging presented as bilateral peripheral subpleural scattered ground-glass opacities. Pleural effusion is absent in COVID-19 patients while it is not rare in MERS and might be
observed in 20–33% of affected individuals. |
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32865490; The Pathology of Severe COVID-19-Related Lung Damage |
Kommoss, FKF, Schwab, et al |
Deutsches Arzteblatt international |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this article, we describe the sequence of pathological changes in COVID-19 and discuss the implications for approaches
to treatment. Standardized autopsies were performed on thirteen patients who had died of COVID-19. The findings were analyzed together with clinical data from the patients' medical records. Most (77%) of the deceased patients were men. Their median age at
death was 78 years (range, 41-90). Most of them had major pre-existing chronic diseases, most commonly arterial hypertension. The autopsies revealed characteristic COVID-19-induced pathological changes in the lungs, which were regarded as the cause of death
in most patients. The main histological finding was sequential alveolar damage, apparently due in large measure to focal capillary microthrombus formation. Alveolar damage leads to the death of the patient either directly or by the induction of pulmonary parenchymal
fibrosis. Diffuse lung damage was seen exclusively in invasively ventilated patients. |
|
Spontaneous pneumomediastinum in an elderly COVID-19 patient: A case report |
Kong, N, Gao, et al |
World Journal of Clinical Cases |
Clinical data| Données cliniques |
Here we report the case of an elderly patient diagnosed with coronavirus disease 2019 (COVID-19) who neither got mechanical
ventilation nor had chest trauma but were found to develop SPM for unknown reason. |
|
Kuchinski, KS, Jassem, et al |
Journal of Clinical Virology |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Introduction: During the first month of the SARS-CoV-2 outbreak, rapid development of PCR-based diagnostic tests became
a global priority so that timely diagnosis, isolation, and contact tracing could minimize the advancing pandemic surge. Designing these tests for broad, long-term detection was complicated by limited information about the novel virus’ genome sequence and how
it might mutate during global spread and adaptation to humans. Methods: We assessed eight widely adopted lab developed PCR tests for SARS-CoV-2 against 15,001 SARS-CoV-2 genome sequences. Using a custom bioinformatic pipeline called PCR_strainer, we identified
all mismatches and sequence variants in genome locations targeted by 15 sets of primer/probe oligonucleotides from these assays. Results: For 12 out of 15 primer/probe sets, over 98 % of SARS-CoV-2 genomes had no mismatches. Two primer/probe sets contained
a single mismatch in the reverse primer that was present in over 99 % of genomes. One primer/probe set targeted a location with extensive polymorphisms with 23 sequence observed variants at the forward primer location. One of these variants, which contains
three nucleotide mismatches, arose in February as part of the emergence of a viral clade and was present in 18.8 % of the genomes we analyzed. Discussion: Most early PCR diagnostic tests for SARS-CoV-2 remain inclusive of circulating viral diversity, but three
assays with extensive mismatches highlight assay design challenges for novel pathogens and provide valuable lessons for PCR assay design during future outbreaks. Our bioinformatics pipeline is also presented as a useful general-purpose tool for assessing PCR
diagnostics assays against circulating strains. © 2020 |
|
|
COVID-19: Severity of the pandemic and responses of Indian states |
Kujur, SK, Goswami, et al |
Journal of Public Affairs |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
Do Indian states with comprehensive labor measures experience low fatality due to COVID-19? An analysis of the relationship
between labor measures of the state government in India and the severity of the pandemic reveals that states such as Uttar Pradesh, Delhi, Kerala, Odisha, and Bihar that have adopted inclusive labor measures have witnessed lesser case fatality ratios. In contrast,
states like West Bengal, Gujarat, Punjab, Madhya Pradesh, and Maharashtra with inadequate labor measures have experienced high levels of COVID-19-related fatalities. The impressive approach adopted by the successful states can be considered as a model to deal
with the despairing labor force during the global pandemic. © 2020 John Wiley & Sons Ltd |
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Coronavirus disease-19 (COVID-19) associated with acute necrotising pancreatitis (ANP) |
Kumaran, NK, Karmakar, et al |
BMJ Case Rep |
Clinical data| Données cliniques |
Coronavirus is a severe infectious disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
and has led to increased mortality worldwide. Multiple reports have been published citing that gastrointestinal symptoms are common in patients with COVID-19 infection. It has also been found that the ACE2 receptor of SARS-CoV-2 is expressed more in the pancreas
than the lungs. Despite this, little attention has been paid to the extent and details of pancreatic injury caused by COVID-19. Lack of awareness regarding the COVID-19 status of patients presenting with pancreatitis may expose healthcare workers to SARS-CoV-2
while performing interventions to manage complications of pancreatitis such as necrosis. We report a case of COVID-19-induced acute necrotising pancreatitis in the absence of any known risk factors. |
|
La Torre, G, Massetti, et al |
J Clin Med |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
BACKGROUND: The aim of this study was to investigate the diagnostic accuracy of symptoms and signs in healthcare workers
(HCW) with Sars-CoV-2. METHODS: This was a case-control study. Cases consisted of symptomatic healthcare workers who had a positive SARS-CoV-2 real-time polymerase chain reaction (RT-PCR) test, while controls were symptomatic healthcare workers with a negative
RT-PCR test. For each symptom, ROCs were plotted. Diagnostic accuracy was calculated using the sensitivity, specificity, and positive and negative predictive values. A logistic regression analysis was carried out for calculating the OR (95% CI) for each symptom
associated to the SARS-CoV-2 positivity. RESULTS: We recruited 30 cases and 75 controls. Fever had the best sensitivity while dyspnea, anosmia, and ageusia had the highest specificity. The highest PPVs were found again for dyspnea (75%), anosmia (73.7%), and
ageusia (66.7%). Lastly, the highest NPVs were related to anosmia (81.4%) and ageusia (79.3%). Anosmia (OR = 14.75; 95% CI: 4.27-50.87), ageusia (OR = 9.18; 95% CI: 2.80-30.15), and headache (OR = 3.92; 95% CI: 1.45-10.56) are significantly associated to SARS-CoV-2
positivity. CONCLUSIONS: Anosmia and ageusia should be considered in addition to the well-established fever, cough, and dyspnea. In a resource-limited setting, this method could save time and money. |
|
|
32768693; Early identification of COVID-19 cytokine storm and treatment with anakinra
or tocilizumab |
Langer-Gould, A, Smith, et al |
International Journal of Infectious Diseases |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
Objective: To examine outcomes among patients who were treated with the targeted anti-cytokine agents, anakinra or
tocilizumab, for COVID-19 -related cytokine storm (COVID19-CS). Methods: We conducted a retrospective cohort study of all SARS-coV2-RNA-positive patients treated with tocilizumab or anakinra in Kaiser Permanente Southern California. Local experts developed
and implemented criteria to define COVID19-CS. All variables were extracted from electronic health records. Results: At tocilizumab initiation (n = 52), 50 (96.2%) were intubated, and only seven (13.5%) received concomitant corticosteroids. At anakinra initiation
(n = 41), 23 (56.1%) were intubated, and all received concomitant corticosteroids. Fewer anakinra-treated patients died (n = 9, 22%) and more were extubated/never intubated (n = 26, 63.4%) compared to tocilizumab-treated patients (n = 24, 46.2% dead, n = 22,
42.3% extubated/never intubated). Patients who died had more severe sepsis and respiratory failure and met COVID-CS laboratory criteria longer (median = 3 days) compared to those extubated/never intubated (median = 1 day). After accounting for differences
in disease severity at treatment initiation, this apparent superiority of anakinra over tocilizumab was no longer statistically significant (propensity score-adjusted hazards ratio 0.46, 95% confidence interval 0.18–1.20). Conclusions: Prompt identification
and treatment of COVID19-CS before intubation may be more important than the specific type of anti-inflammatory treatment. Randomized controlled trials of targeted anti-cytokine treatments and corticosteroids should report the duration of cytokine storm in
addition to clinical severity at randomization. © 2020 Southern California Permanente Medical Group |
|
Test sensitivity is secondary to frequency and turnaround
time for COVID-19 surveillance |
Larremore, DanielB, Wilder, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique |
The COVID-19 pandemic has created a public health crisis. Because SARS-CoV-2 can spread from individuals with pre-symptomatic,
symptomatic, and asymptomatic infections, the re-opening of societies and the control of virus spread will be facilitated by robust surveillance, for which virus testing will often be central. After infection, individuals undergo a period of incubation during
which viral titers are usually too low to detect, followed by an exponential viral growth, leading to a peak viral load and infectiousness, and ending with declining viral levels and clearance. Given the pattern of viral load kinetics, we model surveillance
effectiveness considering test sensitivities, frequency, and sample-to-answer reporting time. These results demonstrate that effective surveillance depends largely on frequency of testing and the speed of reporting, and is only marginally improved by high
test sensitivity. We therefore conclude that surveillance should prioritize accessibility, frequency, and sample-to-answer time; analytical limits of detection should be secondary. |
|
Latini, A, Agolini, et al |
Genes |
Coronavirology| Coronavirologie |
The recent global COVID-19 public health emergency is caused by SARS-CoV-2 infections and can manifest extremely variable
clinical symptoms. Host human genetic variability could influence susceptibility and response to infection. It is known that ACE2 acts as a receptor for this pathogen, but the viral entry into the target cell also depends on other proteins. The aim of this
study was to investigate the variability of genes coding for these proteins involved in the SARS-CoV-2 entry into the cells. We analyzed 131 COVID-19 patients by exome sequencing and examined the genetic variants of TMPRSS2, PCSK3, DPP4, and BSG genes. In
total we identified seventeen variants. In PCSK3 gene, we observed a missense variant (c.893G>A) statistically more frequent compared to the EUR GnomAD reference population and a missense mutation (c.1906A>G) not found in the GnomAD database. In TMPRSS2 gene,
we observed a significant difference in the frequency of c.331G>A, c.23G>T, and c.589G>A variant alleles in COVID-19 patients, compared to the corresponding allelic frequency in GnomAD. Genetic variants in these genes could influence the entry of the SARS-CoV-2.
These data also support the hypothesis that host genetic variability may contribute to the variability in infection susceptibility and severity. |
|
|
Prioritizing COVID-19 tests based on participatory surveillance and spatial
scanning |
Leal-Neto, O, Santos, et al |
International journal of medical informatics |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
This study aimed to identify, describe and analyze priority areas for COVID-19 testing combining Participatory Surveillance
(PS) and Traditional Surveillance (TS) in the city of Caruaru, Brazil. PS had 861 active users, presenting an average of 1.2 reports per user per week while TS had 1588 individuals were positive for this clinical outcome. The spatial scanning analysis detected
18 clusters and 6 of them presented statistical significance (p-value < 0.1). Clusters 3 and 4 presented an overlapping area that was chosen by the local authority to deploy the COVID-19 serology, where 50 individuals were tested. From there, 32 % (n = 16)
presented reagent results for antibodies related to COVID-19. |
|
Lee, IH, Lee, et al |
Infection, Genetics and Evolution |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
Here we investigated whether genetic variation in the key genes for viral entry to host cells—ACE2 and TMPRSS2—and
sensing of viral genomic RNAs (i.e., TLR3/7/8) could explain the variation in incidence across diverse ethnic groups. Overall, these genes are under strong selection pressure and have very few nonsynonymous variants in all populations. Genetic determinant
for the binding affinity between SARS-CoV-2 and ACE2 does not show significant difference between populations. Non-genetic factors are likely to contribute differential population characteristics affected by COVID-19. Nonetheless, a systematic mutagenesis
study on the receptor binding domain of ACE2 is required to understand the difference in host-viral interaction across populations. |
|
|
Lee, S, Kim, et al |
JAMA Internal Medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this study was to quantitatively describe SARS-CoV-2 molecular viral shedding in asymptomatic and symptomatic
patients in a community treatment center in Cheonan, Republic of Korea. We found that 110 (36.3%) out of 303 patients were asymptomatic at the time of isolation and 21 of these (19.1%) developed symptoms during isolation. The cycle threshold values of reverse
transcription–polymerase chain reaction for SARS-CoV-2 in asymptomatic patients were similar to those in symptomatic patients. |
|
|
Lee, YM, Kim, et al |
American Journal of Infection Control |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) |
The objective of this study was to determine the contamination degree of an isolation room of a patient with COVID-19
using additional ATP monitoring, before and after cleaning, to determine the proper approach to prevent the hospital spread of SARS-CoV-2. SARS-CoV-2 was not detected in any surface sample in our study and post cleaning ATP values was significantly decreased
indicating that routine cleaning may be enough to manage the hospital environment for preventing the outbreak of COVID-19. |
|
|
Lei, H, Xu, et al |
J Infect Dis |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
In this study, the extent to which non-pharmaceutical interventions (NPIs) targeting COVID-19 have affected seasonal
influenza transmission was explored. Indicators of seasonal influenza activity in the epidemiological year 2019/20 were compared with those in 2017/18 and 2018/19. Results show that the incidence rate of seasonal influenza reduced by 64% in 2019/20 (p&0.001). |
|
|
Assessing COVID-19 Transmission to Healthcare Personnel: the Global ACT-HCP Case-Control
Study |
Lentz, RJ, Colt, et al |
Infect Control Hosp Epidemiol |
Epidemiology| Épidémiologie Transmission |
The objective of this case-control study was to characterize associations between exposures within and outside the
medical workplace with healthcare personnel (HCP) SARS-CoV-2 infection, including the effect of various forms of respiratory protection. HCP infection was associated with non-aerosol-generating contact with COVID-19 patients (adjusted OR 1.4, 95% CI 1.04–1.9,
p=0.03) and extra-occupational exposures including gatherings of ten or more, patronizing restaurants or bars, and public transportation (adjusted ORs ranging 3.1-16.2). Respirator use during aerosol-generating procedures (AGPs) was associated with lower odds
of HCP infection (adjusted OR 0.4, 0.2 to 0.8, p=0.005), as was exposure to intensive care and dedicated COVID units, negative pressure rooms, and personal protective equipment (PPE) observers (adjusted ORs ranging 0.4-0.7). |
|
Coronavirus Disease 2019 Induced Inflammatory Response are Associated with
Changes in Lipid Profiles |
Li, C, Z |
Research Square prepub |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this retrospective study of patients in China was to investigate the relationships between lipid profiles
and inflammation markers among patients with Covid-19. Results indicate that patients with Covid-19 are associated with decreased lipid and lipoprotein levels. Covid-19 infection induced inflammation response and cytokine storm were associated with a shift
of lipids, lipoproteins toward a more atherogenic lipid profile. |
|
Li, DJ, Kao, et al |
International journal of environmental research and public health |
Public Health response| Interventions de santé publique |
We aimed to develop a beneficial survey tool with favorable quality and availability, the Societal Influences Survey
Questionnaire (SISQ), to evaluate social influences on people during this pandemic. The SISQ was developed with 15 items and 4-point Likert scales consisting of five factors. These include social distance, social anxiety, social desirability, social information,
and social adaptation. The questionnaire was deployed on 1912 Taiwanese and construct validity and reliability were performed to verify the SISQ. The results demonstrated that the SISQ has acceptable reliability. As for multiple comparison, females scored
higher than males in factor of social distance. Unemployed participants and those without partners scored higher in several domains of factors. |
|
|
32851093; Clinical Characteristics of Diabetic Patients with COVID-19 |
Li, G, Deng, et al |
Journal of diabetes research |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study is aimed at describing the characteristics of COVID-19 patients (n = 199) in Wuhan. The cases were divided
into diabetic and nondiabetic groups according to the history of taking antidiabetic drugs or by plasma fasting blood glucose level at admission, and the difference between groups were compared. Compared with nondiabetics, patients with diabetes had an older
age, high levels of fasting plasma glucose (FPG), D-dimer, white blood cell, blood urea nitrogen (BUN) and total bilirubin (TBIL), lower levels of lymphocyte, albumin and oxygen saturation (SaO2), and higher mortality. |
|
SARS-CoV-2 spike produced in insect cells elicits high neutralization titers
in non-human primates |
Li, T, Zheng, et al |
Emerg Microbes Infect |
Coronavirology| Coronavirologie Vaccine Research| Recherche sur les vaccins Animal
model | Modèle animal |
Here we expressed and evaluated as potential candidates four versions of the spike (S) protein using an insect cell
expression system: receptor binding domain (RBD), S1 subunit, the wild-type S ectodomain (S-WT), and the prefusion trimer-stabilized form (S-2P). We showed that RBD appears as a monomer in solution, whereas S1, S-WT, and S-2P associate as homotrimers with
substantial glycosylation. Cryo-electron microscopy analyses suggested show that S-2P assumes an identical trimer conformation as the similarly engineered S protein expressed in 293 mammalian cells but with reduced glycosylation. Overall, the four proteins
confer excellent antigenicity with convalescent COVID-19 patient sera in enzyme-linked immunosorbent assay (ELISA), yet show distinct reactivities in immunoblotting. RBD, S-WT and S-2P, but not S1, induce high neutralization titers (>3-log) in mice after a
three-round immunization regimen. Our results suggest that the prefusion trimer-stabilized SARS-CoV-2 S-protein from insect cells may offer a potential candidate strategy for the development of a recombinant COVID-19 vaccine. |
|
Intelligent Manufacturing Systems in COVID-19 Pandemic and Beyond: Framework and
Impact Assessment |
Li, X, Wang, et al |
Chinese Journal of Mechanical Engineering (English Edition) |
Public Health response| Interventions de santé publique |
In this study, we create a novel intelligent manufacturing framework for the production recovery under the pandemic
and build an assessment model to evaluate the impacts of the intelligent manufacturing (IM) technologies on industrial networks. Considering the constraints of the IM resources, we formulate an optimization model to schedule the allocation of IM resources
according to the mutual market demands and the severity of the pandemic. |
|
In vivo antiviral host transcriptional response to SARS-CoV-2 by viral load,
sex, and age |
Lieberman, NAP, Peddu, et al |
PLoS Biol |
Clinical data| Données cliniques |
Here, we examined host response gene expression across infection status, viral load, age, and sex among shotgun RNA
sequencing profiles of nasopharyngeal (NP) swabs from 430 individuals with PCR-confirmed SARS-CoV-2 and 54 negative controls. Older individuals had reduced expression of the Th1 chemokines CXCL9/10/11 and their cognate receptor CXCR3, as well as CD8A and granzyme
B, suggesting deficiencies in trafficking and/or function of cytotoxic T cells and natural killer (NK) cells. Relative to females, males had reduced B cell–specific and NK cell–specific transcripts and an increase in inhibitors of nuclear factor kappa-B (NF-κB)
signaling, possibly inappropriately throttling antiviral responses. Collectively, our data demonstrate that host responses to SARS-CoV-2 are dependent on viral load and infection time course, with observed differences due to age and sex that may contribute
to disease severity. |
|
Lin, YT, Cheng, et al |
Hong Kong Journal of Emergency Medicine |
Clinical data| Données cliniques |
A 34-year-old man presented to our emergency department with progressive rhinorrhoea, a sore throat, and recent travel
to the United States (Texas) and Mexico. He was diagnosed with COVID-19 after a positive throat swab test. This case demonstrates Taiwan’s unique epidemic prevention strategy, including the utilization of face masks, compact screening indications, quarantine
arrangements, and the effective disposition of confirmed cases. |
|
|
32735938; Evaluating the newly developed BioFire COVID-19 test for SARS-CoV-2 molecular
detection |
Liotti, FM, Menchinelli, et al |
Clinical Microbiology and Infection |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We compared the performance of BioFire COVID-19 test with that of Quanty COVID-19 assay (Clonit, Milan, Italy), which
also provides quantitative results, for detection of SARS-CoV-2 RNA in nasal/oropharyngeal (N/OP) patient samples. Compared to the reference method, the BioFire COVID-19 test sensitivity, specificity, positive predictive value and negative predictive value
(with their 95% confidence intervals) were 93.0 (85.4–97.4), 100.0 (89.7–100.0), 100.0 (95.5–100.0) and 85.0 (70.2–94.3), respectively. |
|
Liu, CF, Lyu, et al |
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi |
Epidemiology| Épidémiologie Transmission Clinical data| Données cliniques |
In chinese: This study investigates and analyzes the family cluster epidemics that occurred in the Inner Mongolia Autonomous
Region of China and the relationship between them, the transmission mode of COVID-19, and guides residents to take personal protection to avoid family cluster epidemics. [In Chinese]. |
|
|
Liu, S, Zhang, et al |
Diabetes Metab |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aimed to explore the association between stratified fasting blood glucose (FBG) levels and poor outcomes in patients
hospitalized for COVID-19. Compared with patients with normal FBG levels, patients with elevated FBG were older and more likely to have comorbidities. On multivariable analyses, patients with FBG at 6.1–6.9 mmol/L [odds ratio (OR): 5.38, 95% confidence interval
(CI): 1.18–24.52; P = 0.030] had a higher risk of progression to critical illness than those with FBG ≥ 7.0 mmol/L (OR: 3.94, 95% CI: 1.03–15.15; P = 0.046). |
|
|
Liu, WD, Chang, et al |
Journal of the Formosan Medical Association |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
In this preliminary report, we presented six patients with mild to moderate COVID-19. They were treated with hydroxychloroquine
(HCQ) for 14 days from the day of COVID-19 diagnosis. Serial viral load from respiratory specimens were performed every other day. Among the six patients, the mean duration from symptom onset to last detectable viral load was 34 ± 12 days, which was similar
to those without specific treatment in previous reports and prolonged virus shedding is still observed regardless HCQ. |
|
|
Liu, X, Liu, et al |
J Med Virol |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
This hospital-based retrospective study of 435 medical staff sought to explore the role of thymosin drugs in the prevention
of a novel coronavirus disease (COVID‐19). In the similar exposure environment, compared to medical staff who did not take preventive medicine, the use of thymosin drugs, before exposure and after exposure had an insignificant effect, and the adverse drug
reaction (ADR) was increased, especially when thymosin drugs used together with α‐interferon. |
|
|
Home quarantine compliance is low in children with fever during COVID-19 epidemic |
Lou, Q, Su, et al |
World Journal of Clinical Cases |
Public Health response| Interventions de santé publique |
The objective of this study is to explore the factors that influence home quarantine compliance in children with fever
during the COVID-19 epidemic in China. Among the ten quarantine measures, the proportion of families adhering to keeping 1.5 m distance, proper hand hygiene, wearing masks at home, and proper cough etiquette was very low (< 30% for each measure). Our analysis
showed that compliance was related to gender and age of children, gender and age of primary caregiver, number of children in the family, and intensity of information on quarantine measures. |
|
Lovetrue, B |
Medical hypotheses |
Coronavirology| Coronavirologie |
We present the AI-discovered aetiology of COVID-19, based on a precise disease model of COVID-19 built under five weeks
that best matches the epidemiological characteristics, transmission dynamics, clinical features, and biological properties of COVID-19. Results indicate that SARS-CoV-2 implements a unique unbiased survival strategy of balancing viral replication with viral
spread by increasing its dependence on (i) ACE2-expressing cells for viral entry and spread, (ii) PI3K signaling in ACE2-expressing cells for viral replication and egress, and (iii) viral- non-structural-and-accessory-protein-dependent immunomodulation to
balance viral spread and viral replication. |
|
|
32800590; Fulminant myocarditis and cardiogenic shock during SARS-CoV-2 infection |
Lozano Gómez, H, Pascual Bielsa, et al |
Medicina clinica |
Clinical data| Données cliniques |
We present the case of a 53-year-old man, previously healthy, who came to the emergency room due to dyspnea and fever
of 38 ° C of 10 days of evolution. This case shows a clinical presentation of acute myocarditis involving a wide spectrum of symptoms, from chest pain to cardiogenic shock. [In Spanish]. |
|
Lu, QB, Jiang, et al |
Journal of Infection |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Here by performing a retrospective multi-center study, we try to evaluate the adjusted effect of the common preexisting
comorbidities on COVID-19 related death, based on which, the therapy effect of three widely used anti-hypertension drugs were assessed. By multivariate logistic regression model adjusting age, sex, and delay from symptom onset to hospital admission, six comorbidities
showed significant associations with the disease outcome, with malignancy exhibiting the highest risk of death, followed by chronic kidney diseases (CKD), cerebrovascular diseases (CVD), hypertension, chronic heart diseases (CHD), and diabetes mellitus (DM). |
|
|
Lu, Y, Li, et al |
EClinicalMedicine |
Clinical data| Données cliniques |
In this prospective study, diffusion tensor imaging (DTI) and 3D high-resolution T1WI sequences were acquired in 60
recovered COVID-19 patients and 39 age- and sex-matched non-COVID-19 controls in order to identify the existence of potential brain micro-structural changes related to SARS-CoV-2. Study findings revealed possible disruption to micro-structural and functional
brain integrity in the recovery stages of COVID-19, suggesting the long-term consequences of SARS-CoV-2. |
|
|
Lund, LC, Kristensen, et al |
PLoS Med |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
We conducted a population-based cohort study using Danish administrative and health registries. in order to study whether
use of NSAIDs was associated with adverse outcomes and mortality during SARS-CoV-2 infection. Results indicate that use of NSAIDs was not associated with 30-day mortality, hospitalization, ICU admission, mechanical ventilation, or renal replacement therapy
in Danish individuals who tested positive for SARS-CoV-2. |
|
|
UVA radiation could be a significant contributor to
sunlight inactivation of SARS-CoV-2 |
Luzzatto-Fegiz, Paolo, Temprano-Coleto, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Recent experiments have demonstrated that SARS-CoV-2 is inactivated by simulated sunlight; however, there are still
many unknowns, including the mechanism of action and which part of the light spectrum is principally responsible. Our modelling and analysis indicates the need for targeted experiments that can separately assess the effects of UVA and UVB on SARS-CoV-2, and
that sunlight inactivation models may need to be expanded to also include the effect of UVA. A first UVA-inclusive model is also proposed here. These findings have implications for how to improve the safety of the built environment, and for the seasonality
of COVID-19 |
|
Ma, Q, Li, et al |
Phytomedicine |
Therapeutics| Thérapeutique |
The study was designed to investigate the antiviral and anti-inflammatory activities of KD-1 against the novel SARS-CoV-2
and HCoV-229E and its potential effect in regulating host immune response in vitro. Study results find that KD-1 could significantly inhibit SARS-CoV-2 and HCoV-229E replication in vitro. KD-1 could also markedly reduce the production of proinflammatory cytokines
(TNF-α, IL-6, IL-1β, MCP-1, and IP-10) at the mRNA levels. Moreover, KD-1 could significantly reduce the protein expression of p-NF-κB p65, NF-κB p65, and p-IκBα, while increasing the expression of IκBα in Huh-7 cells. |
|
|
Incorrect Use of Face Masks during the Current COVID-19 Pandemic among the General
Public in Japan |
Machida, M, Nakamura, et al |
Int J Environ Res Public Health |
Public Health response| Interventions de santé publique |
We set out to determine the prevalence of wearing masks to prevent COVID-19 and compliance with appropriate measures
for the correct use of face masks among the general public in Japan where wearing medical masks is a “cultural” normality through an online questionnaire (n = 2141). The prevalence of wearing masks was 80.9% and compliance rates with appropriate measures ranged
from 38.3% to 83.5%. Only 23.1% complied with all recommendations. Compliance rates were overall low in men and persons with low household incomes. |
|
Majumder, R, Mandal, et al |
J Biomol Struct Dyn |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This molecular docking study aimed to screen plant-based natural compounds from Sigma-Aldrich plant profiler chemical
library to find out potential COVID-19 Mpro inhibitors. Our virtual molecular docking results have shown that there are twenty-eight natural compounds with a greater binding affinity toward the COVID-19 Mpro inhibition site as compared to the co-crystal native
ligand Inhibitor N3 (-7.9 kcal/mol). |
|
|
Mancilla-Galindo, Javier, Vera-Zertuche, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We sought to develop and validate a multivariable prediction model of death in Mexican patients with COVID-19, by using
demographic and patient history predictors. To validate the model, 592,160 patients studied between June 1 and July 23, 2020 were included. Eight predictors (age, sex, diabetes, COPD, immunosuppression, hypertension, obesity, and CKD) were included in the
PH-Covid19 scoring system (range of values: -2 to 25 points). The predictive model has a discrimination of death of 0.8 (95%CI:0.796-0.804) |
|
|
Escalation of sleep disturbances amid the COVID-19 pandemic: a cross-sectional international
study |
Mandelkorn, U, Genzer, et al |
J Clin Sleep Med |
Public Health response| Interventions de santé publique |
This international survey sought to identify which populations have experienced changes in sleeping patterns during
the pandemic and their extent. 3,062 respondents from 49 countries accessed the survey website completed the study and in a secondary study 1,022 adult US respondents were recruited for pay. The survey tool included demographics and items adapted from validated
sleep questionnaires on sleep duration, quality and timing, and sleeping pills consumption. Forty percent of the respondents reported a decreased sleep quality vs. before COVID-19 crisis. Self-reported sleeping pill consumption increased by 20% (p<0.001).
