Subject: Daily Scan of COVID-19 Scientific Publications / survol journalier des publications scientifiques du COVID-19,
2020-08-31
Good afternoon,
There are 1174 citations in today’s scan. 621 were considered primary research or review literature.
Highlights today include:
CANADA
·
Zhang et al.
in this ecological study did not find an association with ambient temperature and COVID-19 incidence in four Canadian provinces January to May 2020.
·
Yawney & Gadsden
used predictive models to study the impact of COVID-19 on the Canadian population. Social distancing was modelled through the isolation of a subset of the susceptible population, and comparative studies were performed
considering a range in the proportion of individuals isolated. Numerical approximation techniques were used to simulate the pessimistic base case for which no preventative measures are taken and for various social distancing regimes. Social distancing results
are consolidated into two groups - those that flatten the curve and those that completely halt the disease spread. Mathematical formulations show that the turning point between these two regimes is when the effective reproductive rate, denoted Re, is equal
to 1.
·
Zhao et al.
In this study, we developed a simple likelihood-based framework to estimate the instantaneous CFR of infectious diseases. We used the publicly available COVID-19 surveillance data in Canada for demonstration. We estimated the mean fatality ratio of reported
COVID-19 cases (rCFR) in Canada was estimated at 6.9% (95%CI: 4.5–10.6). We emphasize the extensive implementation of the constructed instantaneous CFR that is to identify the key determinants affecting the mortality risk.
PUBLIC HEALTH INTERVENTION
·
Kinoshita and Tanaka studied the impact of routine BCG vaccination in young generation on the prevention of local COVID-19 spread in Japan,
and demonstrated that routine infant BCG vaccine coverage in young people showed a protective effect against local COVID-19 spread in Japan.
·
D’Aurizio et al.
We present No Face-Touch, a system able to estimate hand proximity to face and notify the user whenever a face-touch movement is detected. In its complete setup, the system consists of an application running on the smartwatch
and a wearable accessory. Its ease of implementation allows this solution to be ready-to-use and large-scale deployable. We developed two gesture detection approaches compatible with sensors embedded in recent smartwatches, i.e. inertial and magnetic sensors.
After preliminary tests to tune target gesture parameters, we tested the two approaches and compared their accuracy. The final phase of this project consisted in exploiting the most robust approach in a daily living scenario during a 6-days campaign. Experimental
results revealed the effectiveness of the proposed system, demonstrating its impact in reducing the number of face-touches and their duration.
IPAC
·
Belmin et al investigated COVID-19-related outcomes in 17 French nursing homes that implemented voluntary staff confinement with residents (794
staff, 1250 residents) relative to those that did not (9513 facilities with 385 290 staff members and 695 060 residents). They found that self-confinement of staff members with residents may help protect nursing home residents from mortality related to COVID-19
and residents and staff from COVID-19 infection, with markedly lower proportions of outbreaks, residents infected, residents dying, and staff infected in self-confined facilities.
EPIDEMIOLOGY
·
Malhotra et al
have conducted one of the largest cohort studies (preprint) and analysed clinico-epidemiological attributes of >22,000 COVID-19 patients from India. Amongst the 22,684 tested, 2158 (9.5%) were positive for COVID-19. They show that women and symptomatic
individuals had higher odds of testing positive as compared to men and asymptomatic individuals, respectively. Of 1729 cases prospectively followed, 74% remained asymptomatic. The age group of 50-59 years, intra-familial positivity, alcohol intake, smoking
and comorbidities were associated with clinical symptom positivity.
·
Almario et al.
analyzed the data from an online survey Of 53,130 participants, 3,386 (6.4%) reported a positive COVID-19 test. The authors found that individuals using Proton Pump Inhibitors (PPIs) had significantly increased odds of reporting a positive COVID-19 test
compared to those not taking PPIs
·
Lopez-Otero et al
found that treatment with ACEI/ARB (combined and individually) had no effect on mortality, heart failure, hospitalization rate, ICU admission, or major acute cardiovascular events. This neutral effect remained in a subgroup analysis of patients requiring
hospitalization.
CLINICAL DATA
·
Goldshtrom, et al.
report a case series of seven neonates with congenital heart and lung malformations born to women who tested positive for SARS-CoV-2 during their pregnancy at a single academic medical center in New York City.
THERAPEUTICS
·
Mather, et al.
report an observational study of consecutive COVID-19-positive patients receiving famotidine therapy and those not receiving famotidine, between February 24, 2020, and May 13, 2020. Famotidine use in hospitalized patients
with COVID-19 is associated with a lower risk of mortality, lower risk of combined outcome of mortality and intubation, and lower levels of serum markers for severe disease in hospitalized patients with COVID-19.
DIAGNOSTICS
·
Spinicci et al.
In the near future, the overlap of Coronavirus disease 2019 (COVID-19) and dengue epidemics is a concrete threat in tropical regions. Co-epidemics of COVID-19 and dengue could be an overwhelming challenge for health systems in
low- and middle-income countries. In this work, we investigated potential serological cross-reactions between COVID-19 and dengue patients. Among 32 COVID-19 positive sera, no positive Dengue virus (DENV) IgG/IgM results were observed. On the other hand, one
false-positive result was observed among 44 DENV-positive sera tested for COVID-19 antibodies with each of the two rapid tests used. Further data on accuracy of COVID-19 diagnostic test are urgently warranted.
PUBLIC HEALTH RESPONSE
·
Kaspar, K.,
reports central cognitive variables that may constitute people’s motivations for social distancing, using an app, and providing health-related data requested by two apps that differ in their direct utility for the individual
user. Multiple regression analyses showed that the present model could explain 55% of the interindividual variance in the participants’ motivation for social distancing, 46% for using a contact tracing app, 42% for providing their own infection status to a
contact tracing app, and 34% for using a data donation app.
·
Borch et al. conducted an observational study in Denmark during the reopening
of schools and daycare facilities for children aged 0-12 years (April 22nd to May 1st 2020). A questionnaire was sent out to parents in four municipalities consisting of 20 questions about frequency of hand washing, use of hand sanitiser, symptoms of irritant
contact dermatitis (ICD), atopic dermatitis, allergy and predispositions. They concluded that a higher frequency of hand washing during the COVID-19 reopening increased the incidence of ICD in children. Hand hygiene is essential in our fight against novel
coronavirus, but prophylactic initiatives are important to reduce the possible long-term consequences of ICD in children.
ECONOMICS
·
Walmsley et al.
estimated the macroeconomic impacts of mandatory business closures, due to COVID-19, in the U.S. and many other countries. The authors estimated a 20.3% decline of U.S. GDP on an annual basis and a 22.4% employment
decline for the three-month scenario. If the mandatory closures are extended to six months because of a second wave, these negative impacts would slightly more than double.
Regards,
Lisa Waddell, Tricia Corrin, Rukshanda Ahmad, Robyn Odell, Maribeth Mitri, Julie Theriault, Dobrila Todoric, Alejandra Dubois, Christina Bancej, Austyn Baumeister, Anam Khan, Musaab Younis, Lien Mi Tien, Dima Ayache, Angela Sloan, Kaitlin
Young, Chatura Prematunge, Ainsley Otten
Focus areas: Modelling/ prediction, Epidemiology, Transmission, Clinical data, Surveillance, Coronavirology, Diagnostics / Pathogen detection, Therapeutics,
Vaccine Research, Public health interventions, Public Health response, Public Health Priorities, IPAC, Health care response, immunology, economics, animal model, zoonoses, Review Literature, Commentary/Editorial, news
Domaines cibles: Modélisation/prédiction, Épidémiologie, Transmission, Données cliniques, Surveillance, Coronavirologie, Diagnostics
/ Détection d'agents pathogènes, Thérapeutique, Recherche sur les vaccins, Interventions de santé publique, Priorités de santé publique, PCI,
Réponse des soins de santé, immunologie, économie, modèle animal, zoonoses, Revue de littérature, Commentaire/Éditorial, journaux
|
PUBLICATIONS |
AUTHORS / AUTEURS |
SOURCE |
FOCI / DOMAINE |
SUMMARY / SOMMAIRE |
Insomnia and stress of physicians during COVID-19 outbreak |
Abdulah, DM, Musa, et al |
Sleep Medicine: X |
Healthcare Response | Réponse des soins de santé |
This study aimed to measure severity of sleep difficulty and its correlation with duration of deal with suspected/confirmed
cases of novel coronavirus (COVID-19) in physicians. In this cross-sectional study, 268 physicians from different medical settings were included during the COVID-19 outbreak. The mean age and experience of physicians were 35.06 (33–70 years) and 10.13 years.
The median duration of dealing with suspected/confirmed cases of COVID-19 was 1.0 (0–30 days). The mean sleep score and stress of physicians were 8.43 of 24.0 and 4.20 of 10, respectively. More than two-thirds of the physicians were sleepless (68.3%) and majority
had stress (93.7%). The study did not find a significant difference in sleep score of physicians with different specialties (P = 0.059). However, most physicians were sleepless; including anesthesia and intensive care (77.8%); general physicians (80.8%), and
obstetrics and gynecology (80.0%). They were sleepless in morning (58.7%); evening (77.8%); night (100%); and multi-shift (70.9%). The physicians who dealt with suspected or confirmed cases of COVID-19 or with stress had more escalated sleep compared to those
who did not deal with patients or without stress (9.39 vs. 7.17 and 8.78 vs. 2.69 P < 0.001). The sleep of physicians was escalated with increasing stress (r = 0.558; P < 0.001) and a number of days that physicians dealt with suspected/confirmed cases of COVID-19
(r = 0.210; P = 0.001), respectively. |
|
Adequacy of Logistic models for describing the dynamics of COVID-19 pandemic |
Abusam, A, Abusam, et al |
Infectious Disease Modelling |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This study used the data for Kuwait to assess the adequacy of the two most commonly used logistic models for describing the dynamics COVID-19.
|
|
Inequality in the impact of the coronavirus shock: Evidence from real time surveys |
Adams-Prassl, A, Boneva, et al |
Journal of Public Economics |
Economics | Économie |
We present real time survey evidence from the UK, US and Germany showing that the immediate labor market impacts of Covid-19 differ considerably across
countries |
|
Spatio-temporal analysis of meteorological factors in abating the spread of
COVID-19 in Africa |
Adekunle, IA, Tella, et al |
Heliyon |
Epidemiology| Épidémiologie Transmission |
Africa, with a mostly relatively warmer temperature differs from other regions of the world and in addition, has recorded far fewer cases compared to Asian,
Europeans and the Americans (North and South). We rely on the generalised additive model (GAM) and found wind speed to positively relate to COVID-19 growth while mean temperature and relative humidity to inversely relates to COVID-19 growth curve in Africa.
We accounted for potential cofounders in the core GAM model and discuss policy implications. |
|
Designing of Epitope-Based Vaccine from the Conserved
Region of the Spike Glycoprotein of SARS-CoV-2 |
Agarwal, Vidhu, Tiwari, et al |
bioRxiv |
Coronavirology| Coronavirologie Vaccine Research| Recherche sur les vaccins |
A conserved peptide region of SARS-CoV-2 spike glycoprotein was used for predicting suitable B cell and T cell epitopes. This is an in-silico based study
that predicts a novel T cell epitope from the conserved spike glycoprotein that could act as a target for designing of the epitope-based vaccine. Further, B cell epitopes have also been found but the main work focuses on T cell epitope as the immunity generated
by it is long lasting as compared to B cell epitope. |
|
Ahamad, S, Kanipakam, et al |
J Biomol Struct Dyn |
Coronavirology| Coronavirologie |
We have focused our work on mutations in two of the several functional domains in the virus spike glycoprotein, namely,
receptor-binding domain (RBD) and heptad repeat 1 (HR1) domain. In our study, several mutations like R408I, L455Y, F486L, Q493N, Q498Y, N501T of RBD (319-591), and A930V, D936Y of HR1 (912-984) have been studied to examine its role on the spike glycoprotein
native structure. Comparisons of MD simulations in the WT and mutants revealed a significant de-stabilization effect of the mutations on RBD and HR1 domains. We have investigated the impact of mapped mutations on the stability of the spike glycoprotein, before
binding to the receptor, which may be consequential to its binding properties to the receptor and other ligands. |
|
|
Lost Happiness — Loss of Life Satisfaction in the Corona Crisis |
Ahlheim, M, Bruckmeyer, et al |
Wirtschaftsdienst |
Public Health response| Interventions de santé publique |
(In German) This study illustrates the loss of life satisfaction, and with it the psychological costs of the COVID-19
pandemic and the lockdown measures taken, for self-employed and women. Building on the data collected by Windsteiger et al. (2020) and their internet interviews at the peak of lockdown measures, and looking at specific population subgroups, this essay illustrates
that many solo self-employed and women report a significant decline in life satisfaction, and that these effects are strongest where solo self-employment coincides with economic losses and childcare responsibilities for women with children of dependent age. |
|
Ahmed, ST |
Information (Switzerland) |
Public Health response| Interventions de santé publique |
This paper reports on data collected using media diaries from 15 university students in the United Arab Emirates documenting
their news consumption in April 2020. Faced with a potentially infinite amount of information and news, participants demonstrate how they are managing news overload (MNO) using a number of complementary strategies. Results show that while consumption patterns
vary, all diaries indicate that users' ability to navigate the news landscape in a way that fulfils their needs is influenced by news sources; platform reliability and verification; sharing activity; and engagement with news. |
|
|
Deep transfer learning-based automated detection
of COVID-19 from lung CT scan slices |
Ahuja, S, Panigrahi, et al |
Applied Intelligence |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
In this proposed research work; the COVID-19 is detected using transfer learning from CT scan images decomposed to
three-level using stationary wavelet. The result of the experimental evaluation confirms that the ResNet18 pre-trained transfer learning-based model offered better classification accuracy on the considered image dataset compared with the alternatives. |
|
COVID-19 and e-wallet usage intention: A
multigroup analysis between Indonesia and Malaysia |
Aji, HM, Berakon, et al |
Cogent Business and Management |
Public Health response| Interventions de santé publique |
Physical distancing policy that is encouraged by the World Health Organization (WHO) has inspired consumers to do contactless
activities, including payment transaction. Government authorities in a growing number of countries are taking actions to encourage contactless payments as the COVID-19 pandemic escalates. People are worried that novel coronavirus (SARS-Cov2) can be transmitted
through physical money. It drives them to shift to e-wallet. Due to a lack of study on this topic, the present study contributes to the literature by examining the effect of perceived risk, government support, and perceived usefulness on customers’ intention
to use e-wallet during COVID-19 outbreak. To give more fruitful insight, another major contribution of this study is investigating the group difference between Indonesia and Malaysia in the overall model. Questionnaires are distributed to the respondents by
using a proportional sampling technique. As a result, 259 total respondents from Indonesia and 207 from Malaysia are collected. Both countries are selected because Indonesia and Malaysia can be considered as the two-worst countries in ASEAN affected by COVID-19.