Multivariable analysis indicated that female sex, being in quarantine, 31 to 45-year age group, reduced physical activity and adverse impact on livelihood were independently associated with more severe worsening of sleep quality during the pandemic. |
|
Conserved HLA binding peptides from five non-structural proteins of SARS-CoV-2—An
in silico glance |
Marchan, J |
Human immunology |
Coronavirology| Coronavirologie |
This immunoinformatics work aimed to identify HLA-I and HLA class II (HLA-II) binding peptides from these key SARS-CoV-2
NSPs, thereby providing more immunogenic targets with strong potential to fight COVID-19. Five severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) non-structural proteins (NSPs) (NSP7, NSP8, NSP9, NSP12, and NSP13) were screened to identify potential
human leukocyte antigen (HLA) binding peptides. These peptides showed robust viral antigenicity, immunogenicity, and a marked interaction with HLA alleles. |
|
Mascia, D, Kahlberg, et al |
Annals of Vascular Surgery |
Healthcare Response | Réponse des soins de santé |
The aim of this study was to report the experience of one of the major “hubs” for vascular surgery in Lombardy, Italy,
during the first 7 weeks after total lockdown due to COVID-19 pandemic. Results indicate that late referral in the pandemic period could seriously worsen limb prognosis; this aspect should be known and addressed by health care providers. Vascular surgical
outcomes in pre-COVID and COVID era were comparable in our experience. |
|
|
Matiz, A, Fabbro, et al |
Int J Environ Res Public Health |
Public Health response| Interventions de santé publique |
In the present study, a sample of Italian female teachers (n = 66, age: 51.5 ± 7.9 years) was assessed with self-report
instruments one month before and one month after the start of the Covid-19 lockdown: mindfulness skills, empathy, personality profiles, interoceptive awareness, psychological well-being, emotional distress and burnout levels were measured. Meanwhile, they
received an 8-week Mindfulness-Oriented Meditation (MOM) course, through two group meetings and six individual video-lessons. Based on baseline personality profiles, analyses of variance were performed in a low-resilience (LR, n = 32) and a high-resilience
(HR, n = 26) group. The LR and HR groups differed at baseline in most of the self-report measures. Pre–post MOM significant improvements were found in both groups in anxiety, depression, affective empathy, emotional exhaustion, psychological well-being, interoceptive
awareness, character traits and mindfulness levels. Improvements in depression and psychological well-being were higher in the LR vs. HR group. We conclude that mindfulness-based training can effectively mitigate the psychological negative consequences of
the Covid-19 outbreak, helping in particular to restore well-being in the most vulnerable individuals. |
|
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Complex dynamics in susceptible-infected models for COVID-19 with multi-drug resistance |
Matouk, AE |
Chaos, Solitons and Fractals |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this work, complex dynamics in Susceptible-Infected (SI) model and multi-drug resistance (MDR) and its fractional-order
counterpart are investigated in order to understand complex behaviors and predict spread of severe infectious diseases such as COVID-19. |
|
Mauro, A, De Grazia, et al |
Clinics and Research in Hepatology and Gastroenterology |
Clinical data| Données cliniques |
Our aim was to evaluate incidence of upper gastrointestinal bleeding (UGIB) and use of upper GI endoscopy in COVID-19
inpatients. Out of 4871 COVID-19 positive patients, 23 presented signs of UGIB and were included in the study (incidence 0.47%). The majority (78%) were on anticoagulant therapy or thromboprophylaxis. Mortality and rebleeding were not different between patients
having upper GI endoscopy before or after 24 h/not performed. Glasgow Blatchford score was similar between the two groups (13;12–16 vs 12;9–15). |
|
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Maculopapular rash in COVID-19 patient treated with lopinavir/ritonavir |
Mazan, P, Lesiak, et al |
Postepy Dermatologii i Alergologii |
Clinical data| Données cliniques |
We present a 35-year-old male admitted with COVID-19. The patient was hospitalized in the isolation unit and treated
with oral lopinavir/ritonavir 400/100 BID. There was an assumption that optic neuritis could have been an unspecific symptom of the coronavirus infection. Following 10 days of lopinavir/ritonavir administration, the patient developed an itchy, maculopapular
rash while being hospitalized. Based on current reports we cannot state with certainty that the maculopapular rash observed in our patient is only drug-induced, especially due to the unspecific course of the infection in this patient. There is a suspicion
that COVID19 could be a cofactor for maculopapular rash. However, the role of SARS-CoV-2 in inducing skin lesions is still uncertain and needs to be clarified based on further research and observations. |
|
Mazza, C, Ricci, et al |
International Journal of Environmental Research and Public Health |
Public Health response| Interventions de santé publique |
The present study aimed at investigating the psychological distress of parents during the lockdown, identifying contributing
factors. For parents living only with child(ren), high levels of psychological distress depended exclusively on their levels of neuroticism. For parents living with at least one other person in addition to child(ren), distress levels were also mediated by
child behavioral and emotional difficulties. Motherhood emerged as a significant factor contributing to greater distress. Furthermore, parent psychological distress decreased in line with increased child age. The results confirm that neuroticism is an important
risk factor for mental health. |
|
|
32853842; The bullseye sign: A variant of the reverse halo sign in COVID-19
pneumonia |
McLaren, TA, Gruden, et al |
Clinical imaging |
Clinical data| Données cliniques |
The predominant pulmonary imaging findings on chest CT in the novel 2019 coronavirus infection (COVID-19) are bilateral
ground glass opacities. The reverse halo sign is uncommon. This is a report of the new “bullseye sign,” which is considered a variant of the reverse halo sign and favored to represent a focus of organizing pneumonia. The specificity of this finding is unclear,
however its presence should alert radiologists to the possibility of COVID-19 infection. |
|
Meyer, J, McDowell, et al |
Int J Environ Res Public Health |
Public Health response| Interventions de santé publique |
We aimed to evaluate the impact of COVID-19-related public health guidelines on physical activity (PA), sedentary behavior,
mental health, and their interrelations. Cross-sectional data were collected from 3052 US adults 3–8 April 2020 (from all 50 states). Self-reported PA was lower post-COVID among participants reporting being previously active (mean change: −32.3% [95% CI: −36.3%,
−28.1%]) but largely unchanged among previously inactive participants (+2.3% [−3.5%, +8.1%]). No longer meeting PA guidelines and increased screen time were associated with worse depression, loneliness, stress, and PMH (p < 0.001). Self-isolation/quarantine
was associated with higher depressive and anxiety symptoms compared to social distancing (p < 0.001). |
|
|
Mi, B, Chen, et al |
Acta Orthop |
Healthcare Response | Réponse des soins de santé |
Following the outbreak of COVID, many hip fracture patients were unable to gain timely admission and surgery. We assessed
whether delayed surgery improves hip joint function and reduces major complications better than nonoperative therapy. Findings showed that delayed surgery compared with nonoperative therapy significantly improved hip function and reduced various major complications. |
|
|
Striking Similarities between CDRs in Some mAbs That Neutralize COVID-19 |
Mi, T, Burgess, et al |
ACS Medicinal Chemistry Letters |
Coronavirology| Coronavirologie |
Four of five different monoclonal antibodies (mAbs) that have been crystallized in complex with the receptor binding
domain (RBD) of the SARS-CoV-2 spike protein (S) have remarkably similar primary and secondary loop structures at the heavy chain complementarity-determining regions (HCDR) 1 and 2. All these reports give a structural basis for the deceptively difficult problem
of accurate peptidomimetic loop mimic design. |
|
Impact of COVID-19 on Lung Transplant Activity in Germany-A Cross-Sectional Survey |
Michel, S, Witt, et al |
Thorac Cardiovasc Surg |
Healthcare Response | Réponse des soins de santé |
We aimed to provide a cross-sectional overview of current limitations or adaptions in lung transplant programs in Germany
in from January to May 2020 due to the COVID-19 pandemia caused by SARS-CoV2. The results suggest that the influence of the COVID-19 pandemia on lung transplantation activity in Germany has been moderate so far. Nevertheless, adaptions such as extensive testing
of donors and recipients were introduced to reduce the likelihood of infections and increase patient safety. Alertness to changes in COVID-19 reproduction rates might be required until effective antiviral therapy or vaccination is available. |
|
Mieth, M, M |
Research Square prepub |
Public Health response| Interventions de santé publique Infection Prevention and Control/
Prévention et contrôle des infections (IPAC/PCI) |
We use an indirect questioning technique to test whether the prevalence of hygiene practices may be lower when confidentiality
of responding is guaranteed. In the direct questioning group 94.5 % of the participants claimed to practice proper hand hygiene; in the indirect questioning group a significantly lower estimate of only 78.1 % was observed. These results indicate that estimates
of the degree of commitment to measures designed to counter the spread of the disease may be significantly inflated by social desirability in direct questionings. Indirect questioning techniques with higher levels of confidentiality seem helpful in obtaining
more realistic estimates of the degree to which people follow the recommended personal hygiene measures. |
|
|
Mon-López, D, de la Rubia Riaza, et al |
Int J Environ Res Public Health |
Public Health response| Interventions de santé publique |
The objectives of the study were: (i) to compare training and recovery conditions before and during the isolation period
in handball players according to gender and competitive level, and (ii) to analyse the impact of psychological factors during the isolation period in Spain. We conclude that the COVID-19 isolation period caused reductions in training volume and intensity and
decreased sleep quality. Furthermore, psychological components have a significant impact on training and recovery conditions. |
|
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32721580; Hepatic Disorders With the Use of Remdesivir for Coronavirus 2019 |
Montastruc, F, Thuriot, et al |
Clinical Gastroenterology and Hepatology |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
We performed a pharmacovigilance analysis of VigiBase, the World Health Organization’s individual case safety reports
database, to describe hepatic impairment reports with remdesivir. We found 387 reports with remdesivir registered in VigiBase, and among them 130 hepatic adverse effects (34%) were reported. In the majority of cases (122, 94%), remdesivir was the sole suspected
drug. Most cases were serious (94, 72%) (ie, resulting in hospitalization or prolongation of hospital stay). The mean time to onset of hepatic disorders was 5.4 days. Increased hepatic enzymes were the most frequent adverse drug reactions reported (114, 88%),
involving the liver transaminases (aspartate transaminase and alanine transaminase) in 79 cases (61%) and bilirubin in 4 cases (3%). Other cases were reported as hepatic failure or hepatitis. Compared with hydroxychloroquine, lopinavir/ritonavir, or tocilizumab,
the use of remdesivir was associated with an increased risk of reporting hepatic disorders (ROR, 1.94; 95% CI, 1.54–2.45). When we restricted the analysis to tocilizumab users (reference group), the ROR remained significant (1.60; 95% CI, 1.13–2.27). |
|
Mor, S, Kumar, et al |
Chemosphere |
Public health interventions*| Interventions de santé publique |
The variation in ambient air quality during COVID-19 lockdown was studied in Chandigarh, located in the Indo-Gangetic
plain of India. Total 14 air pollutants, including particulate matter (PM10, PM2.5), trace gases (NO2, NO, NOx, SO2, O3, NH3, CO) and VOC's (benzene, toluene, o-xylene, m,p-xylene, ethylbenzene) were examined along with meteorological parameters. he results
showed significant reductions during the first and second phases for all pollutants. However, concentrations increased during the third phase. The concentrations of SO2, O3, and m,p-xylene kept on increasing throughout the study period, except for benzene,
which continuously decreased. The percentage decrease in the concentrations during consecutive periods of lockdown were 28.8%, 23.4% and 1.1% for PM2.5 and 36.8%, 22.8% and 2.4% for PM10 respectively. The Principal Component Analysis (PCA) and characteristic
ratios identified vehicular pollution as a primary source during different phases of lockdown. During the lockdown, residential sources showed a significant adverse impact on the air quality of the city. Regional atmospheric transfer of pollutants from coal-burning
and stubble burning were identified as secondary sources of air pollution. |
|
|
Modelling the transmission of infectious diseases
inside hospital bays: implications for Covid-19 |
Moreno Martos, David, Parcell, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Transmission Healthcare Response | Réponse
des soins de santé |
In this study we consider a mathematical modelling and computational approach to describe the spread of SARS-CoV-2
among hospitalised patients. We focus on 4-bed bays and 6-bed bays, which are commonly used to accommodate various non-Covid-19 patients in many hospitals across UK. Our results show that 4-bed bays reduce the spread of SARS-CoV-2 compared to 6-bed bays. Moreover,
we show that the position of a new (not infected) patient in specific beds in a 6-bed bay might also slow the spread of the disease. Finally, we propose that regular SARS-CoV-2 testing of hospitalised patients would allow appropriate placement of infected
patients in specific (Covid-only) hospital bays. |
|
Moretti, A, Menna, et al |
International Journal of Environmental Research and Public Health |
Public Health response| Interventions de santé publique |
The purpose of this cross-sectional study was to examine the impact of home working on perceived job productivity and
satisfaction, work-related stress, and musculoskeletal (MSK) issues. We included 51 mobile workers, collecting data about demographic characteristics, working experience, job productivity, and stress. Participants declared that they were less productive (39.2%)
but less stressed (39.2%) and equally satisfied (51%) compared to the time of office working. Regarding MSK disorders, low back pain (LBP) was referred by 41.2% of home workers and neck pain by 23.5% of them. Neck pain worsened in 50% of home workers, while
LBP did not exacerbate in 47.6% of cases. Home workers with MSK pain reported a lower job satisfaction. Depending on our data, the home environment seems to be not adequate in the mobile worker population, with an increased risk for mental health and MSK problems,
particularly affecting the spine. |
|
|
An unusual course of disease in two patients with COVID-19: pulmonary cavitation |
Muheim, M, Weber, et al |
BMJ Case Rep |
Clinical data| Données cliniques |
Two 59-year-old male patients with COVID-19 pneumonia developed pulmonary cavitation with air-fluid level, accompanied
by right-sided chest pain several weeks after first onset of symptoms. Considering a possible bacterial abscess formation, both patients were started on antibiotics. No microbiological pathogen was detected in further investigations (sputum analysis, bronchoscopy
with bronchoalveolar lavage and CT-guided drainage of the cavitation). Histopathological analysis of the drained fluid was non-specific, and the aetiology remained not fully understood. We report pulmonary cavitation as a rare finding in late stage COVID-19
pneumonia. As both our patients presented with localised chest pain prior to detection of the lesions, new onset of this symptom should warrant further investigation. |
|
Mukhtar, A, Lotfy, et al |
Anaesthesia Critical Care and Pain Medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this study, we present our experience with the use of non-invasive mechanical ventilation (NIV) in patients with
COVID-19 who were admitted to ICU with ARDS. The study included all patients with laboratory-confirmed COVID-19 who were admitted to ICU at Cairo University Hospital during the period from May 14, 2020 until July 1, 2020. The overall mortality reaches 18%
with high mortality rate in patients requiring IMV (75%). In conclusion, use of NIV with a predefined algorithm in subjects with moderate-to-severe COVID-19 ARDS was successful in 77% of the subjects. |
|
|
Oropharyngeal hemorrhage in patients with COVID-19: A multi-institutional case
series |
Mulcahy, CF, Ghulam-Smith, et al |
American Journal of Otolaryngology - Head and Neck Medicine and Surgery |
Clinical data| Données cliniques |
We report five cases of oropharyngeal hemorrhage in COVID-19 patients on mechanical ventilation requiring evaluation
by otolaryngologists at George Washington University Hospital (GWUH) and Boston Medical Center (BMC) from March to April 2020. All five patients were managed conservatively; four required packing with Kerlix gauze by an otolaryngologist. Two patients had the
additional requirement of extracorporeal membrane oxygenation (ECMO) and associated anticoagulation. Three patients improved with oropharyngeal packing; two had persistent bleeding. Three patients expired. Endotracheal tubes were repositioned less frequently
due to the COVID-19 pandemic. |
|
Musca, SC |
Frontiers in Medicine |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
We propose to use data from patients with rheumatic diseases (RA, SLR) who have been chronically taking HCQ medication
since before the COVID-19 outbreak (hereafter: HCQpa), in order to evaluate the potential of HCQ for preventing infection with SARS-CoV-2. This can be achieved with relative ease by considering whether COVID-19 prevalence is significantly lower in HCQpa than
in the general population (i.e., all people that are not HCQpa). Our analyses show that systematic testing for COVID-19 in as few as 5,000 HCQpa is all that is needed for a test of whether HCQ has a prophylactic action against COVID-19, even for a COVID-19
prevalence value as low as 250 per 100,000, provided that test sensitivity is at least equal to its specificity. For higher COVID-19 prevalence values, the number of HCQpa needed is even lower. |
|
|
Impact of COVID-19 on Acute Stroke Presentation at a Comprehensive Stroke Center |
Nagamine, M, Chow, et al |
Frontiers in Neurology |
Healthcare Response | Réponse des soins de santé |
We retrospectively reviewed the electronic medical records for patients presenting with acute ischemic stroke at a
comprehensive stroke center in March–April 2020 (the early months of COVID-19) and compared to the same time period in 2019. During the first 2 months of COVID-19, there were fewer overall stroke cases who presented to our hospital, and of these cases, there
was delayed presentation in comparison to the same time period in 2019. Recognizing how stroke presentation may be affected by COVID-19 would allow for optimization of established stroke triage algorithms in order to ensure safe and timely delivery of stroke
care during a pandemic. |
|
Negrini, S, Donzelli, et al |
Archives of Physical Medicine and Rehabilitation |
Healthcare Response | Réponse des soins de santé |
This observational cohort study investigates the feasibility and acceptability of telemedicine as a substitute for
outpatient services in emergency situations such as the sudden surge of the COVID-19 pandemic in Italy. We found a rapid decrease (–39%) of outpatient services from the control to the COVID-19 phase (R2=0.85), which partially recovered in the telemed phase
for telephysiotherapy (from –37% to –21%; P<.05) and stabilized for teleconsultation (from –55% to –60%) interventions. Usual face-to-face interventions were required for 0.5% of patients. Patients’ satisfaction with telemedicine was very high (2.8 out of
3). |
|
|
Nicolalde, B, Añ |
Research Square prepub |
Public Health response| Interventions de santé publique |
In this study, we intend to evaluate how often preprints regarding pharmacological interventions against COVID-19 were
cited, in spite of the fact that some of these preprints remained unpublished. Our sample included 97 preprints, of which 23 were published on scholarly journals and 74 remained unpublished (Publication rate of 23,7%). The most common study designs we found
among preprints were basic science research and case series. The number of citations in our sample ranged from 0 to 1409 for published articles, and ranged from 0 to 175 citations for unpublished preprints. Published articles had a significantly higher number
of citations when compared to unpublished preprints (p=0,000013). We did not find a statistical difference in PDF download (p=0,167) and abstract reads (p= 0,181). In the published articles, the time from posting on a preprint server to publication on a journal
ranged from 0 to 98 days (median: 42.0 days). The time period from date of submission to a journal to date of acceptance in our sample ranged from 1 to 228 days (median: 23 days). Almost half of the preprints that were subsequently published (47,8%) had modifications
made to the result section after peer-review. |
|
|
Nonweiler, J, Rattray, et al |
Children (Basel) |
Public Health response| Interventions de santé publique |
We conducted a cross-sectional U.K. parent-reported study from 2nd April–2nd June 2020, using the Strengths and Difficulties
Questionnaire. CYP with NDDs (n = 371), compared to neurotypical controls, had a higher prevalence of emotional symptoms (42% vs. 15%) and conduct problems (28% vs. 9%), and fewer prosocial behaviours (54% vs. 22%). All groups had worse emotional symptoms
than pre-COVID groups, and those with attention-deficit/hyperactivity disorder showed inflated conduct problems, while those with autism spectrum disorder exhibited decreased prosocial behaviours. Females with ASD had higher emotional symptoms compared to
males. CYP with NDDs, and those without, showed higher levels of parent-reported mental health problems than comparable cohorts pre-COVID-19. |
|
|
Norris, MC, Kalustian, et al |
A&A practice |
Clinical data| Données cliniques |
The safety of epidural blood patch in patients with coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is unknown. Here, we report a single case of epidural blood patch to treat a postdural puncture headache in a woman after spinal anesthesia for cesarean delivery. The patient’s headache was relieved, and she did not develop
any other neurological symptoms. |
|
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Preprocessing COVID-19 radiographic images by evolutionary column subset selection |
Nowaková, J, Krömer, et al |
|
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Column subset selection is a hard combinatorial optimization problem with applications in operations research, data
analysis, and machine learning. It involves the search for fixed–length subsets of columns from large data matrices and can be used for low–rank approximation of high–dimensional data. It can be also used to preprocess data for image classification. In this
work, we study column subset selection in the context of radiography image analysis and concentrate on the detection of COVID-19 from chest X–ray imagery. |
|
Nurhayati, Purnama, TB |
Research Square prepub |
Public Health response| Interventions de santé publique |
This study aims to understand the differences in perceptions and responses of ulama in the process of handling and
burial of dead bodies in Indonesia. This study interviewed 6 prominent ulama figures in each of the significant Islamic religious organizations in Indonesia as representatives of each practice of handling and burial of corpse. All scholars / religious leaders
say that the handling and burial of the dead body using the COVID-19 protocol must be carried out by considering the possibility of disease transmission. However, some have adjusted the procedure to the religious values held by the organization. Comprehensive
socialization and coordination can reduce misperceptions and misinformation in the process of handling and burial for corpses with the COVID-19 procedure so that the carrying out of handling and burial of dead bodies can prevent new COVID-19 clusters in the
community. |
|
|
Occidental, M, Flaifel, et al |
J Cutan Pathol |
Clinical data| Données cliniques |
We report our findings from four patients presenting with COVID-19 infection in NYC during the regional peak of cases
(late March to early May) and associated cutaneous lesions in order to further validate the previously described lesions and to expand their underlying histopathological mechanisms. |
|
|
Odeh, R, Gharaibeh, et al |
Diabetes research and clinical practice |
Healthcare Response | Réponse des soins de santé |
This study aims to evaluate the effect of these measures on paediatric patients with type 1 diabetes in terms of acute
metabolic complications and shortages in insulin and glucose measuring supplies. It also evaluates the caregivers’ perceptions of the use of telemedicine during the lockdown. Families (58.3%) faced insulin shortages and 14% had to ration insulin, i.e., decrease
the dose, during the lockdown. Glucose monitoring strips were rationed by 43.4% of families leading to more frequent low/high glucose readings in 75.5% of children of these families. Telemedicine using phones and social media applications was utilized for
communication with healthcare professionals and continuing medical care. Most of the participants (85.5%) described it as a smooth and positive experience. |
|
|
Ofstad, EH, Hauglid, et al |
Tidsskr Nor Laegeforen |
Clinical data| Données cliniques |
A woman in her 60s with covid-19-triggered acute lung failure syndrome had stationary critical illness after three
weeks of intensive care. Day 19 on a respirator, she received treatment with steroids. There was a rapid clinical improvement, and she could be weaned from ventilation support. The improvement may have been accidental or a result of other factors, but we believe
this case study may help to shed light on the use of steroid therapy in severe covid-19. |
|
|
Ogata, AF, Maley, et al |
Clin Chem |
Clinical data| Données cliniques |
We used Single Molecule Array (Simoa) assays to quantitatively detect SARS-CoV-2 spike, S1 subunit, and nucleocapsid
antigens in the plasma of COVID-19 patients. We studied plasma from 64 COVID-19 positive patients, 17 COVID-19 negative patients, and 34 pre-pandemic patients. SARS-CoV-2 S1 and N antigens were detectable in 41 out of 64 COVID-19 positive patients. In these
patients, full antigen clearance in plasma was observed a mean ± 95%CI of 5 ± 1 days after seroconversion and nasopharyngeal RT-PCR tests reported positive results for 15 ± 5 days after viral antigen clearance. Correlation between patients with high concentrations
of S1 antigen and ICU admission (77%) and time to intubation (within one day) was statistically significant. The reported SARS-CoV-2 Simoa antigen assay is the first to detect viral antigens in the plasma of COVID-19 positive patients to date. These data show
that SARS-CoV-2 viral antigens in the blood are associated with disease progression, such as respiratory failure, in COVID-19 cases with severe disease. |
|
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32847836; Oncological care organisation during COVID-19 outbreak |
Onesti, CE, Rugo, et al |
ESMO open |
Healthcare Response | Réponse des soins de santé |
we analysed measures taken in major oncological units in Europe and the USA. Investigators from 21 centres in 10 countries
answered the survey between 10 April and 6 May 2020. A triage for patients with cancer before hospital or clinic visits was conducted by 90.5% of centres before consultations, 95.2% before day care admissions and in 100% of the cases before overnight hospitalisation
by means of phone calls, interactive online platforms, swab test and/or chest CT scan. Permission for caregivers to attend clinic visits was limited in many centres, with some exceptions (ie, for non-autonomous patients, in the case of a new diagnosis, when
bad news was expected and for terminally ill patients). With a variable delay period, the use of personal protective equipment was unanimously mandatory, and in many centres, only targeted clinical and instrumental examinations were performed. Telemedicine
was implemented in 76.2% of the centres. Separated pathways for COVID-19-positive and COVID-19-negative patients were organised, with separate inpatient units and day care areas. Self-isolation was required for COVID-19-positive or symptomatic staff, while
return to work policies required a negative swab test in 76.2% of the centres. |
|
Öz, Y |
Disaster Med Public Health Prep |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
In this study, a model that is by construction able to describe both government actions and individual reactions in
addition to the well known exponential spread is presented. The mathematical study of the influence of the different parameters is presented through different scenarios. Remarkably, the last scenario is also an example of a theoretical mitigation strategy
that shows its maximum in August 2020. In addition, the results of the model are compared with the real data from Turkey using conventional fitting that shows good agreement. |
|
|
Villitis of Unknown Etiology in the Placenta of a Pregnancy Complicated by COVID-19 |
Ozer, E, Cagliyan, et al |
Turk Patoloji Derg |
Clinical data| Données cliniques |
Villitis of unknown etiology (VUE) is noninfectious chronic villitis thought to be associated with fetal growth restriction
and stillbirth. COVID-19 and the pandemic SARS-CoV-2 infection can cause an increased risk in pregnant women for potential maternal and fetal complications from an immunological mechanism. We report a 39-week-gestational-age infant delivered to a 37-year-old
mother diagnosed with SARS-CoV-2 infection at 37 weeks gestation. The placental examination showed the morphological features of VUE. We showed immunohistochemically that macrophages and CD4-positive T cells predominated in the villous tissue, although elevated
numbers of CD8-positive cells were also present. We hypothesize that VUE may represent a maternal anti-viral immune response, in this case to SARS-CoV-2. |
|
Pablos, JL, Galindo, et al |
Annals of the Rheumatic Diseases |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Here, we compare the outcomes of a cohort of patients with rheumatic diseases with a matched control cohort to identify
potential risk factors for severe illness. Most patients (74%) had been hospitalised, and the risk of severe COVID-19 was 31.6% in the rheumatic and 28.1% in the non-rheumatic cohort. Ageing, male sex and previous comorbidity (obesity, diabetes, hypertension,
cardiovascular or lung disease) increased the risk in the rheumatic cohort by bivariate analysis. In logistic regression analysis, independent factors associated with severe COVID-19 were increased age (OR 4.83; 95% CI 2.78 to 8.36), male sex (1.93; CI 1.21
to 3.07) and having a CTD (OR 1.82; CI 1.00 to 3.30). |
|
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PMC7471937; Apparent scaling of virus surface roughness-An example from the pandemic
SARS-nCoV |
Padhy, S, Dimri, et al |
Physica D |
Coronavirology| Coronavirologie |
Morphological diversity of SARS-nCoV particles is not statistically significant. Classification scheme requires the
interaction of envelope-shape and spike distribution. |
|
Padilla, S, Telenti, et al |
International journal of antimicrobial agents |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This longitudinal, prospective cohort study aimed to assess risk of QTc interval prolongation and its predicting factors
in subjects treated with combinations containing hydroxychloroquine (HCQ) for COVID-19. A total of 105 adults were included. Moderate-to-severe QTc prolongation was observed in 14 patients (13%), mostly at Days 3–5 from baseline, with 6 (6%) developing severe
prolongation. Multivariable Cox regression revealed that comedications with known risk of torsades de pointes (TdP), higher neutrophil-to-lymphocyte (NLR) ratio and higher serum hs-cardiac troponin I were major contributors to moderate-to-severe QTc prolongation. |
|
|
Pala, L, Conforti, et al |
Seminars in oncology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Objectives: To evaluate the safety of the management of patients with advanced melanoma treated with immunotherapy
in 2 Cancer Centers located in areas of Italy with a high incidence of COVID-19 infections. One-hundred and sixty-nine patients with stage III and IV melanoma were treated with an immunotherapy regimen at either Istituto Europeo di Oncologia or Città della
Salute e della Scienza University Hospital. One-hundred and four patients continued treatment without interruption or delay, while 49 patients had a treatment delay. The main reasons for treatment delay were older age and/or presence of comorbidities. One-hundred
and twelve patients had at least 1 thoracic CT scan performed and radiological findings suspicious for COVID-19 were observed in only 7 cases (4%). Fifteen patients (9%) developed symptoms potentially related to COVID-19; nasopharyngeal swabs were collected
in 9 patients and only 1 was positive for SARS-CoV-2. |
|
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32864352; COVID-19 - The Availability of ICU Beds in Brazil during the Onset of Pandemic |
Palamim, CVC, Marson, et al |
Annals of global health |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
he epidemiology and geographic data were correlated with the distribution of ICU beds (public and private health systems)
and the number of beneficiaries of private health insurance using Pear-son’s Correlation Coefficient. The same data were correlated using partial correlation controlled by gross domestic product (GDP) and number of beneficiaries of private health insurance.
The distribution of ICUs was uneven between public and private services, and most patients rely on the public health system, which had the lowest number of ICU beds. |
|
Speech pathology telepractice for children with cleft palate in the times of
COVID-19 pandemic |
Pamplona, MDC, Ysunza, et al |
International journal of pediatric otorhinolaryngology |
Healthcare Response | Réponse des soins de santé |
Forty-three children with cleft palate (CCP) were treated with telepractice (TP) intervention in 45 min sessions, 2
times per week for a period of one month. At the onset of the TP intervention period, 84% of the patients demonstrated severe compensatory articulation (CA). At the end of the TP period there was a significant improvement in severity of CA (p < 0.001). |
|
A Predicting Nomogram for Mortality in Patients With COVID-19 |
Pan, D, Cheng, et al |
Frontiers in Public Health |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Our research objective is to establish a reliable nomogram to predict mortality in COVID-19 patients. For the single-center
retrospective study, we collected 21 cases of patients who died in the critical illness area of the Optical Valley Branch of Tongji Hospital, Huazhong University of Science and Technology, from February 9 to March 10. Additionally, we selected 99 patients
discharged during this period for analysis. The predictors included in the nomogram were c-reactive protein, PaO2/FiO2, and cTnI. |
|
Smart epidemic tunnel: IoT-based sensor-fusion assistive technology for COVID-19
disinfection |
Pandya, S, Sur, et al |
International Journal of Pervasive Computing and Communications |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) |
The authors have presented a sensor-fusion-based automatic sanitizer tunnel that detects a human using an ultrasonic
sensor from the height of 1.5 feet and disinfects him/her using the spread of a sanitizer spray. |
|
Patel, M, Gangemi, et al |
BMJ open respiratory research |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This was a retrospective analysis of consecutive patients admitted to Temple University Hospital in Philadelphia, Pennsylvania,
from 10 March 2020 to 24 April 2020 with moderate-to-severe respiratory failure treated with high flow nasal therapy (HFNT). Of the 445 patients with COVID-19, 104 met our inclusion criteria. Forty-three patients (43.43%) were smokers. Saturation to fraction
ratio and chest X-ray scores had a statistically significant improvement from day 1 to day 7. 67 of 104 (64.42%) were able to avoid invasive mechanical ventilation in our cohort. Incidence of hospital-associated/ventilator-associated pneumonia was 2.9%. Overall,
mortality was 14.44% (n=15) in our cohort with 13 (34.4%) in the progressed to intubation group and 2 (2.9%) in the non-intubation group. Mortality and incidence of pneumonia was statistically higher in the progressed to intubation group. |
|
|
Pawlak, A, Dreżewski, et al |
Kardiol Pol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this study was to evaluate clinical and laboratory parameters at the time of admission to the hospital and
to compare them with the treatment and short-term prognosis of COVID-19 patients. One hundred sixty-six consecutive patients hospitalized between March and May of 2020 in in Warsaw were enrolled in the study. Patients were divided into three groups: I – oligosymptomatic
patients who underwent one-day stay in the hospital emergency room, II – symptomatic patients, who have survived the hospitalization and III – symptomatic patients, who have died during the hospitalization. Patients in group I compared with patients in groups
II and III were younger. Laboratory results revealed lower inflammatory and coagulation parameters in group I than group II and III. In multivariable Cox regression analysis senior age, CRP were found to be risk factors for death. Lopinavir/ritonavir, oxygen
therapy and mechanical ventilation were used more frequently in group III than in group II |
|
|
Unexpected diagnosis of COVID-19-associated disorders by SARS-CoV-2-specific serology |
Péré, H, Védie, et al |
Journal of Clinical Virology |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We herein evaluated the analytical performances of the CE IVD-labeled Abbott SARS-CoV-2 IgG assay (Des Plaines, IL,
USA) carried out with the automated Abbott Architect™ i2000 platform at Hôpital Européen Georges Pompidou, Paris, France, using serum sample panels obtained from health-workers with COVID-19 history confirmed by positive nucleic acid amplification-based diagnosis
and from patients randomly selected for whom serum samples were collected before the COVID-19 epidemic. The Abbott SARS-CoV-2 IgG assay showed sensitivity of 94 % and specificity of 100 %. |
|
Pirnay, JP, Selhorst, et al |
Viruses |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
At the beginning of May 2020, 22 out of 70 Belgian soldiers deployed to a military education and training center in
Maradi, Niger, developed mild COVID-19 compatible symptoms. Immediately upon their return to Belgium, and two weeks later, all seventy soldiers were tested for SARS-CoV-2 RNA (RT-qPCR) and antibodies (two immunoassays). Nine soldiers had at least one positive
COVID-19 diagnostic test result. Five of them exhibited COVID-19 symptoms (mainly anosmia, ageusia, and fever), while four were asymptomatic. In four soldiers, SARS-CoV-2 viral load was detected and the genomes were sequenced. Conventional and genomic epidemiological
data suggest that these genomes have an African most recent common ancestor and that the Belgian military service men were infected through contact with locals. |
|
|
Planinc, D, El-Rekaby, et al |
British journal of hospital medicine (London, England : 2005) |
Clinical data| Données cliniques |
Acute stroke showing cerebral infarcts and microbleeds in a 31-year-old man with COVID-19 pneumonia |
|
|
Posteraro, B, Torelli, et al |
J Fungi (Basel) |
Clinical data| Données cliniques |
We report the 53-day clinical course of a complicated type-2 diabetes patient diagnosed with COVID-19, who developed
bloodstream infections initially due to methicillin-resistant Staphylococcus aureus, secondly due to multidrug-resistant Gram-negative bacteria, and lastly due to a possibly fatal Candida glabrata. The patient died of septic shock shortly before the prospect
of receiving potentially effective antifungal therapy. |
|
|
Prado-Vivar, Belen |
SSRN- Lancet prepublication |
Clinical data| Données cliniques |
Here we present the first confirmed case of SARS-CoV-2 reinfection in Ecuador and South America. Our diagnostic laboratory
detected a potential re-infection in one patient who was SARS-COv2 rt-PCR positive twice (in May and July 2020). The first laboratory-confirmed infection presented with mild symptoms and full recovery, reaffirmed by a negative RT-PCR test result obtained two
weeks after symptom onset. More severe COVID-19-like symptoms presented again four weeks after the first event, and a third RT-PCR test was performed which resulted positive. Different SARS-CoV-2 variants were identified in each infection event. For the first
infection, the genome was assigned to the B1.p9 GISAID clade while the variant associated with the second episode was assigned to the A.1.1 GISAID clade. High levels of both SARS-CoV-2 specific IgM and IgG were observed during the second event. |
|
|
Qiu, C, Wang, et al |
Chinese General Practice |
Public Health response| Interventions de santé publique |
To investigate the structure, COVID-19-related knowledge, attitudes, and work characteristics of the community COVID-19
containment team. A self-designed questionnaire was used to conduct a survey with community workers for containing COVID-19. Of the 756 workers, 753(99.6%) who completed the questionnaire effectively were included for final analysis. Three aspects concerning
COVID-19 containment obtained the highest awareness rates:required days for continuing to monitor self-health after discharge, incubation period, and criteria for releasing from quarantine. Younger age was associated with lower awareness rates of the class
of COVID-19 as an infectious disease, and incubation period of COVID-19, but higher awareness rate of COVID-19 main symptoms(P<0.05). Education level was associated with higher or lower awareness rates of the aspects concerning COVID-19 related information(P<0.05)
except the awareness rate of transmission routes. Occupation was associated with significant differences in the awareness rates of the class of COVID-19 as an infectious disease and number of self-health monitoring days(P<0.05). Higher annual household income
per capita was associated with higher awareness rate of number of self-health monitoring days(P<0.05). |
|
|
Radtke, T, Haile, et al |
Journal of Cystic Fibrosis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study was designed to investigate health-related aspects of individuals with cystic fibrosis (CF), with and without
lung transplantation (LTX), their communication with their specialist healthcare providers during the pandemic, potential changes in peoples’ individual therapy regimes and daily physical activity levels. A web-based survey was conducted among Swiss adults
with CF with and without LTX. 327 individuals (25% LTX recipients) were included, 45 individuals reported coronavirus-2019 disease (COVID-19) like symptoms. Of 28 subjects tested, only three subjects were tested positive, all with mild symptoms, no hospitalization
required. Almost half of the survey respondents (45%) reported undertaking less physical activity during the lockdown, while 79% and 91% of participants reported no change in traditional airway clearance and inhalation therapies, respectively. Distress regarding
a potential SARS-CoV-2 infection or worsening of lung disease were no major concerns for subjects. |
|
|
Rahaman, KR, Mahmud, et al |
Int J Environ Res Public Health |
Surveillance Public Health Priorities| Priorités de santé publique |
Results show that the number of testing centers is not enough to cater to the vast population of the country. Additionally,
we found that the number of days it takes to receive the results from the COVID-19 testing centers is not optimal at divisional cities, let alone the remote rural areas. |
|
|
An interesting case of small vessel pathology following coronavirus infection |
Ramadan, SM, Kasfiki, et al |
BMJ Case Rep |
Clinical data| Données cliniques |
We report the case of a 63-year-old woman presenting with upper and lower respiratory tract symptoms followed by a
vasculitic rash on both legs. The patient underwent extensive radiological and laboratory investigations that were negative apart from positive coronavirus OC43. A biopsy of the skin was performed. Considering the clinical presentation and the investigations
performed, the diagnosis of small vessel vasculopathy following coronavirus OC43 has been suggested by the authors. |
|
Collateral effect of COVID-19 on orthopedic and
trauma surgery |
Randau, TM, Jaenisch, et al |
PLoS One |
Healthcare Response | Réponse des soins de santé |
The purpose of this study was to assess the impact of the COVID-19 pandemic on orthopedic and trauma surgery in private
practices and hospitals in Germany. 858 orthopedic and trauma surgeons participated in the survey throughout Germany. In the multiple regression analysis, being employed at a hospital was identified as an independent positive predictor in the indices for “Preparedness”,
“Resources”, and “Informedness” and an independent negative predictor regarding “Depletion”. Self-employment was found to be an independent positive predictor of the financial index “Depletion”. Female surgeons were identified as an independent variable for
a higher level of “Concern”. |
|
Ranga, V, Niemelä, et al |
Vaccines |
Coronavirology| Coronavirologie |
Using in silico analyses, we showed that human major histocompatibility complex (MHC) class I cell-surface molecules
vary in their capacity for binding different SARS-CoV-2-derived epitopes, i.e., short sequences of 8-11 amino acids, and pinpointed five specific SARS-CoV-2 epitopes that are likely to be presented to cytotoxic T-cells and hence activate immune responses. |
|
|
Ricciardiello, L, Ferrari, et al |
Clin Gastroenterol Hepatol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In Italy, since the beginning of the pandemic, colorectal cancer (CRC) screening programs have been forcefully suspended.