The model is tested using PLS-Structural Equation Modeling (SEM) approach. The results show that the effects of government support on the intention to use e-wallets differ between countries. Besides, perceived usefulness fully mediated government support-intention
to use e-wallets relationship, and partially mediated the effect of perceived risk on intention to use e-wallets. © 2020 The Author(s). This open access article is distributed under a Creative Commons Attribution (CC-BY) 4.0 license. |
|
Akeel, H, Khoj, et al |
Entrepreneurship and Sustainability Issues |
Public health interventions*| Interventions de santé publique Public Health response|
Interventions de santé publique |
This paper is evaluating whether education or the standard of living in a country helped citizens to stay at home during
COVID-19 pandemic. The study implemented a cross-sectional regression on Google mobility trend reports as of 29th March, 2020. The cross-sectional regression included 123 countries as a sample for the study. The study found that education index, park mobility
trends and workplace mobility trends were significant variables in explaining the changes in residential area. |
|
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Optimization of machine learning algorithms for predicting infected COVID-19 in
isolated DNA |
Al Kindhi, B |
International Journal of Intelligent Engineering and Systems |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Author proposes an optimization of machine learning methods to predict COVID-19. Optimization of the Decision Tree
method produces an accuracy of 98.3%, optimization of Discriminant Analysis 98.3%, and optimization of SVM and KNN 100% respectively. |
|
Evaluation of the Ion AmpliSeq SARS-CoV-2 Research Panel by Massive Parallel Sequencing |
Alessandrini, F, Caucci, et al |
Genes |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Deep knowledge of the genetic features of SARS-CoV-2 is essential to track the ongoing pandemic through different geographical
areas and to design and develop early diagnostic procedures, therapeutic strategies, public health interventions, and vaccines. We describe protocols and first results of the Ion AmpliSeq™ SARS-CoV-2 Research Panel by a massively parallel sequencing (MPS)
assay. The panel allows for targeted sequencing by overlapping amplicons, thereby providing specific, accurate, and high throughput analysis. A modified reverse transcription reaction, which consists of the use of a SARS-CoV-2 specific primers pool from the
Ion AmpliSeq SARS-CoV-2 Research Panel, was assessed in order to promote viral RNA specific reverse transcription. The aim of this study was to evaluate the effectiveness of the Ion AmpliSeq™ SARS-CoV-2 Research Panel in sequencing the entire viral genome
in different samples. SARS-CoV-2 sequence data were obtained from ten viral isolates and one nasopharyngeal swab from different patients. The ten isolate samples amplified with 12 PCR cycles displayed high mean depth values compared to those of the two isolates
amplified with 20 PCR cycles. High mean depth values were also obtained for the nasopharyngeal swab processed by use of a target-specific reverse transcription. The relative depth of coverage (rDoC) analysis showed that when 12 PCR cycles were used, all target
regions were amplified with high sequencing coverage, while in libraries amplified at 20 cycles, a poor uniformity of amplification, with absent or low coverage of many target regions, was observed. Our results show that the Ion AmpliSeq SARS-CoV-2 Research
Panel can achieve rapid and high throughput SARS-CoV-2 whole genome sequencing from 10 ng of DNA-free viral RNA from isolates and from 1 ng of DNA-free viral RNA from a nasopharyngeal swab using 12 PCR cycles for library amplification. The modified RT-PCR
protocol yielded superior results on the nasopharyngeal swab compared to the reverse transcription reaction set up according to the manufacturer's instructions. |
|
Alhassan, GN, Adedoyin, et al |
Journal of Public Affairs |
Economics | Économie |
The present study relies on recent annual time‐series data to conceptualize the hypothesized claim via Pesaran's Autoregressive
distributed lag techniques. Empirical findings from the bounds test traces the long‐run relationship between public health expenditure and economic growth over the study span. However, unlike previous studies, we introduce life expectancy and death rates in
the model framework. Although health expenditure is not significant, empirical results show that a 1% increase in life expectancy and death rate increases and decreases economic growth by 3.85 and 1.84%, respectively. This suggests the need for Health Policymakers
in Nigeria to implement active strategies that reduce the death rate, which is a blueprint for active engagement in the face of a global pandemic such as COVID‐19. |
|
|
Al-Hosan, A, AlRajeh, et al |
Journal of Public Affairs |
Public Health response| Interventions de santé publique |
This study aimed to detect the role of teaching staff members in increasing university students' awareness, health
protection, moral, and value aspects through the e-learning, and to reveal the differences in the level of the teaching staff members about their roles due to the path of college, academic degree, and academic experience. To achieve these aims of the study,
the descriptive method was applied. The study sample consisted of (101) teaching stuff member in health, scientific, and human specializations at Princess Nourah Bint Abdul Rahman University in Saudi Arabia. The researchers designed a questionnaire to collect
the data that reflects the perceptions of teaching staff members about their cognitive, skill, health, and ethical roles toward responding to the COVID-19 pandemic through distance education. The results indicated that there are high levels of teaching staff
members' perception of their skill, health, and ethical responsibilities to raise students' awareness about the COVID-19 pandemic, while the level of teaching staff members' perception of their cognitive responsibilities to raise students' awareness about
the COVID-19 pandemic was average. The findings indicated there are differences in the perception of the teaching staff members of their cognitive, skill, health, and moral value responsibilities to raise students' awareness about the COVID-19. © 2020 The
Authors. Journal of Public Affairs published by John Wiley & Sons Ltd. |
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Radiological findings spectrum of asymptomatic coronavirus (COVID-19) patients |
Ali, RMM, Ghonimy, et al |
Egyptian Journal of Radiology and Nuclear Medicine |
Clinical data| Données cliniques |
Our study is a prospective study and aims to be familiar with the CT imaging features of asymptomatic cases with COVID-19
pneumonia. A total of 44 asymptomatic cases with COVID-19 pneumonia between March 20, 2020 and May 23, 2020 were enrolled. All patients had a history of exposure to SARS-CoV-2 or recent travel history. All patients had no symptoms. The predominant feature
of CT findings in this cross-sectional study was ground-glass opacity (GGO) (41, 93%) with peripheral (34, 77.3%) distribution, bilateral location (20, 45.5%) with lower lobe predominance (left lower lobe 72% and right lower lobe 50%). |
|
Allam, MF |
Open Public Health Journal |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Due to the international spread of COVID-19, the difficulty of collecting nasopharyngeal swab specimen from all suspected
patients, the costs of RT-PCR and CT, and the false negative results of RT-PCR assay in 41% of COVID-19 patients, a scoring system is needed to classify the suspected patients in order to determine the need for follow-up, home isolation, quarantine or the
conduction of further investigations. A scoring system is proposed as a diagnostic tool for suspected patients. It includes Epidemiological Evidence of Exposure, Clinical Symptoms and Signs, and Investigations (if available). This scoring system is simple,
could be calculated in a few minutes, and incorporates the main possible data/findings of any patient. © 2020 Mohamed Farouk Allam. |
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|
Alm, E, Broberg, et al |
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin |
Coronavirology| Coronavirologie |
We show the distribution of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genetic clades over time and
between countries and outline potential genomic surveillance objectives. We applied three genomic nomenclature systems to all sequence data from the World Health Organization European Region available until 10 July 2020. We highlight the importance of real-time
sequencing and data dissemination in a pandemic situation, compare the nomenclatures and lay a foundation for future European genomic surveillance of SARS-CoV-2. |
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Increased Risk of COVID-19 Among Users of Proton Pump Inhibitors |
Almario, CV, Chey, et al |
Am J Gastroenterol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aimed to determine whether use of PPIs increases the odds for acquiring coronavirus disease 2019 (COVID-19) among
community-dwelling Americans. From May 3 to June 24, 2020, we performed an online survey described to participating adults as a "national health survey. Of 53,130 participants, 3,386 (6.4%) reported a positive COVID-19 test. In regression analysis, individuals
using PPIs up to once daily (aOR 2.15; 95% CI, 1.90-2.44) or twice daily (aOR 3.67; 95% CI, 2.93-4.60) had significantly increased odds for reporting a positive COVID-19 test when compared with those not taking PPIs. |
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Al-Qahtani, A, Elgzar, et al |
Psychiatria Danubina |
Public Health response| Interventions de santé publique |
BACKGROUND: COVID-19 is a global pandemic that endanger the health and enforced social distancing for the whole world.
Social distancing may generate stress, anxiety, and depression. Understanding the psychosocial consequences of COVID19 during social distancing may help decision-makers to take suitable decisions that help in increasing awareness. Evaluate the psychosocial
consequences of COVID-19 pandemic during the social distancing period and explore the relationship between social media use and psychological stress during COVID-19 outbreak among Najran city population. Research design is descriptive correlational research
design. SUBJECTS AND METHODS: A snowball sampling technique, was used to recruit participants live in Najran city during the COVID-19 pandemic (1508 participant). RESULTS: A statistically significant differences (P<0.05) are observed between Saudi and non-Saudi
participants in all social aspects assessed except for time spent on social media. In addition, a high mean of depression, stress, and anxiety subscale scores are observed in non-Saudi compared to the Saudi participants with statistically significant differences
(p=0.000). As well as high DASS-21 total scores in non-Saudi compared to the Saudi participants. Also, there are positive statistically significant correlations (≤0.05) between participants' time spent in social media and their depression, stress, anxiety,
and total DASS scores during the COVID-19 outbreak. CONCLUSION: The findings of the present study indicate that COVID-19 pandemic generates stress, anxiety and depression among Najran population especially, non-Saudi. This poor psychological condition is exaggerated
with prolonged social media use. COVID-19 also has negative impact on social wellbeing and use of social media cannot replace direct contact with friends. The current study results may be utilized to formulate interventions that enhance psychosocial health
and resilience during the COVID-19 outbreak. |
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Alqurshi, A |
Saudi Pharmaceutical Journal |
Public Health response| Interventions de santé publique |
This study investigates the effect emergency remote teaching has had on pharmacy education in Saudi Arabia, and to
provide recommendations that may help set in place a contingency strategy. While it was challenging for the majority of teachers (>60%) to delivery complex scientific concepts over virtual classrooms, >35% of students and 60% of teachers have expressed concerns
on the lack of student–student and student–teacher interactions. A factor that has shown a significantly negative correlation with student overall satisfaction (p < 0.01). Emergency remote teaching has forced teachers to alternative assessment methods, which
the majority (70%) believe had a positive effect on students' overall skills. Almost half of students (45%) were concerned by the lack of guidance accompanied by unfamiliar methods of assessments. |
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Alvarado, A, Franceschi, et al |
Pediatr Nephrol |
Clinical data| Données cliniques |
We present a 15-year-old boy who tested positive for SARS-COV-2 infection and onset of nephrotic syndrome, without
antecedent of kidney disease and who had normal urine tests shortly before being affected by COVID-19. |
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Covid-19 lockdown: Housing built environment’s effects on mental health |
Amerio, A, Brambilla, et al |
International Journal of Environmental Research and Public Health |
Public Health response| Interventions de santé publique |
Since the World Health Organization (WHO) declared the coronavirus infectious disease 2019 (COVID-19) outbreak a pandemic
on 11 March, severe lockdown measures have been adopted by the Italian Government. For over two months of stay-at-home orders, houses became the only place where people slept, ate, worked, practiced sports, and socialized. As consolidated evidence exists on
housing as a determinant of health, it is of great interest to explore the impact that COVID-19 response-related lockdown measures have had on mental health and well-being. We conducted a large web-based survey on 8177 students from a university institute
in Milan, Northern Italy, one of the regions most heavily hit by the pandemic in Europe. As emerged from our analysis, poor housing is associated with increased risk of depressive symptoms during lockdown. In particular, living in apartments <60 m2 with poor
views and scarce indoor quality is associated with, respectively, 1.31 (95% CI: 1046–1637), 1.368 (95% CI: 1166–1605), and 2.253 (95% CI: 1918–2647) times the risk of moderate–severe and severe depressive symptoms. Subjects reporting worsened working performance
from home were over four times more likely to also report depression (OR = 4.28, 95% CI: 3713–4924). Housing design strategies should focus on larger and more livable living spaces facing green areas. We argue that a strengthened multi-interdisciplinary approach,
involving urban planning, public mental health, environmental health, epidemiology, and sociology, is needed to investigate the effects of the built environment on mental health, so as to inform welfare and housing policies centered on population well-being.
© MDPI AG. All rights reserved. |
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Association of Mortality and Recent M. Pneumoniae Infection in COVID-19 Patients |
Amin, D, McKitish, et al |
J Med Virol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Objective: To compare characteristics and outcomes of patients who had COVID-19 with M. Pneumoniae Immunoglobulin M
(IgM) antibodies to those without M Pneumoniae antibodies. We retrospectively reviewed cases admitted over a 4-week period between March 17, 2020 and April 14, 2020 to the Hoboken University Medical Center, New Jersey, USA. Of 139 patients admitted with COVID-19,
79 were positive for M. Pneumoniae IgM. The mortality among those who were M. Pneumoniae IgM positive was significantly higher (adjusted odds ratio 2.28, 95% confidence interval 1.03 to 5.03) compared to those who were M. Pneumoniae IgM negative. |
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Getting back to the "new normal": Autonomy restoration during a global
pandemic |
Anicich, EM, Foulk, et al |
J Appl Psychol |
Public Health response| Interventions de santé publique |
We investigate the psychological recovery process of full-time employees during the 2-week period at the onset of the
Coronavirus pandemic (COVID-19). Using growth curve modeling, we examined the temporal trajectories of two manifestations of impaired autonomy—powerlessness and (lack of) authenticity—to test whether recovery began as the pandemic unfolded. We tested our predictions
using a unique experience-sampling dataset collected over a 2-week period beginning on the Monday after COVID-19 was declared a “global pandemic” by the World Health Organization and a “national emergency” by the U.S. Government (March 16–27, 2020). Results
suggest that autonomy restoration was activated even as the pandemic worsened. Employees reported decreasing powerlessness and increasing authenticity during this period, despite their subjective stress-levels not improving. Further, the trajectories of recovery
for both powerlessness and authenticity were steeper for employees higher (vs. lower) in neuroticism, a personality characteristic central to stress reactions. Importantly, these patterns do not emerge in a second experience-sampling study collected prior
to the COVID-19 crisis (September 9–20, 2019), highlighting how the pandemic initially threatened employee autonomy, but also how employees began to recover their sense of autonomy almost immediately. |
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Ashiru-Oredope, Diane |
Research Square prepub |
Healthcare Response | Réponse des soins de santé |
This study aimed to identify and explore the issues currently facing pharmacy team across Commonwealth countries during
the COVID-19 pandemic. The study also evaluates pharmacy professionals’ understanding of key knowledge areas related to COVID-19. Our study confirms pharmacy professional’s concerns about practice during a pandemic and provides preliminary data on the challenges
and learning needs of the profession. Pharmacy professionals have also demonstrated improved knowledge on the management of COVID-19 and resources available for professionals. |
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Emergency decision support modeling for COVID-19 based on spherical fuzzy information |
Ashraf, S, Abdullah, et al |
International Journal of Intelligent Systems |
Public health interventions*| Interventions de santé publique |
This paper introduces many novel approaches to addressing the emergency situation of COVID‐19 under spherical fuzzy
environment. Fundamentally, the paper includes six main sections to achieve appropriate and accurate measures to address the situation of emergency decision‐making. As the spherical fuzzy set (FS) is a generalized framework of fuzzy structure to handle more
uncertainty and ambiguity in decision‐making problems (DMPs). Results explore the effectiveness of our proposed methodologies and provide accurate emergency measures to address the global uncertainty of COVID‐19. |
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Sentiments and emotions evoked by news headlines of coronavirus disease (COVID-19)
outbreak |
Aslam, F, Awan, et al |
Humanities and Social Sciences Communications |
Public Health response| Interventions de santé publique |
Presently, we extracted and classified sentiments and emotions from 141,208 headlines of global English news sources
regarding COVID-19. The headlines considered were those carrying keyword coronavirus between the time frame Jan 15 - Jun 3, 2020 from top rated 25 English news sources. The results reveal that the news headlines had high emotional scores with a negative polarity.
More precisely, around 52% of the news headlines evoked negative sentiments and only 30% evoked positive sentiments while 18% were neutral. Fear, trust, anticipation, sadness, and anger were the main emotions evoked by the news headlines. Overall, the findings
of this study can be weaved together into important implications for emotional wellbeing and economic perspective. |
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Thorax Magnetic Resonance Imaging Findings in Patients with Coronavirus Disease
(COVID-19) |
Ates, OF, Taydas, et al |
Academic Radiology |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
The aim of this study was to compare the findings found in thorax CT, which is increasingly used in the diagnosis of
the important public health problem of coronavirus disease (COVID-19), and the findings of MRI as an important diagnostic alternative. The most common finding in CT was ground-glass opacities in 29 patients (90.6%), followed by consolidation in 14 patients
(43.75%). Both consolidation and ground-glass opacities were also observed in MRI in all of these patients. Nodules were detected in 12 patients (37.5%) on CT and 11 patients (34.4%) on MRI. The sensitivity and specificity of MRI in nodule detection were calculated
as 91.67% and 100%, respectively. Although thorax CT is widely used in the imaging of COVID-19 infection, due to its advantages, MRI can also be used as an alternative diagnostic tool. |
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Auðardóttir, AM, Rúdólfsdóttir, et al |
Gender, Work and Organization |
Public Health response| Interventions de santé publique |
This study adopts a feminist critical approach to explore how parenting was understood during the COVID‐19 restrictive
measures in Iceland. Data consists of 97 stories that were collected during the peak of COVID‐19 in April 2020 using the story completion method. The stories were thematically analysed. The themes demonstrate the power of neoliberal discourses in framing parenting.
Parenting during a pandemic, especially mothering, is constructed as an overwhelming project that requires detailed organization and management. There is also resistance to neoliberal governmentality through redefining successful parenthood. Furthermore, the
gendered nature of domestic work is questioned, especially the traditional, inactive father who prioritizes his own needs only to fail comically in the domestic sphere. The study contributes to our understanding of gendered parenthood in neoliberal, pandemic
times. |
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Hospital ward adaptation during the COVID-19 pandemic: A national survey of academic medical
centers |
Auerbach, A, O'Leary, et al |
Journal of Hospital Medicine |
Healthcare Response | Réponse des soins de santé |
Importance: Although intensive care unit (ICU) adaptations to the coronavirus disease of 2019 (COVID-19) pandemic have
received substantial attention, most patients hospitalized with COVID-19 have been in general medical units. Objective: To characterize inpatient adaptations to care for non-ICU COVID-19 patients. Design: Cross-sectional survey. Setting: A network of 72 hospital
medicine groups at US academic centers. Main Outcome Measures: COVID-19 testing, approaches to personal protective equipment (PPE), and features of respiratory isolation units (RIUs). Results: Fifty-one of 72 sites responded (71%) between April 3 and April
5, 2020. At the time of our survey, only 15 (30%) reported COVID-19 test results being available in less than 6 hours. Half of sites with PPE data available reported PPE stockpiles of 2 weeks or less. Nearly all sites (90%) reported implementation of RIUs.
RIUs primarily utilized attending physicians, with few incorporating residents and none incorporating students. Isolation and room-entry policies focused on grouping care activities and utilizing technology (such as video visits) to communicate with and evaluate
patients. The vast majority of sites reported decreases in frequency of in-room encounters across provider or team types. Forty-six percent of respondents reported initially unrecognized non-COVID-19 diagnoses in patients admitted for COVID-19 evaluation;
a similar number reported delayed identification of COVID-19 in patients admitted for other reasons. Conclusion: The COVID-19 pandemic has required medical wards to rapidly adapt with expanding use of RIUs and use of technology emerging as critical approaches.
Reports of unrecognized or delayed diagnoses highlight how such adaptations may produce potential adverse effects on care. © 2020 Society of Hospital Medicine. |
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Prediction of daily COVID-19 cases in European countries using automatic ARIMA model |
Awan, TM, Aslam, et al |
Journal of Public Health Research |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Automatic ARIMA, one of the predictive models used for forecasting contagions, was used in this study to predict the
number of confirmed cases for next 10 days in four top European countries through R package “forecast”. The study finds that Auto ARIMA applied on the sample satisfactorily forecasts the confirmed cases of coronavirus for next ten days. The confirmed cases
for the four countries show an increasing trend for the next ten days with Spain with a highest number of expected new confirmed cases, followed by Germany and France. Italy is expected to have lowest number of new confirmed cases among the four countries. |
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Impact of climate and ambient air pollution on the epidemic growth during COVID-19
outbreak in Japan |
Azuma, K, Kagi, et al |
Environmental research |
Epidemiology| Épidémiologie |
Ee conducted a longitudinal cohort study of 28 geographical areas of Japan with documented outbreaks of COVID-19. We
analyzed data obtained from March 13 to April 6, 2020, before the Japanese government declared a state of emergency. The results revealed that the epidemic growth of COVID-19 was significantly associated with increase in daily temperature or sunshine hours.
This suggests that an increase in person-to-person contact due to increased outing activities on a warm and/or sunny day might promote the transmission of COVID-19. Our results also suggested that short-term exposure to suspended particles might influence
respiratory infections caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). |
|
Bae, DJ, Tehrani, et al |
American Journal of Cardiology |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
Coronavirus disease 2019 (COVID-19) is a viral pandemic precipitated by the severe acute respiratory syndrome coronavirus
2. Since previous reports suggested that viral entry into cells may involve angiotensin converting enzyme 2, there has been growing concern that angiotensin converting enzyme inhibitor (ACEI) and angiotensin II receptor blocker (ARB) use may exacerbate the
disease severity. In this retrospective, single-center US study of adult patients diagnosed with COVID-19, we evaluated the association of ACEI/ARB use with hospital admission. Secondary outcomes included: ICU admission, mechanical ventilation, length of hospital
stay, use of inotropes, and all-cause mortality. Propensity score matching was performed to account for potential confounders. Among 590 unmatched patients diagnosed with COVID-19, 78 patients were receiving ACEI/ARB (median age 63 years and 59.7% male) and
512 patients were non-users (median age 42 years and 47.1% male). In the propensity matched population, multivariate logistic regression analysis adjusting for age, gender and comorbidities demonstrated that ACEI/ARB use was not associated with hospital admission
(OR 1.2, 95%CI 0.5 to 2.7, p = 0.652). CAD and CKD/end stage renal disease ESRD] remained independently associated with admission to hospital. All-cause mortality, ICU stay, need for ventilation, and inotrope use was not significantly different between the
2 study groups. In conclusion, among patients who were diagnosed with COVID-19, ACEI/ARB use was not associated with increased risk of hospital admission. © 2020 |
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Tendency to worry and fear of mental health during Italy’s COVID-19 lockdown |
Baiano, C, Zappullo, et al |
International Journal of Environmental Research and Public Health |
Public Health response| Interventions de santé publique |
Background: We tested whether the tendency to worry could affect psychological responses to quarantine by capitalizing
on the opportunity of having collected data before the COVID-19 outbreak on measures of worry, anxiety, and trait mindfulness in a group of university students. Methods: Twenty-five participants completed self-report measures assessing worry (Penn State Worry
Questionnaire, PSWQ), anxiety (Anxiety Sensitivity Index, ASI-3), and trait mindfulness (Mindful Attention Awareness Scale, MAAS) at T0 (pre-lockdown, 4 November 2019–17 February 2020) and T1 (at the end of lockdown, 26 April–30 April 2020). We compared assessments
at the two time points in the whole sample and in high and low worriers (defined at T0 by scores on PSWQ respectively above and below 1.5 SD from mean of the Italian normative sample). Outcomes: High worriers showed at T1 a significant increase of anxiety
sensitivity and fear of mental health in comparison to low worriers. Moreover, in the whole sample, at T1 trait mindfulness was inversely related to worry and fear of mental health. Interpretation: A valuable approach to support individuals experiencing anxiety
related to the COVID-19 outbreak could be represented by mindfulness-based interventions improving the ability to focus attention and awareness on the present moment. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. |
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Bakhshaliyev, N, Uluganyan, et al |
Journal of electrocardiology |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
Background: The combination of Hydroxychloroquine (HCQ) and azithromycin showed effectiveness as a treatment for COVID-19
and is being used widely all around the world. Despite that those drugs are known to cause prolonged QT interval individually there is no study assessing the impact of this combination on electrocardiography (ECG). This study aimed to assess the impact of
a 5-day course of HCQ and azithromycin combination on ECG in non-ICU COVID19(+) patients. Methods: In this retrospective observational study, we enrolled 109 COVID19(+) patients who required non-ICU hospitalization. All patients received 5-day protocol of
HCQ and azithromycin combination. On-treatment ECGs were repeated 3-6 h after the second HCQ loading dose and 48-72 h after the first dose of the combination. ECGs were assessed in terms of rhythm, PR interval, QRS duration, QT and QTc intervals. Baseline
and on-treatment ECG findings were compared. Demographic characteristics, laboratory results were recorded. Daily phone call-visit or bed-side visit were performed by attending physician. Results: Of the 109 patients included in the study, the mean age was
57.3 ± 14.4 years and 48 (44%) were male. Mean baseline PR interval was 158.47 ± 25.10 ms, QRS duration was 94.00 ± 20.55 ms, QTc interval was 435.28 ± 32.78 ms, 415.67 ± 28.51, 412.07 ± 25.65 according to Bazett's, Fridericia's and Framingham Heart Study
formulas respectively. ∆PR was −2.94 ± 19.93 ms (p =.55), ∆QRS duration was 5.18 ± 8.94 ms (p =.03). ∆QTc interval was 6.64 ± 9.60 ms (p =.5), 10.67 ± 9.9 ms (p =.19), 14.14 ± 9.68 ms (p =.16) according to Bazett's, Fridericia's and Framingham Heart Study
formulas respectively. There were no statistically significant differences between QTc intervals. No ventricular tachycardia, ventricular fibrillation or significant conduction delay was seen during follow-up. There was no death or worsening heart function.
Conclusion: The 5-day course of HCQ- AZM combination did not lead to clinically significant QT prolongation and other conduction delays compared to baseline ECG in non-ICU COVID19(+) patients. © 2020 Elsevier Inc. |
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Influence of COVID-19 spread on water drinking demand: The case of Puglia Region (Southern
Italy) |
Balacco, G, Totaro, et al |
Sustainability (Switzerland) |
Public Health response| Interventions de santé publique |
The COVID-19 pandemic affected the lives of millions of people, radically changing their habits in just a few days.
In many countries, containment measures prescribed by national governments restricted the movements of entire communities, with the impossibility of attending schools, universities, workplaces, and no longer allowing for traveling or leading a normal social
life. People were then compelled to revise their habits and lifestyles. In such a situation, the availability of drinking water plays a crucial role in ensuring adequate health conditions for people and tackling the spread of the pandemic. Lifestyle of the
population, climate, water scarcity and water price are influent factors on water drinking demand and its daily pattern. To analyze the effect of restriction measures on water demand, the instantaneous flow data of five Apulian towns (Italy) during the lockdown
have been analyzed highlighting the important role of users' habits and the not negligible effect of commuters on the water demand pattern besides daily volume requested. © 2020 by the authors. |
|
Balmeh, N, Mahmoudi, et al |
Informatics in Medicine Unlocked |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The SARS-CoV-2 causes severe pulmonary infectious disease with an exponential spread-ability. In the present research,
we have tried to look into the molecular cause of disease, dealing with the development and spread of the coronavirus disease 2019 (COVID-19). Therefore, different approaches have investigated against disease development and infection in this research; First,
We identified hsa-miR-1307-3p out of 1872 pooled microRNAs, as the best miRNA, with the highest affinity to SARS-CoV-2 genome and its related cell signaling pathways. Second, the findings presented that this miRNA had a considerable role in PI3K/Act, endocytosis,
and type 2 diabetes, moreover, it may play a critical role in the prevention of GRP78 production and the virus entering, proliferation and development. Third, nearly 1033 medicinal herbal compounds were collected and docked with ACE2, TMPRSS2, GRP78, and AT1R
receptors, which were the most noticeable receptors in causing the COVID-19. Among them, there were three common compounds including berbamine, hypericin, and hesperidin, which were more effective and appropriate to prevent the COVID-19 infection. Also, it
was revealed some of these chemical compounds which had a greater affinity for AT1R receptor inhibitors can be suitable therapeutic targets for inhibiting AT1R and preventing the adverse side effects of this receptor. According to the result, clinical assessment
of these three herbal compounds and hsa-miR-1307-3p may have significant outcomes for the prevention, control, and treatment of COVID-19 infection. © 2020 The Author(s) |
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Bao, Le, Zhang, et al |
arXiv |
Epidemiology| Épidémiologie |
Using the traveler data, we estimated a few indicators of the epidemic that affected decision making and policy. Using
only the traveler data, if the assumed epidemic start date was relatively accurate and the traveler sample was representative of the general population, the growth rate estimated from the traveler data was consistent with the domestic data. |
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Baranidharan, G, Bretherton, et al |
British Journal of Pain |
Public Health response| Interventions de santé publique |
This survey aimed to explore the effect of the pandemic on chronic pain in this group and the views of patients towards
undergoing SCS treatment when routine services should resume. This was a prospective, multi-centre telephone patient survey that analysed data from 330 patients with chronic pain who were on an SCS waiting list. Pain, mental health and patient’s ability to
self-manage pain deteriorated in around 47%, 50% and 38% of patients, respectively. Some patients reported increases in pain medication consumption (37%) and reliance on support network (41%). Patients showed a willingness to attend for COVID-19 testing (92%),
self-isolate prior to SCS (94%) and undergo the procedure as soon as possible (76%). Our findings suggest that even during the COVID-19 pandemic, there remains a strong clinical need for patients with chronic pain identified as likely SCS responders to be
treated quickly. |
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Barata, P, Agarwal, et al |
Journal for ImmunoTherapy of Cancer |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
To report a multi-institutional case series of patients with advanced microsatellite instability high (MSI-H) prostate
adenocarcinoma identified with clinical cell-free DNA (cfDNA) next-generation sequencing (NGS) testing and treated with immune checkpoint inhibitors. Retrospective analysis of patients with metastatic castration-resistant prostate cancer (mCRPC) and MSI-H
tumor detected by a commercially available cfDNA NGS assay Guardant360 (G360, Guardant Health) at eight different Academic Institutions in the USA, from September 2018 to April 2020. From a total of 14 MSI-H metastatic prostate cancer patients at participating
centers, nine patients with mCRPC with 56% bone, 33% nodal, 11% liver and 11% soft-tissue metastases and a median PSA of 29.3 ng/dL, were treated with pembrolizumab after 2 lines of therapy for CRPC. The estimated median time on pembrolizumab was 9.9 (95%
CI 1.0 to 18.8) months. Four patients (44%) achieved PSA50 after a median of 4 (3-12) weeks after treatment initiation including three patients with >99% PSA decline. Among the patients evaluable for radiographic response (n=5), the response rate was 60% with
one complete response and two partial responses. Best response was observed after a median of 3.3 (1.4-7.6) months. At time of cut-off, four patients were still on pembrolizumab while four patients discontinued therapy due to progressive disease and one due
to COVID-19 infection. Half of the patients with PSA50 had both MSI-H and pathogenic alterations in BRCA1 and BRCA2 in their G360 assays. The use of liquid biopsy to identify metastatic prostate cancer patients with MSI-H is feasible in clinical practice and
may overcome some of the obstacles associated with prostate cancer tumor tissue testing. The robust activity of pembrolizumab in selected patients supports the generalized testing for MSI-H. © 2020 The Author(s). |
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Potential chimeric peptides to block the SARS-CoV-2 spike receptor-binding
domain |
Barh, D, Tiwari, et al |
F1000Research |
Coronavirology| Coronavirologie |
Background: There are no known medicines or vaccines to control the COVID-19 pandemic caused by SARS-CoV-2 (nCoV).
Antiviral peptides are superior to conventional drugs and may also be effective against COVID-19. Hence, we investigated the SARS-CoV-2 Spike receptor-binding domain (nCoV-RBD) that interacts with hACE2 for viral attachment and entry. Methods: Three strategies
and bioinformatics approaches were employed to design potential nCoV-RBD - hACE2 interaction-blocking peptides that may restrict viral attachment and entry. Firstly, the key residues interacting with nCoV-RBD - hACE2 are identified and hACE2 sequence-based
peptides are designed. Second, peptides from five antibacterial peptide databases that block nCoV-RBD are identified; finally, a chimeric peptide design approach is used to design peptides that can bind to key nCoV-RBD residues. The final peptides are selected
based on their physiochemical properties, numbers and positions of key residues binding, binding energy, and antiviral properties. Results: We found that: (i) three amino acid stretches in hACE2 interact with nCoV-RBD; (ii) effective peptides must bind to
three key positions of nCoV-RBD (Gly485/Phe486/Asn487, Gln493, and Gln498/Thr500/Asn501); (iii) Phe486, Gln493, and Asn501 are critical residues; (iv) AC20 and AC23 derived from hACE2 may block two key critical positions; (iv) DBP6 identified from databases
can block the three sites of the nCoV-RBD and interacts with one critical position, Gln498; (v) seven chimeric peptides were considered promising, among which cnCoVP-3, cnCoVP-4, and cnCoVP-7 are the top three; and (vi) cnCoVP-4 meets all the criteria and
is the best peptide. Conclusions: To conclude, using three different bioinformatics approaches, we identified 17 peptides that can potentially bind to the nCoV-RBD that interacts with hACE2. Binding these peptides to nCoV-RBD may potentially inhibit the virus
to access hACE2 and thereby may prevent the infection. Out of 17, 10 peptides have promising potential and need further experimental validation. © 2020 Barh D et al. |
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Barone, PW, Keumurian, et al |
BioPharm International |
Public Health response| Interventions de santé publique |
This article presents the results of a survey conducted to gain insight on the impact of the COVID-19 pandemic on biomanufacturing
operations. |
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Bechini, A, Garamella, et al |
Journal of preventive medicine and hygiene |
Public Health response| Interventions de santé publique Healthcare Response | Réponse
des soins de santé |
The aim of the present study was to evaluate the impact of the COVID-19 epidemic on paediatric vaccinations administered
by Tuscan paediatricians, as a proxy of adherence to vaccinations during this epidemic period. Four hundred members of the Tuscany section of the Italian Federation of Paediatricians (FIMP) were invited to participate in a semi-structured online survey. During
the COVID-19 pandemic, almost all (98.2%) of the 223 respondents reported a general decline in outpatient paediatric visits; 65.8% reported a more than 60% reduction (144 answers) in comparison with the situation before the COVID-19 pandemic. A total of 208
paediatricians (93.3%) continued to vaccinate in the period considered: 66/208 (31.7%) reported a reduction in parents' compliance with mandatory vaccination (hexavalent and MMRV vaccines), and 88/208 (42.3%) reported a reduction in compliance with non-mandatory
vaccinations. Almost all paediatricians declared having taken preventive actions to counter the spread of SARS-CoV-2. |
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Wahrnehmungen von Pflegenden im Bereich der Intensivpflege während der COVID-19-Pandemie |
Begerow, A, Michaelis, et al |
Pflege |
Healthcare Response | Réponse des soins de santé |
Perceptions of intensive care nurses during the COVID-19 pandemic - A qualitative survey Abstract. Background: While
at the beginning of the COVID-19 pandemic the need for intensive care is increasing, the specific care needs of patients are still largely unknown. This is a challenge for the work of intensive care staff. |
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Behl, R, Mishra, et al |
Global Business Review |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Transmission |
The study captures the COVID-19 lifecycle in different states of India using predictive analytics. Drawing upon the
seminal susceptible–infected–removed (SIR) model of capturing the spread of viral diseases, this study models the spread of COVID-19 in the ten most infected states of India (as on 30 April 2020). Using publicly available state-wise time series data of COVID-19
patients during the period 1–30 April 2020, the study uses the forecasting technique of auto-regressive integrated moving averages (ARIMA) to predict the likely population susceptible to COVID-19 in each state. Thereafter, based on the SIR model, predictive
modelling of state-wise COVID-19 data is carried out to determine: (a) the predictive accuracy; (b) the likely number of days it would take for the disease to reach the peak number of infections in a state; (c) the likely number of infections at the peak;
and (d) the state-wise end date. The SIR model is implemented by running Python 3.7.4 on Jupyter Notebook and using the package Matplotlib 3.2.1 for visualization. The study offers rich insights for policymakers as well as common citizens. © 2020 International
Management Institute, New Delhi. |
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Belmin, J, Um-Din, et al |
JAMA network open |
Epidemiology| Épidémiologie Infection Prevention and Control/ Prévention et contrôle
des infections (IPAC/PCI) Healthcare Response | Réponse des soins de santé |
This study aimed to investigate COVID-19-related outcomes in French nursing homes that implemented voluntary staff
confinement with residents. This retrospective cohort study was conducted in French nursing homes from March 1 to May 11, 2020. This study included 17 nursing homes in which 794 staff members confined themselves to the facility with their 1250 residents. The
national survey included 9513 facilities with 385 290 staff members and 695 060 residents. Only 1 nursing home with staff who self-confined (5.8%) had cases of COVID-19 among residents, compared with 4599 facilities in the national survey (48.3%) (P < .001).