We aimed to evaluate whether screening procedure delays can affect the outcomes of CRC screening. We built a procedural model considering delays in the time to colonoscopy and estimating the effect on mortality due to up-stage migration of patients. With a
delay of 0-3 months, 74% of CRC is expected to be stage I-II, while with a delay of 4-6 months there would be a 2%-increase for stage I-II and a concomitant decrease for stage III-IV (p=0.068). Compared to baseline (0-3-months), moderate (7-12-months) and
long (>12-months) delays would lead to a significant increase in advanced CRC (from 26% to 29% and 33%, respectively; p=0.008 and p<0.001, respectively). We estimated a significant increase in the total number of deaths (+12.0%) when moving from a 0-3-months
to a >12-month delay (p=0.005), and a significant change in mortality distribution by stage when comparing the baseline with the >12-months (p<0.001). |
|
|
Rizun, M, Strzelecki, et al |
Int J Environ Res Public Health |
Public Health response| Interventions de santé publique |
The purpose of this study is to investigate the influence of Experience, Enjoyment, Computer Anxiety, and Self-Efficacy
on students’ acceptance of shifting education to distance learning. The study utilizes an online survey to obtain data from 1692 Polish undergraduate and graduate students in both full- and part-time study. Results showed that the best predictor of student’s
acceptance of shifting education to distance learning is Enjoyment, followed by Self-Efficacy. Both Perceived Ease of Use and Perceived Usefulness predict student’s Attitude Towards Using and Intention to Use the distance learning. |
|
|
Rosés-Gibert, P, Gimeno Castillo, et al |
World J Pediatr |
Clinical data| Données cliniques |
A retrospective descriptive study was performed collecting data on 36 patients under 14 years old, presenting suspicious
acral skin manifestations for coronavirus disease 2019 (COVID-19). Patients were mostly male (63.8%). The mean age was 11.11 years. 66.67% of patients showed erythematous papules, and 44.44% purpuric macules. Feet were affected in 97.22% of patients and hands
in 5.55%. Lesions were asymptomatic in 50% of patients. 30.55% of patients showed extracutaneous findings, preceding skin lesions in 12.62 days. Seven patients underwent specific severe acute coronavirus 2 (SARS-CoV-2) testing; all of these patients tested
negative. |
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Sáenz, R, Garcia, et al |
J Gerontol B Psychol Sci Soc Sci |
Epidemiology| Épidémiologie |
We use recent data from the Centers for Disease Control and Prevention to compute age-specific death rates (ASDRs)
for three causes of death: deaths from COVID-19, residual deaths, and total deaths for four age-groups (55-64, 65-74, 75-84, and 85 and older) to assess the impact of COVID-19 on older Latino mortality relative to non-Latino Whites and non-Latino Blacks and
also in comparison to residual deaths. our findings show that Latinos have lower ASDRs for non-COVID-19 causes of death across all age groups compared to non-Latino Whites. However, our findings indicate that Latinos have significantly higher ASDRs for COVID-19
deaths than non-Latino Whites. Furthermore, although the Latino advantage for total deaths persists during the pandemic, it has diminished significantly compared to the 1999-2018 period. |
|
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Psychological experience of patients admitted with SARS-CoV-2 infection |
Sahoo, S, Mehra, et al |
Asian Journal of Psychiatry |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The present study suggests that going through the whole experience of COVID-19 infection, in the form of staying in
isolation wards could be very stressful, even for patients who are minimally symptomatic or asymptomatic. Use of adaptive copings, could help reduce the distress. Despite being provided psychological support, about two-fifths of the patients develop psychological
morbidity. |
|
Sahraian, MA, Azimi, et al |
Multiple Sclerosis and Related Disorders |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this study, we evaluated a large population of patients with Multiple sclerosis (MS) with different disease modifying
drugs to show if any of them increases the risk. In addition, this study evaluates the incidence of COVID-19 in patients with MS, the rate of hospitalization or death in these patients. 4647 patients answered the phone contact. Of these, 68 were infected with
the COVID-19. The rate of hospitalization was 25% which is far more than general population. Two patients died from COVID-19. Rituximab was associated with increase rate of COVID-19 infection but not with hospitalization rate. There was no significant correlation
between use of other drugs and rate of infection. |
|
|
Saito, H, Ozaki, et al |
Clinical Case Reports |
Clinical data| Données cliniques |
A 27‐year‐old healthy man presented with sore throat and persistent upper gastrointestinal symptoms for approximately
two months and finally turn out to be infected with COVID‐19. Clinicians in COVID‐19‐endemic areas should suspect COVID‐19 infection in patients even if they have no noticeable respiratory symptoms and only gastrointestinal symptoms. |
|
|
San Roman Orozco, Oscar, Agraz Orozco, et al |
medRxiv |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
A positive relationship is observed between Re, R0, and the levels of mobility presented by Google. This indicates
that an increase in mobility is associated with the transmission of SARS-CoV-2. In February, a significant decrease in mobility is observed, which lasts until approximately May 1st. This period corresponds to an R0 and R(e) between 1.17 and 1.87. After May
1st, there is a sustained increase in mobility levels. And, as of May 16, the effective reproduction index R (e) and the reproduction index R0 begin to increase. |
|
|
Sancheti, A, C |
ArXiv |
Public Health response| Interventions de santé publique |
We describe our system for WNUT-2020 shared task on the identification of informative COVID-19 English tweets. Our
system is an ensemble of various machine learning methods, leveraging both traditional feature-based classifiers as well as recent advances in pre-trained language models that help in capturing the syntactic, semantic, and contextual features from the tweets.
We further employ pseudo-labelling to incorporate the unlabelled Twitter data released on the pandemic. Our best performing model achieves an F1-score of 0.9179 on the provided validation set and 0.8805 on the blind test-set. |
|
|
Effect of COVID-19 lockdown on patients with chronic diseases |
Saqib, MAN, Siddiqui, et al |
Diabetes and Metabolic Syndrome: Clinical Research and Reviews |
Public Health response| Interventions de santé publique |
Background and aims: We sought to measure the effect of lockdown, implemented to contain COVID-19 infection, on routine
living and health of patients with chronic diseases and challenges faced by them. Methods: A semi-structured online questionnaire was generated using “Google forms” and sent to the patients with chronic diseases using WhatsApp. Data were retrieved and analyzed
using SPSS. Results: Out of 181 participants, 98% reported effect of lockdown on their routine living while 45% reported an effect on their health. The key challenges due to lockdown were to do daily exercise, missed routine checkup/lab testing and daily health
care. Conclusion: It is important to strategize the plan for patients with chronic diseases during pandemic or lockdown. © 2020 Diabetes India |
|
Sarangarajan, R, Winn, et al |
J Racial Ethn Health Disparities |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The study objective was to describe a biological framework associating ethnic prevalence of ACE deletion polymorphism
to COVID-19 comorbidities providing rationale for therapeutic utility of ACE-I/ARBs to improve outcomes. In a total of 349 worldwide population samples, frequency of ACE D allele was higher in European, Asian, and Africans cohorts. In the USA, the frequency
of ACE D allele was higher in non-Hispanic Black compared with non-Hispanic White and Mexican Americans. |
|
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32831342; Gestión integral de COVID 19 en un hospital regional en
el noroeste de España |
Sardiña-González, C, López-Reboiro, et al |
Gaceta medica de Mexico |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective of this study was to evaluate the utility of a strategy to comprehensively address the pandemic in a
health area that covers 42,000 people. A regional hospital and social health centers were monitored. Eighteen COVID-19-positive patients were admitted. Mean hospital stay was 9.4 ± 5.3 days, and mortality, 11%. PCR tests were applied to all hospital residents
(n = 827) and workers (n = 519), 36 hospital admissions were avoided. Only 50 patients required close follow-up, out of which four (0.48%) were positive for COVID-19. |
|
Sarrazyn, C, Dhaese, et al |
Infect Control Hosp Epidemiol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aimed to compare the incidence, risk factors, timing and outcome of influenza and Covid-19 associated invasive pulmonary
aspergillosis (IPA) in our institution, a tertiary-care hospital in Belgium, for the 2019-2020 season. Putative IPA was diagnosed in 5 patients of the influenza cohort (3.5%) and 4 of the Covid-19 cohort (3%). The time between admission and diagnosis of IPA
was not different. All patients with Covid-19 associated IPA died versus 3 out of 5 influenza associated IPA, all of whom were ventilated and died in the ICU. |
|
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Pediatric multisystemic inflammatory syndrome associated with SARS-CoV-2 infection |
Schneider, DT, Pütz-Dolderer, et al |
Deutsches Arzteblatt International |
Clinical data| Données cliniques |
This case report describes a 9 year old boy with pediatric multisystemic inflammatory syndrome associated with SARS-CoV-2
infection. PCR was negative for SARS-CoV-2 on two occasions, but the IgG and IgA titers against SARS-CoV-2 were markedly elevated. After initiation of prednisolone treatment, the body temperature swiftly returned to normal with resolution of the vasculitis
and myocarditis. |
|
Sekhavati, E, Jafari, et al |
International journal of antimicrobial agents |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique
RCT |
We aimed to assess the effectiveness of azithromycin (AZM) in patients at a referral centre in Iran. An open-label,
randomised controlled trial was conducted on patients with laboratory-confirmed COVID-19. Initially, there was no significant difference between the general conditions and vital signs of the two groups. The SpO2 levels at discharge were significantly higher,
the respiratory rate was lower and the duration of admission was shorter in the case group. There was no significant difference in the mortality rate between the two groups. Patients who received AZM in addition to HCQ and LPV/r had a better general condition. |
|
|
Structural characterization of Nonstructural protein
1 from SARS-CoV-2 |
Semper, Cameron, Watanabe, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Here, we report the crystal structure of the globular domain of SARS-CoV-2 nonstructural protein 1 (Nsp1), a major
virulence factor shown to facilitate suppression of host gene expression through promotion of host mRNA degradation and interaction with the 40S ribosomal subunit. Combining our high-resolution crystal structure with existing data on the C-terminus of Nsp1
from SARS-CoV-2, we propose a model of the full-length protein. |
|
Application of Health Belief Model on Child's Dental Visit Postponement during the
COVID-19 Pandemic |
Setiawan, AS, Zubaedah, et al |
Eur J Dent |
Public Health response| Interventions de santé publique |
The aim of this cross-sectional survey is to analyze parental perception on child's dental visit postponement using
health belief model (HBM) during the pandemic of COVID-19. Respondents perception were found indifferent in perceived susceptible, perceived severity, and perceived barrier. Whilst confirmed in perceived benefit, cue of action, self-efficacy, and locus of
control. |
|
Favorable outcomes of COVID-19 in recipients of hematopoietic cell transplantation |
Shah, GL, DeWolf, et al |
J Clin Invest |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this study of recipients of cellular therapy we aimed to identify clinical variables associated with COVID-19 severity
and assess lymphocyte populations. We identified 77 SARS-CoV-2 + cellular therapy recipients. Overall survival at 30 days was 78%. Clinical variables significantly associated with the composite endpoint of non-rebreather or higher oxygen requirement and death
included number of co-morbidities, infiltrates, and neutropenia. Immune profiling revealed reductions and rapid recovery in lymphocyte populations across lymphocyte subsets. |
|
32747007; SARS-CoV-2 and Thrombosis: More Than Just by Chance |
Shah, K |
American Journal of the Medical Sciences |
Clinical data| Données cliniques |
Here is a case of a patient diagnosed with SARS-CoV-2 presenting with pulmonary embolism. The patient was started on
therapeutic anticoagulation with heparin. After 5 days, the patient's hemoglobin oxygen saturation was 94% on room air, D-dimer was 2800 ng/mL, and he was discharged home with apixaban. |
|
32856834; The Russian healthcare image transformation during the pandemic
COVID-19 in the info field |
Sharkova, IV |
Problemy sotsial'noi gigieny, zdravookhraneniia i istorii meditsiny |
Healthcare Response | Réponse des soins de santé |
The article represents the results of a studying the information field of the healthcare sector in Russia. Measurements
were made in the Yandex search engine, as well as in the Medialogia media database. The study was conducted between December 01, 2019 and may 15, 2020. The results of the studying are one part of the studying of the image of Russian healthcare and may be necessary
for further work on its correction. |
|
Sharma, A, Goyal, et al |
J Biomol Struct Dyn |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In the present study, in-silico approach of drug development was used to search for potential antiviral plant-derived
compounds as inhibitors against SARS-CoV-2 replication proteins. The docking results suggested that bisdemethoxycurcumin, demethoxycurcumin, scutellarin, quercetin and myricetin showed least binding energy. Further studies of ADME-Tox and bioavailability of
drugs were also performed that exhibited efficient parameters of drug likeness. Our findings suggest that these compounds could be potential inhibitors of SARS-CoV-2 main protease and endoribonuclease |
|
|
Stay-at-Home Stocks Versus Go-Outside Stocks: The Impacts of COVID-19 on the Chinese
Stock Market |
Shen, D, Zhang, et al |
Asia-Pacific Financial Markets |
Economics | Économie |
This paper investigates the distinct market reactions to the COVID-19 outbreak by focusing on two groups of stocks
in the Chinese stock market, i.e., the stay-at-home (SAH) stocks, and the go-outsides (GO) stocks. The empirical results mainly reveal that for the GO stocks, there exists a significantly negative return on the event date and the cumulative abnormal return
reveals reversal pattern. For the SAH stocks, no significantly negative return is observed on the event date and the cumulative abnormal return continues to increase and generally speaking, the reaction of the GO stocks supports the price pressure hypothesis,
while the reaction of the SAH stocks supports the information diffusion hypothesis. |
|
Shen, W, Long, et al |
Nutrients |
Public Health response| Interventions de santé publique |
This study assessed whether emotional eating mediates the associations between perceived stress levels and food choice
motives during the Coronavirus Disease 2019 pandemic. The mediation analyses showed that emotional eating mediates the associations between perceived stress and five food choices motives: mood, convenience, sensory appeal, price, and familiarity. |
|
|
Sheth, KN, Mazurek, et al |
JAMA Neurol |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
The objective of this cohort study was to perform an assessment of brain injury in critically ill patients in intensive
care unit settings, using a portable, low-field MRI device at the bedside. Point-of-care MRI examinations were performed on 50 patients presenting with ischemic stroke, hemorrhagic stroke, subarachnoid hemorrhage, traumatic brain injury, brain tumor, and COVID-19
with altered mental status. Neuroimaging findings were detected in 29 of 30 patients who did not have COVID-19, and 8 of 20 patients with COVID-19 demonstrated abnormalities. There were no adverse events or complications during deployment of the portable MRI
or scanning in an intensive care unit room. |
|
|
32798630; Face touching in the time of COVID-19 in Shiraz, Iran |
Shiraly, R, Shayan, et al |
American Journal of Infection Control |
Public Health response| Interventions de santé publique |
The aim of our study was to establish the frequency of face-touching behavior by the public after quarantine restrictions
were lifted in Shiraz, Iran. The average number of touches to the mucosal zone was calculated per hour and mask wearers (N = 568) were compared with those not wearing a mask (N = 432). 92% were observed touching their face at least once an hour and averaged
10 touches per hour. Nonmask wearers touched their face significantly more often than mask wearers (11 vs 8 times per hour, P < .001). Nonmask wearers were 1.5 times more likely to touch their mucosal zone than mask wearers. |
|
Shirin, A, L |
ArXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique Economics | Économie |
We use daily new case counts of COVID-19 patients reported by local health administrations from different Metropolitan
Statistical Areas within the US to parametrize a model that well describes the propagation of the disease in each area. We then introduce a time-varying control input that represents the level of social distancing imposed on the population of a given area
and solve an optimal control problem with the goal of minimizing the impact of social distancing on the economy in the presence of relevant constraints, such as a desired level of suppression for the epidemics at a terminal time. |
|
|
Peritonsillar abscess and concomitant COVID-19 in a 21-year-old male |
Sideris, AW, Ghosh, et al |
BMJ Case Rep |
Clinical data| Données cliniques |
Transoral drainage of peritonsillar abscess during the COVID-19 pandemic is a high-risk procedure due to potential
aerosolisation of SARS-CoV-2. This case describes conservative management of peritonsillar abscess in a 21-year-old male with COVID-19. |
|
Sigman, SA, Mokmeli, et al |
American Journal of Case Reports |
Clinical data| Données cliniques |
This study reports the first time supportive photobiomodulation therapy (PBMT) was used in a severe case of COVID-19
pneumonia. A 57-year-old African American man with severe COVID-19 received 4 once-daily PBMT sessions. The patient reported substantial improvement in the Community-Acquired Pneumonia assessment tool. |
|
|
Timing of national lockdown and mortality in COVID-19: the Italian experience |
Silverio, A, Di Maio, et al |
Int J Infect Dis |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
The objective of this study was to evaluate if the pandemic mitigation effect of lockdown in Italy have been influenced
by the level of penetration of COVID-19 in Italian Regions at the onset of containment (March 9, 2020). The number of COVID-19 cases and new cases per day before lockdown correlated with mortality in Italy. The mitigation effect of lockdown on mortality depended
on the level of penetration of COVID-19 among Italian Regions at the time of containment. Every day of delay in containment was associated with increased mortality in Italy. |
|
Singer, G, Marudi, et al |
Entropy |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this research, we develop ordinal decision-tree-based ensemble approaches in which an objective-based information
gain measure is used to select the classifying attributes. We perform experiments in which the task is to classify the daily COVID-19 growth rate factor based on environmental factors and containment measures for 19 regions of Italy. We demonstrate that the
ordinal algorithms outperform their non-ordinal counterparts with improvements in the range of 6-25% for a variety of common performance indices. The majority voting approach that combines ordinal and non-ordinal models yields a further improvement of between
3% and 10%. |
|
|
Challenges in heart transplantation during COVID-19: A single-center experience |
Singhvi, A, Barghash, et al |
Journal of Heart and Lung Transplantation |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We sought to describe our practice and experience with performing orthotopic heart transplants (OHT) during the peak
of the pandemic. Of the approximately 400 OHT recipients followed at our institution, 22 acquired COVID-19. Most (n = 16, 86.4%) were hospitalized, 18% required intubation, and 14% required vasopressor support. Five patients (23%) expired. Five patients underwent
OHT during the pandemic. All were successfully discharged and are alive without allograft dysfunction or rejection. |
|
Slagman, A, Behringer, et al |
Deutsches Arzteblatt international |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
In this study, we investigate the number of emergency room consultations during the COVID-19 pandemic of 2020 in Germany
compared to figures from the previous year. A total of 51 361 SARS-CoV2 tests were carried out during the observation period, of which 6.1% (n = 3122) were positive. The COVID-19 pandemic led to a significant drop in medical emergencies of all kinds presenting
to the nation's emergency departments. A recovery effect began to be seen as early as calendar week 15, but the levels seen in 2019 were not yet reached overall by calendar week 22; only the prevalence of myocardial infarction had renormalized by then. |
|
|
Sobaih, AEE, Hasanein, et al |
Sustainability (Switzerland) |
Public Health response| Interventions de santé publique |
This research empirically examines the extent to which social media sites are adopted by faculty members and students
for sustaining formal, i.e., sole and official tools, academic communication after the COVID-19 worldwide pandemic. The results showed that students' personal usage of social media has promoted its effective usage for sustaining formal teaching and learning.
Students used social media for building an online community and supporting each other, whereas faculty members were focused on teaching and learning exclusively. |
|
|
Sockalingam, S, Clarkin, et al |
J Contin Educ Health Prof |
Healthcare Response | Réponse des soins de santé |
We describe the psychological needs of health care professionals (HCPs) during COVID-19 and the implementation of Project
Extension for Community Healthcare Outcomes (ECHO) Coping with COVID (ECHO-CWC) to help HCPs manage COVID-19 distress. Needs assessment data showed that most participants reported feeling increased stress at work, fear of infecting others, and fear of falling
ill from COVID-19, yet most participants accepted the risk associated with work during this time. Participants were highly satisfied with the initial five sessions of ECHO-CWC. |
|
|
Solhpour, A, Jafari, et al |
Trends in Anaesthesia and Critical Care |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study explores the relation between the type of blood group and severe cases of hypoxia among young patients infected
by Covid-19 in Iran. Of 93 patients with severe hypoxia, 61 (65%) patients had blood group type A, 22 (23%) patients had AB, 8 (8%) patients had type B, and only 2 (2%) of patients had blood group type O. In the general population, in our community the distribution
of the blood group reported the blood of 36.49%, 32.09%, 23.68%, and 7.74% as type O, A, B and AB respectively |
|
|
Song, Eric, Zhang, et al |
bioRxiv |
Clinical data| Données cliniques Coronavirology| Coronavirologie Animal model | Modèle
animal |
Here, we used three independent approaches to probe the capacity of SARS-CoV-2 to infect the brain. First, using human
brain organoids, we observed clear evidence of infection with accompanying metabolic changes in the infected and neighboring neurons. Second, using mice overexpressing human ACE2, we demonstrate in vivo that SARS-CoV-2 neuroinvasion, but not respiratory infection,
is associated with mortality. Finally, in brain autopsy from patients who died of COVID-19, we detect SARS-CoV-2 in the cortical neurons, and note pathologic features associated with infection with minimal immune cell infiltrates. |
|
|
Rationalizing Treatment for Gynecological Cancers During the
COVID-19 Pandemic: An Indian Experience |
Srinivasa, GY, Dey, et al |
Indian Journal of Gynecologic Oncology |
Healthcare Response | Réponse des soins de santé |
This study highlights our experience in the management of patients of gynecological malignancies over a period of 2
months during the COVID-19 pandemic. In total, 44.4% of patients on treatment had associated comorbidities that imposed an additional risk. 123/160 patients continued treatment with their initial plan of radiotherapy or chemotherapy. New patients were prioritized
based on the severity of clinical symptoms and whether the expected outcome would significantly affect their survival and quality of life. |
|
Analytic-thinking predicts hoax beliefs and helping behaviors in response to
the COVID-19 pandemic |
Stanley, ML, Barr, et al |
Thinking and Reasoning |
Public Health response| Interventions de santé publique |
Here, we examine a disposition—engagement in analytic-thinking—that might predict beliefs that the pandemic is a hoax
and failures to change behavior in positive ways during that critical early period in March. Our results indicate that individuals less likely to engage effortful, deliberative, and reflective cognitive processes were more likely to believe the pandemic was
a hoax and less likely to have recently engaged in social-distancing and hand-washing in March. |
|
Starks, TJ, Jones, et al |
Drug and alcohol dependence |
Public Health response| Interventions de santé publique |
This study compared marijuana use, other illegal drugs use (i.e. cocaine/crack, methamphetamine, MDMA/ecstasy, GHB,
and ketamine) and sexual behavior with casual partners among sexual minority cismen active on social networking and dating applications before and during the COVID-19 epidemic. While the proportion of participants reporting drug use and condomless anal sex
with casual partners declined in the COVID cohort, the association between drug use and sexual behavior was magnified. Sexual minority men who use drugs are significantly more likely to engage in sexual behaviors that place them at risk for HIV and COVID-19
transmission. |
|
|
Starr, MR, Israilevich, et al |
JAMA Ophthalmology |
Healthcare Response | Réponse des soins de santé |
The objective of this study was to report practice patterns for common ocular complaints during the initial stage of
the COVID-19 pandemic among comprehensive ophthalmology practices in the US. In this cross-sectional study, 40 private practices and 20 university centers were randomly selected from 4 regions across the US. Private practices had shorter times to next available
appointment for cataract extraction and were more likely to evaluate posterior vitreous detachment symptoms. |
|
|
Steinbach, R, Prell, et al |
J Clin Med |
Healthcare Response | Réponse des soins de santé |
Owing to the novel coronavirus disease (COVID-19) pandemic, regular contact with amyotrophic lateral sclerosis (ALS)
patients at our center was severely restricted and patient care was at risk by delay of supportive therapies. We established a triage system based on the D50 disease progression model and were thus able to identify a prospective cohort with high disease aggressiveness
(D50 < 30). We show that a comparable amount of advanced care was induced in a retrospective cohort within a similar time period one year prior to the COVID-19 outbreak. Our workflow to identify high-risk patients via D50 model metrics helped to maintain a
high quality of advanced care planning for our ALS patients. |
|
|
The Role of Asymptomatic Individuals in the COVID-19 Pandemic via Complex Networks |
Stella, L, M |
ArXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
This study aims to model the interactions in the population by means of a complex network and to shed some light on
the effectiveness of localised control measures in Italy in relation to the school opening in mid-September. The advantage of using this SEIR model lies in that it discriminates between asymptomatic and symptomatic cases of COVID-19. A case study on the situation
in Italy is given: first the homogeneous model is used to compare the official data with the data of the recent seroprevalence study from Istat; second, in view of the return to school in mid-September, a study at regional level is conducted. |
|
Managing the risk of a COVID-19 outbreak from border
arrivals |
Steyn, Nicholas, Plank, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Transmission
Public health interventions*| Interventions de santé publique Surveillance |
We model the testing, isolation and transmission of COVID-19 within quarantine facilities to estimate the risk of community
outbreaks being seeded at the New Zealand border. We show that the combination of 14-day quarantine with two tests reduces the risk of releasing an infectious case to around 0.1% per infected arrival. Shorter quarantine periods, or reliance on testing only
with no quarantine, substantially increases this risk. We calculate the fraction of cases detected in the second week of their two week stay and show that this may be a useful indicator of the likelihood of transmission occurring within quarantine facilities.