Five residents (0.4%) in the nursing homes with staff who self-confined had confirmed COVID-19, compared with 30 569 residents (4.4%) with confirmed COVID-19 in the national survey (P < .001); no residents of facilities with self-confinement had possible COVID-19,
compared with 31 799 residents (4.6%) with possible COVID-19 in the national survey (P < .001). Five residents (0.4%) in the nursing homes with staff who self-confined died of COVID-19, compared with 12 516 (1.8%) in the national survey (odds ratio, 0.22;
95% CI, 0.09-0.53; P < .001). Twelve staff members (1.6%) from the facilties with self-confinement had confirmed or possible COVID-19, compared with 29 463 staff members (7.6%) in the national survey (P < .001). |
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SARS-CoV-2 seroprevalence in a Belgian cohort of patients with cystic fibrosis |
Berardis, S, Verroken, et al |
Journal of Cystic Fibrosis |
Epidemiology| Épidémiologie Immunology | Immunologie |
Background: In Belgium, COVID-19 epidemy began on February 4, 2020 with a peak on April 10, 2020. Patients with cystic
fibrosis (CF) followed in the Cliniques universitaires Saint-Luc were rapidly isolated before the government lockdown. Methods: After the peak of the epidemy, we measured anti-SARS-CoV-2 IgM and IgG antibodies in 149 patients and collected clinical data. Results:
Only 3 asymptomatic patients presented IgG against the virus. In one patient hospitalized for COVID-19 (positive molecular testing), we did not detect any anti-SARS-CoV-2 antibodies, as in thirty-five other symptomatic patients considered as possible cases.
Conclusions: Even if respiratory symptoms linked to CF are frequent and compatible with COVID-19, anti-SARS-CoV-2 IgG antibodies were detected only in 3 asymptomatic patients. This reassuring study concerning the risk of COVID-19 in patients with CF illustrates
the difficulty to distinguish COVID-19 symptoms from respiratory exacerbations and the need of generalized molecular testing to make a precise diagnosis. © 2020 |
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Bernardino, R, Gil, et al |
Actas Urologicas Espanolas |
Healthcare Response | Réponse des soins de santé |
We compared the number of elective consultations and urological diagnostic tests, the number and type of elective surgeries,
as well as the demographic characteristics of the patients and the main causes of admission to the Urology Emergency Service (ED) during COVID and non-COVID periods. The multivariate analysis showed an association between the sex of the patient and the fact
of undergoing surgery, with a 65.6% decrease in the probabilities for the male gender. The period (COVID versus non-COVID) did not show a significant association with surgery. |
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Bhandari, S, Shaktawat, et al |
International Journal of Academic Medicine |
Epidemiology| Épidémiologie |
An ecological study was undertaken to compare the standardized trends of cumulative cases of top eight highly COVID-19
affected states of India with linear regression modeling. It was observed that evolution of COVID-19 was the highest in the state of Gujarat (b = 0.186, P < 0.001) followed by Madhya Pradesh (b = 0.166, P < 0.001), Maharashtra (b = 0.159, P < 0.001), Delhi
(b = 0.156, P = 0.02), Rajasthan (b = 0.136, P = 0.98), Uttar Pradesh (b = 0.117, P < 0.001), Tamil Nadu (b = 0.091, P < 0.001), and Andhra Pradesh (b = 0.076, P < 0.001) respectively. |
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Bhat, P, Noval, et al |
International Journal of Infectious Diseases |
Clinical data| Données cliniques |
A 25-year-old male presented with profound hypoxemia despite use of a non-rebreather mask during the SARS-CoV-2 pandemic.
Chest X-ray showed a large right pneumothorax and extensive interstitial disease. Hypoxemia continued despite chest tube placement, necessitating emergent intubation. Computed tomography (CT) of the chest was obtained and nasopharyngeal SARS-CoV-2 PCR was
positive. HIV serology was positive and his absolute CD4+ count was 32 cells/mm3. Given his severe acquired immunodeficiency, radiographic findings were concerning for a life-threatening co-infection with Pneumocystis jirovecii, and treatment with trimethoprim–sulfamethoxazole,
prednisone, and remdesivir was started. Four days later, Pneumocystis pneumonia (PCP) was confirmed by bronchoscopic Pneumocystis antigen. The patient improved clinically and was successfully extubated 21 days later. |
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Changing epidemiology of SARS-CoV in the context of COVID-19 pandemic |
Bhattacharya, S, Basu, et al |
Journal of preventive medicine and hygiene |
Epidemiology| Épidémiologie |
This study is also an endeavor to review and analyze the gradual changes of the genetic makeup of SARS-CoV from evolutionary
and epidemiological perspectives. The raw data of COVID-19 cases and death incidences were collected from the World Health Organization (WHO) website from the time period: 1st April to 6th April, 2020. Western pacific region, European region and Americas
have the greatest number of infected cases (P < 0.001); whereas deaths have been found to be significantly higher in Europe (P < 0.001). Total number of confirmed cases and deaths in south-east Asia are comparatively lower (P < 0.001). Case fatality rate (CFR)
has also found significant for European region. SARS-CoV-2 is considered to be a strain of SARS-CoV that has a high rate of pathogenicity and transmissibility. Result indicated that the European region has been affected mostly for both cases and death incidences.
The novel mutations in SARS-CoV-2 possibly increase the virus infectivity. Genetic heterogeneity of this virus within the human population might originate as the representatives of naturally selected virus quasispecies. |
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Bhattacharyya, R, K |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
The basic Susceptible-Infected-Recovered (SIR) model is extended to include effects of progressive social awareness,
lockdowns and anthropogenic migration in India. It is found that social awareness can effectively contain the spread by lowering the basic reproduction rate R0. The paper also separates the mortality fraction from the clinically recovered fraction and attempts
to model the outcome of lockdowns, in absence and presence of social awareness. It is seen that staggered exits from lockdowns are not only economically beneficial but also helps to curb the infection spread. Moreover, a staggered exit strategy with progressive
social awareness is found to be the most efficient intervention. The paper also explores the effects of anthropogenic migration on the dynamics of the epidemic in a two-zone scenario. |
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Scenarios for the Spread of COVID-19 in Manaus, Northern Brazil |
Bitar, S, Steinmetz, et al |
Anais da Academia Brasileira de Ciencias |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique |
We use a compartmental model to project scenarios for the spread of COVID-19 in the city of Manaus, with different
degrees of social distancing and isolation of infectious individuals. In a scenario without any containment measures, our projections point to more than 50,000 (simultaneously) infectious individuals before the end of April 2020. Only in a scenario with strict
and extensive social distancing (lockdown), implemented and observed as of March 23rd, 2020, would this number be less than 50,000 in the first half of June. Furthermore, an increase in the number of tests or in the collective awareness among the population
regarding the importance of strict distancing measures would have only had a significant impact if implemented before the end of March. |
|
Biviá-Roig, G, La Rosa, et al |
International Journal of Environmental Research and Public Health |
Public Health response| Interventions de santé publique |
This study aimed to analyze the impact of the confinement due to the COVID-19 pandemics on the eating, exercise, and
quality-of-life habits of pregnant women. This was an internet-based cross-sectional survey which collected information about adherence to the Mediterranean diet, physical exercise, health-related quality of life (HRQoL), and perceived obstacles (in terms
of exercise, preparation for delivery, and medical appointments) of pregnant women before and after the confinement. The survey was conducted in 18–31 May 2020. A total of 90 pregnant women participated in this study. There was a significant decrease in the
levels of physical activity (p < 0.01) as well as in HRQoL (p < 0.005). The number of hours spent sitting increased by 50% (p < 0.001), 52.2% were unable to attend delivery preparation sessions because these had been cancelled. However, there were no significant
differences in the eating pattern of these women (p = 0.672). |
|
|
Blekas, A, Voitsidis, et al |
Psychol Trauma |
Healthcare Response | Réponse des soins de santé |
This study assesses the emergence of posttraumatic stress symptoms (PTSS) in Greek health care professionals during
the COVID-19 pandemic. Health care professionals appeared to be moderately stressed from the COVID-19 crisis, with women scoring higher on all clinical scales and the difference between women and men being statistically significant. |
|
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Acute loss of smell and taste among patients with symptoms compatible with covid-19 |
Bodnia, NC, Katzenstein, et al |
Danish Medical Journal |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
INTRODUCTION: The aim of this study was to describe the clinical symptoms, including affection of sense of smell and
taste, among participants in a party held in Copenhagen after which many participants reported symptoms compatible with coronavirus disease 2019 (COVID-19). METHODS: A 37-item questionnaire was sent electronically to all 95 participants seven weeks after the
party. The questionnaire included questions about the type, timing and duration of COVID-19 symptoms. RESULTS: In total, 65 of 95 (68%) participants responded, among whom 51/65 (78%) had symptoms compatible with COVID-19; 53% (27/51) had affection of their
sense of smell and taste; 70% (19/27) reported a total loss of taste. These symptoms continued for 1-3 weeks for 78% and 3-6 weeks for 22% (6/27). Interestingly, 11/27 (41%) reported that they had not fully regained their sense of taste and 3/27(11%) were
still very affected by this symptom. Moreover, 44% of the respondents who had lost their sense of taste perceived this symptom as moderate to severe. Eighty-one percent (22/27) reported a total loss of smell. This symptom continued for 1-3 and > 3 weeks in
74% and 26%, respectively. At the time of the investigation, 48% had not fully regained their sense of smell and 7% were still very affected. More than half of the respondents who lost their sense of smell perceived this symptom as moderate to severe. CONCLUSIONS:
Many patients with clinically diagnosed COVID-19 report an affected sense of smell and taste. The duration of these symptoms currently remains unknown. FUNDING: none. TRIAL REGISTRATION: not relevant. © 2020, Danish Medical Association. All rights reserved. |
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Böjti, PP, Stang, et al |
Orvosi hetilap |
Healthcare Response | Réponse des soins de santé |
Our goal was to assess the effect of COVID-19 pandemic on Hungarian acute ischemic stroke care. We compared demographical
and clinical characteristics, rate of intravenous and endovascular therapies and therapeutic time parameters of acute ischemic strokes admitted to a university stroke centre in a COVID-epidemic period (01/03/2020-30/04/2020) and an identical period of 2019.
86 patients were admitted during the COVID-period and 97 in the control period. In the COVID-period, the proportion of patients arriving beyond 24 hours after onset increased by 13% (p = 0.046), the rate of endovascular interventions remained unchanged (8%),
the rate of intravenous thrombolysis decreased from 26% to 16%, the mean onset-to-treatment time of thrombolysis increased by 20 minutes, while the mean door-to-treatment time increased by only 5 minutes. Behind the shift of arrival time categories, multivariable
(year of examination, NIHSS, age) logistic regression shows that the year of examination might play a leading role (p = 0.096). |
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COVID-19 reopening causes
high risk of irrit ant cont act dermat it is in children |
Borch, L, Thorsteinsson, et al |
Danish Medical Journal |
Public Health response| Interventions de santé publique |
The aim of the present study was to evaluate if frequent hand washing increases the incidence of irritant contact dermatitis
(ICD) in children. We conducted an observational study in Denmark during the reopening of schools and daycare facilities for children aged 0-12 years (April 22nd to May 1st 2020). A questionnaire was sent out to parents in four municipalities consisting of
20 questions about frequency of hand washing, use of hand sanitiser, symptoms of ICD, atopic dermatitis, allergy and predispositions. The study included 6,273 children. In children without any prior symptoms of dermatitis, 42.4% experienced ICD (dry, red and
itchy skin) due to increased hand hygiene. Schoolchildren had a 1.5 times greater relative risk of developing ICD than preschool children. Frequency of hand washing was a strong risk factor, whereas this was not the case for alcohol-based hand sanitiser. Hand
washing 7-10 times/day and >10 times/day increased the relative risk by 1.83 and 2.23 times, respectively. |
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Moral Suasion and the Private Provision of Public Goods: Evidence from the COVID-19
Pandemic |
Bos, B, Drupp, et al |
Environmental and Resource Economics |
Economics | Économie |
Based on a survey experiment with a representative sample of around 3500 Germans at the beginning of the pandemic,
we study how moral appeals affect contributions with low and high opportunity costs, hand washing and social distancing, to reduce the infection externality as well as the support for governmental regulation. We find that Deontological moral suasion, appealing
to individual moral duty, is effective in increasing planned social distancing and hand-washing, while a Consequentialist appeal only increases planned hand-washing. Both appeals increase support for governmental regulation. Exploring heterogeneous treatment
effects reveals that younger respondents are more susceptible to Deontological appeals. Our results highlight the potential of moral appeals to induce intended private contributions to a public good or the reduction of externalities, which can help to overcome
collective action problems for a range of environmental issues. |
|
International electronic health record-derived COVID-19 clinical course profiles:
the 4CE consortium |
Brat, GA, Weber, et al |
npj Digital Medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We leveraged the largely untapped resource of electronic health record data to address critical clinical and epidemiological
questions about COVID-19. To do this, we formed an international consortium (4CE) of 96 hospitals across five countries (www.covidclinical.net). Data covered 27,584 COVID-19 cases with 187,802 laboratory tests. Case counts and laboratory trajectories were
concordant with existing literature. Laboratory tests at the time of diagnosis showed hospital-level differences equivalent to country-level variation across the consortium partners. Despite the limitations of decentralized data generation, we established
a framework to capture the trajectory of COVID-19 disease in patients and their response to interventions. |
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COVID-19 Infection in an Immunosuppressed Patient with Arthritis |
Braun-Moscovici, Y, Zisman, et al |
The Israel Medical Association journal : IMAJ |
Clinical data| Données cliniques |
This case report describes a COVID-19 Infection in an immunosuppressed patient with arthritis. |
|
Braunstein, ED, Reynbakh, et al |
J Cardiovasc Electrophysiol |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
A mobile telemetry system was successfully implemented for inpatient use during the COVID‐19 pandemic and was shown
to be useful to inform patient management, detect occult arrhythmias, and monitor the QT‐interval. Patients with advanced age and structural heart disease may be more likely to benefit from this system. |
|
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Changes in air pollution during COVID-19 lockdown in Spain: A multi-city study |
Briz-Redón, Á, Belenguer-Sapiña, et al |
Journal of Environmental Sciences (China) |
Public health interventions*| Interventions de santé publique |
This study investigated the impact of short-term lockdown during the period from March 15th to April 12th 2020 on the
atmospheric levels of CO, SO2, PM10, O3, and NO2 over 11 representative Spanish cities. The possible influence of several meteorological factors (temperature, precipitation, wind, sunlight hours, minimum and maximum pressure) on the pollutants' levels were
also considered. The results obtained show that the 4-week lockdown had significant impact on reducing the atmospheric levels of NO2 in all cities except for the small city of Santander as well as CO, SO2, and PM10 in some cities, but resulted in increase
of O3 level. |
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Stranded College Students amid Corona Virus Disease 2019 Pandemic: An Existential
Phenomenology |
Cahapay, MB |
Journal of Loss and Trauma |
Public Health response| Interventions de santé publique |
This paper explores the lived experiences of college students who are stranded in the middle of the COVID-19 crisis.
It follows the approach of Heideggerian existential phenomenology in studying ontology or what it means to be. Five college students were purposively selected to participate in the study. The researcher gained insight into each world of the students using
interview procedures and thematic analysis. The results are presented through emerging themes and contextual ground. A conceptual structure that depicts the essence of the lived experiences of the stranded college students is offered in the end of the paper |
|
Cakiroglu, S, Yeltekin, et al |
J Pediatr Hematol Oncol |
Public Health response| Interventions de santé publique |
We aimed to detect the anxiety levels of children with hematologic or oncologic disease and of their parents after
the COVID-19 outbreak. Even though they were in the high-risk group, children with a hematology-oncology disease and their families had pandemic-related anxiety levels comparable to those of healthy peers and their families. |
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|
Calvo-Cebrián, A, Alonso-Roca, et al |
J Ultrasound Med |
Clinical data| Données cliniques |
We assess whether lung ultrasound (LUS) examinations performed by primary care (PC) physicians are a useful tool to
detect lung injury and may help in decisions about hospital referral. The proposed LUS severity scale was significantly associated with the main outcome of appropriate referral (P = 0.001): the higher the scale, the higher the percentage of adequate referrals. |
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Tuberculosis and COVID-19: An overlapping situation during pandemic |
Can Sarınoğlu, R, Sili, et al |
Journal of infection in developing countries |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
INTRODUCTION: The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for
the coronavirus disease 2019 (COVID-19). First COVID-19 case was detected in March, 10, 2020 in Turkey and as of May, 18, 2020 148,067 cases have been identified and 4096 citizens have died. Tuberculosis (TB) is a worldwide public health concern, incidence
of tuberculosis (per 100,000 people) in Turkey was reported at 14, 1 in 2018. During pandemic COVID-19 was the main concern in every clinic and as we discuss here overlapping respiratory diseases may result in delaying of the diagnosis and treatment. METHODOLOGY:
There were 4605 respiratory samples examined between March 23 and May 18 for COVID-19 and 185 samples for Mycobacterium tuberculosis in our laboratory. The Xpert Ultra assay was performed for the diagnosis of pulmonary tuberculosis; SARS-CoV-2 RNA was determined
by real-time PCR (RT-PCR) analysis in combined nasopharyngeal and deep oropharyngeal swabs of suspected cases of COVID-19. RESULTS: Both of SARS-CoV-2 and M. tuberculosis tests were requested on the clinical and radiological grounds in 30 patients. Here we
discussed 2 patients who were both COVID-19 and TB positive. One patient already diagnosed with tuberculosis become COVID-19 positive during hospitalization and another patient suspected and treated for COVID-19 received the final diagnosis of pulmonary TB
and Human Immunodeficiency Virus infection. CONCLUSIONS: We want to emphasize that while considering COVID-19 primarily during these pandemic days, we should not forget one of the "great imitators", tuberculosis within differential diagnoses. Copyright (c)
2020 Rabia Can Sarınoğlu, Uluhan Sili, Emel Eryuksel, Sehnaz Olgun Yildizeli, Cagatay Cimsit, Aysegul Karahasan Yagci. |
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Intravenous tPA for Acute Ischemic Stroke in Patients with COVID-19 |
Carneiro, T, Dashkoff, et al |
Journal of Stroke and Cerebrovascular Diseases |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
We present a multicenter case series from 9 centers in the United States of patients with acute neurological deficits
consistent with AIS and COVID-19 who were treated with IV tPA. We identified 13 patients (mean age 62 (±9.8) years, 9 (69.2%) male). All received IV tPA and 3 cases also underwent mechanical thrombectomy. All patients had systemic symptoms consistent with
COVID-19 at the time of admission: fever (5 patients), cough (7 patients), and dyspnea (8 patients). The median admission NIH stroke scale (NIHSS) score was 14.5 (range 3–26) and most patients (61.5%) improved at follow up (median NIHSS score 7.5, range 0–25).
No systemic or symptomatic intracranial hemorrhages were seen. Stroke mechanisms included cardioembolic (3 patients), large artery atherosclerosis (2 patients), small vessel disease (1 patient), embolic stroke of undetermined source (3 patients), and cryptogenic
with incomplete investigation (1 patient). Three patients were determined to have transient ischemic attacks or aborted strokes. Two out of 12 (16.6%) patients had elevated fibrinogen levels on admission (mean 262.2 ± 87.5 mg/dl), and 7 out of 11 (63.6%) patients
had an elevated D-dimer level (mean 4284.6 ±3368.9 ng/ml). |
|
COVID-19 challenge: proactive management of a Tertiary University Hospital in
Veneto Region, Italy |
Carretta, G, Contessa, et al |
Pathogens and Global Health |
Healthcare Response | Réponse des soins de santé |
Background: The aim of this study is to describe the successful emergency plan implemented by Padova University Hospital
(AOUP) during the COVID-19 pandemic. Methods: The emergency plan included early implementation of procedures aimed at meeting the increasing demand for testing and care while ensuring safe and timely care of all patients and guaranteeing the safety of healthcare
workers. Results: From 21 February to 1 May 2020, there were 3,862 confirmed cases of SARS-CoV-2 infection in the Province of Padua. A total of 485 patients were hospitalized in AOUP, of which 91 were admitted to the ICU; 12 .6% of admitted patients died.
The average bed occupancy rate in the ICU was 61.1% (IQR 43.6%:77.4%). Inpatient surgery and inpatient admissions were kept for 76% and 74%, respectively, compared to March 2019. A total of 123,077 swabs were performed, 19.3% of which (23,725 swabs) to screen
AOUP workers. The screening of all staff showed that 137 of 7,649 (1.8%) hospital workers were positive. No healthcare worker died. Discussion: AOUP strategy demonstrated effective management of the epidemic thanks to the timely implementation of emergency
procedures, a well-coordinated effort shared by all hospital Departments, and their continuous adjustment to the ongoing epidemic. Timely screening of all hospital workers proved to be particularly important to defend the hospital, avoiding epidemic clusters
due to unknown positive cases. © 2020 Informa UK Limited, trading as Taylor & Francis Group. |
|
Castellvi, J, Jerico, et al |
International Journal of Surgery Open |
Healthcare Response | Réponse des soins de santé |
Background: In the oncological patient, an COVID-19-Infection, whether symptomatic or asymptomatic, a surgical procedure
may carry a higher postoperative morbidity and mortality. The aim of this study was to describe the impact on clinical practice of sequential preoperative screening for COVID-19-infection in deciding whether to proceed or postpone surgery. Methods: Prospective,
cohort study, based on consecutive patients’ candidates for an oncological surgical intervention. Sequential preoperative screening for COVID-19-infection: two-time medical history (telematic and face-to-face), PCR and chest CT, 48 h before of surgical intervention.
COVID-19-infection was considered positive if the patient had a suggestive medical history and/or PCR-positive and/or CT of pneumonia. Results: Between April 15th and May 4th, 2020, 179 patients were studied, 97 were male (54%), mean (sd) age 66.7 (13,6).
Sequential preoperative screening was performed within 48 h before to surgical intervention. The prevalence of preoperative COVID-19-infection was 4.5%, 95%CI:2.3–8.6% (8 patients). Of the operated patients (171), all had a negative medical history, PCR and
chest CT. The complications was 14.8% (I-II) and 2.5% (III-IV). There was no mortality. The hospital stay was 3.1 (sd 2.7) days. In the 8 patients with COVID-19-infection, the medical history was suggestive in all of them, 7 presented PCR-positive and 5 had
a chest CT suggestive of pneumonia. The surgical intervention was postponed between 15 and 21 days. Conclusion: Preoperative screening for COVID-19-infection using medical history and PCR helped the surgeon to decide whether to go ahead or postpone surgery
in oncological patients. The chest CT may be useful in unclear cases. © 2020 The Authors |
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SARS-CoV-2 neutralizing antibody levels are correlated with severity of COVID-19
pneumonia |
Chen, W, Zhang, et al |
Biomedicine and Pharmacotherapy |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this study, we collected blood samples from 49 patients recently recovered from COVID-19. Serum NAbs were measured
using a novel surrogate virus neutralization test (sVNT). The median time to blood collection (for NAb analysis) from illness onset, viral clearance and discharge were 43.0 days (IQR, 36.0–50.0), 27.0 days (IQR, 20.5–37) and 17.0 days (IQR, 15.0–33.0), respectively.
Patients had a median NAb titer of 1: 40 (IQR, 1:15–1:120). NAbs were not detected in two asymptomatic children who quickly cleared the virus. NAb titers were higher in patients with older age (p = 0.020), symptomatic infection (p = 0.044), more profound lung
involvement (p＜0.001), abnormal C-reactive protein level (p＜0.01)
and elevated lactate dehydrogenase (p = 0.019). Multivariable analysis revealed that severity of pneumonia and having comorbidity positively correlated with NAb titers in recovered patients (p = 0.02), while use of corticosteroids negatively impacted NAb titers
(p = 0.01). Our study suggests that some COVID-19 patients may not have detectable NAb after recovery. SARS-CoV-2 NAb titers are positively correlated with severity of COVID-19 pneumonia. |
|
Chen, Y, Zhang, et al |
Science of the Total Environment |
Public health interventions*| Interventions de santé publique |
We investigated the concentration of both gaseous and particulate pollutants and aerosol light absorption at different
levels of (RMPHE) in an urban area of southwestern China. During the lockdown, PM2.5, PM10, SO2, NOx, and BC decreased by 30–50%, compared to the pre-Level 1 RMPHE period. Meanwhile, the decrease of NOx caused the rise of O3 by up to 2.3 times due to the volatile
organic compounds (VOCs) limitation. The aerosol light absorption coefficient at multiple wavelengths decreased by 50%, and AAE decreased by 20% during the Level 1 RMPHE. BrC played essential roles in light absorption after the RMPHE was announced, accounting
for 54.0% of the aerosol absorption coefficient at 370 nm. Moreover, the lockdown down-weighted the fraction of fossil fuel in BC concentrations to 0.43 (minima). This study characterizes air pollution at the most basic level and can provide policymakers with
references for the “baseline.” |
|
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Have traffic restrictions improved air quality? A shock from COVID-19 |
Chen, Z, Hao, et al |
Journal of Cleaner Production |
Public health interventions*| Interventions de santé publique |
Using daily data before and after the outbreak of COVID-19, an exogenous shock, this paper analyzes the effects of
private vehicle restriction policies on air pollution. We find that the private vehicle restriction policies reduce the degree of air pollution to a certain extent. However, their effect varies with other policies implemented in the same period and the economic
development of the city itself. Through the analysis of different categories of restrictions, we find that restriction policy for local fuel vehicles and the restriction policy based on the last digit of license plate numbers have the best effect in reducing
air pollution. Under the background of COVID-19 epidemic and the implementation of private vehicle restriction policies and other traffic control policies during this period, we have also obtained other enlightenment on air pollution control. |
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Twitter Interaction to Analyze Covid-19 Impact in Ghana, Africa from March to July |
Chire Saire, Josimar, Panford-Quainoo, et al |
arXiv |
Public Health response| Interventions de santé publique |
In this study, we use text mining to draw insights from data collected from the social network, Twitter. Our exploration
of the data led us to understand the most frequent topics raised in the Greater Accra region of Ghana from March to July 2020. We observe that the engagement of users of this social network was initially high in March but declined from April to July. The reason
was probably that the people were becoming more adapted to the situation after an initial shock when the disease was announced in the country. We also found certain words in these tweets of users that enabled us to understand the sentiments and mental state
of individuals at the time. |
|
Chire-Saire, Josimar |
arXiv |
Public Health response| Interventions de santé publique |
This paper aims to explore the impact of lockdown over the psychological aspect of the people of all the Spanish speaking
South American capitals. We have utilized infodemiology approach by employing large-scale Twitter data-set over 33 million feeds in order to understand people's interaction over the months of this on-going coronavirus pandemic. At the beginning of the pandemic,
people demonstrated strong emotions (i.e. anxiety, worry, fear) which declined over time even though the actual pandemic is worsening by having more positive cases, and inflicting more deaths. |
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|
Cholankeril, G, Podboy, et al |
Gastroenterology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Aiming to characterize the gastrointestinal manifestations in patients with SARS-CoV-2 at their institution( California)
, authors performed a retrospective analysis on data collected from consecutive patients who presented to our institution between March 4, 2020, and March 24, 2020. Results add to the growing body of literature that note a significant proportion of concurrent
gastrointestinal manifestations related to the SARS-CoV-2. Elevation in AST levels was the lone variable correlated to disease activity. |
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|
Chowdhary, A, Tarai, et al |
Emerg Infect Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In New Delhi, India, candidemia affected 15 critically ill coronavirus disease patients admitted to an intensive care
unit during April-July 2020. Candida auris accounted for two thirds of cases; case-fatality rate was high (60%). Hospital-acquired C. auris infections in coronavirus disease patients may lead to adverse outcomes and additional strain on healthcare resources. |
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Frequency of COVID-19 IgG Antibodies among Special Police Squad Lahore, Pakistan |
Chughtai, OR, Batool, et al |
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP |
Epidemiology| Épidémiologie Immunology | Immunologie |
OBJECTIVE: To find out the sero-prevalence of COVID-19 IgG antibodies among policemen performing duties at high risk
areas of Lahore, Pakistan. STUDY DESIGN: Cross-sectional, observational study. PLACE AND DURATION OF STUDY: Chughtai Lab Lahore from 20th to 30th May 2020. METHODOLOGY: One hundred and fifty-four young policemen (mean age 27.1 ±3.8 years) were included in
the study after written consent. Squad officers who had any sign of acute respiratory infection were excluded from the study. The participants were asked to fill a questionnaire regarding nature of exposure with the infected cases, kind of personal protective
equipment they are provided with and living arrangements. Three ml of blood samples were collected from the participants and immediately sent to the lab for analysis. COVID-19 IgG antibodies were analysed using chemiluminescence immunoassay method on Architect
Ci8200 (Abbott). SPSS 23.0 was used for data analysis. RESULTS: All participants were males and mean age was 27.1 ±3.8 years. Out of 154 squad members, 24 were reactive for COVID-19 IgG antibodies and performing duties at the areas of high virus exposure.
None of COVID-19 IgG reactive cases exhibited symptoms and most of them performed duties at high risk areas with only masks provided as personal protective equipment. Only 10% of the participants who were exposed to confirmed cases of COVID-19 were found to
have anti-COVID IgG. CONCLUSION: COVID-19 IgG antibody reactive cases may not show any symptoms. Police force is at high risk of exposure. Serosurveys can help to find the spread of infection in the community and aid in planning healthcare strategies. Key
Words: COVID-19, SARS CoV-2, Seroprevalence, Pandemic, Asymptomatic cases. |
|
Chun, TT, Judelson, et al |
Journal of Vascular Surgery |
Healthcare Response | Réponse des soins de santé |
The objective of this study was to describe the structure, practice patterns, and outcomes of these vascular access
teams during the COVID-19 pandemic. Implementation of a dedicated central venous access line team during a pandemic or other health care crisis is a way by which physicians trained in central venous access can contribute their expertise to a stressed health
care system. A line team composed of physicians with vascular skill sets provides relief to resource-constrained intensive care unit, ward, and emergency medicine teams with a low rate of iatrogenic complications relative to historical reports. |
|
|
Clark, Tristan, Brendish, et al |
SSRN- Lancet prepublication |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
We performed a prospective, interventional, non-randomised, controlled study of molecular point-of-care testing (POCT)
in adults presenting to hospital with suspected COVID-19. POCT was associated with large reductions in time to results and improvements in infection control measures, and had high diagnostic accuracy. |
|
|
Colombo, L, Macheda, et al |
Respiratory Medicine Case Reports |
Clinical data| Données cliniques |
Background: Although the most known feature of SARS-CoV-2 associated infection is a mild to severe pneumonia, increasing
evidence suggests the existence of an infection-associated risk of both arterial and venous thromboembolism (VTE), but the exact magnitude of this phenomenon is still unknown. Given that, it is important for the Emergency Physician to remember that a SARS-CoV-2
associated respiratory failure can be caused not only by the pulmonary parenchymal inflammation that characterizes the pneumonia, but also by an associated pulmonary thromboembolism. Case report: A healthy 73-years old woman admitted to the ED for dyspnea,
fever and thoracic pain. Cardiac ultrasound, electrocardiogram and clinical findings suggested a diagnosis of cardiogenic obstructive shock due to acute pulmonary embolism, successfully treated with thrombolysis. A CT angiography confirmed the pulmonary embolism
(EP) diagnosis and showed bilateral pneumonia, caused by SARS-CoV-2 infection. Conclusion: Considering the high prevalence of thromboembolic events in COVID-19 patients it is mandatory for the emergency physician to systematically evaluate signs of pulmonary
thromboembolism, in order to perform the most patient-tailored therapy as soon as possible. © 2020 The Author(s) |
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Encephalitis associated with COVID-19 in a 13-year-old girl: A case report |
Conto-Palomino, N, Cabrera-Bueno, et al |
Medwave |
Clinical data| Données cliniques |
There are limited reports of neurological symptoms in the pediatric population with COVID-19. We report a 13-year-old
girl with three days of illness characterized by headache, non-explosive vomiting, fever, and sudden-onset sensory disorder associated with difficulty in standing and hemiparesis in limbs without evidence of meningeal signs. Brain tomography revealed diffuse
brain edema, and the cerebrospinal fluid study was consistent with a viral infection. COVID-19 was diagnosed based on serology. The patient had an untoward clinical course despite treatment with hydroxychloroquine, azithromycin, and corticosteroids, dying
on the third day of hospitalization. Encephalitis in a patient with COVID-19 is not frequently reported in the pediatric population. It should be considered in the differential diagnosis in patients who arrives at the emergency with a sensory disorder or neurological
symptomatology in the context of the COVID-19 pandemic. |
|
Pulmonary embolism or thrombosis in ARDS COVID-19 patients: A French monocenter
retrospective study |
Contou, D, Pajot, et al |
PLoS One |
Clinical data| Données cliniques |
We aimed to assess the rate and to describe the clinical features and the outcomes of ARDS COVID-19 patients diagnosed
with PE during ICU stay. The low rate of lower limb venous thrombosis together with the high rate of distal pulmonary thrombus argue for a local immuno-thrombotic process associated with the classic embolic process. |
|
Costa, SF, Buss, et al |
Journal of Clinical Virology |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We evaluated a rapid chromatographic immunoassay (IgG/IgM antibodies) and an ELISA assay to diagnose COVID-19 in patient
sat two Brazilian hospitals. A total of 122 subjects with COVID-19 were included: 106 SARS-COV-2 RT-PCR-positive patients and 16 RT-PCR-negative patients with symptoms and chest computed tomography (CT) consistent with COVID-19. Ninety-six historical blood
donation samples were used as controls. The sensitivity of the chromatographic immunoassay in all RT-PCR-positive patients, irrespective of the timing of symptom onset, was 85.8% (95% binomial CI 77.7% to 91.9%). This increased with time after symptom onset,
and at >14 days was 94.9% (85.9% to 98.9%). The specificity was 100% (96.4% to 100%). 15/16 (94%) RT- PCR-negative cases tested positive. The most frequent comorbidities were hypertension and diabetes mellitus and the most frequent symptoms were fever, cough,
and dyspnea. All RT-PCR-negative patients had pneumonia. The most frequent thoracic CT findings were ground glass changes (n = 11, 68%), which were bilateral in 9 (56%) patients, and diffuse reticulonodular infiltrates (n = 5, 31%). |
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Cotrin, P, Peloso, et al |
American Journal of Orthodontics and Dentofacial Orthopedics |
Healthcare Response | Réponse des soins de santé |
The present study aimed to evaluate the most common urgencies and emergencies in orthodontics during the COVID-19 pandemic
and to assess how orthodontists in Brazil were dealing with patients and challenges. The most frequent urgencies were bracket breakage, archwire breakage, and breakage of molar tubes and/or bands. Stainless steel fixed appliances were the most common type
of appliance related to unscheduled appointments. The majority of patients got in touch with the orthodontist using the professional WhatsApp messenger (WhatsApp Inc, Menlo Park, Calif). Orthodontists were more concerned with the financial impact of the pandemic
than with the orthodontic treatment itself. |
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Cotta, RM, Naveira‐cotta, et al |
Biology |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique Public Health response| Interventions de santé publique |
A SIRU‐type epidemic model is employed for the prediction of the COVID‐19 epidemy evolution in Brazil, and analyze
the influence of public health measures on simulating the control of this infectious disease. Then, the available data on reported cases in Brazil from February 15th until March 29th, is used for estimating parameters and then predicting the first phase of
the epidemy evolution from these initial conditions. The data for the reported cases in Brazil from March 30th until April 23rd are reserved for validation of the model. Then, public health interventions are simulated, aimed at evaluating the effects on the
disease spreading, by acting on both the transmission rate and the fraction of the total number of the symptomatic infectious individuals, considering time variable exponential behaviors for these two parameters. This first constructed model provides fairly
accurate predictions up to day 65 below 5% relative deviation, when the data starts detaching from the theoretical curve. From the simulated public health intervention measures through five different scenarios, it was observed that a combination of careful
control of the social distancing relaxation and improved sanitary habits, together with more intensive testing for isolation of symptomatic cases, is essential to achieve the overall control of the disease and avoid a second more strict social distancing intervention.