We use the model to test surveillance strategies and evaluate the likely size of the outbreak at the time it is first detected. |
|
The administration of low molecular weight heparin in severe case of COVID-19, a case
report |
Suastika, NKW, Suega, et al |
Eastern Journal of Medicine |
Clinical data| Données cliniques |
Coagulopathy and disseminated intravascular coagulation (DIC) is one of the complications of the corona virus disease
2019 (Covid-19) that can lead to death. This case emphasizes the administration of low molecular weight heparin (LMWH) to prevent venous thromboembolism (VTE) in severe case of Covid-19. |
|
Sugg, MM, Spaulding, et al |
Science of the Total Environment |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Clinical
data| Données cliniques |
This GIS-based spatial modeling study aimed to determine the association between nursing home-level metrics and county-level,
place-based variables with COVID-19 confirmed cases in nursing homes across the United States. Spatial cluster analysis identified specific regions with statistically higher COVID-19 cases and deaths among residents. Multivariate analysis identified risk factors
at the nursing home level including, total count of fines, total staffing levels, and LPN staffing levels. County-level or place-based factors like per-capita income, average household size, population density, and minority composition were significant predictors
of COVID-19 cases in the nursing home. |
|
|
Sun, J, Tang, et al |
Clin Microbiol Infect |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
We determined the kinetics of viral load in several body fluids through real time reverse transcription polymerase
chain reaction (rRT-PCR), serum antibodies of IgA, IgG and IgM by enzyme linked immunosorbent assay (ELISA), and neutralizing antibodies by microneutralization assay in 35 COVID-19 cases from two hospitals in Guangdong, China. We revealed a prolonged shedding
of virus RNA in upper respiratory tract, and evaluated the consistency production of IgG, IgA, IgM and neutralizing antibodies in COVID-19 cases. |
|
|
Sun, YX, Shen, et al |
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi |
Epidemiology| Épidémiologie Public Health response| Interventions de santé publique |
We aim to understand the epidemiological characteristics of COVID-19 monitoring cases in Yinzhou district based on
health big data platform to provide evidence for the construction of COVID-19 monitoring system. The monitoring system of COVID-19 based on the health big data platform was working well but the confirmed cases monitoring detection rate need to be improved. |
|
|
Sundarasen, S, Chinna, et al |
International Journal of Environmental Research and Public Health |
Public Health response| Interventions de santé publique |
This study examines its impact on the anxiety level of university students in Malaysia during the peak of the crisis
and the pertinent characteristics affecting their anxiety. |
|
|
A Duty to treat? A Right to refrain? Bangladeshi physicians in moral dilemma during
COVID-19 |
Swazo, NK, Talukder, et al |
Philos Ethics Humanit Med |
Healthcare Response | Réponse des soins de santé |
In the case of COVID-19 pandemic in a developing country such as Bangladesh, however, the fact is that some physicians
decline either to report for duty or to treat patients presenting with COVID-19 symptoms. The presence of a moral dilemma (i.e., conflict of obligations) in the pandemic situation of clinical care requires institutional authorities to exercise tolerance of
individual physician moral decision about the duty to care. Hospital or government authority should respond to such decisions without introducing immediate sanction. |
|
Taboada, M, Rodríguez, et al |
Journal of clinical anesthesia |
Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response |
Réponse des soins de santé |
We prospectively evaluated patients admitted to the Clinical University Hospital of Santiago, Spain, between March
15, 2020 and April 15, 2020, with laboratory-confirmed COVID-19 disease who had mild or moderate ARDS needing oxygen therapy. We wanted to determine whether prone position would impact the oxygenation and describe treatments and short-term outcomes of these
patients. In the present investigation we observed that PP was associated with significant increase in oxygenation (StO2/FiO2) in hospitalized non-ICU patients with ARDS by COVID-19. |
|
|
The influence of sex and gender domains on COVID-19 cases and mortality |
Tadiri, CP, Gisinger, et al |
Cmaj |
Epidemiology| Épidémiologie |
We found institutionalized gender inequality (as measured by the United Nations Development Project’s Gender Inequality
Index) to be positively associated with the male:female ratio reported cases of coronavirus disease 2019 (COVID-19) among countries that report sex-disaggregated data; males accounted for more cases in countries with higher gender inequality. Institutionalized
gender and culturally entrenched roles and norms may influence who is most at risk of acquiring infection or who is able to receive a test. |
|
Tatar, E, Karatas, et al |
Transfusion and Apheresis Science |
Clinical data| Données cliniques |
Here, a 66-year-old female kidney transplant patient who presented with respiratory failure and treated with IVIg and
Favipiravir after the diagnosis of severe COVID-19 pneumonia was presented. |
|
|
An Investigation of Machine Learning Algorithms on COVID-19 Dataset |
Theerthagiri, P, J |
Research Square prepub |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This paper studies the different machine learning classification algorithms to predict the COVID-19 recovered and deceased
cases. |
|
Tomczyk, S, Rahn, et al |
Frontiers in Psychology |
Public Health response| Interventions de santé publique |
The study aims to to identify causes and patterns of non-compliance in the German population to further optimize risk
and health communication. With 25% of the sample reporting full compliance, and 51% differing in terms of public and personal compliance, these findings challenge the sustainability of strict regulatory measures. Moreover, young males were most likely to express
low compliance, stressing the need for selective health promotion efforts. |
|
|
Trifirò, G, Massari, et al |
Drug Safety |
Epidemiology| Épidémiologie Therapeutics| Thérapeutique |
The aim of this large-scale, retrospective Italian cohort study was to investigate whether prior exposure to ACEIs
and/or ARBs was associated with all-cause mortality among over 40,000 hospitalised COVID-19 patients compared with calcium channel blockers (CCBs), a potential therapeutic alternative. |
|
|
Tu, D, Shu, et al |
Journal of Infection |
Epidemiology| Épidémiologie Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes Immunology | Immunologie |
On March 19–20, 2020, pediatric medical workers (n = 325) in one hospital in Wuhan were recruited. They were divided
into three groups depending on their level of contact with confirmed and/or suspected COVID-19 cases during the outbreak. Three different immunological detection methods were used to measure SARS-CoV-2 serum antibodies. The overall positive rate for SARS-CoV-2
IgG and IgM antibodies was 43.08 and 5.85%, respectively. Results suggests the colloidal gold detection kit used in this research is not sensitive enough to be useful in accurate antibody detection, whereas the DTFA and ELISA positive rate performed similarly. |
|
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Umemura, Y, Yamakawa, et al |
J Clin Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
To elucidate the specific pattern of coagulopathy induced by COVID-19 pneumonia, this retrospective, observational
study targeted consecutive adult patients with COVID-19-induced acute respiratory distress syndrome (ARDS) and compared hemostatic biomarkers with non-COVID-19-induced septic ARDS. The hematological phenotype of COVID-19-induced coagulopathy is quite different
from that in typical SIC characterized by systemic hypercoagulation and suppressed fibrinolysis. Instead, local thrombus formation might be promoted in severe COVID-19. |
|
|
Urwyler, P, Moser, et al |
Frontiers in Immunology |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
The aim of the present study was to assess the safety and potential benefits of human recombinant C1 esterase inhibitor
(conestat alfa), a complement, contact activation and kallikrein-kinin system regulator, in severe COVID-19. In this uncontrolled case series, targeting multiple inflammatory cascades by conestat alfa was safe and associated with clinical improvements in the
majority of severe COVID-19 patients. |
|
|
Risk Factors for COVID-19: Community Exposure and Mask-Wearing |
van den Broek-Altenburg, Eline, Atherly, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
This study reports prevalence of COVID-19 in the general population of the Northest U.S.; and identifies factors that
affect exposure to the virus. We found a positivity rate of 2.2 percent, a hospitalization rate of 1.2 percent and an adjusted IFR of 0.55 percent. The number of contacts with adults and seniors increases the probability of becoming infected. Occupation, living
in apartment versus a house, and wearing a facial mask outside work increased probability of COVID-19 infection. |
|
van der Velden, PG, Contino, et al |
Journal of affective disorders |
Public Health response| Interventions de santé publique |
We assessed if the prevalence of high Anxiety and Depression Symptoms (ADS) levels and lack of Emotional Support (ES)
in the Dutch population increased, and if risk factors of ADS and ES changed. No increase in the prevalence of ADS and lack of ES was found. Some risk factors remained significant after the outbreak, while others changed notably. |
|
|
Left gonadal vein thrombosis in a patient with COVID-19-associated coagulopathy |
Veyseh, M, Pophali, et al |
BMJ Case Rep |
Clinical data| Données cliniques |
We report an unusual case of ovarian vein thrombosis and pulmonary embolism associated with COVID-19 presenting with
abdominal pain. To our knowledge, this is the first reported case of COVID-19 with absent respiratory symptoms and presentation with venous thrombosis in an unusual location. |
|
32711040; USEFULNESS OF SALIVA SAMPLES FOR DETECTING SARS-CoV-2 RNA AMONG LIVER
DISEASE PATIENTS |
Villar, LM, da Costa, et al |
Journal of Infection |
Epidemiology| Épidémiologie Clinical data| Données cliniques Diagnostics / Pathogen
detection| Diagnostics / Détection d'agents pathogènes |
This is the first report of SARS CoV-2 detection in saliva samples among liver disease patients showing best results
until 7 days of beginning of symptoms. There is an urgency for alternative methods for SARS-CoV-2 RNA detection to overcome swab availability and increase the access of diagnosis in Brazil. |
|
Vogel, Annette, Kanevsky, et al |
bioRxiv |
Vaccine Research| Recherche sur les vaccins Animal model | Modèle animal |
In this study, we report the 40 design, preclinical development, immunogenicity and anti-viral protective effect in
rhesus 41 macaques of the BNT162b2 vaccine candidate. The BNT162b2 vaccine candidate fully 50 protected the lungs of immunised rhesus macaques from infectious SARS-CoV-2 challenge. 51 BNT162b2 is currently being evaluated in a global, pivotal Phase 2/3 trial
(NCT04368728). |
|
|
Wakfie-Corieh, C, Blanes García, et al |
Eur J Nucl Med Mol Imaging |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We evaluated the extra-parenchymal lung involvement in asymptomatic cancer patients with COVID-19 pneumonia through
18F-FDG PET-CT. In cancer patients with asymptomatic COVID-19 pneumonia, 18F-FDG PET-CT findings are more frequently limited to thoracic structures, suggesting that an early and silent distant involvement is very rare. Pulmonary embolism is a frequent and
potentially severe finding raising special concern. |
|
|
Walker, J, Fleece, et al |
Clin Infect Dis |
Epidemiology| Épidémiologie Infection Prevention and Control/ Prévention et contrôle
des infections (IPAC/PCI) |
We describe the impact of universal masking and universal testing at admission on high risk exposures to SARS-CoV-2
for healthcare workers. Universal masking decreased the rate per patient day of high risk exposures by 68%, and universal testing further decreased those exposures by 77%. |
|
|
Walsh-Messinger, Julie, Kaouk, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We compared olfaction data from asymptomatic students, who were assessed as SARS-CoV-2 was unknowingly spreading locally,
to students tested prior to the arrival of the virus. the exposed group was significantly more likely to have hyposmia (OR=7.74; CI, 3.1, 19.40), particularly the subgroup assessed in the final week before campus closure (OR=13.61; CI, 3.40, 35.66;). The
exposed cohort also rated odors as less unpleasant (P<.001, CLES=0.77). A limitation of our study is that participants were not tested for COVID-19 as testing was unavailable in the area. |
|
|
Wang, H, L |
Research Square prepub |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this study is to explore the global and segmental myocardial performance of the severe and mild COVID-19
patients. Findings suggested that left ventricular performance was subclinically impaired during COVID-9 infection irrespective of infection severity. The cardiac function had an increasing trend for severe patients treated in ICU. |
|
|
Wang, J, Hang, et al |
Medicine |
Clinical data| Données cliniques |
We report the case of a patient with mild symptoms of coronavirus disease (COVID-19), who achieved clinical recovery
but showed persistently positive SARS-CoV-2 nucleic acid test results until Day 92 after disease onset. |
|
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Excessive Neutrophils and Neutrophil Extracellular Traps in COVID-19 |
Wang, J, Li, et al |
Frontiers in Immunology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aim to to clarify the pathogenesis of neutrophils leading to severe pneumonia in COVID-19. A retrospective analysis
was performed on 55 COVID-19 patients classified as mild (n = 22), moderate (n = 25), and severe (n = 8). Neutrophilia occurred in 6 of 8 severe patients at 7–19 days after symptom onset, showing that excessive neutrophils and associated NETs could explain
the pathogenesis of lung injury in COVID-19 pneumonia. |
|
Wang, M, Li, et al |
Medicine (Baltimore) |
Clinical data| Données cliniques |
We report a case of serious neurological damage and mental abnormalities in a patient who was finally confirmed to
have COVID-19 based on IgM and IgG antibodies in the cerebrospinal fluid (CSF). |
|
|
Wang, M, Yang, et al |
Medicine (Baltimore) |
Clinical data| Données cliniques |
We present the clinical data of 5 critically ill COVID-19 patients admitted, between January 16 and February 26, 2020,
in intensive care unit. We find the time of initiating the CPT may be an important factor affecting its efficacy, and its therapeutic effect in the treatment of COVID-19, in the late stage, is limited. |
|
|
Retropharyngeal Abscess in an adult with Pneumonia during COVID-19 Outbreak
in China |
Wang, T, L |
Research Square prepub |
Clinical data| Données cliniques |
We report a 40-year-old male with retropharyngeal abscesses turned to our department complaining dyspnea and dysphagia.
In addition, his chest CT scan shows a suspected COVID-19 infection. By presenting this case, we aim at raising awareness of different surgical drainage methods and summarizing our experience in the management of retropharyngeal abscesses during the outbreak
of COVID-19. |
|
Investigating College Students' Mental Health During the COVID-19 Pandemic: An Online Survey
Study |
Wang, X, Hegde, et al |
J Med Internet Res |
Public Health response| Interventions de santé publique |
This article reports findings of an online survey regarding mental health conditions of college students in a large
university in the United States during COVID-19. The proportion of respondents showing depression, anxiety and/or suicidal thoughts is alarming. Respondents reported academic, health, and lifestyle-related concerns caused by the pandemic. Given the unexpected
length and severity of the pandemic, these concerns need to be further understood and addressed. |
|
Wang, X, Li, et al |
Epidemiol Infect |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The present study aims to explore whether the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio
(PLR) are associated with the risk of death in patients with COVID-19. The pooled analysis revealed that the NLR at admission was significantly elevated for non-survivors, when compared to survivors (P<0.001). |
|
|
Case Report: Opportunities for Treatment of Severe COVID-19 Patients—Lessons From
a Death Case |
Wang, Y, Niu, et al |
Frontiers in Medicine |
Clinical data| Données cliniques |
We treated a 57-year-old man who was initially diagnosed with a severe type of the infection, but he progressed to
a critical condition and eventually died. We hope our findings will provide some advice and help for treating severe and critical COVID-19 cases: immediate invasive mechanical ventilation if there is no obvious improvement after using non-invasive ventilation
for several hours; and due to transfer risks, accurate assessment of the patient's condition and strict medical conditions are highly required. |
|
Wang, Z, Xiao, et al |
Pattern Recognition |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
This study aims to develop and test an efficient and accurate deep learning scheme that assists radiologists in automatically
recognizing and localizing COVID-19. Compared to the radiologists’ discrimination and localization results, the accuracy of COVID-19 discrimination using the Discrimination-DL yielded 98.71%, while the accuracy of localization using the Localization-DL was
93.03%. This work represents the feasibility of using a novel deep learning-based CAD scheme to efficiently and accurately distinguish COVID-19 from CAP and detect localization with high accuracy and agreement with radiologists. |
|
|
Wańkowicz, P, Szylińska, et al |
J Clin Med |
Public Health response| Interventions de santé publique |
the aim of this study was to assess the mental health factors among people with systemic lupus erythematosus by quantifying
the severity of anxiety, depression, and sleep disorders during the SARS-CoV-2 pandemic. |
|
|
32858060; Evaluation of SARS-CoV-2 prototype serologic test in hospitalized
patients |
Wheeler, SE, Shurin, et al |
Clinical biochemistry |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Immunology
| Immunologie |
We sought to clinically assess commercial prototype SARS-CoV-2 IgG and IgA assays for use in screening for prior infection
and convalescent plasma donation. Prototype SARS-CoV-2 IgG and IgA assays from Euroimmun were assessed utilizing remnant specimens. We found these assays to be clinically acceptable for the high prevalence population tested, for instance, for convalescent
plasma donation. |
|
Seasonal influenza activity in young children before the COVID-19 outbreak in Wuhan, China |
Xia, Z, Yang, et al |
Transboundary and Emerging Diseases |
Epidemiology| Épidémiologie Surveillance |
The activity of influenza A at the end of 2019 was higher than previous two years in children younger than 6 years
old in Wuhan, China. The 2019–2020 winter peak of seasonal influenza preceded the COVID-19 outbreak, with a higher and earlier peak than those of the 2017–2018 and 2018–2019 seasons. We speculate this could be due to the earlier CNY holiday season in 2019–2020
than in previous two years. We compared these results with those of two previous studies to further discuss the possible interference between influenza and COVID-19 in young children. |
|
32851078; CT Findings in a Novel Coronavirus Disease (COVID-19) Pneumonia at Initial
Presentation |
Xiang, C, Lu, et al |
BioMed research international |
Clinical data| Données cliniques |
Background: COVID-19 first broke out in China and spread rapidly over the world. Objectives: To describe the CT features
of COVID-19 pneumonia and to share our experience at initial diagnoses. Patients and Methods. Data from 53 patients (31 men, 22 women; mean age, 53 years; age range, 16-83 years) with confirmed COVID-19 pneumonia were collected. Their complete clinical data
was reviewed, and their CT features were recorded and analyzed. Results: The average time between onset of illness and the initial CT scan was six days (range, 1-42 days). A total of 399 segments were involved and distributed bilaterally (left lung: 186 segments
46.6%], right lung: 213 segments 53.4%]) and peripherally (38 71.7%] patients). Multiple lobes (45 84.9%]) and bilateral lower lobes (left lower lobe: 104 26.1%], right lower lobe: 107 26.8%], and total: 211 52.9%]) were the most commonly involved. Ground-glass
opacity with consolidation (24 45.3%]) and pure ground-glass opacity (28 52.8%]) were the main findings. The other findings were crazy-paving (14 26.4%]), bronchiectasis (12 22.6%]), atelectasis (7 13.2%]), parenchymal bands (6 11.3%]), air bronchogram (6
11.3%]), interlobular thickening (5 9.4%]), reticular pattern (1 1.9%]), and pleural effusion (1 1.9%]). Conclusions: Most COVID-19 pneumonia patients had abnormalities on chest CT images at initial presentation. Imaging features combined with patient's exposure
history and onset symptoms could facilitate the identification of the suspected patient for further examinations. |
|
Practice and function of transitional wards in treatment of non-coronavirus
disease 2019 patients |
Xiao-Ming, L, Bo-Rong, et al |
Academic Journal of Second Military Medical University |
Healthcare Response | Réponse des soins de santé |
As the outbreak of coronavirus disease 2019 (COVID-19) continues, hospitals in Wuhan have invested great efforts to
combat the epidemic. The risk of nosocomial infection and cross infection should not be ignored, and the treatment of non-COVID-19 patients was challenged. According to the characteristics of COVID-19, our hospital has established a transitional ward, enforced
the screening and exclusion procedures of COVID-19. We also scientifically formulated and smoothly operated various programs and procedures for the treatment of emergency and critical patients, so that non- COVID-19 patients can be treated in time, ensuring
medical safety and nursing quality, also effectively avoiding the spread of COVID-19 in non-isolated areas of the hospital, which has played a very important role at the outbreak stage of the epidemic. |
|
Xie, H, Cheng, et al |
Medicine |
Healthcare Response | Réponse des soins de santé |
The first case of atypical pneumonia caused by coronavirus disease 2019 (COVID-19) was reported in Wuhan, China in
December 2019. Since then, cases of novel coronavirus-infected pneumonia (NCIP) have been reported throughout China as well as in 25 other countries. With the rapid growth of this global outbreak, psychological disorders or impact among the healthcare nurses
caused by the COVID-19 pandemic is of great importance and worth to be evaluated. Here, we aimed to determine the levels of stress and psychological disorders of nurses who provided nursing care during the COVID-19 outbreak. A total of 159 nurses who provided
healthcare work for COVID-19 patients were enrolled in our study. The psychological disorders and stress level were assessed via a questionnaire implemented by the mobile app. The results showed that the nurses who worked in the non-critical care ward (general
ward in which the invasive medical procedure such as mechanical ventilation is absent) scored significantly higher on the traumatization condition (P < .05) and stress level (P < .01) as well as the impact of event scale -revised level (P < .01) compared with
those worked in the critical care ward. In contrast to the previous report, our findings revealed that the future intervention for preventing the mental crisis among the healthcare nurses needs to be focusing on the individuals in the non-critical care ward
instead of those in the critical care ward under the spreading of COVID-19. |
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32867381; The impact of risk perception on social distancing during the COVID-19 pandemic
in China |
Xie, K, Liang, et al |
International Journal of Environmental Research and Public Health |
Public Health response| Interventions de santé publique |
Social distancing is one of the most recommended policies worldwide to reduce diffusion risk during the COVID-19 pandemic.
Based on a risk management perspective, this study explores the mechanism of the risk perception effect on social distancing in order to improve individual physical distancing behavior. The data for this study were collected from 317 Chinese residents in May
2020 using an internet-based survey. A structural equation model (SEM) and hierarchical linear regression (HLR) analyses were conducted to examine all the considered research hypotheses. The results show that risk perception significantly affects perceived
understanding and social distancing behaviors in a positive way. Perceived understanding has a significant positive correlation with social distancing behaviors and plays a mediating role in the relationship between risk perception and social distancing behaviors.
Furthermore, safety climate positively predicts social distancing behaviors but lessens the positive correlation between risk perception and social distancing. Hence, these findings suggest effective management guidelines for successful implementation of the
social distancing policies during the COVID-19 pandemic by emphasizing the critical role of risk perception, perceived understanding, and safety climate. |
|
Xiong, Z, Chen, et al |
Chinese General Practice |
Healthcare Response | Réponse des soins de santé |
Background: It was difficult for primary care to take emergency actions to contain COVID-19 at the beginning of its
outbreak, and the management of screening and triage procedure was disorderly. To address the situation, it is critical to make a sound management method for appropriately screening, triage, treat and transfer the patients. Objective: To evaluate the effect
of an approach for unified management of COVID-19 screening and triage in members within a regional medical consortium. Methods: This study was carried out in a regional medical consortium with five unified features including unified goal, legal person, information
platform, service team and salary scheme. An approach developed by our research group, has been used for unified management(of relevant goals, healthcare workers and procedure) of COVID-19 screening and triage in this consortium led by a tertiary hospital,
together with 18 stations of a community health center, and the implementation results between January 25 and April 4, 2020 were analyzed. Results: During this period, of the 173 841 cases screened and triaged in the tertiary hospital, 440 were triaged to
the COVID-19 fever clinic, 2 051 to the general fever clinic, 271 to the quarantine ward due to suspected COVID-19 symptoms, and 4 were confirmed and referred to the designated hospital. The 18 stations of community heath centers screened and triaged 52 525
cases, including 25 who were triaged to the COVID-19 fever clinic, and 122 to the general fever clinic. There were no missed screening of suspected COVID-19 cases and cross infections within the medical consortium. Conclusion: Our unified management approach
has effectively facilitated the development of COVID-19 screening and triage from disorderly to orderly within the regional medical consortium, demonstrating good effects in containing the COVID-19 pandemic. |
|
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Performance of Two Risk-Stratification Models in Hospitalized Patients With Coronavirus
Disease |
Xu, R, Hou, et al |
Frontiers in Medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response |
Réponse des soins de santé |
Background: Despite an increase in the familiarity of the medical community with the epidemiological and clinical characteristics
of coronavirus disease 2019 (COVID-19), there is presently a lack of rapid and effective risk stratification indicators to predict the poor clinical outcomes of COVID-19 especially in severe patients. Methods: In this retrospective single-center study, we
included 117 cases confirmed with COVID-19. The clinical, laboratory, and imaging features were collected and analyzed during admission. The Multi-lobular infiltration, hypo-Lymphocytosis, Bacterial coinfection, Smoking history, hyper-Tension and Age (MuLBSTA)
Score and Confusion, Urea, Respiratory rate, Blood pressure, Age 65 (CURB65) score were used to assess the death and intensive care unit (ICU) risks in all patients. Results: Among of all 117 hospitalized patients, 21 (17.9%) patients were admitted to the
ICU care, and 5 (4.3%) patients were died. The median hospital stay was 12 (10–15) days. There were 18 patients with MuLBSTA score ≥ 12 points and were all of severe type. In severe type, ICU care and death patients, the proportion with MuLBSTA ≥ 12 points
were greater than that of CURB65 score ≥ 3 points (severe type patients, 50 vs. 27.8%; ICU care, 61.9 vs. 19.0%; death, 100 vs. 40%). For the MuLBSTA score, the ROC curve showed good efficiency of diagnosis death (area under the curve AUC], 0.956; cutoff value,
12; specificity, 89.5%; sensitivity, 100%) and ICU care (AUC, 0.875; cutoff value, 11; specificity, 91.7%; sensitivity, 71.4%). The K–M survival analysis showed that patients with MuLBSTA score ≥ 12 had higher risk of ICU (log-rank, P = 0.001) and high risk
of death (log-rank, P = 0.000). Conclusions: The MuLBSTA score is valuable for risk stratification and could effectively screen high-risk patients at admission. The higher score at admission have higher risk of ICU care and death in patients infected with
COVID. |
|
Yan, Huan, Jiao, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Bats are the suggested natural hosts for severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2, the
latter of which caused the coronavirus disease 2019 (COVID-19) pandemic. The interaction of viral Spike proteins with their host receptor angiotensin-converting enzyme 2 (ACE2) is a critical determinant of potential hosts and cross-species transmission. Here
we use virus-host receptor binding and infection assays to show that ACE2 orthologs from 24, 21, and 16 of 46 phylogenetically diverse bat species, including those in close and distant contact with humans, do not support entry of SARS-CoV, SARS-CoV-2, and
both of these coronaviruses, respectively. Furthermore, we used genetic and functional analyses to identify genetic changes in bat ACE2 receptors associated with viral entry restrictions. Our study demonstrates that many, if not most, bat species are not potential
hosts of SARS-CoV and SARS-CoV-2, and provides important insights into pandemic control and wildlife conservation.Competing Interest StatementThe authors have declared no competing interest. |
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|
Yin, P, Zeng, et al |
Annals of Oncology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
A retrospective study was performed to evaluate asymptomatic infections in 5119 individuals without typical symptoms
of COVID-19 infection (including 2818 patients with cancer and 2301 caregivers without cancer). The incidence of asymptomatic infection was 2.9% (81/2818) in patients with cancer, whereas it was 2.1% (49/2301) in their caregivers. There was no statistical
difference in infection risk between patients with cancer and their caregivers [relative risk 1.36, 95% confidence interval (CI) 0.95–1.95]. |
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|
Yoon, JC, Montgomery, et al |
Clin Infect Dis |
Epidemiology| Épidémiologie Infection Prevention and Control/ Prévention et contrôle
des infections (IPAC/PCI) |
BACKGROUND: In response to reported COVID-19 outbreaks among people experiencing homelessness (PEH) in other U.S. cities,
we conducted multiple, proactive, facility-wide testing events for PEH living sheltered and unsheltered and homelessness service staff in Atlanta, Georgia. We describe SARS-CoV-2 prevalence and associated symptoms and review shelter infection prevention and
control (IPC) policies. METHODS: PEH and staff were tested for SARS-CoV-2 by reverse transcription polymerase chain reaction (RT-PCR) during April 7-May 6, 2020. A subset of PEH and staff was screened for symptoms. Shelter assessments were conducted concurrently
at a convenience sample of shelters using a standardized questionnaire. RESULTS: Overall, 2,875 individuals at 24 shelters and nine unsheltered outreach events underwent SARS-CoV-2 testing and 2,860 (99.5%) had conclusive test results. SARS-CoV-2 prevalence
was 2.1% (36/1,684) among PEH living sheltered, 0.5% (3/628) among PEH living unsheltered, and 1.3% (7/548) among staff. Reporting fever, cough, or shortness of breath in the last week during symptom screening was 14% sensitive and 89% specific for identifying
COVID-19 cases compared with RT-PCR. Prevalence by shelter ranged 0%-27.6%. Repeat testing 3-4 weeks later at four shelters documented decreased SARS-CoV-2 prevalence (0%-3.9%). Nine of 24 shelters completed shelter assessments and implemented IPC measures
as part of the COVID-19 response. CONCLUSIONS: PEH living in shelters experienced higher SARS-CoV-2 prevalence compared with PEH living unsheltered. Facility-wide testing in congregate settings allowed for identification and isolation of COVID-19 cases and
is an important strategy to interrupt SARS-CoV-2 transmission. |
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Seroprevalence of SARS-CoV-2 antibodies among healthy blood donors in Karachi,
Pakistan |
Younas, A, Waheed, et al |
Transfusion and Apheresis Science |
Epidemiology| Épidémiologie Immunology | Immunologie |
Background: Covid-19 spread through blood transfusion has not yet been reported. Despite the prevailing pandemic, there
are no recommendations available as yet for testing SARS-CoV-2 antibodies as part of blood screening. Objective: To determine the seroprevalence of SAR-CoV-2 antibodies, its clinical significance and to identify if total antibodies(IgA, IgM, IgG) should be
tested or just the specific IgG antibodies only. Method: Consecutive blood donors donated were screened for standard serological panel of HbsAg, Anti-HCV, Anti-HIV and Syphilis using Cobas-411 analyser and Malaria. All seronegative donors were then screened
for COVID serology using the same instrument. These results were compared with the blood donors’ seroprevalence checked in a cohort in the first week of June 2020. Pre-COVID-19 period (October 2019) blood donors’ archived samples were also compared. Donors
who were positive on ECLIA were then tested for specific antibodies (IgM or IgG) by ELISA. Results: A total of 380 healthy blood donors were included. All were males with the mean age being 30.6 ± 6.3 years. Ten pre-pandemic samples did not show COVID-19 antibodies,
whereas out of 70 samples in the 3rd week of June, only 15 (21.4 %) were positive. However, in July out of the 300 blood donors, 113 (37.7 %) were found to be reactive. To reconfirm our findings, these 113 donors were then tested on ELISA for presence of IgG
specifically. Out of these 128 samples, 81 were IgG positive, 23 were borderline positive and 24 were negative. Conclusion: Almost 40 % of blood donors are now seroconverted for COVID-19. This is a reflection of widespread seroprevalence in the adult male
population. © 2020 |
|
Zabarsky, TF, Bhullar, et al |
American Journal of Infection Control |
Epidemiology| Épidémiologie Transmission Healthcare Response | Réponse des soins de
santé |
In our facility, 25% of personnel with coronavirus disease 2019 (COVID-19) had a higher-risk exposure to an infected
patient or co-worker and 14% reported a higher-risk exposure in the community. All higher-risk exposures to infected patients occurred on non-COVID-19 units, often when there was a delay in diagnosis because COVID-19 was not initially suspected. Higher-risk
exposures to co-workers with COVID-19 often involved lapses in compliance with masking in nonpatient care areas such as nursing stations and staff work or break rooms. |
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Outcome of COVID-19 patients with use of Tocilizumab: A single center experience |
Zain Mushtaq, M, Bin Zafar Mahmood, et al |
International immunopharmacology |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
COVID-19 pandemic has become a global concern. Cytokine release syndrome (CRS) complicates acute respiratory distress
syndrome (ARDS) and causes multi-organ failure which can subsequently lead to mortality in COVID-19 patients. Tocilizumab, an interleukin-6 antagonist, has shown to salvage patients with cytokine release storm. In this study, we aim to evaluate therapeutic
response of Tocilizumab in COVID-19 patients. A single-arm retrospective review of 40 patients with COVID-19, admitted to The Aga Khan University Hospital Karachi, from March 2020 to May 2020 was performed. Selection of patients for use of Tocilizumab was
based on severity of disease, rapid clinical deterioration, presence of CRS and absence of any absolute contraindication to Tocilizumab. Improvement after Tocilizumab was defined as improvement in oxygen requirement and inflammatory parameters. Serum levels
of inflammatory cytokines like C-reactive protein, ferritin, D-dimer and lactate dehydrogenase levels were monitored before and after administering Tocilizumab. Mean age was 62.4 years and 33 (82.5%) were male. 19 (47.5%) patients were critically sick, 18
(45%) were severely sick and 3 (7.5%) were moderately sick. 29 (77.5%) patients showed significant improvement in oxygen requirement, inflammatory parameters and chest x-rays, out of which 28 patients were discharged home. The mean duration between administration
of Tocilizumab and overall improvement was 4.3 ± 3.2 days. Hence, Tocilizumab can be used as a possible treatment option in patients with COVID-19 induced CRS but needs monitoring for its adverse effects. |
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Dynamics identification and forecasting of COVID-19 by switching Kalman filters |
Zeng, X, Ghanem, et al |
Computational Mechanics |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
The COVID-19 pandemic has captivated scientific activity since its early days. Particular attention has been dedicated
to the identification of underlying dynamics and prediction of future trend. In this work, a switching Kalman filter formalism is applied on dynamics learning and forecasting of the daily new cases of COVID-19. The main feature of this dynamical system is
its ability to switch between different linear Gaussian models based on the observations and specified probabilities of transitions between these models. It is thus able to handle the problem of hidden state estimation and forecasting for models with non-Gaussian
and nonlinear effects. The potential of this method is explored on the daily new cases of COVID-19 both at the state-level and the country-level in the US. The results suggest a common disease dynamics across states that share certain features. We also demonstrate
the ability to make short to medium term predictions with quantifiable error bounds. |
|
32865077; Retrospective analysis of clinical characteristics of 405 patients with
COVID-19 |
Zhan, T, Liu, et al |
Journal of International Medical Research |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Objective: This study was performed to investigate the clinical characteristics of patients with coronavirus disease
2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods: We analyzed the electronic medical records of 405 hospitalized patients with laboratory-confirmed COVID-19 in the Third Hospital of Wuhan. Results: The
patients’ median age was 56 years, 54.1% were female, 11.4% had a history of smoking, and 10.6% had a history of drinking. All cases of COVID-19 were community-acquired. Fever (76.8%) and cough (53.3%) were the most common clinical manifestations, and circulatory
system diseases were the most common comorbidities. Gastrointestinal symptoms were present in 61.2% of the patients, and 2.9% of the patients were asymptomatic. Computed tomography showed ground-glass opacities in most patients (72.6%) and consolidation in
30.9%. Lymphopenia (72.3%) and hypoproteinemia (71.6%) were observed in most patients. About 20% of patients had abnormal liver function. Patients with severe disease had significantly more prominent laboratory abnormalities, including an abnormal lymphocyte
count and abnormal C-reactive protein, procalcitonin, alanine aminotransferase, aspartate aminotransferase, D-dimer, and albumin levels. Conclusion: SARS-CoV-2 causes a variety of severe respiratory illnesses similar to those caused by SARS-CoV-1. Older age,
chronic comorbidities, and laboratory abnormalities are associated with disease severity. |
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32779737; The absorbing filter Oxiris in severe coronavirus disease 2019 patients: A case
series |
Zhang, H, Zhu, et al |
Artificial Organs |
Clinical data| Données cliniques |
Hypercytokines cause acute respiratory distress syndrome (ARDS) in coronavirus disease 2019 (COVID-19) patients, which
is the main reason for intensive care unit treatment and the leading cause of death in COVID-19 patients. Cytokine storm is a critical factor in the development of ARDS. This study evaluated the efficacy and safety of Oxiris filter in the treatment of COVID-19
patients. Five patients with COVID-19 who received continuous renal replacement therapy (CRRT) in Henan provincial people's hospital between January 23, 2019 and March 28, 2020, were enrolled in this study. Heart rate (HR), mean arterial pressure (MAP), oxygenation
index (PaO2/FiO2), renal function, C-reactive protein (CRP), cytokines, procalcitonin (PCT), acute physiology and chronic health evaluation II (APACHE II), sequential organ failure score (SOFA), and prognosis were compared after CRRT. Five COVID-19 patients,
three males and two females, aged 70.2 ± 19.6 years, were enrolled. After treatment, HR (101.4 ± 14.08 vs. 83.8 ± 6.22 bpm/min), CRP (183 ± 25.21 vs. 93.78 ± 70.81 mg/L), IL-6 (3234.49 (713.51, 16038.36) vs. 181.29 (82.24, 521.39) pg/mL), IL-8 (154.86 (63.97,
1476.1) vs. 67.19 (27.84, 85.57) pg/mL), and IL-10 (17.43 (9.14, 41.22) vs. 4.97 (2.39, 8.70) pg/mL), APACHE II (29 ± 4.92 vs. 18.4 ± 2.07), and SOFA (17.2 ± 1.92 vs. 11.2 ± 3.4) significantly decreased (P <.05), while MAP (75.8 ± 4.92 vs. 85.8 ± 6.18 mm Hg),
and PaO2/FiO2 (101.2 ± 7.49 vs. 132.6 ± 26.15 mm Hg) significantly increased (P <.05). Among the five patients, negative conversion of nucleic acid test was found in three cases, while two cases died. No adverse events occurred during the treatment. Our study
observed a reduced level of overexpressed cytokines, stabilization of hemodynamic status, and staged improvement of organ function during the treatment with Oxiris filter. |
|
Zhang, J, Han, et al |
Infection and Drug Resistance |
Healthcare Response | Réponse des soins de santé |
Objective: A large number of isolation wards were built to screen suspected patients because of the outbreak of coronavirus
disease 2019 (COVID-19). The particularity of the isolation wards would lead to more medical resource consumption and heavier hospital control tasks. Therefore, we adopted a vital signs telemetry system in the isolation wards to improve this situation. Materials
and Technologies: Twenty sets of vital signs telemetry system were installed in the east district of the isolation area and the wards were used as the telemetry system wards (TSWs). The wards in the west district were used as the routine wards (RW). The daily
telephone questionnaire was used to collect the frequency and time of ward rounds by medical staff and lasted for one week. Results: Within one-week survey, the average frequency of RW rounds was 3.00 ± 1.00 times per day, and the average time was 93.57 ±
66.25 min. The daily frequency of RW rounds was 0.428 ± 0.394 times per capita, and the time was 7.88 ± 2.36 min. There was a statistically significant difference in the time of ward rounds per capita, which presented that the daily time of TSW rounds per
capita was shorter than that of RW rounds. No security events related to telemetry equipment were found throughout the study. Conclusion: The application of vital signs telemetry system as an alternative to traditional ward monitoring is considered feasible.
The use of telemetry system can significantly reduce the consumption of medical resources, the workload of medical staff along with the administration and labor cost for isolation wards. The telemetry system provides sensitive and reliable real-time monitoring
for the key indicators used for disease judgment and can make an accurate warning of the patients with disease aggravation in time. Thus, it is worthy of promotion and wide application. |
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|
Zhang, L, K |
Research Square prepub |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Background: Corona Virus Disease 2019 (CVID-19) is spreading across the world and the epidemic is also a great stress
event for individuals which may trigger lots of mental health issue. This study aims to investigate the relationship between depressive symptoms and stress in individuals with infectious history of COVID-19 in Wuhan and the mediating effect of purpose in life.
Method: A total of 128 individuals with infectious history of COVID-19 who were discharged from designated hospital and furtherly accepted health management of 14-day rehabilitation, isolation and medical observation at Qingshan District Rehabilitation Station
in Wuhan were selected for the testing of Center for Epidemiologic Studies Depression Scale (CES-D), Impact of Event Scale (IES) and purpose-in-life test (PLT). Results: The depressive emotion, somatic symptoms and total score of CES-D in male group were significantly
lower than that of in female participants (P＜0.001). The total score
of CES-D was negatively correlated with all factors of PLT and positively correlated with all factors in IES (P＜0.05
or 0.01). The feeling of life, life goal, intrusiveness and awareness had significant predictive effects on the total score of CES-D(P＜0.05
or 0.01), which could explain 69.3% of variations in the total score of CES-D. The purpose in life played a partial mediating effect between the stress and depressive symptoms in individuals with infectious history of COVID-19, and the mediating effect accounted
for 13.33% of the total effect. Conclusions: The females with infectious history of COVID-19 had more severe symptoms of depression. The stress of COVID-19 infectious history had predictive effect on depressive symptoms and purpose in life was mediator between
stress and depressive symptoms. |
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|
Zhang, XR, Huang, et al |
Journal of affective disorders |
Epidemiology| Épidémiologie Public Health response| Interventions de santé publique |
Background: COVID-19 has gained intense attention globally. However, little is known about the COVID-19-ralated mental
health status among workers. Methods: The cross-sectional online survey with 123,768 workers was conducted from February 2, 2020 to February 7, 2020 on a mega-size labor-intensive factory in Shenzhen, China. Oral consent was obtained prior to the questionnaire
survey. The information collected in the survey included demographic characteristics, psychological symptoms, COVID-19-related information, and demands for psychological education and interventions. Symptoms of anxiety and depression were measured by the Zung's
Self-Rating Anxiety Scale and Self-Rating Depression Scale. Logistic regression models were performed to determine the association between related factors and mental health status. Results: The prevalence of anxiety and depression symptoms was 3.4% and 22.8%,
respectively. The dominant epidemic-related factors were having confirmed cases in the community (odds ratio OR], 2.75, 95% CI, 2.37–3.19) and having confirmed friends (OR, 2.44; 95% CI, 1.69–3.52) for the increased risk of anxiety and depression symptoms,
respectively. Nevertheless, major traditional risk factors such as general or poor health status and always drinking alcohol were still the dominant factors associated with the increased risk of anxiety and depression symptoms. Overall, 67.3% and 26.8% workers
reported desire for psychological education and interventions, respectively. Limitations: All assessments were self-reported, resulting in a risk of method bias. Conclusions: Our findings show a relatively low prevalence of anxiety symptoms, a relatively high
prevalence of depression symptoms, and urgent demand for psychological education and interventions among workers during the COVID-19 outbreak. |
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|
Zhang, YD, Gao, et al |
Jpn J Nurs Sci |
Healthcare Response | Réponse des soins de santé |
AIM: Workplace social capital refers to relationship networks formed by individuals in an organization through long-term
mutually beneficial interactions and cooperation with members. These relationship networks can create value and resources for organizations and individuals. This current study aimed to explore the potential impact of workplace social capital on the association
between perceived stress and professional identity in clinical nurses during the COVID-19 outbreak. METHODS: In this cross-sectional study, 308 Chinese clinical nurses filled out the Chinese Workplace Social Capital Scale, the Chinese Perceived Stress Scale,
and the Chinese Nurse's Professional Identity Scale. Descriptive analysis, independent samples t test, analysis of variance, Pearson correlation analyses, and bootstrap method were performed to analyze the data. RESULTS: Perceived stress was negatively correlated
with professional identity (r = -0.455, p .05). Instead, it mediated that relationship (95% CI -0.61 to -0.19, p < .05), and its mediating effect was -0.37. CONCLUSIONS: In the early stages of the COVID-19 outbreak, workplace social capital among the investigated
clinical nurses failed to buffer the negative impact of perceived stress on professional identity, but it did play a part in mediating perceived stress and professional identity. A healthy workplace should be provided to clinical nurses to improve their professional
identity, while lowering perceived stress. |
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|
Dynamics of COVID-19 mathematical model with stochastic perturbation |
Zhang, Z, Zeb, et al |
Advances in Difference Equations |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Acknowledging many effects on humans, which are ignored in deterministic models for COVID-19, in this paper, we consider
stochastic mathematical model for COVID-19. Firstly, the formulation of a stochastic susceptible–infected–recovered model is presented. Secondly, we devote with full strength our concentrated attention to sufficient conditions for extinction and persistence.
Thirdly, we examine the threshold of the proposed stochastic COVID-19 model, when noise is small or large. Finally, we show the numerical simulations graphically using MATLAB. |
|
Zhao, Y, D |
Research Square prepub |
Epidemiology| Épidémiologie Transmission Clinical data| Données cliniques Diagnostics
/ Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Background: As a new infectious disease, coronavirus disease 2019 (COVID-19) is not fully understood. During January
- July 2020, there were two clusters infections in Beijing, China. This study was to analyze the features of the two COVID-19 infections in Beijing. Methods: In this retrospective single-center study, 89 cases with the positive novel coronavirus nucleic acid
test were collected from January to July 2020 in Beijing. They were divided into January-March group and June-July group. Two groups of data were compared. Results: The eighty-nine cases, 47 males and 42 females, mean age (41±14 years), were used for our study.
The most common symptoms were fever (46/89, 52%) and cough (34/89, 38%). The clinical classification were moderate type (56/89,63%), mild type (24/89, 27%), severe type (4/89, 4%), critical type (0), respectively. Ground glass opacity (GGO) (47%) was the majority
CT pattern. The frequency of involvement of lower lobe was higher than that of upper lobe (P＜0.01).
In January - March group, there were 5 patients (18%) exposure to Wuhan, 15 patients (54%) family clusters, 5 patients (18%) colleague clusters, 3 patients (11%) imported cases. In June-July group, 41 patients (68%) had an exposure to Xinfadi market of Beijing,
6 patients (10%) family clusters, and 14 patients (23%) colleague clusters. The number of patients with fever, cough, chest CT severity score and the number of lesion lung lobes in January-March group was higher than that in June-July group (P＜0.05).
Conclusions: Two COVID-19 clusters were dominated moderate and mild type, but few severe types. Patients in June-July group had less symptoms, imaging and family clusters than that in January-March group. This suggested that closely monitoring, early quarantined,
nucleic acid test of COVID-19 and chest CT were important measures to prevent epidemic. |
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Zheng, H, Tan, et al |
British journal of anaesthesia |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We retrospectively reviewed demographic and clinical data available from electronic medical records at a branch of
Tongji Hospital (Wuhan, China), a 1050 bed hospital designated for severe and critically ill COVID-19 patients. The overall case-fatality rate (CFR) was 12.7% (228 deaths among 1792 confirmed cases) and the median length of hospital stay among deceased patients
was 11 (IQR 6 -20) days. CFR was elevated among male and older patients. |
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|
Zheng-Hao, X, Cheng, et al |
Academic Journal of Second Military Medical University |
Coronavirology| Coronavirologie Immunology | Immunologie |
Objective To investigate the efficacy of neutralizing antibodies induced by severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) receptor-binding domain (RBD) and spike (S) protein S1 subunit. Methods The SARS-CoV-2 RBD and mouse immunoglobulin G1 (IgG1) Fc fragment (mFc) fusion protein expression plasmid pVRCRBD- mFc was constructed and transfected into human embryonic
kidney 293T cells. The RBD-mFc fusion protein in the cell supernatants was detected by Western blotting. The effect of RBD-mFc in cell supernatants and CHO recombinant S1-human IgG1 Fc (S1-hFc) fusion protein on SARS-CoV-2 infection was detected by microneutralization
test. BALB/c mice were immunized with plasmid pVRC-RBD-mFc and S1-hFc fusion protein via intramuscular injection. Anti-S1 IgG antibodies in mouse sera were detected by enzyme-linked immunosorbent assay (ELISA), and the virus neutralization activity of mouse
sera was detected by microneutralization test. Results The RBD-mFc fusion protein could be detected in the culture supernatants of 293T cells transfected with the plasmid pVRC-RBD-mFc, the concentrated supernatants and the S1- hFc fusion protein could inhibit
SARS-CoV-2 infection on Vero E6 cells in a concentration-dependent manner. Anti-S1 IgG antibodies could be detected in the sera of mice immunized with plasmid pVRC-RBD-mFc and S1-hFc fusion protein, and the sera of both groups could neutralize SARS-CoV-2 infection.
The serum antibody titers and virus neutralization activity of S1- hFc fusion protein immunized mice were significantly higher than those of plasmid pVRC-RBD-mFc immunized mice (both P<0.01). Conclusion Both SARS-CoV-2 RBD and S1 subunit may be used as effective
vaccine antigens. Compared with DNA vaccine, recombinant subunit vaccine can induce neutralizing antibody more effectively.. |
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Zhong, B, Huang, et al |
Computers in Human Behavior |
Public Health Priorities| Priorités de santé publique Public Health response| Interventions
de santé publique |
This study investigates the possible association between social media usage and the mental health toll from the coronavirus
at the peak of Wuhan's COVID-19 outbreak. Informed by the Crisis and Emergency Risk Communication Model and Health Belief Model, it proposes a conceptual model to study how people in Wuhan – the first epicenter of the global COVID-19 pandemic – used social
media and its effects on users' mental health conditions and health behavior change. The results show that social media usage was related to both depression and secondary trauma, which also predicted health behavior change. But no relation was detected between
health behavior change and mental health conditions. As the virus struck, social media usage was rewarding to Wuhan people who gained informational, emotional, and peer support from the health information shared on social media. An excessive use of social
media, however, led to mental health issues. The results imply that taking a social media break may promote well-being during the pandemic, which is crucial to mitigating mental health harm inflicted by the pandemic. |
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Zhou, Y, Wang, et al |
Journal of affective disorders |
Healthcare Response | Réponse des soins de santé |
Background: To our best knowledge, this was the first time to investigate the prevalence and risk factors of psychological
disturbances, including depression, anxiety, somatization symptoms, insomnia and suicide, among frontline medical staff, who were working with the COVID-10 infected patients directly. Methods: Patient Health Questionnaire Depression (PHQ-9), Generalized Anxiety
Disorder Questionnaire scale (GAD-7), Symptom Check List-90 (SCL-90) somatization, Insomnia Severity Index (ISI), and the suicidal module of the Mini International Neuropsychiatric Interview were used for online survey. Results: A total of 606 frontline hospital
staff and1099 general population were recruited. The prevalence of depression, anxiety, somatization symptoms, insomnia, and suicide risk in frontline medical staffs were 57.6%, 45.4%, 12.0%, 32.0% and 13.0%, respectively. Except for suicide risk, the prevalence
of other psychological disorders in frontline medical staff were higher than those in general population (all p<0.01). Among the frontline medical staff, the daily working hours were associated with all psychological disturbance (all p<0.01), women with anxiety
(p = 0.02), body mass index (BMI) with anxiety and insomnia (p = 0.02, p = 0.03). Age was negatively associated with depression, anxiety, and insomnia (all p<0.01). Finally, years of working and family income were negatively associated with suicide risk (p
= 0.03, p<0.001). Conclusion: Our study demonstrates that during the outbreak of COVID-19, the frontline medical staff are more likely to suffer from psychological disturbances than general population. It is noticeable that daily working hours are a risk factor
for all measured psychological disturbances, and some other variables may be involved in certain psychological disturbances of frontline medical staff. |
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Zhou, ZJ, Qiu, et al |
Sustainable Cities and Society |
Coronavirology| Coronavirologie |
The novel human coronavirus (SARS-CoV-2) causes the coronavirus disease 2019 (COVID-19) pandemic worldwide. Control
of COVID-19 pandemic is vital for public health and is the prerequisite to maintain social stability. However, the origin and transmission route of SARS-CoV-2 is unclear, bringing huge difficult to virus control. Monitoring viral variation and screening functional
mutation sites are crucial for prevention and control of infectious diseases. In this study, we developed a user-friendly software, named BioAider, for quick sequence annotation and mutation analysis on large-scale genome-sequencing data. Herein, we detected
14 substitution hotspots within 3,240 SARS-CoV-2 genome sequences, including 3 groups of potentially linked substitution. NSP13-Y541C was crucial substitution which might affect the unwinding activity of the viral helicase. In particular, we discovered a SR-rich
region of SARS-CoV-2 distinct from SARS-CoV, indicating more complex replication mechanism and unique N-M interaction of SARS-CoV-2. Interestingly, the quantity of SSRX repeat fragments in SARS-CoV-2 provided further evidence of its animal origin. Overall,
we developed an efficient tool for rapid identification of viral genome mutations which could facilitate viral genomic studies. Using this tool, we have found critical clues for the transmission route of SARS-CoV-2 which would provide theoretical support for
the epidemic control of pathogenic coronaviruses. |
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Zhu, B, Jin, et al |
Diabetes research and clinical practice |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Aims: Coronavirus disease 2019 (COVID-19) has become a recognized worldwide pandemic. Researchers now know that mortality
from COVID-19 can be reduced through early prevention measures. This retrospective, multi-centered study of 293 COVID-19 patients without diabetes explores the association between fasting blood glucose (FBG) levels and the risk of COVID-19 disease progression,
with the goal of providing clinical evidence for glycemic targets in patients. Methods: The multivariate stepwise binary logistic regression analysis was used to test the dose–response effects of FBG levels on the risk of severe and critical condition in COVID-19
patients. Results: FBG levels were plotted in quintiles with set at <4.74, 4.74–5.21, 5.21–5.78, 5.78–7.05, and
≧7.05 mmol/L. The constituent ratio of severe or critical
cases in each FBG quintile was 20.7%, 1.7%, 13.8%, 27.1%, and 67.2%, respectively (P < 0.0001). When the second quintile was used as the reference, the adjusted odds ratios (AORs) (95%CI) for the risk of severe/critical condition in COVID-19 was 25.33 (2.77,
231.64), 1.00 (Reference), 3.13 (0.33, 29.67), 10.59 (1.23, 91.24), 38.93 (4.36, 347.48) per FBG quintile respectively (P < 0.001). Conclusions: We provide evidence of J-shaped associations between FBG and risk of severe and critical condition in non-diabetes
patients with COVID-19, with nadir at 4.74–5.78 mmol/L. |
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Visual Variations between Pairs of SARS-CoV-2 Genomes on Integrated Density
Matrix |
Zhu, M, Z |
Research Square prepub |
Coronavirology| Coronavirologie |
This paper is the B2 module of the MAS. The quantification matrix is formed according to the four-base arrangement
in the genome sequence. The differences in new coronavirus genome sequencing sequences in different samples were demonstrated by using the most concise methods. Using 4 primitive variable value measures, changes in the virus genome sequence base order conditions
were determined. When two relatively large genomic sequences are slightly different, the integrated distribution of the difference calculation is subtly similar to the Bose-Einstein distribution, while the sum calculation shows a powerful distribution complexity.
It can be formed under the macroscopic angle and can distinguish 16 combinations of supersymmetric structures. In view of the abundant transformation structure in this kind of transformation system, the detailed exploration remains to be followed by the systematic
expansion of theory and medical application. |
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Cluster Analysis of Visual Differences on Pairs of SARS-CoV-2 Genomes |
Zhu, M, Z |
Research Square prepub |
Coronavirology| Coronavirologie |
This paper represents sample results for the C2 and C3 modules of the MAS. Genomic index maps were generated for SARS-CoV-2
genomes from different samples worldwide, and eleven other viral genomes were selected for comparisons. Each 2D genomic index map acts as a pair of X-Y coordinate scatter points located in a specific geometric region restricted. Supported by the principle
of entropy invariance and visual distributions, it is convenient to identify the variations of SARS-CoV-2 genomes in the global scope. In view of this powerful transformation structure, future exploration of the detailed systematic expansion of theory and
medical applications for COVID-19 patients is required. |
|
Zia, A |
International Journal of Information and Learning Technology |
Public Health response| Interventions de santé publique |
Purpose: This study explores the factors responsible for influencing online classes for business school during the
COVID-19 pandemic. This study also examines the level of influence of these factors on online classes. Design/methodology/approach: Primary data were collected online from 716 business school students using a questionnaire developed by the researcher. Smart
PLS3 software was used to analyze the data. Findings: Attitude, curriculum, motivation, technology and training were found to have an impact on online classes. Three variables (attitude, motivation and training) have a positive impact on online classes, whereas
two variables (curriculum and technology) have a negative impact on the online classes. All the factors have been found to be significant except technology which is found to have an insignificant impact (p = 0.356) on online classes. Research limitations/implications:
Only one university’s students were surveyed. Practical implications: Outlines the factors which have a positive and significant impact on online classes during COVID-19 pandemic. This study can be generalized through a student's community across the world
as the students face similar problems associated with online classes during the COVID-19 pandemic. Social implications: Suggest factors that can be considered while COVID-19 pandemic during social distancing to make online classes more effective and to reduce
the impact of this pandemic. Originality/value: No study has documented the factors associated to impact the online classes during the COVID-19 pandemic. |
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Zoran, MA, Savastru, et al |
Sci Total Environ |
Epidemiology| Épidémiologie Transmission |
This paper investigates the correlation between the high level of coronavirus SARS-CoV-2 infection accelerated transmission
and lethality, and surface air pollution in Milan metropolitan area, Lombardy region in Italy. For January-April 2020 period, time series of daily average inhalable gaseous pollutants ozone (O(3)) and nitrogen dioxide (NO(2)), together climate variables (air
temperature, relative humidity, wind speed, precipitation rate, atmospheric pressure field and Planetary Boundary Layer) were analyzed. In spite of being considered primarily transmitted by indoor bioaerosols droplets and infected surfaces or direct human-to-human
personal contacts, it seems that high levels of urban air pollution, and climate conditions have a significant impact on SARS-CoV-2 diffusion. Exhibited positive correlations of ambient ozone levels and negative correlations of NO(2) with the increased rates
of COVID-19 infections (Total number, Daily New positive and Total Deaths cases), can be attributed to airborne bioaerosols distribution. The results show positive correlation of daily averaged O(3) with air temperature and inversely correlations with relative
humidity and precipitation rates. Viral genome contains distinctive features, including a unique N-terminal fragment within the spike protein, which allows coronavirus attachment on ambient air pollutants. At this moment it is not clear if through airborne
diffusion, in the presence of outdoor and indoor aerosols, this protein "spike" of the new COVID-19 is involved in the infectious agent transmission from a reservoir to a susceptible host during the highest nosocomial outbreak in some agglomerated industrialized
urban areas like Milan is. Also, in spite of collected data for cold season (winter-early spring) period, when usually ozone levels have lower values than in summer, the findings of this study support possibility as O(3) can acts as a COVID-19 virus incubator.
Being a novel pandemic coronavirus version, it might be ongoing during summer conditions associated with higher air temperatures, low relative humidity and precipitation levels. |
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Zotzmann, V, L |
Research Square prepub |
Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response |
Réponse des soins de santé |
Introduction: Subpleural consolidations have been found in lung ultrasound in patients with COVID-19, possibly deriving
from pulmonary embolism (PE). The diagnostic utility of impact of lung ultrasound in critical-ill patients with COVID-19 for PE diagnostics however is unclear. Methods: We retrospectively evaluated all SARS-CoV2-associated ARDS patients admitted to our ICU
between March 8th and May 31th 2020. They were enrolled in this study, when a lung ultrasound and a computed tomography pulmonary angiography (CTPA) were documented. In addition, wells score was calculated to estimate the probability of PE. The CTPA was used
as the gold standard for the detection of PE. Results: Twenty patients met the inclusion criteria. In 12/20 patients (60%) (sub-) segmental PE were detected by CT-angiography. Lung ultrasound found subpleural consolidations in 90% of patients. PE-typical large
supleural consolidations with a size ≥1cm were detectable in 65% of patients and were significant more frequent in patients with PE compared to those without (p=0.035). Large consolidations predicted PE with a sensitivity of 77% and a specificity of 71%. The
Wells score was significantly higher in patients with PE compared to those without (2.7±0.8 and 1.7±0.5, respectively, p=0.042) and predicted PE with an AUC of 0.81. When combining the two modalities, comparing patients with considered/probable PE using LUS
plus a Wells score ≥2 to patients with possible/unlikely PE in LUS plus a Wells score 2, this might indicate a high-risk for PE in COVID-19. |
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AbdelMassih, A, F |
Research Square prepub |
Review Literature| Revue de littérature |
SR-MA: A computer run has been performed EMBASE, Medline and the Cochrane Central Register (From 1st November 2019
to 1st of August 2020). These findings suggest that while vertical transmission is unlikely, there appears to be an underlying risk of placental insufficiency due to the prothrombotic tendency observed in COVID-19 infection. |
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Social Protection as a Key Tool in Crisis Management: Learnt Lessons from the COVID-19
Pandemic |
Abdoul-Azize, H, El Gamil, et al |
Global Social Welfare |
Review Literature| Revue de littérature |
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Pandeconomic crisis and its impact on small open economies: A case study of COVID-19 |
Abuselidze, G, Slobodianyk, et al |
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Review Literature| Revue de littérature |
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32663356; Haematological manifestations of COVID-19: From cytopenia to coagulopathy |
Agbuduwe, C, Basu, et al |
European journal of haematology |
Review Literature| Revue de littérature |
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Favipiravir: A new and emerging antiviral option in COVID-19 |
Agrawal, U, Raju, et al |
Medical Journal Armed Forces India |
Review Literature| Revue de littérature |
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COVID-19 epidemic: a special focus on diagnosis, complications and management |
Ai, L, Jiang, et al |
Expert Rev Clin Pharmacol |
Review Literature| Revue de littérature |
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Akaji, K, Konno, et al |
Molecules (Basel, Switzerland) |
Review Literature| Revue de littérature |
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Almeida-Espinosa, A, Sarmiento-Ardila, et al |
Gaceta medica de Mexico |
Review Literature| Revue de littérature |
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Current meta-analysis does not support the possibility of COVID-19 reinfections |
Arafkas, M, Khosrawipour, et al |
J Med Virol |
Review Literature| Revue de littérature |
MA: searched for all peer-reviewed articles in the search engine of the National Center for Biotechnology Information.
Reports of COVID-19 reinfections all appear within a vulnerable timeframe, where affected patients are still tested positive for COVID-19 via PCR. According to our data, it is most likely that all reported cases of COVID-19 reinfections are in fact protracted
initial infections. |
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32854430; Targeting the sAC-Dependent cAMP Pool to Prevent SARS-Cov-2 Infection |
Aslam, M, Ladilov, et al |
Cells |
Review Literature| Revue de littérature |
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32831339; Proposal for the management of COVID-19-associated coagulopathy in children |
Ávila-Castro, D, Ortiz-Torres, et al |
Gaceta medica de Mexico |
Review Literature| Revue de littérature |
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Medicinal Plants as Sources of Active Molecules Against COVID-19 |
Benarba, B, Pandiella, et al |
Frontiers in Pharmacology |
Review Literature| Revue de littérature |
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Bentlage, E, Ammar, et al |
International Journal of Environmental Research and Public Health |
Review Literature| Revue de littérature |
SR: In May 2020, two electronic databases (PubMed; Web of Science) were used to search for relevant studies. This systematic
review revealed that reduced physical activity levels are of serious concern during home confinement in pandemic times.
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Bhandari, P, Subramaniam, et al |
Gut |
Review Literature| Revue de littérature |
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Current scenario and future prospect in the management of COVID-19 |
Borah, P, Deb, et al |
Curr Med Chem |
Review Literature| Revue de littérature |
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Face Masks are Beneficial Regardless of the Level of Infection in the Fight Against COVID-19 |
Burnett, ML, Sergi, et al |
Disaster Med Public Health Prep |
Review Literature| Revue de littérature |
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Chaabouni, M, Feki, et al |
Advances in respiratory medicine |
Review Literature| Revue de littérature |
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Largest democracy in the world crippled by COVID-19: current perspective and experience
from India |
Changotra, R, Rajput, et al |
Environment, Development and Sustainability |
Review Literature| Revue de littérature |
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New and developing diagnostic platforms for COVID-19: a systematic review |
Chauhan, N, Soni, et al |
Expert Rev Mol Diagn |
Review Literature| Revue de littérature |
SR: searches on Google scholar, PubMed and online resources were conducted on the period of year 2017 to mid-2020.
The search has identified the potential applications of nucleic acid technology, diagnostics radiology examinations, and in-vitro diagnostic kits in detection of COVID-19 infections.