Finally, the full dataset available by the completion of the present work is employed in redefining the model to yield updated epidemy evolution estimates. |
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Crabb, BT, Lyons, et al |
JAMA network open |
Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response |
Réponse des soins de santé |
Importance: International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10)
codes are used to characterize coronavirus disease 2019 (COVID-19)-related symptoms. Their accuracy is unknown, which could affect downstream analyses. Objective: To compare the performance of fever-, cough-, and dyspnea-specific ICD-10 codes with medical
record review among patients tested for COVID-19. Design, Setting, and Participants: This cohort study included patients who underwent quantitative reverse transcriptase-polymerase chain reaction testing for severe acute respiratory syndrome coronavirus 2
at University of Utah Health from March 10 to April 6, 2020. Data analysis was performed in April 2020. Main Outcomes and Measures: The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of ICD-10 codes for fever
(R50*), cough (R05*), and dyspnea (R06.0*) were compared with manual medical record review. Performance was calculated overall and stratified by COVID-19 test result, sex, age group (64 years), and inpatient status. Bootstrapping was used to generate 95% CIs,
and Pearson χ2 tests were used to compare different subgroups. Results: Among 2201 patients tested for COVD-19, the mean (SD) age was 42 (17) years; 1201 (55%) were female, 1569 (71%) were White, and 282 (13%) were Hispanic or Latino. The prevalence of fever
was 66% (1444 patients), that of cough was 88% (1930 patients), and that of dyspnea was 64% (1399 patients). For fever, the sensitivity of ICD-10 codes was 0.26 (95% CI, 0.24-0.29), specificity was 0.98 (95% CI, 0.96-0.99), PPV was 0.96 (95% CI, 0.93-0.97),
and NPV was 0.41 (95% CI, 0.39-0.43). For cough, the sensitivity of ICD-10 codes was 0.44 (95% CI, 0.42-0.46), specificity was 0.88 (95% CI, 0.84-0.92), PPV was 0.96 (95% CI, 0.95-0.97), and NPV was 0.18 (95% CI, 0.16-0.20). For dyspnea, the sensitivity of
ICD-10 codes was 0.24 (95% CI, 0.22-0.26), specificity was 0.97 (95% CI, 0.96-0.98), PPV was 0.93 (95% CI, 0.90-0.96), and NPV was 0.42 (95% CI, 0.40-0.44). ICD-10 code performance was better for inpatients than for outpatients for fever (χ2 = 41.30; P < .001)
and dyspnea (χ2 = 14.25; P = .003) but not for cough (χ2 = 5.13; P = .16). Conclusions and Relevance: These findings suggest that ICD-10 codes lack sensitivity and have poor NPV for symptoms associated with COVID-19. This inaccuracy has implications for any
downstream data model, scientific discovery, or surveillance that relies on these codes. |
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D’Imperio, H, Gagliardi, et al |
Revista de la Federacion Argentina de Cardiologia |
Healthcare Response | Réponse des soins de santé |
Introduction: The pandemic declared by the WHO for the SARS CoV2 virus led Argentina to initiating a mandatory quarantine
on March 19th, 2020. Due to this, the health system prepares the care for COVID-19 cases, but the impact in this scenario on other prevalent pathologies such as cardiovascular ones, is unknown. Materials and methods: A cross-sectional survey was conducted
by telephone to the centers participating in the ARGEN-IAM-ST registry. The questionnaire was developed mainly to inqui-re about the institutional organization, ambulatory care, critical care hospitalization and health personnel infected with SARS-CoV2. Results:
There were 80 centers surveyed, 55% of them public, 97% with critical care service. There was a crisis committee constituted for the pandemic, by 91% of the institutions. Outpatient care measures were taken in 65% of the centers to comply with social distancing.
The admission of patients with cardiovascular pathologies in critical care units was reduced for 89% and the magnitude of the drop averaged 57% (SD ± 18). In 19 centers (24%), the institution's health personnel infected with SARS-Cov2 were recorded. Conclusion:
A high percentage of centers participating in the continuous ARGEN-IAM-ST registry created crisis committees to reorganize care; and almost two thirds of them took measures for outpatient follow-up; and there has been a significant drop in the occupancy of
beds in critical units for cardiovascular patients. © 2020, Federacion Argentina de Cardiologia. All rights reserved. |
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Ferritin as a Marker of Severity in COVID-19 Patients: A Fatal Correlation |
Dahan, S, Segal, et al |
The Israel Medical Association journal : IMAJ |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
BACKGROUND: Ferritin, the cellular protein storage for iron, has emerged as a key molecule in the immune system, orchestrating
the cellular defense against inflammation. At the end of 2019, the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) rapidly spread throughout China and other countries around the world, resulting in a viral pandemic. OBJECTIVES: To evaluate
the correlation between ferritin and disease severity in coronavirus disease-2019 (COVID-19). METHODS: In this cross-sectional study, we obtained clinical and laboratory data regarding 39 hospitalized patients with confirmed COVID-19 from two hospitals in
Israel. RESULTS: A significant increase in ferritin levels was demonstrated in patients with moderate and severe disease, compared to patients with mild disease (P = 0.006 and 0.005, respectively). Severe patients had significantly higher levels of ferritin
(2817.6 ng/ml) than non-severe patients (708.6 ng/ml) P = 0.02. CONCLUSIONS: In this preliminary cross-sectional study, elevated ferritin levels were shown to correlate with disease severity in 39 patients from Israel with confirmed COVID-19 infection. Our
results further strengthen the hypothesis that severe COVID-19 disease might be due to an underlying dysregulated hyperimmune response. In order to identify these patients early and prioritized resources, we believe that all patients with COVID-19 should be
screened for hyperferritinemia. |
|
Dai, J, Yang, et al |
Risk Management and Healthcare Policy |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this study was to estimate the incubation period of COVID-19 using epidemiological contact tracing data,
and to explore whether there were different incubation periods among different age groups. The incubation period of COVID-19 follows a Weibull distribution and has a median of 5.8 days with a bootstrap 95% CI: 5.4– 6.7 days. Of the symptomatic cases, 95% showed
symptoms by 14.3 days (95% CI: 13.0– 15.7), and 99% showed symptoms by 18.7 days (95% CI: 16.7– 20.9). The incubation periods were not found significantly different between male and female. Elderly cases had significant longer incubation periods than young
age cases (HR 1.49 with 95% CI: 1.09– 2.05). The median incubation period was estimated at 4.0 days (95% CI: 3.5– 4.4) for cases aged under 30, 5.8 days (95% CI: 5.6– 6.0) for cases aged between 30 and 59, and 7.7 days (95% CI: 6.9– 8.4) for cases aged greater
than or equal to 60. |
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COVID-19 driven care changes in high risk patients from an outpatient to a community
setting |
Daly, ML, Zimmer, et al |
Pflege |
Healthcare Response | Réponse des soins de santé |
Background: COVID-19 has led to a change in care for patients with chronic conditions, involving a transfer of drug
administration from an outpatient to a community setting. AIM: To investigate patient preferences for treatment settings in the light of the current pandemic. METHODS: Patients, who prior to the pandemic had attended two different outpatient clinics in a university
hospital for their infusions or injections, were interviewed by telephone. The semi-structured interviews were analyzed using qualitative and quantitative methods. RESULTS: Out of 49 patients with either anti-inflammatory or immunoglobulin treatments (response
rate: 83 %), 24 (49.0 %) switched from subcutaneous (sc) injections in the hospital to the community setting, 18 (36.7 %) from intravenous infusions (iv) in the hospital to sc administration at home and 7 (14.3 %) moved to iv at home. During the pandemic 38
(80.9 %) wanted to continue their treatment at home, but after the pandemic 22 (46.8 %) would opt to go back to the hospital. Satisfaction was high with both settings, slightly favoring drug administration in hospital. Qualitative data shows that patients
while emphasizing the importance of the relationship with the healthcare team, had increased concerns about safety as a result of COVID-19. CONCLUSIONS: The experience during the COVID-19 pandemic has increased self-management-skills in some patients, but
long-term follow-up is needed. It has repercussions for future shared decision making for patients and their healthcare teams. |
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Preventing Undesired Face-Touches with Wearable Devices and Haptic Feedback |
D'Aurizio, N, Baldi, et al |
IEEE Access |
Public health interventions*| Interventions de santé publique |
We present No Face-Touch, a system able to estimate hand proximity to face and notify the user whenever a face-touch
movement is detected. In its complete setup, the system consists of an application running on the smartwatch and a wearable accessory. Its ease of implementation allows this solution to be ready-to-use and large-scale deployable. We developed two gesture detection
approaches compatible with sensors embedded in recent smartwatches, i.e. inertial and magnetic sensors. After preliminary tests to tune target gesture parameters, we tested the two approaches and compared their accuracy. The final phase of this project consisted
in exploiting the most robust approach in a daily living scenario during a 6-days campaign. Experimental results revealed the effectiveness of the proposed system, demonstrating its impact in reducing the number of face-touches and their duration. |
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Davies, B, Grimes, et al |
New Zealand Economic Papers |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique Economics | Économie |
When COVID-19 struck, the New Zealand government had two choices: enter lockdown immediately or delay its decision.
Delay would have enabled more information to emerge about health and economic dynamics, while preserving the option to act at a later date. However, delay may have destroyed the option to eradicate COVID-19. We model the government’s decision when faced with
the uncertainty around health and economic dynamics generated by COVID-19. Our model captures both two-sided uncertainty and the dynamic consequences that flow from the government’s initial decision. Our analysis will help guide future policy decisions amid
similarly complex uncertainties. © 2020 New Zealand Association of Economists Incorporated. |
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De Angelis, M, Petracca, et al |
Multiple Sclerosis and Related Disorders |
Clinical data| Données cliniques |
We report on two multiple sclerosis (MS) patients treated with cladribine, with heterogeneous demographics and clinical
features, who developed mild or no symptoms from COVID-19 and produced anti-SARS-CoV-2 antibodies, notwithstanding low lymphocyte levels. Benign COVID-19 clinical course and anti-SARS-CoV-2 antibody production can occur in MS patients with lymphopenia, suggesting
the possibility to respond to COVID-19 vaccination, once available, in this vulnerable population. |
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Debnath, P, Debnath, et al |
ChemistrySelect |
Therapeutics| Thérapeutique |
The recently emerged 2019 Novel Coronavirus (SARS-CoV-2) and associated COVID-19 disease cause serious or even fatal
respiratory tract infection. Observing the spread, illness and death caused by COVID-19, the World Health Organization (WHO) declared COVID-19 a pandemic. To date, there is no approved therapeutics or effective treatment available to combat the outbreak. This
urgent situation is pressing the world to respond with development of novel vaccine or a small molecule therapeutics for SARS-CoV-2. In line with these efforts, the structure of several proteins of SARS-CoV-2 has been rapidly resolved and made publicly available
to facilitate global efforts to develop novel drug candidates. In this paper, we aim to find out the small molecule inhibitors for ADP-ribose phosphatase of SARS-CoV-2. In order to identify potential inhibitors, we applied sequential E-pharmacophore and structure-based
virtual screening (VS) of MolPort database containing 113687 number of commercially available natural compounds using Glide module. Six potential inhibitors having admirable XP glide score range from −11.009 to −14.684 kcal/mol and good binding affinity towards
active sites were identified. All the molecules are commercially available for further characterization and development by scientific community. The in vitro activity of selected inhibitors can be done easily which will provide useful information for clinical
treatment of novel coronavirus pneumonia. © 2020 Wiley-VCH GmbH |
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Defenbaugh, N, Dickey, et al |
International Journal of Academic Medicine |
Healthcare Response | Réponse des soins de santé |
Aims: The aim of this article is to examine how the facilitation of narrative sessions aids in 'flattening the curve'
of distress and anxiety experienced by healthcare professionals during the COVID-19 pandemic. Methods and Material: Sixty-eight participants were surveyed. Quantitative and qualitative data were collected through postsession surveys, copies of stories submitted
by participants, and de-identified statements captured by facilitators during the sessions. Two primary themes were used (i.e., difficult/challenging and uplifting/inspiring) to structure the writing prompt and to analyze participant stories. Using a layered
account, the authors narrate their experiences as session facilitators and the anonymous experiences of session participants. Results: Results show that 90% of participants reported the ability to listen more closely, 92.5% reported improved resilience, and
92.5% reported the ability to immediately apply what they practiced or witnessed in the narrative sessions. Conclusion: Engaging in narrative writing and sharing stories verbatim in online sessions has the potential to address moral distress, increase active
listening, and build resilience for health-care professionals. This article highlights the critical role of engaging health-care professionals in reflective practices to process, reflect, and share their personal and professional experiences related to the
impact of COVID-19. The following core competencies are addressed in this article: Interpersonal and communication skills. © 2020 International Journal of Academic Medicine | Published by Wolters Kluwer - Medknow. |
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Post-lockdown spread of COVID-19 from cities to vulnerable forest-fringe villages
in Central India |
DeFries, R, Agarwala, et al |
Current science |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique |
Seasonal migration to cities is a common livelihood strategy for forest-fringe households in central India. Based on
a previously collected household survey of 5000 villages across 500 forest-fringe villages in 32 dis-tricts of central India, we identify migration patterns over the last 5 years. Villages with seasonal workers are widely dispersed (75% of surveyed villages)
and 81% of destination cities had reported COVID-19 cas-es at the beginning of the lockdown. Using a disease spread model to assess distancing strategies if return-ing migrants carry the virus to villages, we find that lenient restrictions for people within
a village com-bined with maximal restrictions between villages could reduce the number of people exposed compared with moderate restrictions both within and between villages. Such a 'village bubble' strategy could reduce the risk of spread among vulnerable
populations and requires that essential goods reach villages. © Indian Academy of Sciences. |
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DePace, NL, Soloway, et al |
Medicine |
Clinical data| Données cliniques |
RATIONALE: It is recommended that patients with Rheumatic diseases that are at high risk of developing active infections
be screened for Tuberculosis, Hepatitis B, and Hepatitis C before receiving second-line immunosuppressive therapies. With the emergence 2019 novel coronavirus (SARS-CoV-2), expanded guidelines have not been proposed for screening in these patients before starting
advanced therapy. PATIENT CONCERNS: We present an unique circumstance whereas a patient with a 5 year history of inflammatory muscle disease, diagnosed by clinical history and muscle biopsy with elevated creatine kinase levels, suffered a hypoxemic cardiopulmonary
arrest due to asymptomatic SARS-CoV-2 after receiving advanced immunosuppressive therapy. DIAGNOSES: The patient presented with an acute exacerbation of inflammatory muscle disease with dysphagia, muscle weakness, and elevated creatine kinase. INTERVENTIONS:
After no improvement with intravenous immunoglobulin the patient received mycophenolate and plasma exchange therapy. OUTCOMES: Subsequently the patient suffered a fatal hypoxemic cardiopulmonary arrest. Polymerase chain reaction test was positive for SARS-CoV-2
RNA. LESSONS: We conclude that rheumatic patients, asymptomatic for SARS-CoV-2 infection, be screened and tested before initiating second-line immunosuppressive treatment. |
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Facial nerve palsy: an atypical clinical manifestation of COVID-19 infection in a family
cluster |
Derollez, C, Alberto, et al |
Eur J Neurol |
Clinical data| Données cliniques |