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Chela, HK, Pasha, et al |
World Journal of Clinical Cases |
Review Literature| Revue de littérature |
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Approach to the Patient with COVID-19-Associated Thrombosis: A Case-Based
Review |
Chen, EC, Zon, et al |
Oncologist |
Review Literature| Revue de littérature |
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Chen, X, Guo, et al |
Frontiers in Immunology |
Review Literature| Revue de littérature |
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Chowdhury, P, Shumon, et al |
Sustainability (Switzerland) |
Review Literature| Revue de littérature |
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32831319; Manifestaciones neurológicas en la enfermedad del coronavirus
2019 |
Corona, T, Rodríguez-Violante, et al |
Gaceta medica de Mexico |
Review Literature| Revue de littérature |
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Cunha, LL, Perazzio, et al |
Frontiers in Immunology |
Review Literature| Revue de littérature |
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Di Gennaro, F, Marotta, et al |
Trop Med Infect Dis |
Review Literature| Revue de littérature |
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Ethical issues and arguments for a learning health care system in the covid-19 pandemic |
Diac, I, Udriștioiu, et al |
Romanian Journal of Legal Medicine |
Review Literature| Revue de littérature |
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Infection as a Stroke Risk Factor and Determinant of Outcome After Stroke |
Elkind, MSV, Boehme, et al |
Stroke |
Review Literature| Revue de littérature |
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Bibliometric Analysis on COVID-19: A Comparison of Research Between English and Chinese
Studies |
Fan, J, Gao, et al |
Frontiers in Public Health |
Review Literature| Revue de littérature |
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COVID-19 in Latin America: A bibliometric analysis of scientific publications in health |
Gallegos, M, Cervigni, et al |
Electronic Journal of General Medicine |
Review Literature| Revue de littérature |
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Giorli, A, Ferretti, et al |
Current Treatment Options in Neurology |
Review Literature| Revue de littérature |
SR-MA: PubMed, Scopus and Web of Science databases were reviewed from May 5, 2020, to June 1, 2020. Patient with new
onset olfactory dysfunction should be investigated for COVID-19. Anosmia is more frequent in non-hospitalized COVID-19 patients than in hospitalized ones. |
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Goli, M |
Journal of Food Safety |
Review Literature| Revue de littérature |
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32860390; SARS-CoV2: Diagnostic tests available to the clinician |
Hadweh, P, Orfanidou, et al |
Hellenic journal of nuclear medicine |
Review Literature| Revue de littérature |
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Hall, ME, Church, et al |
Brain Sci |
Review Literature| Revue de littérature |
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Safe intrahospital transport of critically ill COVID-19 patients |
Inci, K |
Journal of Critical and Intensive Care |
Review Literature| Revue de littérature |
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32867310; The Role of NLRP3 Inflammasome in the Pathogenesis of Traumatic Brain Injury |
Irrera, N, Russo, et al |
International journal of molecular sciences |
Review Literature| Revue de littérature |
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Jia, Q, Guo, et al |
International journal of environmental research and public health |
Review Literature| Revue de littérature |
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Jotz, GP, Stein, et al |
International Archives of Otorhinolaryngology |
Review Literature| Revue de littérature |
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Cardiac Arrhythmias in Critically Ill Patients With COVID-19: A Brief Review |
Karamchandani, K, Quintili, et al |
Journal of cardiothoracic and vascular anesthesia |
Review Literature| Revue de littérature |
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Kneale, D, O'Mara-Eves, et al |
F1000Research |
Review Literature| Revue de littérature |
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COVID-19 in Children and Adolescents with Endocrine Conditions |
Kostopoulou, E, Güemes, et al |
Horm Metab Res |
Review Literature| Revue de littérature |
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Leblanc, JF, Germain, et al |
Transfusion |
Review Literature| Revue de littérature |
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32832666; Shattering barriers toward clinically meaningful MSC therapies |
Levy, O, Kuai, et al |
Science advances |
Review Literature| Revue de littérature |
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32849658; Will Hydroxychloroquine Still Be a Game-Changer for COVID-19 by Combining
Azithromycin? |
Li, C, Cheng, et al |
Frontiers in Immunology |
Review Literature| Revue de littérature |
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32849656; Crosstalk Between Platelets and Microbial Pathogens |
Li, C, Li, et al |
Frontiers in Immunology |
Review Literature| Revue de littérature |
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Liu, Q, Xu, et al |
Journal of Infection and Public Health |
Review Literature| Revue de littérature |
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32831326; El gran desafío de la latencia de SARS-CoV-2: el testículo
como reservorio |
López-Romero, R, Nambo-Lucio, et al |
Gaceta medica de Mexico |
Review Literature| Revue de littérature |
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Major, R, Selvaskandan, et al |
J Am Soc Nephrol |
Review Literature| Revue de littérature |
Rapid Review: data available on the World Health Organization International Clinical Trials Registry Platform4 (WHO-ICTRP;
data extracted April 22nd, 2020). |
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Immunothrombosis and thromboinflammation in host defense and disease |
Martinod, K, Deppermann, et al |
Platelets |
Review Literature| Revue de littérature |
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COVID-19: Therapeutics and interventions currently under consideration |
McFee, RB |
Disease-a-Month |
Review Literature| Revue de littérature |
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Recommendations for the management of patients with hyperglycemia or diabetes mellitus
and COVID-19 |
Medina-Chávez, JH, Colín-Luna, et al |
Medicina Interna de Mexico |
Review Literature| Revue de littérature |
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Recommendations for the integral treatment of older adults with COVID-19 |
Medina-Chávez, JH, Colín-Luna, et al |
Medicina Interna de Mexico |
Review Literature| Revue de littérature |
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Bariatric Surgical Practice and Patient Care during the COVID-19 Pandemic |
Mikami, D, Noria, et al |
Bariatric Surgical Practice and Patient Care |
Review Literature| Revue de littérature |
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32853310; Promising and potential drugs for the treatment of COVID-19 |
Moneriz, C, Castro-Salguedo, et al |
Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia |
Review Literature| Revue de littérature |
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Naja, M, Wedderburn, et al |
British journal of hospital medicine (London, England : 2005) |
Review Literature| Revue de littérature |
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Nasonov, EL |
Nauchno-Prakticheskaya Revmatologiya |
Review Literature| Revue de littérature |
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Temporary regulation of employment due to force majeure derived
from COVID-19 |
Natividad, KS |
Actualidad Juridica Iberoamericana |
Review Literature| Revue de littérature |
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Ng, YPM, Low, et al |
Am J Perinatol |
Review Literature| Revue de littérature |
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32850151; Pulmonary Fibrosis in COVID-19 Survivors: Predictive Factors and Risk Reduction
Strategies |
Ojo, AS, Balogun, et al |
Pulmonary Medicine |
Review Literature| Revue de littérature |
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NeuroCOVID: critical review of neuropsychiatric manifestations of SARS-CoV-2 infection |
Oliveira, R, Sotero, et al |
Ir J Med Sci |
Review Literature| Revue de littérature |
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Digital technology, tele-medicine and artificial intelligence in ophthalmology:
A global perspective |
Olivia Li, JP, Liu, et al |
Prog Retin Eye Res |
Review Literature| Revue de littérature |
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Owji, H, Negahdaripour, et al |
International immunopharmacology |
Review Literature| Revue de littérature |
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Pal, A, Gowdy, et al |
Frontiers in Immunology |
Review Literature| Revue de littérature |
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Body Mass Index and Prognosis of COVID-19 Infection. A Systematic Review |
Peres, KC, Riera, et al |
Frontiers in Endocrinology |
Review Literature| Revue de littérature |
SR: searched in Cochrane Library, EMBASE, MEDLINE, WHO-Global Literature on Coronavirus Disease, OpenGrey, and Medrxiv.
Most of the included studies showed some degree of association to: (a) higher BMI and worse clinical presentation and (b) obesity and need of hospitalization. |
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Pérez-Bartolomé, F, Sánchez-Quirós, et al |
Archivos de la Sociedad Espanola de Oftalmologia |
Review Literature| Revue de littérature |
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Pinto, S, Quintarelli, et al |
Journal of the neurological sciences |
Review Literature| Revue de littérature |
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Prezioso, C, Pietropaolo, et al |
J Neurovirol |
Review Literature| Revue de littérature |
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Prudêncio, C, Vieira, et al |
Antibiotics (Basel) |
Review Literature| Revue de littérature |
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Rossi Monteiro, EM, Lima Nascimento, et al |
International Archives of Otorhinolaryngology |
Review Literature| Revue de littérature |
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Salmon, MK |
Journal of Consumer Health on the Internet |
Review Literature| Revue de littérature |
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Samrat, SK, Tharappel, et al |
Virus research |
Review Literature| Revue de littérature |
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Sanchez-Cordero, S, Vilallonga, et al |
Bariatric Surgical Practice and Patient Care |
Review Literature| Revue de littérature |
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Coupled human-environment system amid COVID-19 crisis: A conceptual model
to understand the nexus |
Sarkar, P, Debnath, et al |
Science of the Total Environment |
Review Literature| Revue de littérature |
MA: searched the ISI Web of Science (WoS) – Core Collection database published until April 30, 2020 (with an open initial
date). Results revealed a suite of positive and negative impacts of COVID-19 on both the sub-components. |
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Laparoscopic Surgery in COVID-19 Era-Safety and Ethical Issues |
Serban, D, Smarandache, et al |
Diagnostics (Basel) |
Review Literature| Revue de littérature |
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Shah, AD, Calabro-Kailukaitis, et al |
R I Med J (2013) |
Review Literature| Revue de littérature |
Rapid Review |
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Shahzad, F, Anderson, et al |
Nutrients |
Review Literature| Revue de littérature |
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32867260; Probiotics: Versatile Bioactive Components in Promoting Human Health |
Sharifi-Rad, J, Rodrigues, et al |
Medicina (Kaunas, Lithuania) |
Review Literature| Revue de littérature |
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Singh, AK, Misra, et al |
Diabetes and Metabolic Syndrome: Clinical Research and Reviews |
Review Literature| Revue de littérature |
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Singh, S, Roy, et al |
Psychiatry research |
Review Literature| Revue de littérature |
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Sobti, A, Fathi, et al |
Surgeon |
Review Literature| Revue de littérature |
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Suchomel, M, Steinmann, et al |
Journal of Hospital Infection |
Review Literature| Revue de littérature |
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A Review on the Serum Electrolytes and Trace Elements Role in the Pathophysiology
of COVID-19 |
Taheri, M, Bahrami, et al |
Biol Trace Elem Res |
Review Literature| Revue de littérature |
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Tang, EW, Bobenchik, et al |
R I Med J (2013) |
Review Literature| Revue de littérature |
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Teixeira da Silva, JA, Tsigaris, et al |
Scientometrics |
Review Literature| Revue de littérature |
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Turan, O, Hakim, et al |
International Journal of Gynecology and Obstetrics |
Review Literature| Revue de littérature |
SR: Relevant databases were searched up until May 29, 2020. Advanced gestation, maternal age, obesity, diabetes mellitus,
and a combination of elevated D-dimer and interleukin-6 levels are predictive of poor pregnancy outcomes in COVID-19. The rate of iatrogenic preterm birth and cesarean delivery is high; vertical transmission may be possible but has not been proved.
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Venkata Mohan, S, Hemalatha, et al |
Chem Eng J |
Review Literature| Revue de littérature |
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Strategic responses to the COVID-19 pandemic in Pacific Alliance countries |
Vivas, V, Villar, et al |
Management Research |
Review Literature| Revue de littérature |
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Clinical efficacy of Lianhua Qingwen integrated with Western medicine
on COVID-19 by Meta-analysis |
Wang, SX, Li, et al |
Chinese Traditional and Herbal Drugs |
Review Literature| Revue de littérature |
MA: Six databases (PubMed, Cochrane Library, Wanfang, Weipu, CBM and CNKI) were searched up to May 27, 2020. Lianhua
Qingwen could be used as adaptive and complementary medicine to improve clinical symptoms and CT for COVID-19. |
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32833200; Coronaviruses: An Updated Overview of Their Replication and Pathogenesis |
Wang, Y, Grunewald, et al |
Methods in Molecular Biology |
Review Literature| Revue de littérature |
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Xu, J, Xiao, et al |
Journal of Stroke and Cerebrovascular Diseases |
Review Literature| Revue de littérature |
MA: search was performed in PubMed, Web of Science, and EMBASE up to August 10th, 2020. This study for the first time
indicated that cerebrovascular disease was an independent risk factor for predicting the adverse outcomes, particularly fatal outcomes, in COVID-19 patients on the basis of adjusted effect estimates. Well-designed studies with larger sample size are needed
for further verification. |
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Yeoh, SH, Yong, et al |
Eur J Ophthalmol |
Review Literature| Revue de littérature |
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Zerwes, S, Steinbauer, et al |
Gefasschirurgie |
Review Literature| Revue de littérature |
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Zhang, YY, Li, et al |
Frontiers in Immunology |
Review Literature| Revue de littérature |
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Virions and respiratory droplets in air: Diffusion, drift, and contact with
the epithelium |
Zhdanov, VP, Kasemo, et al |
Biosystems |
Review Literature| Revue de littérature |
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Zhu, Y, Li, et al |
Asian Journal of Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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Bacille Calmette–Guérin (BCG) vaccination and COVID-19. Scientific brief |
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Pediatria i Medycyna Rodzinna |
Review Literature| Revue de littérature |
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32853319; Pathogenic, clinical and diagnostic characteristics of the SARS-CoV-2
pandemic |
Abarca Rozas, B, Vargas Urra, et al |
Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia |
Commentary/Editorial| Commentaire/Éditorial |
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Abbas, A, Memon, et al |
Journal of Hospital Infection |
Commentary/Editorial| Commentaire/Éditorial |
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Drug Repurposing Study Pinpoints Potential COVID-19 Antivirals |
Abbasi, J |
Jama |
Commentary/Editorial| Commentaire/Éditorial |
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Abbaspour, F, Soltani, et al |
Anatolia |
Commentary/Editorial| Commentaire/Éditorial |
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Abbaszadeh-Kasbi, A, Nikzad, et al |
International Journal of Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Abdelmassih, AF, Kamel, et al |
Cardiovascular Endocrinology and Metabolism |
Commentary/Editorial| Commentaire/Éditorial |
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Abdelmassih, AF, Ramzy, et al |
Cardiovascular Endocrinology and Metabolism |
Commentary/Editorial| Commentaire/Éditorial |
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The
efficient role played by criminal law and precautionary measures in contain COVID-19 pandemic |
Abdullah, FM |
Journal of Legal, Ethical and Regulatory Issues |
Commentary/Editorial| Commentaire/Éditorial |
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Abraham, P, Cherian, et al |
Indian J Med Res |
Commentary/Editorial| Commentaire/Éditorial |
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Abrams, EM, Primeau, et al |
J Allergy Clin Immunol Pract |
Commentary/Editorial| Commentaire/Éditorial |
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Abreu-Hernández, LF, Valdez-García, et al |
Gaceta medica de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
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Adeli, SH, Aghaali, et al |
Journal of Mazandaran University of Medical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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32782163; What about social determinants of health against xenophobia? |
Adja, KYC, Wu, et al |
Public health |
Commentary/Editorial| Commentaire/Éditorial |
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Adunlin, G, Adedoyin, et al |
Journal of Human Behavior in the Social Environment |
Commentary/Editorial| Commentaire/Éditorial |
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Peshawar city in
Pakistan: A potential hotspot for COVID-19 outbreak due to inflow of travellers |
Afridi, WA, Hussain, et al |
Journal of Medical Sciences (Peshawar) |
Commentary/Editorial| Commentaire/Éditorial |
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Plastic surgery practices amidst global COVID-19 pandemic: Indian consensus |
Agarwal, R, Singhal, et al |
Journal of Plastic, Reconstructive and Aesthetic Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Pre-operative CT Chest as a screening tool for COVID-19: An appraisal of current evidence |
Agrawal, V, Yadav, et al |
Br J Surg |
Commentary/Editorial| Commentaire/Éditorial |
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Agus, GB, Bavera, et al |
Acta Phlebologica |
Commentary/Editorial| Commentaire/Éditorial |
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Akasov, RA, Khaydukov, et al |
Frontiers in immunology |
Commentary/Editorial| Commentaire/Éditorial |
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Akbudak, IH |
Journal of Critical and Intensive Care |
Commentary/Editorial| Commentaire/Éditorial |
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32856807; Human resource management in healthcare organizations |
Aksenova, EI, Vashalomidze, et al |
Problemy sotsial'noi gigieny, zdravookhraneniia i istorii meditsiny |
Commentary/Editorial| Commentaire/Éditorial |
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Impacts of rumors and conspiracy theories surrounding COVID-19 on preparedness programs |
Ali, I |
Disaster Med Public Health Prep |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 and healthcare workers in pakistan: Are we losing this
fight? |
Ali, S, Noreen, et al |
Journal of Medical Sciences (Peshawar) |
Commentary/Editorial| Commentaire/Éditorial |
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Plan for blood banks to protect blood donors and healthcare workers during COVID-19
pandemic |
Ali, SME, Fatima, et al |
Hematology, Transfusion and Cell Therapy |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 and international primary care systems: Rebuilding a stronger primary care |
Allen, LN, Dambha-Miller, et al |
BJGP Open |
Commentary/Editorial| Commentaire/Éditorial |
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Alobaida, S, Lam, et al |
Cmaj |
Commentary/Editorial| Commentaire/Éditorial |
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Altundag, K |
Journal of B.U.ON. |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 pandemic in Africa: What lessons for social work education and practice? |
Amadasun, S |
International Social Work |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19: broadening research expertise to understand workplace transmission |
Anand, P |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Andrès, E, Pessaux, et al |
Revue de Medecine Interne |
Commentary/Editorial| Commentaire/Éditorial |
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Re-positivization of molecular tests in subjects with COVID-19 infection |
Antico, A, Panozzo, et al |
Rivista Italiana della Medicina di Laboratorio |
Commentary/Editorial| Commentaire/Éditorial |
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Inflation expectations, volatility and Covid-19: evidence from the US inflation
swap rates |
Apergis, E, Apergis, et al |
Applied Economics Letters |
Commentary/Editorial| Commentaire/Éditorial |
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Safeguarding Children and Young People During the COVID-19 Pandemic |
Appleton, JV, Sidebotham, et al |
Child Abuse Review |
Commentary/Editorial| Commentaire/Éditorial |
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32826100; Conjunctivitis and COVID-19: The importance of an early detection |
Arias-Peso, B, Rendón-Fernández, et al |
Enfermedades infecciosas y microbiologia clinica |
Commentary/Editorial| Commentaire/Éditorial |
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Armirfarzan, H, Shanahan, et al |
Therapeutic Advances in Respiratory Disease |
Commentary/Editorial| Commentaire/Éditorial |
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Arrizabalaga, O, Otaegui, et al |
F1000Research |
Commentary/Editorial| Commentaire/Éditorial |
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Ashcroft, S, Meeking, et al |
Clin Oncol (R Coll Radiol) |
Commentary/Editorial| Commentaire/Éditorial |
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Babaha, F, Rezaei, et al |
American Journal of the Medical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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A call for action against COVID-19 – Experience of the Social Workers’ Syndicate
in Lebanon |
Badran, NC |
International Social Work |
Commentary/Editorial| Commentaire/Éditorial |
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A Critical Reflection on Environmental Education During the COVID-19 Pandemic |
Bai, H |
Journal of Philosophy of Education |
Commentary/Editorial| Commentaire/Éditorial |
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Remote work as a preferred measure
to apply in companies in the COVID-19 crisis |
Balaguer, ML |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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A new generation of vaccines based on alphavirus self-amplifying RNA |
Ballesteros-Briones, M, Silva-Pilipich, et al |
Curr Opin Virol |
Commentary/Editorial| Commentaire/Éditorial |
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Analogies and lessons from COVID-19 for tackling the extinction and climate crises |
Balmford, A, Fisher, et al |
Curr Biol |
Commentary/Editorial| Commentaire/Éditorial |
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Barbier, EB |
Environmental and Resource Economics |
Commentary/Editorial| Commentaire/Éditorial |
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Barona, CE |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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32831333; Salud mental en tiempos de COVID-19. La tecnología como herramienta
de soporte |
Barrios-Borjas, D, Béjar-Ramos, et al |
Gaceta medica de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
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Baumgart, DC |
npj Digital Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Ethics Roundtable: Distribution of Critical Care Resources in the Setting of a COVID-19
Surge |
Baumrucker, SJ, Carter, et al |
Am J Hosp Palliat Care |
Commentary/Editorial| Commentaire/Éditorial |
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Beaman, J |
City and Community |
Commentary/Editorial| Commentaire/Éditorial |
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Beer, J, Abrouk, et al |
Journal of drugs in dermatology : JDD |
Commentary/Editorial| Commentaire/Éditorial |
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Beerheide, R |
Deutsches Arzteblatt International |
Commentary/Editorial| Commentaire/Éditorial |
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Beerheide, R |
Deutsches Arzteblatt International |
Commentary/Editorial| Commentaire/Éditorial |
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Olfactory and taste disorders in patients with SARS-CoV-2 infection |
Begam, N, Bashar, et al |
International Archives of Otorhinolaryngology |
Commentary/Editorial| Commentaire/Éditorial |
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Behzad, C, Taheri, et al |
Inflamm Bowel Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Beltran-Miranda, P, Muñoz-Cruzado, et al |
Surgery (United States) |
Commentary/Editorial| Commentaire/Éditorial |
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Hemodynamic monitoring of Covid-19 patients. Classical methods and new paradigms |
Bendjelid, K, Muller, et al |
Anaesth Crit Care Pain Med |
Commentary/Editorial| Commentaire/Éditorial |
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32866271; Road to Recovery: COVID-19 Tests, Bends, and Breaks Texas Practices |
Berlin, J |
Texas medicine |
Commentary/Editorial| Commentaire/Éditorial |
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32866273; Quarantine's Quandary: Some Texans Unable to Self-Isolate |
Berlin, J |
Texas medicine |
Commentary/Editorial| Commentaire/Éditorial |
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ASI’s Consensus Guidelines: ABCs of What to Do and What Not During the COVID-19
Pandemic |
Bhattacharya, K, Bhattacharya, et al |
Indian Journal of Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Bi, J, Wei, et al |
Radiother Oncol |
Commentary/Editorial| Commentaire/Éditorial |
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Birgand, G, Blanckaert, et al |
Journal of Infection |
Commentary/Editorial| Commentaire/Éditorial |
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Bleetman, A |
British journal of hospital medicine (London, England : 2005) |
Commentary/Editorial| Commentaire/Éditorial |
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"When Will We Have a Vaccine?" - Understanding Questions and Answers about Covid-19 Vaccination |
Bloom, BR, Nowak, et al |
N Engl J Med |
Commentary/Editorial| Commentaire/Éditorial |
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Boehm, K, Thomas, et al |
Urology |
Commentary/Editorial| Commentaire/Éditorial |
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32763262; The proper use of corticosteroids for 2019-nCov pneumonia: Towards promising
results? |
Boglione, L, Rostagno, et al |
Journal of Infection |
Commentary/Editorial| Commentaire/Éditorial |
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Boin, A, Brock, et al |
Canadian Public Administration |
Commentary/Editorial| Commentaire/Éditorial |
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Borkow, G, L |
Research Square prepub |
Commentary/Editorial| Commentaire/Éditorial |
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Bos, LDJ, Sinha, et al |
The European respiratory journal |
Commentary/Editorial| Commentaire/Éditorial |
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Olfactory and gustative disorders for the diagnosis of COVID-19 |
Boudjema, S, Finance, et al |
Travel Med Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Boukhris, M, Azzalini, et al |
Cardiovascular Revascularization Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Brantsæter, AB |
Tidsskr Nor Laegeforen |
Commentary/Editorial| Commentaire/Éditorial |
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Breny, JM |
Health Educ Behav |
Commentary/Editorial| Commentaire/Éditorial |
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Mechanisms and consequences of COVID-19 associated liver injury: What can we affirm? |
Brito, CA, Barros, et al |
World Journal of Hepatology |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7471758; Measuring Measurement - What is Metrology and why does it matter? |
Brown, RJC |
Measurement (Lond) |
Commentary/Editorial| Commentaire/Éditorial |
|
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Patients Left Behind: Ethical Challenges in Caring for Indirect Victims of the Covid-19
Pandemic |
Bruno, B, Rose, et al |
Hastings Center Report |
Commentary/Editorial| Commentaire/Éditorial |
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Buléon, C, Minehart, et al |
British journal of anaesthesia |
Commentary/Editorial| Commentaire/Éditorial |
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Cabrera-Rayo, A, Cortés-Meza, et al |
Medicina Interna de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
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Cai, T, Tandogdu, et al |
J Urol |
Commentary/Editorial| Commentaire/Éditorial |
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Defining transition finance and embedding it in the post-Covid-19 recovery |
Caldecott, B |
Journal of Sustainable Finance and Investment |
Commentary/Editorial| Commentaire/Éditorial |
|
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32747134; Response to “Should estrogen be used in the co-treatment of COVID-19
patients?” |
Cano, A, Ramírez, et al |
Maturitas |
Commentary/Editorial| Commentaire/Éditorial |
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Cao, L, Guo, et al |
American Journal of Infection Control |
Commentary/Editorial| Commentaire/Éditorial |
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Cao, X, Wang, et al |
Journal of Clinical Lipidology |
Commentary/Editorial| Commentaire/Éditorial |
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Cárdenas-Bravo, L, Cabrera-Rayo, et al |
Medicina Interna de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
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Cardwell, M |
Hastings Center Report |
Commentary/Editorial| Commentaire/Éditorial |
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32807622; Was child abuse underdetected during the COVID-19 lockdown? |
Caron, F, Plancq, et al |
Archives de Pediatrie |
Commentary/Editorial| Commentaire/Éditorial |
|
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Carrau Carbonell, JM |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Castello, C |
Soins Pediatrie/Puericulture |
Commentary/Editorial| Commentaire/Éditorial |
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Voice Therapy in the Context of the COVID-19 Pandemic: Guidelines for Clinical
Practice |
Castillo-Allendes, A, Contreras-Ruston, et al |
Journal of Voice |
Commentary/Editorial| Commentaire/Éditorial |
|
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Ceriello, A |
Diabetes research and clinical practice |
Commentary/Editorial| Commentaire/Éditorial |
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Pandemie
covid-19 – jenom rizika a negativní dopady nebo i příležitosti? |
Černý, V, Beneš, et al |
Anesteziologie a Intenzivni Medicina |
Commentary/Editorial| Commentaire/Éditorial |
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32831329; COVID-19 y la nutrición clínica. ¿Por qué es importante? |
Cervantes-Pérez, E, Cervantes-Guevara, et al |
Gaceta medica de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
|
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COVID-19 during pregnancy and lactation:
What do we already know? |
Ceulemans, M, Cuppers, et al |
Nederlands tijdschrift voor geneeskunde |
Commentary/Editorial| Commentaire/Éditorial |
|
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The evolving pandemic of COVID-19 and increasing role of cardiac computed tomography |
Chaganti, BT, Cherukuri, et al |
Coron Artery Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
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32778413; Reply To: Response to COVID-19 by the surgical community |
Chapman, R |
Surgery (United States) |
Commentary/Editorial| Commentaire/Éditorial |
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32860389; The modifications brought about by the COVID-19 pandemic to Nuclear Medicine
practice |
Chatzipavlidou, V |
Hellenic journal of nuclear medicine |
Commentary/Editorial| Commentaire/Éditorial |
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32819798; The Indirect Impact of COVID-19 on Children With Asthma |
Chavasse, R, Almario, et al |
Archivos de Bronconeumologia |
Commentary/Editorial| Commentaire/Éditorial |
|
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Chen, Q |
Frontiers of Environmental Science and Engineering |
Commentary/Editorial| Commentaire/Éditorial |
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Chirikure, S |
African Archaeological Review |
Commentary/Editorial| Commentaire/Éditorial |
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Stretching the public purse: budgetary responses to COVID-19 in Canada |
Cho, CH, Kurpierz, et al |
Journal of Public Budgeting, Accounting and Financial Management |
Commentary/Editorial| Commentaire/Éditorial |
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Cho, S, Clark-Gareca, et al |
TESOL Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Clarizia, O |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Haemoperfusion should only be used for COVID-19 in the context of randomized trials |
Clark, EG, Hiremath, et al |
Nat Rev Nephrol |
Commentary/Editorial| Commentaire/Éditorial |
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Clark, NF, Taylor-Robinson, et al |
Frontiers in Plant Science |
Commentary/Editorial| Commentaire/Éditorial |
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Clemente-Herrera, A, Sánchez-De La Torre, et al |
Medicina Interna de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
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Cocco, A |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Comert, B |
Journal of Critical and Intensive Care |
Commentary/Editorial| Commentaire/Éditorial |
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32833360; Prise en charge ambulatoire des patients COVID-19 : premiers
enseignements |
Cornuz, J, Selby, et al |
Revue medicale suisse |
Commentary/Editorial| Commentaire/Éditorial |
|
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Pneumonia by SARS-CoV-2: Diagnosis by computed tomography of the thorax |
Correa-Prieto, F |
Medicina Interna de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
|
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Coulter, A, Richards, et al |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Contractual business networks and pandemic: A forward-looking
agenda? |
Crea, C |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
|
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COVID-19 Emergency and Post-Emergency in Italian Cancer Patients: How Can Patients
Be Assisted? |
Crispo, A, Montagnese, et al |
Frontiers in Oncology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Curran, CS, Rivera, et al |
Frontiers in Pharmacology |
Commentary/Editorial| Commentaire/Éditorial |
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32796092; Trend of main STIs during COVID-19 pandemic in Milan, Italy |
Cusini, M, Benardon, et al |
Sexually transmitted infections |
Commentary/Editorial| Commentaire/Éditorial |
|
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da Motta Reis, JS, De Oliveira Silva, et al |
International Journal for Quality Research |
Commentary/Editorial| Commentaire/Éditorial |
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D'Ambrosio, M |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Darlington, B |
Jung Journal: Culture and Psyche |
Commentary/Editorial| Commentaire/Éditorial |
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Davido, B, Seang, et al |
Clin Microbiol Infect |
Commentary/Editorial| Commentaire/Éditorial |
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Davoli, F, Poletti, et al |
Advances in respiratory medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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Urology Chief Resident Turned Medicine Intern: Experience during the COVID-19
New York City Pandemic |
Davuluri, M |
J Urol |
Commentary/Editorial| Commentaire/Éditorial |
|
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Pandemic
and adequacy of the rule making powers of the european supervisory authorities |
De Marinis, GB |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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32849619; Impact of Hydroxychloroquine on Antibody Responses to the SARS-CoV-2 Coronavirus |
de Miranda Santos, IKF, Costa, et al |
Frontiers in immunology |
Commentary/Editorial| Commentaire/Éditorial |
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Coronavirus Disease-2019 Conundrum: RAS Blockade and Geriatric-Associated Neuropsychiatric
Disorders |
de Miranda, AS, Teixeira, et al |
Frontiers in Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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de Villiers, C, Cerbone, et al |
Journal of Public Budgeting, Accounting and Financial Management |
Commentary/Editorial| Commentaire/Éditorial |
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Preparing for COVID-19’s Effect on Legionella and Building Water Systems |
Deem, S |
Journal - American Water Works Association |
Commentary/Editorial| Commentaire/Éditorial |
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Del Carpio-Orantes, L |
Medicina Interna de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
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Brief notes on unemployment protection and cessation of activity
before the coronavirus crisis |
Del Prado, DP |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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del Río, JA |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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The impact
of Covid-19 on supply chain management and global economy development |
Derevyankina, ES, Yankovskaya, et al |
International Journal of Supply Chain Management |
Commentary/Editorial| Commentaire/Éditorial |
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Cardiovascular and cardiometabolic prevention: High-level priority in the era
of COVID-19 |
Dhindsa, D, Wong, et al |
Cardiovascular Endocrinology and Metabolism |
Commentary/Editorial| Commentaire/Éditorial |
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Di Benedetto, L, Sangsue, et al |
Revue medicale suisse |
Commentary/Editorial| Commentaire/Éditorial |
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32773086; Giovanni Di Guardo: Animal Models and Pathogenetic Insights to Covid-19 |
Di Guardo, G |
Journal of comparative pathology |
Commentary/Editorial| Commentaire/Éditorial |
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32801118; Ischaemic stroke associated with COVID-19 and racial outcome disparity
in North America |
Dmytriw, AA, Phan, et al |
Journal of Neurology, Neurosurgery and Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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32819707; Does COVID-19 Increase the Risk for Spontaneous Pneumothorax? |
do Lago, VC, Cezare, et al |
American Journal of the Medical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Doggrell, SA |
Expert Opin Investig Drugs |
Commentary/Editorial| Commentaire/Éditorial |
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Legal regime
of vaccines in Spain: Reflections on the situation created by the coronavirus |
Doménech, JB |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Domínguez, KC |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Donagh, B |
Child Abuse Review |
Commentary/Editorial| Commentaire/Éditorial |
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Expert Consensus for Treating Cancer Patients During the Pandemic of SARS-CoV-2 |
Dong, S, Luo, et al |
Frontiers in Oncology |
Commentary/Editorial| Commentaire/Éditorial |
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Dougherty, PJ |
Clin Orthop Relat Res |
Commentary/Editorial| Commentaire/Éditorial |
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Durojaye, E, Nanima, et al |
Commonwealth Law Bulletin |
Commentary/Editorial| Commentaire/Éditorial |
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Brief considerations
on the impacts of coronavirus pandemic in private relationships |
Ehrhardt, M, J |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Eisenhut, M, Shin, et al |
Frontiers in Physiology |
Commentary/Editorial| Commentaire/Éditorial |
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Elam, AR, Ehrlich, et al |
JAMA Ophthalmology |
Commentary/Editorial| Commentaire/Éditorial |
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Eldanasory, OA, Rabaan, et al |
Travel Med Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Care in crisis: COVID-19 as a catalyst for universal child care in the United
States |
Elias, NM, D’Agostino, et al |
Administrative Theory and Praxis |
Commentary/Editorial| Commentaire/Éditorial |
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Elshafei, MN, Khalil, et al |
Medicine (Baltimore) |
Commentary/Editorial| Commentaire/Éditorial |
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Recommendations for the management of newborn in relation to infection due to SARS-CoV-2 |
Estrada-Ruelas, I, Gutiérrez-Padilla, et al |
Medicina Interna de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
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Evora, PRB |
Brazilian journal of cardiovascular surgery |
Commentary/Editorial| Commentaire/Éditorial |
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32860397; Non-Oncological PET/CT imaging during SARS-CoV-2 pandemic |
Exadaktylou, P, Papadopoulos, et al |
Hellenic journal of nuclear medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Extremera, N |
Revista de Psicologia Social |
Commentary/Editorial| Commentaire/Éditorial |
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Falicov, C, Niño, et al |
Family process |
Commentary/Editorial| Commentaire/Éditorial |
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Federico, A |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Online literature circles during the COVID-19 pandemic: Engaging undergraduate students in
Indonesia |
Ferdiansyah, S, Ridho, et al |
TESOL Journal |
Commentary/Editorial| Commentaire/Éditorial |
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32818700; Clinical presentation at the onset of COVID-19 and allergic rhinoconjunctivitis |
Ferreli, F, Gaino, et al |
Journal of Allergy and Clinical Immunology: In Practice |
Commentary/Editorial| Commentaire/Éditorial |
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Coronavirus
and commercial leases. exceptional rules for a state of emergency? |
Figlia, GC |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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The COVID-19 pandemic and organisational commitment of senior hotel managers |
Filimonau, V, Derqui, et al |
International Journal of Hospitality Management |
Commentary/Editorial| Commentaire/Éditorial |
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Fink, L |
Information Systems Management |
Commentary/Editorial| Commentaire/Éditorial |
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Gesundheitspersonal und
COVID-19: Infektionszahlen nehmen zu |
Fischer-Fels, J |
Deutsches Arzteblatt International |
Commentary/Editorial| Commentaire/Éditorial |
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Flaatten, H, Beil, et al |
British journal of anaesthesia |
Commentary/Editorial| Commentaire/Éditorial |
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32768364; Misinterpreting data in lipidology in the era of COVID-19 |
Fogacci, F, Borghi, et al |
Journal of Clinical Lipidology |
Commentary/Editorial| Commentaire/Éditorial |
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Impacts of the SARS-CoV-2 Pandemic on the Mental Health of the Elderly |
Fontes, WHDA, Gonçalves Júnior, et al |
Frontiers in Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Frezza, G |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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A Novel Strategy to Mitigate the Hyperinflammatory Response to COVID-19 by Targeting
Leukotrienes |
Funk, CD, Ardakani, et al |
Frontiers in Pharmacology |
Commentary/Editorial| Commentaire/Éditorial |
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32830001; Adjustment for international surgical outreach missions due to COVID-19 |
Fuzaylov, G, Dabek, et al |
Burns |
Commentary/Editorial| Commentaire/Éditorial |
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32603717; Experience in patients with hidradenitis suppurativa and COVID-19 symptoms |
Galán, JL, Silvente, et al |
Journal of the American Academy of Dermatology |
Commentary/Editorial| Commentaire/Éditorial |
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The council of Europe and the COVID-19 pandemic
(coronavirus) |
Gallart, JAC |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Facial Masking for Covid-19 - Potential for "Variolation" as We Await a Vaccine |
Gandhi, M, Rutherford, et al |
N Engl J Med |
Commentary/Editorial| Commentaire/Éditorial |
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Letter to the Editors: Liver Biochemistries in Hospitalized Chinese Patients With Severe COVID-19 |
Gao, Y, Liu, et al |
Hepatology |
Commentary/Editorial| Commentaire/Éditorial |
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Garcia-Revilla, J, Deierborg, et al |
Frontiers in Immunology |
Commentary/Editorial| Commentaire/Éditorial |
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Consecuences of the ingratitude effect: From influenza A to COVID-19 |
Garrido-Peña, F, López-Fernández, et al |
Enfermeria Clinica |
Commentary/Editorial| Commentaire/Éditorial |
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Examining the Relationship Between Institutionalized Racism and COVID-19 |
Gay, T, Hammer, et al |
City and Community |
Commentary/Editorial| Commentaire/Éditorial |
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Geyer, HL, Kaufman, et al |
Tremor and other hyperkinetic movements (New York, N.Y.) |
Commentary/Editorial| Commentaire/Éditorial |
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Gianfrancesco, M, Hyrich, et al |
Annals of the Rheumatic Diseases |
Commentary/Editorial| Commentaire/Éditorial |
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32860396; Nuclear
thyroidology in pandemic times: The paradigm shift of COVID-19 |
Giannoula, E, Vrachimis, et al |
Hellenic journal of nuclear medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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Giménez, AO |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Submission
and payment of certain tax returns during the state of alert |
Giner, VG, Guijarro, et al |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Pandemic, balance
of contractual positions and fair remedy. Short notes |
Giorgini, E |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
|
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Giova, S |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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32768697; Vitamin D3 and K2 and their potential contribution to reducing the COVID-19
mortality rate |
Goddek, S |
International Journal of Infectious Diseases |
Commentary/Editorial| Commentaire/Éditorial |
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Practical keys to the recovery of paid leave regulated in royal
decree law 10/2020 |
Gómez, CA |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Gómez-Arnau, J, González-Lucas, et al |
Revista de Psiquiatria y Salud Mental |
Commentary/Editorial| Commentaire/Éditorial |
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Góngora Gómez, O, Riverón Carralero, et al |
Revista Internacional de Acupuntura |
Commentary/Editorial| Commentaire/Éditorial |
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Management of cancer patients during COVID-19 pandemic at developing countries |
González-Montero, J, Valenzuela, et al |
World Journal of Clinical Cases |
Commentary/Editorial| Commentaire/Éditorial |
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Goode, JVR, Page, et al |
Journal of the American Pharmacists Association |
Commentary/Editorial| Commentaire/Éditorial |
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Goodnough, R, Canseco, et al |
Clin Toxicol (Phila) |
Commentary/Editorial| Commentaire/Éditorial |
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Rethinking the Approach to Continuing Professional Development Conferences in
the Era of COVID-19 |
Gottlieb, M, Egan, et al |
J Contin Educ Health Prof |
Commentary/Editorial| Commentaire/Éditorial |
|
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Govender, I |
South African Family Practice |
Commentary/Editorial| Commentaire/Éditorial |
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Gray, S, Clough, et al |
Journal of Hospital Infection |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 and legalized criminality: notes from the Arizona Borderlands, Part 2 |
Green, L |
Dialectical Anthropology |
Commentary/Editorial| Commentaire/Éditorial |
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32761155; Selecting a SARS-CoV-2/COVID Molecular Testing Method for Your Laboratory |
Greene, DN |
The journal of applied laboratory medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Greenspan, H, San José Estépar, et al |
Medical image analysis |
Commentary/Editorial| Commentaire/Éditorial |
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Gregory, AJ, Grant, et al |
Journal of cardiothoracic and vascular anesthesia |
Commentary/Editorial| Commentaire/Éditorial |
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32831327; Role of SARS-CoV-2 neurotropism and neuroinvasion in COVID-19 patients disease
severity |
Grijalva-Otero, I |
Gaceta medica de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
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Right restriction or restricting rights? The UK acts to address
COVID-19 |
Grogan, J |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Grondona, M |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Guedes, F, Boléo-Tomé, et al |
Pulmonology |
Commentary/Editorial| Commentaire/Éditorial |
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Considerations in the management of the airway in the patient with COVID-19 |
Guevara-Valerio, H, Marí-Zapata, et al |
Medicina Interna de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
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The state of alarm and the
use of the royal decreelaw to modify tax regulations |
Guijarro, FH |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Gupta, A, Gupta, et al |
Indian Journal of Otolaryngology and Head and Neck Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Economics & ethics of the COVID-19 vaccine: How prepared are we? |
Gupta, I, Baru, et al |
Indian J Med Res |
Commentary/Editorial| Commentaire/Éditorial |
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Impact of
COVID-19 pandemic on child and adolescent mental health |
Gupta, T, Nebhinani, et al |
Journal of Indian Association for Child and Adolescent Mental Health |
Commentary/Editorial| Commentaire/Éditorial |
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Gutenbrunner, C, Stokes, et al |
Journal of Rehabilitation Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Haers, PE, Swennen, et al |
International journal of oral and maxillofacial surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Hailay, A, Aberhe, et al |
Asthma Res Pract |
Commentary/Editorial| Commentaire/Éditorial |
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32798631; Outbreak investigation of COVID-19 in hospital food service workers |
Hale, M, Dayot, et al |
American Journal of Infection Control |
Commentary/Editorial| Commentaire/Éditorial |
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Hamilton, JL |
Journal of pediatric nursing |
Commentary/Editorial| Commentaire/Éditorial |
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Hammond, MI, Sharma, et al |
Journal of the American Academy of Dermatology |
Commentary/Editorial| Commentaire/Éditorial |
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32747135; Should estrogen be used in the co-treatment of COVID-19 patients?