Typical clinical manifestations related to COVID-19 include fever, fatigue and respiratory syndrome. However, an increasing
number of reports of neurological manifestations emerged(1) . We report the case of a 57-year-old woman referred early April 2020 to the neurology inpatient ward because of acute left-side facial nerve palsy noticed upon awakening. |
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Dias, FA, Chance, et al |
Research in Social Stratification and Mobility |
Public Health response| Interventions de santé publique |
In this paper, we present evidence from the Current Population Survey examining the effects of the COVID-19 crisis
on parental status and gender inequalities in employment in the United States. We show that the drop in the employment rate in post-outbreak months was largely driven by mass layoffs and not by workers quitting their jobs. Results from fixed-effects regression
models show a strong fatherhood premium in the likelihood of being laid off for post-outbreak months compared to mothers, men without children, and women without children. We also found that the “fatherhood premium” was higher among lower-educated and mid-educated
workers. These findings show that gaps in layoff rates exacerbated pre-existing forms of parental status and gender inequality in employment. Possible mechanisms are discussed, but more work is needed to explain why employers were less likely to lay off fathers
following the outbreak, and the short- and long-term consequences of the COVID-19 pandemic in reinforcing parental status and gender inequality in employment in the United States. |
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Student Feedback on Distance Learning in the Quantitative Chemical Analysis Laboratory |
Dickson-Karn, N |
Journal of chemical education |
Public Health response| Interventions de santé publique |
The COVID-19 pandemic forced the conversion of the quantitative chemical laboratory from a face-to-face format to a
distance learning format for the latter half of the Spring 2020 semester. This work provides insight into two different types of assignments given to students during this time: a lab report and a short-answer assignment. It was found that students had difficulty
writing lab reports when they did not perform the experiment themselves. The short-answer assignment helped focus attention on the important concepts of the lab experiment, but improvements could be made to improve learning. Student comments in the survey
suggest the importance of in-person laboratory instruction for their understanding of chemistry. |
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A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures |
Dinnon, KH, 3, et al |
Nature |
Therapeutics| Thérapeutique Vaccine Research| Recherche sur les vaccins Animal model
| Modèle animal |
We used reverse genetics5 to remodel the interaction between S and mACE2 resulting in a recombinant virus (SARS-CoV-2
MA) that could utilize mACE2 for entry. SARS-CoV-2 MA replicated in both the upper and lower airways of both young adult and aged BALB/c mice. Our mouse-adapted SARS-CoV-2 model demonstrates age-related disease pathogenesis and supports the clinical use of
pegylated IFN lambda-1a treatment in human COVID-19 infections. |
|
Diomidous, M |
Medical archives (Sarajevo, Bosnia and Herzegovina) |
Healthcare Response | Réponse des soins de santé |
The present research study is an effort to investigate the relationship between the physical activity and sleep disorders
among health care professionals, particularly among medical doctors and nurses. A total number of 204 questionnaires have been distributed to medical doctors and nurses working in public hospitals in Athens Greece from the middle of February until the middle
of April 2020. The majority of the participants were women 71,3% and 28,7% were men. From a total of 204 half of them were medical doctors and half of them were nurses. 43% were married, 49% were single and 8% were divorced and there were no widows. Regarding
the participant nurses, 43% had a university degree and 38,4% had a technological education degree. The results of the statistical analysis showed that there are positive correlations between the level of physical activity during the daily work and the free
time of the participants with parameters that are related to sleep disorders. |
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Hydroxychloroquine-Associated Hypoglycemia in Hemodialysis Patients With COVID-19 |
Dirim, AB, Demir, et al |
Kidney International Reports |
Clinical data| Données cliniques |
Authors report 3 nondiabetic hemodialysis patients who developed hypoglycemia after hydroxychloroquine treatment for
COVID-19. |
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Dobrusin, A, Hawa, et al |
Clinical Gastroenterology and Hepatology |
Healthcare Response | Réponse des soins de santé |
We conducted a survey of GI patients’ and physicians’ satisfaction with telehealth during the COVID-19 pandemic. A
total of 13,084 patients from 2 community-based GI practices in Michigan and the Washington, DC, region who participated in a telehealth visit from March to May 2020 were sent an online satisfaction survey by e-mail. Responses were received from 1492 patients
as of June 17, 2020. |
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Reduced vitamin K status as a potentially modifiable risk factor of severe COVID-19 |
Dofferhoff, ASM, Piscaer, et al |
Clin Infect Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We hypothesized that vitamin K may be implicated in coronavirus disease 2019 (COVID-19), linking pulmonary and thromboembolic
disease. Dp-ucMGP was severely increased in COVID-19 patients, indicating extrahepatic vitamin K insufficiency, which was related to poor outcome while hepatic procoagulant factor II remained unaffected. A clinical trial could assess whether vitamin K administration
improves COVID-19 outcomes. |
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Dutta, R, Buragohain, et al |
Virus research |
Coronavirology| Coronavirologie |
In this study, an attempt was made to document the genome-wide codon usage profile and the various factors influencing
the codon usage patterns of SARS-CoV-2 in human and dog. The SARS-CoV-2 genome showed relative abundance of A and U nucleotides and relative synonymous codon usage analysis revealed that the preferred synonymous codons mostly end with A/U. The analysis of
ENc-GC3s, Neutrality and Parity rule 2 plots indicated that natural selection and other undefined factors dominate the overall codon usage bias in SARS-CoV-2 whereas the impact of mutation pressure is comparatively minor. The codon adaptation index and relative
codon deoptimization index of SARS-CoV-2 deciphered that human is more favoured host for adaptation compared to dog. These results enhance our understanding of the factors involved in evolution of the novel human SARS-CoV-2 and its adaptability in dog. |
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Elhadi, M, Msherghi, et al |
Journal of psychosomatic research |
Healthcare Response | Réponse des soins de santé |
The aim of this study was to assess the psychological status of healthcare workers during the COVID-19 outbreak, which
has compounded Libya's existing civil war-related problems. A multi-center cross-sectional survey on depressive symptoms, anxiety symptoms, and abuse was conducted. The data of 745 eligible healthcare workers from 15 hospitals were analyzed. Depressive and
anxiety symptoms were compared to the basic characteristics of the participants to determine the association. A total of 420 (56.3%) participants had depressive symptoms, while 348 (46.7%) had anxiety symptoms. Age, residency status, department, stigmatization,
and living in a conflict zone were significantly associated with depressive symptoms. Age, department, years of experience, working hours per week, internal displacement, stigmatization, living in a conflict zone, and verbal abuse were significantly associated
with anxiety symptoms. |
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Elnadoury, O, Beattie, et al |
J Aerosol Med Pulm Drug Deliv |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
We describe a unique method of administering continuous epoprostenol nebulization and intermittent nebulized antibiotics,
mucolytics, and bronchodilators, using Aerogen vibrating mesh nebulizers without interruptions in epoprostenol or opening the ventilator circuit. This approach was successful in allowing concomitant delivery of intermittent and continuous nebulized therapy
without interruptions. To our knowledge, this method has not been previously described in the literature and may be helpful to bedside clinicians facing a similar clinical scenario. |
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Erekson, DM, Bailey, et al |
Counselling Psychology Quarterly |
Healthcare Response | Réponse des soins de santé |
In this article, we examine how Counseling and Psychological Services (CAPS) at a large private university in the western
United States addressed the abrupt suspension of in-person mental health services and switch to telebehavioral health due to the Covid-19 pandemic. We found that CAPS had a decrease in scheduled appointments and no change in attendance rates. We estimate that
premature termination impacted about 32–34% of individual therapy clients and 29–37% of group clients. The number of new users for our online therapeutic platforms did not appear to be affected. Clients in 2020 were not significantly more distressed than clients
in the previous 3 years and we found no significant differences in outcome between 2020 and previous years, indicating that levels of distress and treatment trajectories remained similar across years |
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Effects of data aggregation on time series analysis of seasonal infections |
Falconi, TMA, Estrella, et al |
International Journal of Environmental Research and Public Health |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Time series analysis in epidemiological studies is typically conducted on aggregated counts, although data tend to
be collected at finer temporal resolutions. The decision to aggregate data is rarely discussed in epidemiological literature although it has been shown to impact model results. We present a critical thinking process for making decisions about data aggregation
in time series analysis of seasonal infections. We systematically build a harmonic regression model to characterize peak timing and amplitude of three respiratory and enteric infections that have different seasonal patterns and incidence. We show that irregularities
introduced when aggregating data must be controlled during modeling to prevent erroneous results. Aggregation irregularities had a minimal impact on the estimates of trend, amplitude, and peak timing for daily and weekly data regardless of the disease. However,
estimates of peak timing of the more common infections changed by as much as 2.5 months when controlling for monthly data irregularities. Building a systematic model that controls for data irregularities is essential to accurately characterize temporal patterns
of infections. With the urgent need to characterize temporal patterns of novel infections, such as COVID-19, this tutorial is timely and highly valuable for experts in many disciplines. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. |
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A scoping review of respirator literature and a survey among dental professionals |
Farronato, M, Boccalari, et al |
International Journal of Environmental Research and Public Health |
Healthcare Response | Réponse des soins de santé |
An online survey was administered to 256 Italian dentists. The results from this survey were in agreement with the
available literature. The findings concurred that the prolonged use of respirators was associated with headaches (47.5%), severe exertion and discomfort (50.8%), moderate concentration problems (54.3%), moderate breathing difficulties (63.5%), and consequently,
an impaired work ability (85.5%). These findings were not influenced by the number of hours spent wearing the respirator. Despite several side effects, FFP2 respirators are fundamental in protecting dentists and their importance was acknowledged. |
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Farsalinos, K, Eliopoulos, et al |
International Journal of Molecular Sciences |
Therapeutics| Thérapeutique |
While SARS-CoV-2 uses angiotensin converting enzyme 2 (ACE2) as the receptor for cell entry, it is important to examine
other potential interactions between the virus and other cell receptors. Based on the clinical observation of low prevalence of smoking among hospitalized COVID-19 patients, we examined and identified a “toxin-like” amino acid (aa) sequence in the Receptor
Binding Domain of the Spike Glycoprotein of SARS-CoV-2 (aa 375–390), which is homologous to a sequence of the Neurotoxin homolog NL1, one of the many snake venom toxins that are known to interact with nicotinic acetylcholine receptors (nAChRs). We present
the 3D structural location of this “toxin-like” sequence on the Spike Glycoprotein and the superposition of the modelled structure of the Neurotoxin homolog NL1 and the SARS-CoV-2 Spike Glycoprotein. We also performed computational molecular modelling and
docking experiments using 3D structures of the SARS-CoV-2 Spike Glycoprotein and the extracellular domain of the nAChR α9 subunit. We identified a main interaction between the aa 381–386 of the SARS-CoV-2 Spike Glycoprotein and the aa 189–192 of the extracellular
domain of the nAChR α9 subunit, a region which forms the core of the “toxin-binding site” of the nAChRs. The mode of interaction is very similar to the interaction between the α9 nAChR and α-bungarotoxin. A similar interaction was observed between the pentameric
α7 AChR chimera and SARS-CoV-2 Spike Glycoprotein. The findings raise the possibility that SARS-CoV-2 may interact with nAChRs, supporting the hypothesis of dysregulation of the nicotinic cholinergic system being implicated in the pathophysiology of COVID-19.
Nicotine and other nicotinic cholinergic agonists may protect nAChRs and thus have therapeutic value in COVID-19 patients. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. |
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Fasano, A, Elia, et al |
Parkinsonism and Related Disorders |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Specific pre-existing medical conditions (e.g. hypertension or obesity), advanced age and male sex appear linked to
more severe manifestations of SARS Co-V2 infection, thus raising the question of whether Parkinson's disease (PD) poses an increased risk of morbidity and mortality in COVID-19 patients. In order to describe the outcome of COVID-19 in multi-centre a cohort
of PD patients and explore its potential predictors, we gathered the clinical information of 117 community-dwelling patients with COVID-19 followed in 21 tertiary centres in Italy, Iran, Spain, and the UK. Overall mortality was 19.7%, with a significant effect
of co-occurrence of dementia, hypertension, and PD duration. The frailty caused by advanced PD poses an increased risk of mortality during COVID-19. |
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Feitosa, EL, Júnior, et al |
International Journal of Medical Sciences |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The SARS-CoV-2 spread quickly across the globe. The World Health Organization (WHO) on March 11 declared COVID-19 a
pandemic. The mortality rate, hospital disorders and incalculable economic and social damages, besides the unproven efficacy of the treatments evaluated against COVID-19, raised the need for immediate control of this disease. Therefore, the current study employed
in silico tools to rationally identify new possible SARS-CoV-2 main protease (Mpro) inhibitors. That is an enzyme conserved among the coronavirus species; hence, the identification of an Mpro inhibitor is to make it a broad-spectrum drug. Molecular docking
studies described the binding sites and the interaction energies of 74 Mpro-ligand complexes deposited in the Protein Data Bank (PDB). A structural similarity screening was carried out in order to identify possible Mpro ligands that show additional pharmacological
properties against COVID-19. We identified 59 hit compounds and among them, melatonin stood out due to its prominent immunomodulatory and anti-inflammatory activities; it can reduce oxidative stress, defence cell mobility and efficiently combat the cytokine
storm and sepsis. In addition, melatonin is an inhibitor of calmodulin, an essential intracellular component to maintain angiotensin-converting enzyme 2 (ACE-2) on the cell surface. Interestingly, one of the most promising hits in our docking study was melatonin.
It revealed better interaction energy with Mpro compared to ligands in complexes from PDB. Consequently, melatonin can have response potential in early stages for its possible effects on ACE-2 and Mpro, although it is also promising in more severe stages of
the disease for its action against hyper-inflammation. These results definitely do not confirm antiviral activity, but can rather be used as a basis for further preclinical and clinical trials. © The author(s). |
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Weight changes during the COVID-19 home confinement. Effects on psychosocial variables |
Fernandez-Rio, J, Cecchini, et al |
Obesity Research and Clinical Practice |
Public Health response| Interventions de santé publique |
Introduction: The goal was to assess individuals’ weight changes and their connections with depressive symptoms, optimism
and physical activity. Method: 4379 Spanish citizens, 16–84 years, participated. Results: Most participants declared no weight changes. Males, young and obese individuals had greater weight variability. Depressive symptoms were linked to larger weight changes.