What is the rationale? |
Hamzaoglu, K, Erel, et al |
Maturitas |
Commentary/Editorial| Commentaire/Éditorial |
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Han, L |
Social Semiotics |
Commentary/Editorial| Commentaire/Éditorial |
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Hardy, B, Marshall, et al |
British journal of anaesthesia |
Commentary/Editorial| Commentaire/Éditorial |
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CRITCON-Pandemic levels: A stepwise ethical approach to clinician responsibility |
Harvey, D, Gardiner, et al |
Journal of the Intensive Care Society |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 Water Contamination Concerns Underscore Need to Engage With Consumers |
Heath, A |
Journal - American Water Works Association |
Commentary/Editorial| Commentaire/Éditorial |
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Digital Contact tracing in the COVID-19 Pandemic: A tool far from reality |
Hegde, A, Masthi, et al |
Digital Health |
Commentary/Editorial| Commentaire/Éditorial |
|
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[Radiological manifestations
of pulmonary diseases in COVID-19] |
Heidinger, BH, Kifjak, et al |
Radiologe |
Commentary/Editorial| Commentaire/Éditorial |
|
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Organizational Strategies for Managing COVID-19 Survivors who Return for Care |
Henderson, DK, Haessler, et al |
Infect Control Hosp Epidemiol |
Commentary/Editorial| Commentaire/Éditorial |
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Hennekam, S, Ladge, et al |
J Appl Psychol |
Commentary/Editorial| Commentaire/Éditorial |
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Operations Transition to Mitigate COVID-19 on an Interventional Radiology Service |
Hevert, EAC, Stokes, et al |
Seminars in Interventional Radiology |
Commentary/Editorial| Commentaire/Éditorial |
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Hsueh, SJ, Lee, et al |
Journal of the Formosan Medical Association |
Commentary/Editorial| Commentaire/Éditorial |
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Segmenting areas of potential contamination for adaptive robotic disinfection
in built environments |
Hu, D, Zhong, et al |
Building and Environment |
Commentary/Editorial| Commentaire/Éditorial |
|
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Hu, YJ, Wake, et al |
JAMA Pediatrics |
Commentary/Editorial| Commentaire/Éditorial |
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32846080; Airborne Transmission of Covid-19: Implications for Irish Hospitals |
Humphreys, H, Fitzpatrick, et al |
Irish medical journal |
Commentary/Editorial| Commentaire/Éditorial |
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32796109; Cancelled medical student placements: The COVID-19 effect |
Hunter, J, Murdoch, et al |
Postgraduate medical journal |
Commentary/Editorial| Commentaire/Éditorial |
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Huston, P, Campbell, et al |
BJGP Open |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19: Is the UK carrying out more tests than anywhere else in Europe? |
Iacobucci, G |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Exploring Children’s Social and Emotional Representations of the COVID-19 Pandemic |
Idoiaga, N, Berasategi, et al |
Frontiers in Psychology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Iorio, G |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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'Contratti di Soggiorno'
and COVID-19. first part. In the emergency period |
Irti, C |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
|
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Isidori, A, de Leval, et al |
Frontiers in Oncology |
Commentary/Editorial| Commentaire/Éditorial |
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Detection of SARS-CoV-2 RNA in Blood of Patients with COVID-19: What Does It Mean? |
Jacobs, JL, Mellors, et al |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Operational considerations for case management of COVID-19 in health facility and
community |
Jarosińska, A, Walicka, et al |
Pediatria i Medycyna Rodzinna |
Commentary/Editorial| Commentaire/Éditorial |
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Jiang, HJ, Tang, et al |
Clin J Am Soc Nephrol |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19 pneumonia and pulmonary vascular disease: A UK Centre perspective |
John Wort, S, Arachchillage, et al |
Respiratory Medicine and Research |
Commentary/Editorial| Commentaire/Éditorial |
|
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Jue, JS, Alameddine, et al |
J Urol |
Commentary/Editorial| Commentaire/Éditorial |
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32645372; A Tale of Two Eras: The Effect of the COVID-19 Pandemic on Stone Disease
Presentations |
Kachroo, N, Wright, et al |
Urology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Kahan, BC, Morris, et al |
BMC Med |
Commentary/Editorial| Commentaire/Éditorial |
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Descriptive characteristics of hospitalized adult smokers and never-smokers with COVID-19 |
Kalan, ME, Ghobadi, et al |
Tobacco Induced Diseases |
Commentary/Editorial| Commentaire/Éditorial |
|
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Kalemci, S, Sarıhan, et al |
International immunopharmacology |
Commentary/Editorial| Commentaire/Éditorial |
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Kamara, M, Regamey, et al |
Revue medicale suisse |
Commentary/Editorial| Commentaire/Éditorial |
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Kammerer, NB, Stummer, et al |
Entropy |
Commentary/Editorial| Commentaire/Éditorial |
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Repeated celebrity suicide in India during COVID-19 crisis: An urgent call for attention |
Kar, SK, Arafat, et al |
Asian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
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Mental illnesses among COVID-19 patients: Possible immunological underpinnings |
Kar, SK, Verma, et al |
Asian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
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Karan, A, Ali, et al |
Medical hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
|
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32778522; Covid-19-induced coagulopathy and observed benefits with anticoagulation |
Karimzadeh, S, Dong, et al |
Transfusion and Apheresis Science |
Commentary/Editorial| Commentaire/Éditorial |
|
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Kay, JB, Wood, et al |
European Journal of Cultural Studies |
Commentary/Editorial| Commentaire/Éditorial |
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Setting up a Research Poster During COVID-19 Lockdown: A Reflection |
Kazmierczak, T, Bistany, et al |
J Christ Nurs |
Commentary/Editorial| Commentaire/Éditorial |
|
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32830937; An Opportunity to Advance Kidney Health Becomes a Responsibility |
Kear, TM |
Nephrology nursing journal : journal of the American Nephrology Nurses' Association |
Commentary/Editorial| Commentaire/Éditorial |
|
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Choosing the new normal for surgical education using alternative platforms |
Keller, DS, Grossman, et al |
Surgery (United Kingdom) |
Commentary/Editorial| Commentaire/Éditorial |
|
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Keren, A, Lev, et al |
J Med Ethics |
Commentary/Editorial| Commentaire/Éditorial |
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Khan, MM, Parab, et al |
Indian Journal of Otolaryngology and Head and Neck Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Kim, J, Giroux, et al |
Journal of Advertising |
Commentary/Editorial| Commentaire/Éditorial |
|
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Smoking and SARS-CoV-2: Are Polish health professionals at higher risk of infection? |
Koczkodaj, P, Cedzynska, et al |
Tobacco Induced Diseases |
Commentary/Editorial| Commentaire/Éditorial |
|
|
32833361; COVID-19 et médecine ambulatoire - Le défi du diagnostic ! |
Kokkinakis, I, Favrat, et al |
Revue medicale suisse |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Kolesnikov, AV, Chumakova, et al |
International Journal of Supply Chain Management |
Commentary/Editorial| Commentaire/Éditorial |
|
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Kolivras, A, Thompson, et al |
JAAD Case Reports |
Commentary/Editorial| Commentaire/Éditorial |
|
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32652189; Approach to VIPs during the COVID-19 pandemic and beyond |
Kong, HE, Stoff, et al |
Journal of the American Academy of Dermatology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Kotsiou, OS, Zidros, et al |
Science of the Total Environment |
Commentary/Editorial| Commentaire/Éditorial |
|
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32860394; COVID-19 pandemic: Implications for radionuclide therapy in Nuclear Medicine
departments |
Koukouraki, S, Kapsoritakis, et al |
Hellenic journal of nuclear medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Koutsikos, J, Angelidis, et al |
Hellenic journal of nuclear medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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Krentz, AJ |
Cardiovascular Endocrinology and Metabolism |
Commentary/Editorial| Commentaire/Éditorial |
|
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COVID-19 Precautions Helped Limit Cases Linked to Milwaukee Primary |
Kuehn, BM |
Jama |
Commentary/Editorial| Commentaire/Éditorial |
|
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Kumar, A, Nayar, et al |
International Journal of Mental Health |
Commentary/Editorial| Commentaire/Éditorial |
|
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Efficacy of Vascular Virtual Medical Student Education During the COVID-19 Pandemic |
Kuo, M, Poirier, et al |
J Vasc Surg |
Commentary/Editorial| Commentaire/Éditorial |
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32807635; Pre-existing diabetes is worse for SARS-CoV-2 infection; an endothelial
perspective |
La Sala, L, Luzi, et al |
Nutrition, Metabolism and Cardiovascular Diseases |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19: Evidens-, eminens-, eller erfaringsbasert
behandling? |
Laake, JH, Aasmundstad, et al |
Tidsskr Nor Laegeforen |
Commentary/Editorial| Commentaire/Éditorial |
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Lam, IA, Bittar, et al |
Revista Cubana de Pediatria |
Commentary/Editorial| Commentaire/Éditorial |
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Lambert, DG |
British journal of anaesthesia |
Commentary/Editorial| Commentaire/Éditorial |
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Lau, CS, Kamaludin, et al |
Proceedings of Singapore Healthcare |
Commentary/Editorial| Commentaire/Éditorial |
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32679176; The impact of COVID-19 pandemic on adult cardiac surgery procedures |
Lazaros, G, Oikonomou, et al |
Hellenic Journal of Cardiology |
Commentary/Editorial| Commentaire/Éditorial |
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Lazzaroni, MG, Piantoni, et al |
Blood reviews |
Commentary/Editorial| Commentaire/Éditorial |
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Lee, SJ, Kim, et al |
Clinical oncology |
Commentary/Editorial| Commentaire/Éditorial |
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Leitner, S |
Mind and Society |
Commentary/Editorial| Commentaire/Éditorial |
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Lemke, S, Claeys, et al |
Land |
Commentary/Editorial| Commentaire/Éditorial |
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Leppert, W, Pawłowski, et al |
Palliative Medicine in Practice |
Commentary/Editorial| Commentaire/Éditorial |
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Leung, CK, Chen, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
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Reflections on Israeli hospital-based social work with COVID-19 patients and their
families |
Levin-Dagan, N, Strenfeld-Hever, et al |
International Social Work |
Commentary/Editorial| Commentaire/Éditorial |
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Lewis, C |
European Journal of Women's Studies |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 outbreak, government capital injections, and shadow banking efficiency |
Li, X, Xie, et al |
Applied Economics |
Commentary/Editorial| Commentaire/Éditorial |
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32721412; HIIT: A potential rehabilitation treatment in COVID-19 pneumonia with
heart disease |
Li, Y, Liu, et al |
International journal of cardiology |
Commentary/Editorial| Commentaire/Éditorial |
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Li, Y, Weng, et al |
Medicine (Baltimore) |
Commentary/Editorial| Commentaire/Éditorial |
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32773258; Therapeutic plasma exchange resolving COVID-19 related ARDS |
Lin, JH, Lu, et al |
Journal of the Formosan Medical Association |
Commentary/Editorial| Commentaire/Éditorial |
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Lindquist, EA |
Canadian Public Administration |
Commentary/Editorial| Commentaire/Éditorial |
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Lipworth, B, Chan, et al |
Journal of Allergy and Clinical Immunology |
Commentary/Editorial| Commentaire/Éditorial |
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Liu, M, Zhu, et al |
Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Liu, Y, Yang, et al |
Medicine (Baltimore) |
Commentary/Editorial| Commentaire/Éditorial |
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Redistributing work during covid-19 Penn State University Libraries' job bank |
Lo, LS, Lush, et al |
College and Research Libraries News |
Commentary/Editorial| Commentaire/Éditorial |
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Liability
for damages caused by infection of COVID-19 in retail stores and commercial establishments |
López, FP |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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The so-called consumer protective measures of occasion of COVID-19 |
López, MJR |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Lotzin, A, Acquarini, et al |
European Journal of Psychotraumatology |
Commentary/Editorial| Commentaire/Éditorial |
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Low, S, Oates, et al |
Clinical radiology |
Commentary/Editorial| Commentaire/Éditorial |
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Lozada-Martínez, I, Bolaño-Romero, et al |
World Neurosurgery |
Commentary/Editorial| Commentaire/Éditorial |
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Lübbert, C |
Deutsches Arzteblatt International |
Commentary/Editorial| Commentaire/Éditorial |
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Lumpuy-Castillo, J, Lorenzo-Almorós, et al |
Int J Mol Sci |
Commentary/Editorial| Commentaire/Éditorial |
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Luo, Z, Li, et al |
JAMA network open |
Commentary/Editorial| Commentaire/Éditorial |
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Lynch, MR, Tang, et al |
R I Med J (2013) |
Commentary/Editorial| Commentaire/Éditorial |
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32682066; Moving forward: Ensuring quality research in vascular surgery during COVID-19 |
Ma, X, Luc, et al |
Journal of Vascular Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Information Technology in Support of Our Heroes during the COVID-19 Pandemic: A
Commentary |
Magid, SK, Nelson, et al |
HSS Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Mahmud, E, Dauerman, et al |
Journal of the American College of Cardiology |
Commentary/Editorial| Commentaire/Éditorial |
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Avicenna's Points of View in Epidemics: Some Advice on Coronavirus 2 (COVID-19) |
Mahroozade, S, Mohammadi Kenari, et al |
Complement Med Res |
Commentary/Editorial| Commentaire/Éditorial |
|
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Malviya, A |
International Journal of Infectious Diseases |
Commentary/Editorial| Commentaire/Éditorial |
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32807592; Early speech-language rehabilitation for stroke patients
during the Covid-19 outbreak |
Mammi, P, Bidini, et al |
Journal of Stroke and Cerebrovascular Diseases |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19: Brief check through the pathologist's eye (autopsy archive) |
Mansueto, G |
Pathology Research and Practice |
Commentary/Editorial| Commentaire/Éditorial |
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International
child abduction in times of coronavirus: An opportunity for the abducting parent? |
Marimón, MG |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Martell, K, McGeachy, et al |
Radiother Oncol |
Commentary/Editorial| Commentaire/Éditorial |
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Privacy, location data and contact tracing apps in the COVID-19
public health strategy |
Martínez, BA |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Moratorium in the payment of
mortgages during the state of alarm by COVID-19 |
Martínez, IJR |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Measures under COVID-19 and commercial law (part i: Company and
stock market aspects) |
Martínez, JMC |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Measures
to reduce the adverse effects of COVID-19 on rentals of usual housing |
Matamoros, PC |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
|
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Mathur, C |
Dialectical Anthropology |
Commentary/Editorial| Commentaire/Éditorial |
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Mauri, D, Tzachanis, et al |
Journal of B.U.ON.: official journal of the Balkan Union of Oncology |
Commentary/Editorial| Commentaire/Éditorial |
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Immunity to COVID-19 and issues of screening for SARS-COV-2 antibodies |
Mayanskiy, NA |
Bulletin of Russian State Medical University |
Commentary/Editorial| Commentaire/Éditorial |
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Prevalence of Third-Party Tracking on COVID-19-Related Web Pages |
McCoy, MS, Libert, et al |
Jama |
Commentary/Editorial| Commentaire/Éditorial |
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McFee, DRB |
Disease-a-Month |
Commentary/Editorial| Commentaire/Éditorial |
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Meese, J, Frith, et al |
Media International Australia |
Commentary/Editorial| Commentaire/Éditorial |
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32777019; Attacks on Public Health Officials during COVID-19 |
Mello, MM, Greene, et al |
JAMA - Journal of the American Medical Association |
Commentary/Editorial| Commentaire/Éditorial |
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Mendía, AP |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Menon, V, Padhy, et al |
Aust N Z J Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Merhi, B, Gohh, et al |
R I Med J (2013) |
Commentary/Editorial| Commentaire/Éditorial |
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Mericle, AA, Sheridan, et al |
Journal of substance abuse treatment |
Commentary/Editorial| Commentaire/Éditorial |
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SARS-CoV-2:
Neue Virusvariante ist infektiöser, verändert aber nicht den Verlauf von COVID-19 |
Meyer, R |
Deutsches Arzteblatt International |
Commentary/Editorial| Commentaire/Éditorial |
|
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Meylan, P |
Revue Medicale Suisse |
Commentary/Editorial| Commentaire/Éditorial |
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Meza, D |
International Journal of Latin American Religions |
Commentary/Editorial| Commentaire/Éditorial |
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Managing Remote Projects Effectively with an Action Dashboard |
Michalak, R, Rysavy, et al |
Journal of Library Administration |
Commentary/Editorial| Commentaire/Éditorial |
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Miller, S, Bone, et al |
Indian Journal of Orthopaedics |
Commentary/Editorial| Commentaire/Éditorial |
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32773261; SARS-CoV 2 and the pathobiology of the respiratory control mechanisms
in the brainstem |
Mishra, R, Florez-Perdomo, et al |
Journal of the Formosan Medical Association |
Commentary/Editorial| Commentaire/Éditorial |
|
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The missing discourse on mental health of psychiatrists during COVID-19 |
Mitra, S, Kavoor, et al |
Aust N Z J Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
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Mittal, S, Madan, et al |
Primary Care Diabetes |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19, Companion Animals, Comparative Medicine, and One Health |
Mobasheri, A |
Frontiers in Veterinary Science |
Commentary/Editorial| Commentaire/Éditorial |
|
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Integrative Medicine as a Panpharmacon for COVID-19 Pandemic: A Call for Global Advocacy |
Mohanty, S, Singh, et al |
Annals of Neurosciences |
Commentary/Editorial| Commentaire/Éditorial |
|
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Child care in times
of pandemic. Notes to rethink the Argentine experience |
Molina de Juan, MF |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Montalbano, MF, Dieudonné-Rahm, et al |
Revue medicale suisse |
Commentary/Editorial| Commentaire/Éditorial |
|
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No arguments for extra risk from ibuprofen in SARS-COV2 infection |
Moore, N |
Therapies |
Commentary/Editorial| Commentaire/Éditorial |
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Extraordinary measures derived from COVID-19 regarding the duration
of temporary contracts |
Moragues, FR |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Moreno, GP |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
|
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COVID-19 Patient Education and Consumer Health Information Resources and Services |
Morgan-Daniel, J, Ansell, et al |
Journal of Consumer Health on the Internet |
Commentary/Editorial| Commentaire/Éditorial |
|
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32833365; COVID-19 et médecine ambulatoire - Migrations forcées :
enjeux d’équité en santé |
Morisod, K, Bodenmann, et al |
Revue medicale suisse |
Commentary/Editorial| Commentaire/Éditorial |
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32780804; Prevalence of SARS-CoV-2 Antibodies in Health Care Personnel in the New
York City Area |
Moscola, J, Sembajwe, et al |
JAMA - Journal of the American Medical Association |
Commentary/Editorial| Commentaire/Éditorial |
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Good bye to the free circulation of foreign investments only in
times of coronavirus? |
Mota, CE |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
|
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The Italian society indication for rhinologists during Covid-19: Italy phase 2 |
Motta, G, Passali, et al |
International Archives of Otorhinolaryngology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Mukherjee, A, Babu, et al |
Journal of Earth System Science |
Commentary/Editorial| Commentaire/Éditorial |
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Müller, SM, Mueller, et al |
Biology (Basel) |
Commentary/Editorial| Commentaire/Éditorial |
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Mumtaz, M |
Int J Soc Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Murphy, JA, Shelley, et al |
Serials Review |
Commentary/Editorial| Commentaire/Éditorial |
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Muthamilarasan, M, Prasad, et al |
Trends Plant Sci |
Commentary/Editorial| Commentaire/Éditorial |
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Nagendrappa, S, Shoib, et al |
Asian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
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32852178; Covid-19 : se préparer à l’arrivée des premiers vaccins |
Nau, JY |
Revue medicale suisse |
Commentary/Editorial| Commentaire/Éditorial |
|
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32833371; COVID-19: Que sait-on aujourd’hui sur ses différentes
séquelles ? |
Nau, JY |
Revue medicale suisse |
Commentary/Editorial| Commentaire/Éditorial |
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Naudet, F, Locher, et al |
Spatial and Spatio-temporal Epidemiology |
Commentary/Editorial| Commentaire/Éditorial |
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Nelan, PJ |
J Christ Nurs |
Commentary/Editorial| Commentaire/Éditorial |
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The Covid-19 pandemic and local government finance: Czechia and Slovakia |
Nemec, J, Špaček, et al |
Journal of Public Budgeting, Accounting and Financial Management |
Commentary/Editorial| Commentaire/Éditorial |
|
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Neussel, W |
Deutsches Arzteblatt International |
Commentary/Editorial| Commentaire/Éditorial |
|
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Primary health care beyond COVID-19: dealing with the pandemic in Cameroon |
Ngo Bibaa, LO |
BJGP Open |
Commentary/Editorial| Commentaire/Éditorial |
|
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From wartime loudspeakers to digital networks: communist persuasion and pandemic
politics in Vietnam |
Nguyen-Thu, G |
Media International Australia |
Commentary/Editorial| Commentaire/Éditorial |
|
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Ní Shé, É, O'Donnell, et al |
Int J Environ Res Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
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Niles, PM, Asiodu, et al |
Health Equity |
Commentary/Editorial| Commentaire/Éditorial |
|
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Availability of drugs for severe covid-19 in sub-Saharan Africa |
Njonnou, SRS, Ouankou, et al |
Pan African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
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Surgery Clerkship Curriculum Changes at an Academic Institution during the COVID-19
Pandemic |
Nnamani Silva, ON, Hernandez, et al |
Journal of Surgical Education |
Commentary/Editorial| Commentaire/Éditorial |
|
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32773341; Could the antipsychotic chlorpromazine be a potential treatment for
SARS-CoV-2? |
Nobile, B, Durand, et al |
Schizophrenia research |
Commentary/Editorial| Commentaire/Éditorial |
|
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32762960; Safety of powered dermatome during the COVID-19 pandemic |
Noblet, TM, Jivan, et al |
Burns |
Commentary/Editorial| Commentaire/Éditorial |
|
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Nuccio, MR |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
|
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Nueno, MA |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
|
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32763151; Control of epidemics by jails: lessons for COVID-19 from HIV |
Ohuabunwa, T, Spaulding, et al |
The Lancet HIV |
Commentary/Editorial| Commentaire/Éditorial |
|
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An Environment for Computer Programming Classes Under COVID-19 Situation |
Okamoto, S, Sakamoto, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
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Oliveri, L |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
|
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Long-Term Implications of Post-ACA Health Reform on State Health Care Policy |
O'Mahen, PN, Petersen, et al |
J Gen Intern Med |
Commentary/Editorial| Commentaire/Éditorial |
|
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Ong, WLK, Lechmiannandan, et al |
Urology |
Commentary/Editorial| Commentaire/Éditorial |
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Ong, WY, Go, et al |
Mol Neurobiol |
Commentary/Editorial| Commentaire/Éditorial |
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Ostojic, SM |
Therapeutic Advances in Respiratory Disease |
Commentary/Editorial| Commentaire/Éditorial |
|
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A psychiatrist's perspective from a COVID-19 epicentre: a personal account |
Pacchiarotti, I, Anmella, et al |
BJPsych Open |
Commentary/Editorial| Commentaire/Éditorial |
|
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Management of politraumatized patients during epidemiological emergency SARS-CoV-2 |
Padilla-Martínez, CD |
Medicina Interna de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
|
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Palop Larrea, V, Hernández Rodríguez, et al |
Medicina clinica |
Commentary/Editorial| Commentaire/Éditorial |
|
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32860395; Nuclear Medicine and Oncology in the COVID-19 pandemic era |
Panagiotidis, E |
Hellenic journal of nuclear medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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32860391;
The consequences of COVID-19 pandemic in the routine of Nuclear Medicine Departments |
Papanastasiou, E |
Hellenic journal of nuclear medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Social work in the social distancing era in Korea: A reflective essay |
Park, TI, Yang, et al |
International Social Work |
Commentary/Editorial| Commentaire/Éditorial |
|
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32847834; Covid-19: Hong Kong scientists report first confirmed case of reinfection |
Parry, J |
BMJ (Clinical research ed.) |
Commentary/Editorial| Commentaire/Éditorial |
|
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Paschali, A, Anagnostopoulos, et al |
Hellenic journal of nuclear medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Pascucci, F, Garetto, et al |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Patel, K, Straudi, et al |
Int J Environ Res Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
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32682029; Optimizing education for dermatology residents during the COVID-19 pandemic |
Patel, P, Guzman, et al |
Journal of the American Academy of Dermatology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Pawar, M, Singh, et al |
Clinics in dermatology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Pegorari, MS, Ohara, et al |
Physiother Theory Pract |
Commentary/Editorial| Commentaire/Éditorial |
|
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32826107; EMS dispatch center activity during the COVID-19 containment |
Penverne, Y, Jenvrin, et al |
American Journal of Emergency Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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Off-label medical prescription
and COVID-19: An ethical-legal reflexion |
Pereira, AGD |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
|
|
32762876; Lung ACE2 and ADAM17 in pulmonary arterial hypertension: Implications
for COVID-19? |
Pérez-Vizcaíno, F |
Journal of Heart and Lung Transplantation |
Commentary/Editorial| Commentaire/Éditorial |
|
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Contamination compulsions and obsessive-compulsive disorder during COVID-19 |
Perkes, IE, Brakoulias, et al |
Aust N Z J Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Petersen, FC, Dahle, et al |
Frontiers in Molecular Biosciences |
Commentary/Editorial| Commentaire/Éditorial |
|
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Pfingsten, KR, Baden, et al |
Deutsches Arzteblatt International |
Commentary/Editorial| Commentaire/Éditorial |
|
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Pinheiro, MDCN, Freitas Junior, et al |
Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia |
Commentary/Editorial| Commentaire/Éditorial |
|
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Learning from the Outside World: Challenges and Reflections of COVID-19 |
Piterman, L |
Chinese General Practice |
Commentary/Editorial| Commentaire/Éditorial |
|
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Management of hepatitis C in children and adolescents during COVID-19 pandemic |
Pokorska-Śpiewak, M, Śpiewak, et al |
World Journal of Hepatology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Epidemiological emergency
and renegotiation commitments in professional football contracts |
Polidori, S |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Pontiroli, AE, La Sala, et al |
Diabetes research and clinical practice |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
Popkova, E, DeLo, et al |
Research in International Business and Finance |
Commentary/Editorial| Commentaire/Éditorial |
|
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Acrocyanosis and digital necrosis are associated with poor prognosis in COVID-19 |
Pourdowlat, G, Naderi, et al |
Clinical Case Reports |
Commentary/Editorial| Commentaire/Éditorial |
|
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Air conditioning system usage and SARS-CoV-2 transmission dynamics in Iran |
Pourkarim, MR, Thijssen, et al |
Medical hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Indonesia’s fight against COVID-19: the roles of local government units and
community organisations |
Pradana, M, Rubiyanti, et al |
Local Environment |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Teleconsultation in private cardiology practice during the Covid crisis |
Pradeau, V, Villacèque, et al |
Archives des Maladies du Coeur et des Vaisseaux - Pratique |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Prats, CF |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
|
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32777028; Recovery from Severe COVID-19: Leveraging the Lessons of Survival from Sepsis |
Prescott, HC, Girard, et al |
JAMA - Journal of the American Medical Association |
Commentary/Editorial| Commentaire/Éditorial |
|
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32866272; Surge Response: How the Panhandle Handled One of the State's Biggest
COVID-19 Outbreaks |
Price, S |
Texas medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Brazilian Child Protection Professionals' Resilient Behavior during the COVID-19
Pandemic |
Priolo Filho, SR, Goldfarb, et al |
Child Abuse Negl |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Provenzi, L, Baroffio, et al |
Frontiers in Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
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Travel
packages and traveler's rights in the Italian legal order at the time of the coronavirus |
Pucci, M |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Special Issues Encountered When Cancer Patients Confront COVID-19 |
Qi, L, Wang, et al |
Frontiers in Oncology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Rab, S, Javaid, et al |
Diabetes and Metabolic Syndrome: Clinical Research and Reviews |
Commentary/Editorial| Commentaire/Éditorial |
|
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Proposal of research model for the detection of COVID-19 among asymptomatic carriers |
Rajendra Santosh, AB, Krishnamurthy, et al |
International Archives of Otorhinolaryngology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Ramírez Navalón, Ma R |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Measures under COVID-19 and commercial law (part II: Insolvency
issues) |
Ramírez, FP |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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First trimester miscarriage in a pregnant woman infected with COVID-19 in Pakistan |
Rana, DMS, Usman, et al |
J Infect |
Commentary/Editorial| Commentaire/Éditorial |
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32778446; Novel coronavirus outbreak in Pakistan: Beware of dengue |
Rana, MS, Ikram, et al |
Journal of the Formosan Medical Association |
Commentary/Editorial| Commentaire/Éditorial |
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Ransing, R, Ramalho, et al |
Brain, behavior, and immunity |
Commentary/Editorial| Commentaire/Éditorial |
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Rao, A |
Indian J Med Res |
Commentary/Editorial| Commentaire/Éditorial |
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Paradigm Shifts in Cardiac Care: Lessons Learned From COVID-19 at a Large
New York Health System |
Rao, G, Singh, et al |
Current problems in cardiology |
Commentary/Editorial| Commentaire/Éditorial |
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Rasimas, JJ |
Psychosomatics |
Commentary/Editorial| Commentaire/Éditorial |
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Rawashdeh, MA, Saade, et al |
Radiol Med |
Commentary/Editorial| Commentaire/Éditorial |
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Razak, NA |
International Journal of Supply Chain Management |
Commentary/Editorial| Commentaire/Éditorial |
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Rees, S, Wells, et al |
Aust N Z J Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Resnick, MJ |
J Urol |
Commentary/Editorial| Commentaire/Éditorial |
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32862217; COVID-19 and cancer: Revisiting "The comfort zone" |
Retsas, S |
Hellenic journal of nuclear medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Reyna-Figueroa, J, Bejarano-Juvera, et al |
Gaceta medica de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
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Rapid Response to COVID-19 in Agriculture:
A Model for Future Crises |
Riden, HE, Schilli, et al |
J Agromedicine |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19: Doctors call for action after patients are left unable to get tests |
Rimmer, A |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Rocha, R, Aziz, et al |
Animal Conservation |
Commentary/Editorial| Commentaire/Éditorial |
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The visiting arrangement
in time of epidemic: The judicial criteria because of COVID-19 |
Rodrigo, GM |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Rodríguez, ER |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Inequality viewed through the mirror of COVID-19 (La desigualdad ante el espejo
del COVID-19) |
Rodríguez-Bailón, R |
Revista de Psicologia Social |
Commentary/Editorial| Commentaire/Éditorial |
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Rodríguez-Padial, L, Arias, et al |
Revista espanola de cardiologia |
Commentary/Editorial| Commentaire/Éditorial |
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Rojas, PN |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Rokni, L, Park, et al |
Asia Pac J Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Romeo, F |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Rooks, A |
Manufacturing Engineering |
Commentary/Editorial| Commentaire/Éditorial |
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32771315; Dental Teleradiology: A Powerful Strategy to Overcome the Impact of COVID-19 |
Rosado, LPL, Crusoé-Rebello, et al |
Academic Radiology |
Commentary/Editorial| Commentaire/Éditorial |
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The Potential of Algal Biotechnology to Produce Antiviral Compounds and Biopharmaceuticals |
Rosales-Mendoza, S, García-Silva, et al |
Molecules |
Commentary/Editorial| Commentaire/Éditorial |
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Ros-Castelló, V, Quereda, et al |
Movement Disorders Clinical Practice |
Commentary/Editorial| Commentaire/Éditorial |
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Law as experience. From “coronation
cases” to “coronavirus cases” |
Rosenvald, N |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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32833367; SARS-CoV-2 and sodium
transport: a diabolical strategy |
Rossier, BC |
Revue medicale suisse |
Commentary/Editorial| Commentaire/Éditorial |
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The potential threat of multisystem inflammatory syndrome in children during the COVID-19
pandemic |
Rothan, HA, Byrareddy, et al |
Pediatr Allergy Immunol |
Commentary/Editorial| Commentaire/Éditorial |
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Rotondo, V |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Rudski, L, Januzzi, et al |
Journal of the American College of Cardiology |
Commentary/Editorial| Commentaire/Éditorial |
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Ruggeri, L, Giobbi, et al |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Care of pediatric patient with COVID-19 at doctor’s office and ambulatory management |
Ruiz-Pérez, S, Sánchez-De la Vega, et al |
Medicina Interna de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
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Rusconi, S, Hayden, et al |
Future Virology |
Commentary/Editorial| Commentaire/Éditorial |
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The COVID-19 crisis, between
good faith and opportunistic behavior |
Ruzyk, CEP |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Potential Applications of Microfluidics to Acute Kidney Injury Associated with
Viral Infection |
Ryan, H, Simmons, et al |
Cellular and Molecular Bioengineering |
Commentary/Editorial| Commentaire/Éditorial |
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Sacco, A |
La Medicina del lavoro |
Commentary/Editorial| Commentaire/Éditorial |
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32800797; Emergence of co-infection of COVID-19 and dengue: A serious public health
threat |
Saddique, A, Rana, et al |
Journal of Infection |
Commentary/Editorial| Commentaire/Éditorial |
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Risk Communication in COVID-19 Outbreak: Two Sides of the Same Coin |
Safarpour, H, Farahi-Ashtiani, et al |
Disaster Med Public Health Prep |
Commentary/Editorial| Commentaire/Éditorial |
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Practical Tips for Ambulatory Care in COVID-19: Lessons Learned in a New York Health
System |
Sagar, A, Gottridge, et al |
Am J Med Qual |
Commentary/Editorial| Commentaire/Éditorial |
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Sahin, D, Tanacan, et al |
American Journal of Obstetrics and Gynecology |
Commentary/Editorial| Commentaire/Éditorial |
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“A stitch in time”: group work during the covid-19 scare in the Nicobar Islands,
India |
Saini, A |
Social Work with Groups |
Commentary/Editorial| Commentaire/Éditorial |
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32853328; Ethical considerations related to the COVID-19 "passport" |
Salas, SP |
Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia |
Commentary/Editorial| Commentaire/Éditorial |
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32771570; CMR in the Era of COVID-19: Evaluation of Myocarditis in the Subacute
Phase |
Salerno, M, Kwong, et al |
JACC: Cardiovascular Imaging |
Commentary/Editorial| Commentaire/Éditorial |
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32850105; Evaluation of the COVID-19 Pandemic Intervention Strategies with Hesitant F-AHP |
Samanlioglu, F, Kaya, et al |
Journal of healthcare engineering |
Commentary/Editorial| Commentaire/Éditorial |
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Samboma, TA |
International Social Work |
Commentary/Editorial| Commentaire/Éditorial |
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Sánchez-Arreola, LD, Fernández-Durán, et al |
Medicina Interna de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
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Sánchez-Arreola, LD, Fernández-Durán, et al |
Medicina Interna de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
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Sankaran, B |
Trends in Biomaterials and Artificial Organs |
Commentary/Editorial| Commentaire/Éditorial |
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TEAM to Defeat COVID-19: A Management Strategy Plan to Address Return to Play in
Sports Medicine |
Santos-Ferreira, D, Tomás, et al |
Orthopaedic Journal of Sports Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Sayan, A, Coftas, et al |
British Journal of Oral and Maxillofacial Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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The disparate impact of COVID-19 remote learning on English learners in the United States |
Sayer, P, Braun, et al |
TESOL Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Challenges to Medical Education on Surgical Services During the COVID-19 Pandemic |
Schaffir, J, Strafford, et al |
Medical Science Educator |
Commentary/Editorial| Commentaire/Éditorial |
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The world in the fog. Late consequences
of COVID-19: Fatigue pandemic feared |
Schlenger, R |
Deutsche Apotheker Zeitung |
Commentary/Editorial| Commentaire/Éditorial |
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32833363; COVID-19 et médecine ambulatoire - Soins intensifs :
survie à quel prix ? |
Schneider, A |
Revue medicale suisse |
Commentary/Editorial| Commentaire/Éditorial |
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Guidance
for building operations during the COVID-19 pandemic |
Schoen, LJ |
ASHRAE Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Reply to "Treatment considerations for patients with pemphigus during the COVID-19
pandemic" |
Schultz, B, Pearson, et al |
J Am Acad Dermatol |
Commentary/Editorial| Commentaire/Éditorial |
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32846454; Welche Schutzmaske schützt vor COVID-19? Was ist evidenzbasiert? |
Schulze-Röbbecke, R, Reska, et al |
Aktuelle Urologie |
Commentary/Editorial| Commentaire/Éditorial |
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32773160; The Shift Towards Digital Appointments: the Response to COVID-19 Affecting
Uro-Oncology |
Scott, E, Kubiak, et al |
Clinical oncology |
Commentary/Editorial| Commentaire/Éditorial |
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Sefrin, P |
Notarzt |
Commentary/Editorial| Commentaire/Éditorial |
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The universal electronic
communications service to fight COVID-19 |
Segovia, BA |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Sellal, F, Tazii, et al |
Pratique Neurologique - FMC |
Commentary/Editorial| Commentaire/Éditorial |
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32763102; Medication shortages during the COVID-19 pandemic: Saving more than COVID
lives |
Sen-Crowe, B, McKenney, et al |
American Journal of Emergency Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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32829992; The Florida COVID-19 mystery: Lessons to be learned |
Sen-Crowe, B, Sutherland, et al |
American Journal of Emergency Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Never let a good crisis go to waste: Pauline Hanson’s exploitation of COVID-19 on
Facebook |
Sengul, K |
Media International Australia |
Commentary/Editorial| Commentaire/Éditorial |
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"Contratti di Soggiorno"
and COVID-19. part two. In the post-emergency period |
Senigaglia, R |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
|
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COVID-19 India: An insight into the impact of lockdown and community behavioural
response |
Sharma, S, Paul, et al |
International Social Work |
Commentary/Editorial| Commentaire/Éditorial |
|
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Dexamethasone to combat cytokine storm in COVID-19: Clinical trials and preliminary
evidence |
Sharun, K, Tiwari, et al |
Int J Surg |
Commentary/Editorial| Commentaire/Éditorial |
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Testing the obligations of presence in academia in the COVID-19 era |
Shelley-Egan, C |
Sustainability (Switzerland) |
Commentary/Editorial| Commentaire/Éditorial |
|
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Shin, DS |
TESOL Journal |
Commentary/Editorial| Commentaire/Éditorial |
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32856837; Basic aspects of organizing medical training in the context
of a coronavirus pandemic |
Shkrumyak, AR, Kaminina, et al |
Problemy sotsial'noi gigieny, zdravookhraneniia i istorii meditsiny |
Commentary/Editorial| Commentaire/Éditorial |
|
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Letter to Highlight the Effects of Isolation on Elderly During COVID-19 Outbreak |
Shuja, KH, Shahidullah, et al |
Int J Geriatr Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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32868475; Editors' note: Miller Fisher syndrome and polyneuritis cranialis in
COVID-19 |
Siegler, JE, 3, et al |
Neurology |
Commentary/Editorial| Commentaire/Éditorial |
|
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32833364; COVID-19 et médecine ambulatoire - Patient·e·s âgé·e·s :
qu’avons-nous appris ? |
Sing Ho, LK, Rubli Truchard, et al |
Revue medicale suisse |
Commentary/Editorial| Commentaire/Éditorial |
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Singh, N, Gupta, et al |
Journal of Indian Association for Child and Adolescent Mental Health |
Commentary/Editorial| Commentaire/Éditorial |
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Sivaloganathan, AA, Nasim-Mohi, et al |
British journal of anaesthesia |
Commentary/Editorial| Commentaire/Éditorial |
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Soares, FR |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Oral and maxillofacial surgical services amid COVID-19 pandemic: Perspective from
Tanzania |
Sohal, KS, Simon, et al |
Tropical Medicine and Health |
Commentary/Editorial| Commentaire/Éditorial |
|
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Soheili, S, Shariat, et al |
Work (Reading, Mass.) |
Commentary/Editorial| Commentaire/Éditorial |
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Post-COVID-19 policy:
Discipline and ? questioning a (de) humanized technology |
Soler, ES |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
|
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Brief legal considerations on dying in coronavirus times in Spain |
Sordo, JE |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Soriano-Martínez, JN, Correa-Flores, et al |
Medicina Interna de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
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32833362; COVID-19 et médecine ambulatoire - Urgences : patient·e·s
à risque de décompensation |
Staeger, P, Carron, et al |
Revue medicale suisse |
Commentary/Editorial| Commentaire/Éditorial |
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Stambulova, NB, Schinke, et al |
International Journal of Sport and Exercise Psychology |
Commentary/Editorial| Commentaire/Éditorial |
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Stanojevic, S, Beaucage, et al |
Canadian Journal of Respiratory, Critical Care, and Sleep Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Taking Shared Print to the Next Level: The Partnership for Shared Book Collections |
Stearns, S, Revitt, et al |
Journal of Library Administration |
Commentary/Editorial| Commentaire/Éditorial |
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Stein, RA, Young, et al |
Int J Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Stevens, MP, Patel, et al |
Infect Control Hosp Epidemiol |
Commentary/Editorial| Commentaire/Éditorial |
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Hydroxychloroquine use in COVID-19: Is the risk of cardiovascular toxicity justified |
Stevenson, A, Kirresh, et al |
Open Heart |
Commentary/Editorial| Commentaire/Éditorial |
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Straub, A, Pastor, et al |
Drug Alcohol Rev |
Commentary/Editorial| Commentaire/Éditorial |
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Surmelioglu, N, Demirkan, et al |
Journal of Critical and Intensive Care |
Commentary/Editorial| Commentaire/Éditorial |
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Ta, QTH, Nadeem, et al |
Research in Social and Administrative Pharmacy |
Commentary/Editorial| Commentaire/Éditorial |
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The occupational risks prevention in the COVID-19 health crisis:
Main measures and responsabilities |
Taléns Visconti, EE |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Tan, JY, Conceicao, et al |
Journal of Hospital Infection |
Commentary/Editorial| Commentaire/Éditorial |
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Tang, J |
R I Med J (2013) |
Commentary/Editorial| Commentaire/Éditorial |
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Tanrıverdi, G, Bakır, et al |
J Air Transp Manag |
Commentary/Editorial| Commentaire/Éditorial |
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Hypertension and diabetes mellitus in patients with COVID 19: A viewpoint on
mortality |
Tascioglu, D, Yalta, et al |
Cardiovascular Endocrinology and Metabolism |
Commentary/Editorial| Commentaire/Éditorial |
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Tay, YX, Sng, et al |
Journal of Medical Imaging and Radiation Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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A neglected issue in hospital emergency and disaster planning: Non-standard employment
in hospitals |
Tekeli-Yesil, S, Kiran, et al |
International Journal of Disaster Risk Reduction |
Commentary/Editorial| Commentaire/Éditorial |
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32863965; Emerging evidence of myocardial injury in COVID-19: A path through the smoke |
Tersalvi, G, Veronese, et al |
Theranostics |
Commentary/Editorial| Commentaire/Éditorial |
|
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Testal, EG |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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The US politicisation of the pandemic: Raul Grijalva on masks, BAME, and covid-19 |
Thacker, PD |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Thao, TTN, Labroussaa, et al |
Methods in Molecular Biology |
Commentary/Editorial| Commentaire/Éditorial |
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Coronavirus 2019, Microthromboses, and Platelet Activating Factor |
Theoharides, TC, Antonopoulou, et al |
Clinical therapeutics |
Commentary/Editorial| Commentaire/Éditorial |
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Thompson, A, Khan, et al |
Journal of Maxillofacial and Oral Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Challenges in the delivery of critical care in India during the COVID-19 pandemic |
Tirupakuzhi Vijayaraghavan, BK, Nainan Myatra, et al |
Journal of the Intensive Care Society |
Commentary/Editorial| Commentaire/Éditorial |
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Preparing for ‘COVID-27’: Lessons in management focus – An Australian general
aviation perspective |
Tisdall, L, Zhang, et al |
Journal of Air Transport Management |
Commentary/Editorial| Commentaire/Éditorial |
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Psychosocial Support for Healthcare Workers During the COVID-19 Pandemic |
Tomlin, J, Dalgleish-Warburton, et al |
Frontiers in Psychology |
Commentary/Editorial| Commentaire/Éditorial |
|
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32814648; Comment on «Chilblains in lockdown: An old acquaintance in the context
of COVID 19» |
Torres-Navarro, I, Sánchez-Arráez, et al |
Anales de Pediatria |
Commentary/Editorial| Commentaire/Éditorial |
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Toth, E, Dancy, et al |
Eur Heart J |
Commentary/Editorial| Commentaire/Éditorial |
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Tsoleridis, T, Ball, et al |
Methods in Molecular Biology |
Commentary/Editorial| Commentaire/Éditorial |
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Tsui, BCH, Pan, et al |
British journal of anaesthesia |
Commentary/Editorial| Commentaire/Éditorial |
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Ulloa-Gutiérrez, R, Ivankovich-Escoto, et al |
Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia |
Commentary/Editorial| Commentaire/Éditorial |
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Hepatology and the “new reality” ushered in by the COVID-19 pandemic |
Uribe, M, Aquino-Matus, et al |
Annals of Hepatology |
Commentary/Editorial| Commentaire/Éditorial |
|
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DPP4 and ACE2 in Diabetes and COVID-19: Therapeutic Targets for Cardiovascular Complications? |
Valencia, I, Peiró, et al |
Frontiers in Pharmacology |
Commentary/Editorial| Commentaire/Éditorial |
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Valotassiou, V, Angelidis, et al |
Hellenic journal of nuclear medicine |
Commentary/Editorial| Commentaire/Éditorial |
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van den Bemt, L, Chavannes, et al |
Huisarts en Wetenschap |
Commentary/Editorial| Commentaire/Éditorial |
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van den Oord, S, Vanlaer, et al |
Public administration review |
Commentary/Editorial| Commentaire/Éditorial |
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van der Velden, RMJ, Hermans, et al |
International Journal of Care Coordination |
Commentary/Editorial| Commentaire/Éditorial |
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Van Orden, KA |
American Journal of Geriatric Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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32815593; Beta-Adrenergic Blockers as a Potential Treatment for COVID-19 Patients |
Vasanthakumar, N |
BioEssays |
Commentary/Editorial| Commentaire/Éditorial |
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SARS-CoV-2 dysregulation of PTBP1 and YWHAE/Z gene expression: A primer of neurodegeneration |
Vavougios, GD |
Medical hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
|
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Diagnosis and treatment of acute surgical diseases in patients with Covid-19 |
Vechyorko, VI, Anosov, et al |
Bulletin of Russian State Medical University |
Commentary/Editorial| Commentaire/Éditorial |
|
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Excessive
hardship due to the COVID-19 outbreak (an analysis from modern european contract law) |
Velencoso, LMM |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
|
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Verma, HK, Merchant, et al |
Biomedical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Vesely, MD, Perkins, et al |
Journal of the American Academy of Dermatology |
Commentary/Editorial| Commentaire/Éditorial |
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Vestergaard, LS, Mølbak, et al |
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin |
Commentary/Editorial| Commentaire/Éditorial |
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Vijayasarathi, A, Khosa, et al |
Clinical imaging |
Commentary/Editorial| Commentaire/Éditorial |
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Post-coronavirus civil justice, from the crisis to some of the
reforms envisaged |
Vilar, SB |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
|
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Villaseñor-Colín, C |
Medicina Interna de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
|
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Virgadamo, P |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
|
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The silent
victims of the pandemic: Children and adolescents during the COVID-19 crisis |
Vyjayanthi, NV, Banerjee, et al |
Journal of Indian Association for Child and Adolescent Mental Health |
Commentary/Editorial| Commentaire/Éditorial |
|
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Wadia, R |
British dental journal |
Commentary/Editorial| Commentaire/Éditorial |
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Rapid Supportive Response to a Traumatic "Zoombombing" During the COVID-19 Pandemic |
Walsh, CG, Unertl, et al |
Acad Med |
Commentary/Editorial| Commentaire/Éditorial |
|
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32768306; Patient Care Rounds in the Intensive Care Unit During COVID-19 |
Wang, H, Poehler, et al |
Joint Commission Journal on Quality and Patient Safety |
Commentary/Editorial| Commentaire/Éditorial |
|
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Wang, J, Yu, et al |
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi |
Commentary/Editorial| Commentaire/Éditorial |
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Wangamati, CK, Sundby, et al |
Sex Reprod Health Matters |
Commentary/Editorial| Commentaire/Éditorial |
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Watson, J, Richter, et al |
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Appendix: Process and definitions.
A daily search for new publications is conducted in PubMed, Scopus,
BioRxiv and MedRxiv, SSRN,
Research Square,
arXiv for all publications related to COVID-19 disease or SARS-CoV-2 using the search terms (COVID-19 OR SARS-CoV-2
OR "novel CoV" OR "novel coronavirus" OR nCoV) adapted to each database. The capture is cross-referenced with publication announcements on the COVID-19 dashboards set up by a number of publishers and google. Publishers include
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ, Wiley,
Springer Nature, ChinaCDCweekly.
Additionally the database is cross-referenced with other literature scans e.g.
WHO publication list and activities by collaborators. Members of the Emerging Sciences group develop 1 -2 point summaries of each publication. Please email Lisa Waddell for additional information:
Lisa.Waddell@canada.ca.
References are compiled in a reworks database that has citations since the beginning of the outbreak. All references can be accessed at this
link and by the categories listed below. The daily scan has also been compiled in an excel sheet and copies can be provided upon request or
accessed
here.
Category Definitions:
Modelling/ prediction: Predictive modeling is a process that uses data mining and probability
to forecast outcomes. Each model is made up of a number of predictors, which are variables that are likely to influence future results.
Epidemiology:
the branch of medicine which deals with the incidence, distribution, and possible control of diseases and other factors relating to health. Includes Ro, attack rates, case number doubling time, case fatality
rate, serial interval, clinical attack rate, asymptomatic fraction, proportion of asymptomatic and infective*
Transmission: The passage of a pathogen causing communicable disease from an infected host
to an uninfected host via direct or indirect routes.
Clinical data
of cases: Includes clinical parameters such as incubation period, latent period, period of communicability, duration of illness, duration of hospitalization, host risk factors, as well as clinical profiles of patients; presenting symptoms, symptoms over
course of illness, sequelae, comorbidities.*
Surveillance: Public health surveillance is the continuous, systematic collection, analysis and
interpretation of health-related data. Surveillance data will likely be number of cases suspected/confirmed, number of deaths, number recovered. *
Coronavirology: All research relating to the virus; its characteristics, genetic make-up, phylogenetic
analyses
Diagnostics / Pathogen detection:
All studies on identification of the virus; culture, PCR, antibody/antigen tests etc.
Therapeutics:
Studies of substances that may be used to treat infected hosts including passive immunization products.
Vaccine Research:
Studies of vaccine candidates to prevent infection with 2019-nCoV including clinical trials.
Public Health Priorities:
These citations will focus on what the current research priorities are and/or where knowledge gaps exist.
Public Health interventions*:
Any study evaluating how effective a public health intervention is or maybe (in the case of a predictive model).
Public Health response:
These papers are typically overviews of past and current activities, they often also identify knowledge gaps and suggest future activities or objectives.
Infection Prevention and Control/
Prévention et contrôle des infections (IPAC/PCI): Any research on the effectiveness of IPC interventions should also be tagged as IPC
Health care Response:
This foci would include a description of activities to deal with 2019-nCoV cases including, but not limited to: set up of a special emergency multi-disciplinary intensive care team; Bed and medical equipment preparation/ stock piling supplies; Education
and training of staff; Early case recognition and classification of disease severity.
Economics: papers discussing/ forecasting the economics of COVID-19 pandemic.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Review Literature:
All articles that summarize the published literature can be tagged as a review. This includes systematic review, meta-analysis, scoping review, overviews, umbrella reviews*
Commentary/Editorial:
For commentaries, editorials, letters to the editor, other types of opinion pieces where there is no new data collected by the author or analysis conducted by the author, please tag these within the commentary category.
News articles that have not scientific information.
*Lists are not exhaustive
Annexe: Processus et définitions.
Une recherche quotidienne des nouvelles publications est effectuée dans PubMed, Scopus,
BioRxiv and MedRxiv,
SSRN,
Research Square,
arXiv
pour toutes les publications relatives à la maladie COVID-19 ou au SRAS-CoV-2 en utilisant les termes de recherche (COVID-19 OU SARS-CoV-2 OU « novel CoV » OU « novel coronavirus » OU nCoV). La saisie renvoie à des annonces de publication
sur les tableaux de bord du nCoV mis en place par un certain nombre d'éditeurs et par Google. Parmi les éditeurs figurent
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ,
Wiley,
Springer Nature,
ChinaCDCweekly. En outre, la base de données renvoie à d'autres survols de publications, e.g.
la liste des publications de l'OMS,
et à des activités des collaborateurs. Les membres du groupe scientifique émergent préparent des résumés en 1 ou 2 points de chaque publication. Pour en savoir plus, veuillez envoyer un courriel à Lisa Waddell au :
Lisa.Waddell@canada.ca.
Les références sont compilées dans une base de données Refworks qui contient des citations depuis le début de l'épidémie. Toutes les références sont accessibles à partir de ce
lien et par les catégories énumérées ci-dessous. L'analyse quotidienne a également été compilée
dans une feuille Excel et des copies peuvent être fournies sur demande ou consultées
ici.
Définitions des catégories :
Modélisation / prédiction :
La modélisation prédictive est un processus qui utilise l'exploration de données et la probabilité pour prévoir les résultats. Chaque modèle est composé de plusieurs prédicteurs, qui sont des variables susceptibles d'influencer les résultats futurs.
Épidémiologie :
Branche de la médecine qui traite de l'incidence, de la répartition et du contrôle éventuel des maladies et d'autres facteurs liés à la santé. Comprend le taux de reproduction de base (Ro),
les taux d'attaque, le temps de doublement du nombre de cas, le taux de létalité, l'intervalle sériel, le taux d'attaque clinique, la fraction asymptomatique, la proportion de cas asymptomatiques et infectieux*.
Transmission :
Passage d'un agent pathogène causant une maladie transmissible d'un hôte infecté à un hôte non infecté par des voies directes ou indirectes.
Données cliniques
des cas : Comprend les paramètres cliniques tels que la période d'incubation, la période de latence, la période de contagiosité, la durée de la maladie, la durée de l'hospitalisation, les facteurs de risque de l'hôte, ainsi que les profils
cliniques des patients; les symptômes présentés, les symptômes au cours de la maladie, les séquelles, les comorbidités.*
Surveillance : La surveillance
de la santé publique est la collecte, l'analyse et l'interprétation continues et systématiques de données relatives à la santé. Les données de surveillance concerneront probablement le nombre de cas suspects / confirmés, le nombre de décès, le nombre de personnes
guéries. *
Coronavirologie : Toutes les recherches relatives
au virus, ses caractéristiques, sa constitution génétique et les analyses phylogénétiques.
Diagnostics / Détection d'agents pathogènes :
Toutes les études sur l'identification du virus : culture, PCR, tests de dépistage d'anticorps ou d’antigènes, etc.
Thérapeutique :
Étude des substances pouvant être utilisées pour traiter les hôtes infectés, y compris les produits d'immunisation passive.
Recherche sur les vaccins : Études des candidats à la
vaccination pour prévenir l'infection par le 2019-nCoV, y compris des essais cliniques.
Priorités de santé publique :
Ces citations porteront sur les priorités actuelles de recherche et/ou sur les lacunes dans les connaissances.
Interventions de santé publique* :
Toute étude évaluant l'efficacité (réelle ou possible) d'une intervention de santé publique (dans le cas d'un modèle prédictif).
Réponse de la santé publique :
Ces articles sont généralement des aperçus des activités passées et actuelles, qui identifient souvent les lacunes dans les connaissances et suggèrent des activités ou des objectifs futurs.
Prévention et contrôle des infections/Infection Prevention and Control (PCI/IPAC) :
Les recherches sur l'efficacité des interventions en PCI doivent également être marquées comme PCI.
Réponse des soins de santé :
Ce point comprendrait une description des activités pour traiter les cas de 2019-nCoV, notamment : mise en place d'une équipe multidisciplinaire spéciale de soins intensifs d'urgence; préparation des lits et des équipements médicaux
/ stockage des fournitures; sensibilisation et formation du personnel; reconnaissance précoce des cas et classification de la gravité de la maladie.
Modèle animal:
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Économie:
documents discutant / prévoyant l'économie de la pandémie de COVID-19
Revue de la documentation :
Tous les articles qui résument les documents publiés peuvent être marqués comme une revue. Cela comprend les revues systématiques, les méta-analyses, les études de la portée, les aperçus, les examens généraux*.
Commentaires/Éditorial :
Pour les commentaires, éditoriaux, lettres à la rédaction, autres types d'articles d'opinion pour lesquels aucune nouvelle donnée n'est collectée ou aucune analyse n'est effectuée par l'auteur, veuillez les marquer dans la catégorie des
commentaires.
journaux
Articles de presse qui n'ont pas d'informations scientifiques.
* Les listes ne sont pas exhaustives