Optimism and MVPA followed a descending pattern from ≥−3 kg. MVPA minutes/week and fulfilling physical activity recommendations were inversely associated to weight changes. Conclusion: The COVID-19 confinement impacted individuals’ weight, expanding depreobesity
to include weight loss. Optimism and physical activity seemed to be “protective elements”. © 2020 Asia Oceania Association for the Study of Obesity |
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COVID-19 and rheumatic autoimmune systemic diseases: report of a large Italian
patients series |
Ferri, C, Giuggioli, et al |
Clin Rheumatol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We investigated the clinical-epidemiological findings of 1641 autoimmune systemic disease Italian patients during the
Covid-19 pandemic. A significantly higher prevalence of patients with definite diagnosis of Covid-19 disease, or with highly suspected Covid-19 disease, or both the conditions together, was observed in the whole autoimmune systemic disease series, compared
to “Italian general population”. |
|
Figueroa, JF, Wadhera, et al |
Health Aff (Millwood) |
Epidemiology| Épidémiologie Public Health Priorities| Priorités de santé publique |
We performed a cross-sectional study of 351 Massachusetts towns/cities (01/01/2020–05/06/2020) and found that a 10
percentage point increase in the Black population was associated with a 312.3 increase in COVID-19 cases per 100,000, while a 10 percentage point increase in the Latino population was associated with an increase of 258.2 cases per 100,000. |
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Filonets, Tatiana, Solovchuk, et al |
SSRN- Lancet prepublication |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique |
A stochastic model of COVID-19 propagation was implemented in order to estimate the effectiveness of mask wearing in
addition to case isolation and contact tracing. We showed that high mask wearing coverage can lead to a better control of the outbreak, even in the absence of a lockdown. A high probability of mask wearing by both infected and healthy people, even in presence
of asymptomatic individuals, significantly increased the probability of controlling the outbreak even with only modest effectiveness of contact tracing. This shows that a second wave of COVID-19 could be avoided by tracing contacts and through the use of masks. |
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Fiorella, C, Lorna, et al |
Multiple Sclerosis and Related Disorders |
Clinical data| Données cliniques |
We report a case of COVID-19 in a patient with multiple sclerosis treated with Alemtuzumab (humanized anti-CD52 monoclonal
anti-body). She is a 24-years old Chilean female, left-handed, who works as engineer, her father had multiple sclerosis |
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Fiorino, G, Gilardi, et al |
Am J Gastroenterol |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
We investigated whether precautions adopted in our inflammatory bowel disease (IBD) unit have minimized the risks of
infection for all patients accessing our facilities in a 1-month period by assessing the rate of coronavirus disease-19 infection in the follow-up period. Neither pharmacological immunosuppression nor access to the hospital seem to be risk factors for infection
in patients with IBD. |
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A non-central beta model to forecast and evaluate pandemics time series |
Firmino, PRA, de Sales, et al |
Chaos, Solitons and Fractals |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
The present paper aims to provide a relatively simple way to model, forecast, and evaluate the time incidence of a
pandemic. The proposed framework makes use of the non-central beta (NCB) probability density function. Specifically, a probabilistic optimisation algorithm searches for the best NCB model of the pandemic, according to the mean square error metric. The resulting
model allows one to infer, among others, the general peak date, the ending date, and the total number of cases as well as to compare the level of difficult imposed by the pandemic among territories. Case studies involving COVID-19 incidence time series from
countries around the world suggest the usefulness of the proposed framework in comparison with some of the main epidemic models from the literature (e.g. SIR, SIS, SEIR) and established time series formalisms (e.g. exponential smoothing - ETS, autoregressive
integrated moving average - ARIMA). |
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Facing new fears during the COVID-19 pandemic: The State of America's mental
health |
Fitzpatrick, KM, Drawve, et al |
Journal of anxiety disorders |
Public Health response| Interventions de santé publique |
The current study examines the intersection of COVID-19 fear, worries and perceived threat with social vulnerabilities
and mental health consequences, namely anxiety and depressive symptomatology. Using an online platform, a national sample (n = 10, 368) of U.S. adults was surveyed during the week of March 23, 2020. Fear and worry are not distributed equally across the country;
rather they are concentrated in places where the largest number of confirmed COVID-19 cases is found. Additionally, data highlight significant differences in the subjective perception of distress across groups with varying social vulnerabilities. Women, Hispanics,
Asians, families with children under 18, and foreign-born respondents reported higher levels of subjective fear and worry compared to their counterparts. Finally, even after controlling for social vulnerability, subjective assessments of distress were positive,
and significantly related to anxiety and depressive symptomatology; prior mental health research from China and Europe confirm what others have begun to document in the United States. |
|
French, MT, Mortensen, et al |
J Ment Health Policy Econ |
Public Health response| Interventions de santé publique |
To gain an understanding of the overall levels and predictors of psychological distress experienced in the first month
of the COVID-19 pandemic in the U.S., a survey was administered online to over 2,000 individuals. We find that protective factors against psychological distress include age, gender (male), and physical health. Factors exacerbating psychological distress include
Hispanic ethnicity and a previous mental illness diagnosis. |
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Fu, HY, Li, et al |
European Journal of Inflammation |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
To analyse the differential indicators of COVID-19 in severe and mild cases and to study the factors affecting the
immune function of patients and the time required for oropharyngeal swabs to become negative. Samples were collected from 37 patients. Lymphocyte, ALB, PAB, CD3+, CD4+ and CD8+ T cell levels in the severe group were lower than those in the mild group, the
P values were 0.048, 0.004, 0.033, 0.033, 0.015 and 0.013, respectively. The neutrophil count and PLR were higher in the severe group compared with that in the patients of mild group; the P values were all 0.000. Age, ALB level, PAB level, hs-CRP level, platelet
count, the NLR, CD3+ T cell count and CD8+ T cell count were the main factors influencing the time to a negative nucleic acid test in oropharyngeal swabs, and the P values were 0.032, 0.043, 0.013, 0.016, 0.042, 0.049, 0.048 and 0.003, respectively. CD8+ T
cells affected the time to a negative nucleic acid test in oropharyngeal swab samples, and the P value was 0.002. There were differences in the PLR, PAB level, ALB level and T cells between the severe and mild groups. The platelet count and PLR were the main
factors influencing the immune function of patients with COVID-19, and CD8+ T cells influenced the negative conversion time of the nucleic acid test in oropharyngeal swabs. |
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Modeling and forecasting of confirmed and recovered cases of COVID-19 in India |
Gautam, A, Jha, et al |
International Journal of Academic Medicine |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Context: The novel coronavirus was reported in the past few weeks of 2019 in the Wuhan city, China, and the spread
and outbreaks of disease require an epidemiological analysis of the disease in the shortest time and increased awareness of effective interventions Aims: This article proposes an objective approach to predicting the continuation of the COVID-19 cases in India
using a simple, but powerful time-series method. Settings and Design: Cumulative confirmed and cumulative recovered cases of COVID-19 in India are taken to forecast the prevalence of incoming 3 weeks. Subjects and Methods: The model is built to predict the
number of confirmed cases and recovered cases based on the data available from March 14, 2020, to April 26, 2020. Statistical Analysis Used: The autoregressive-integrated moving average model was applied to predict the number of confirmed cases and recovered
cases of COVID-19 during the next 3 weeks. Results: Our forecasts suggest a continuing increase in the confirmed COVID-19 cases with sizable associated uncertainty assuming that the data used are reliable and that the future will continue to follow the past
pattern of the disease. Conclusions: The timeline of a live-forecasting exercise with potential implications for planning and decision making is described. The following core competencies are addressed in this article: Medical knowledge, Practice-based learning
and improvement, Systems-based practice. © 2020 International Journal of Academic Medicine | Published by Wolters Kluwer - Medknow. |
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PMC7437427; Acute Ischemic Stroke in a Lupus Anticoagulant-Positive Woman With
COVID-19 |
Gemcioglu, E, Erden, et al |
J Clin Rheumatol |
Clinical data| Données cliniques |
A 34 year old woman was admitted with onset of loss of speech and right hemiparesis. She had experienced a fever and
slight dry cough for 2-3 days before the stroke. She was positive for SARS-CoV-2. Antinuclear antibody and lupus anticoagulant were positive. With maintenance therapy, she recovered the ability to speak and most of her strength on her right side, and her fever
and cough resolved. |
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New anti sars-cov-2 targets for quinoline derivatives chloroquine and hydroxychloroquine† |
Gentile, D, Fuochi, et al |
International Journal of Molecular Sciences |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created a severe global health
crisis. In this paper, we used docking and simulation methods to identify potential targets and the mechanism of action of chloroquine (CQ) and hydroxychloroquine (HCQ) against SARS-CoV-2. Our results showed that both CQ and HCQ influenced the functionality
of the envelope (E) protein, necessary in the maturation processes of the virus, due to interactions that modify the flexibility of the protein structure. Furthermore, CQ and HCQ also influenced the proofreading and capping of viral RNA in SARS-CoV-2, performed
by nsp10/nsp14 and nsp10/nsp16. In particular, HCQ demonstrated a better energy binding with the examined targets compared to CQ, probably due to the hydrogen bonding of the hydroxyl group of HCQ with polar amino acid residues. © 2020 by the authors. Licensee
MDPI, Basel, Switzerland. |
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Geyer, J, Böhm, et al |
Pflege |
Healthcare Response | Réponse des soins de santé |
AIMS: This study aims to describe the current life situation of family carers and people with dementia. METHODS: For
this purpose, 21 telephone interviews with both family carers and people with dementia have been conducted twice during the spring of 2020 and were subsequently evaluated by a content analysis. RESULTS: The interviewees experienced the situation differently.
Especially the social isolation, the higher amount of care, the uncertainty of the situation and the increase in psychological symptoms are described as being stressful. With regard to coping with the situation, discussions are taking place about the support
from the social environment, alternative ways of communication, experiences with comparable crises, the stability of formal care and the handling of information. |
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The The risk of public mobility from hotspots of COVID-19 during travel restriction in
Bangladesh |
Ghosh, P, Mollah, et al |
Journal of infection in developing countries |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
Bangladesh reported the first three laboratory-confirmed COVID-19 cases on March 8, 2020 in Dhaka and Narayanganj cities.
We aimed to understand the risk of open movement from hotspots. We studied 40 individuals who were infected with SARS-CoV-2 virus later at their destination. We developed a route map and density maps using Geographic Information System (GIS). Among the studied
people, the average distance was 140.1 (75.1) kilometers (Km), and the range of distance was from 20.3 to 321.7 kilometers. Among them, 42.5% traveled <100 Km, 40.0% traveled between 100 and 200 Km and 17.5% traveled above 200 Km. Case numbers were increased
13.5 times more on April 20 than the cases as of April 8, 2020. Our analysis suggests that relaxed travel restriction could play an important role to spread COVID-19 transmission domestically. To reduce further spread of COVID-19, the government should closely
monitor the public health intervention to stop the casual movement. |
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Gittins, M, Ashton, et al |
Journal of Stroke and Cerebrovascular Diseases |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Background and aims: Concerns have arisen regarding patient access and delivery of acute stroke care during the COVID-19
pandemic. We investigated key population level events on activity of the three hyperacute stroke units (HASUs) within Greater Manchester and East Cheshire (GM & EC), whilst adjusting for environmental factors. Methods: Weekly stroke admission & discharge counts
in the three HASUs were collected locally from Emergency Department (ED) data and Sentinel Stroke National Audit Programme core dataset prior to, and during the emergence of the COVID-19 pandemic (Jan 2020 to May 2020). Whilst adjusting for local traffic-related
air pollution and ambient measurement, an interrupted time-series analysis using a segmented generalised linear model investigated key population level events on the rate of stroke team ED assessments, admissions for stroke, referrals for transient ischaemic
attack (TIA), and stroke discharges. Results: The median total number of ED stroke assessments, admissions, TIA referrals, and discharges across the three HASU sites prior to the first UK COVID-19 death were 150, 114, 69, and 76 per week. The stable weekly
trend in ED assessments and stroke admissions decreased by approximately 16% (and 21% for TIAs) between first UK hospital COVID-19 death (5th March) and the implementation of the Act-FAST campaign (6th April) where a modest 4% and 5% increase per week was
observed. TIA referrals increased post Government intervention (23rd March), without fully returning to the numbers observed in January and February. Trends in discharges from stroke units appeared unaffected within the study period reported here. Conclusion:
Despite adjustment for environmental factors stroke activity was temporarily modified by the COVID-19 pandemic. Underlying motivations within the population are still not clear. This raises concerns that patients may have avoided urgent health care risking
poorer short and long-term health outcomes. © 2020 Elsevier Inc. |
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Goldshtrom, N, Vargas, et al |
World J Pediatr Congenit Heart Surg |
Transmission Clinical data| Données cliniques |
We report a case series of seven neonates with congenital heart and lung malformations born to women who tested positive
for SARS-CoV-2 during their pregnancy at a single academic medical center in New York City. Neither vertical nor horizontal transmission of SARS-CoV-2 was noted. |
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Analysis of factors influencing students' access to mathematics education in the form
of MOOC |
Gonda, D, Ďuriš, et al |
Mathematics |
Public Health response| Interventions de santé publique |
The paper describes the preparatory course of mathematics, realized in the form of MOOC. This course was created and
implemented based on the principles of pedagogical constructivism. The analysis of the respondents' approach to MOOC revealed a difference between bachelor and master students in the use of MOOC. Bachelors found a strong correlation between their approach
to MOOCs and the way they are educated in secondary schools. The results of the research point to the need of more emphasis should be placed on advancing the learner's skills in navigating and analysing information. The questionnaire filled in by the participants
also monitored the students' access to learning. The results of the experiment confirmed the connection between the preferred approach to learning and students' activities within the MOOC. |
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COVID-19 surveillance in Southeastern Virginia using wastewater-based epidemiology |
Gonzalez, R, Curtis, et al |
Water research |
Epidemiology| Épidémiologie Surveillance |
In this study, three RT-ddPCR assays (N1, N2, N3) were used to detect SARS-CoV-2 RNA in weekly samples from nine WWTPs
in southeastern Virginia. In the first several weeks of sampling, SARS-CoV-2 detections were sporadic. Frequency of detections and overall concentrations of RNA within samples increased from mid March into late July. During the twenty-one week study, SARS-CoV-2
concentrations ranged from 101 to 104 copies 100 mL−1 in samples where viral RNA was detected. Fluctuations in population normalized loading rates in several of the WWTP service areas agreed with known outbreaks during the study. Here we propose several ways
that data can be presented spatially and temporally to be of greatest use to public health officials. As the COVID-19 pandemic wanes, it is likely that communities will see increased incidence of small, localized outbreaks. In these instances, WBE could be
used as a pre-screening tool to better target clinical testing needs in communities with limited resources. |
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Collateral damage caused by COVID-19: Change in volume and spectrum of neurosurgery
patients |
Goyal, N, Venkataram, et al |
Journal of Clinical Neuroscience |
Healthcare Response | Réponse des soins de santé |
The objective of this study is to study the change in the volume and spectrum of surgeries performed during the ongoing
COVID-19 pandemic compared to pre-COVID-19 era. Details of all patients who were operated under department of neurosurgery at our institute since the onset of COVID-19 pandemic in India were collected and compared to the same time period last year. Our study
showed a drastic fall (52.2%) in the number of surgeries performed during the pandemic compared to pre-COVID era. 11.3% of patients operated during COVID-19 pandemic were non-emergent surgeries compared to 57.7% earlier (p = 0.000). There was increase in proportion
of minor cases from 28.8% to 41.5% (p = 0.106). The proportion of spinal cases decreased from 27.9% to 11.3% during the COVID-19 pandemic (p = 0.043). |
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Gramegna, M, Baldetti, et al |
Circulation.Cardiovascular interventions |
Healthcare Response | Réponse des soins de santé |
BACKGROUND: Coronavirus disease 2019 (COVID-19) pandemic has led to a fast and radical transformation in social, economic,
and healthcare networks. COVID-19 outbreak may thus have profound indirect consequences on clinical presentation and management of patients with ST-segment-elevation myocardial infarction (STEMI). Aim of this study was to assess clinical features of patients
with STEMI during COVID-19 pandemic. METHODS: This single-center, prospective study from a regional public service healthcare hub in Milan included all consecutive patients with STEMI admitted to our institute from February 21 to April 1, 2020 (during COVID-19
pandemic). These patients were compared with a historical cohort of patients admitted for STEMI during the analogous time period (February 21 to April 1) in 2018 and 2019, in terms of time from symptoms onset to hospital admission, clinical characteristics,
and in-hospital outcomes. RESULTS: A total of 26 patients were admitted for STEMI during the study period, and 7 (26.9%) of these patients tested positive for severe acute respiratory syndrome coronavirus 2. On admission, medical therapy, including angiotensin-converting
enzyme inhibitors and angiotensin receptor blockers use, was similar between cohorts. Median (interquartile range) time from symptoms onset to hospital admission was significantly longer in 2020 as compared to the historical cohort (15.0 2.0-48.0] versus 2.0
1.0-3.0] hours; P<0.01). A higher proportion of patients presenting with late presentation STEMI was observed in 2020 compared with the historical cohort (50.0% versus 4.8%; P<0.01). Primary percutaneous coronary intervention resulted indicated in 80.8% of
patients in 2020 compared with 100% in the historical cohort (P=0.06). In-hospital death, thromboembolism, mechanical ventilation, or hemodynamic decompensation needing inotropic or mechanical support were similar between years. CONCLUSIONS: These preliminary
results from a cardiovascular regional public service healthcare hub demonstrate a significantly longer time from symptoms onset to hospital admission among patients with STEMI during COVID-19 pandemic compared with the same time period in the previous 2 years. |
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Greenhalgh, M, Dupley, et al |
Int J Clin Pract |
Healthcare Response | Réponse des soins de santé |
AIMS: This retrospective study aims to quantify the early impact of the COVID-19 pandemic on trauma and orthopaedic
surgery at a Major Trauma Centre (MTC) in the United Kingdom. We hypothesise that the social restrictions placed on the public by the government will reduce the amount of trauma presentations and operations performed. METHODS: A database of all trauma patients
at the MTC was retrospectively reviewed from start of social restrictions on 16(th) March 2020, to 22(nd) April 2020 inclusive. Referrals to the orthopaedic team were identified and included; these were sub-classified into major trauma patients, fragility
hip fractures and paediatric trauma. All patients undergoing surgical intervention were identified. The outcome measures were the total number of referrals and trauma operations performed in the time period. This was compared to the corresponding dates of
the 2019. RESULTS: There was an overall decrease in the number of referrals to the orthopaedic team from 537 in 2019 to 265 in 2020 (50.7% reduction). The number of trauma operations carried out at the trust decreased from 227 in 2019 to 129 in 2020 (43.2%
reduction). The number of paediatric referrals decreased from 56 in 2019 to 26 in 2020 (53.6% reduction), and the number of major trauma patients reduced from 147 in 2019 to 95 in 2020 (35.4%). Fragility hip fracture referrals remained similar, with 52 in
2019 compared to 49 in 2020. CONCLUSION: The COVID-19 pandemic has had a profound effect of the provision of trauma and orthopaedic surgery. We report a significant decrease in all orthopaedic referrals during the pandemic, leading to a greatly reduced number
of trauma operations performed. This has allowed for reallocation of staff and resources. We must plan for the lifting of social restrictions, which may lead to an increase in patients presenting with trauma requiring operative intervention. |
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Collaborative facilitation and collaborative inhibition in virtual environments |
Guazzini, A, Guidi, et al |
Future Internet |
Public Health response| Interventions de santé publique |
This study analyzed the impact of a virtual environment (VE) on the recall of individuals and members of nominal and
collaborative groups. The research assessed costs and benefits for collaborative retrieval by testing the effect of experimental conditions, stimulus materials, group size, experimental conditions order, anxiety state, personality traits, gender group composition
and social interactions. A total of 144 participants were engaged in a virtual Deese-Roediger-McDermott (DRM) classical paradigm, which involved remembering word lists across two successive sessions, in one of four protocols. Results suggested, in general,
a reduced collaborative inhibition effect in the collaborative condition than the nominal and individual condition. A combined effect between experimental condition and difficulty of the task appears to explain the presence of collaborative inhibition or facilitation.
Nominal groups appeared to enhance the collaborative groups' performance when virtual nominal groups come before collaborative groups. Variables such as personality traits, gender and social interactions may have a contribution to collaborative retrieval. |
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Gul, S, Tuncay, et al |
Journal of infection in developing countries |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
INTRODUCTION: There are significant differences in the active cases and fatality rates of Covid-19 for different European
countries. METHODOLOGY: The present study employs Monte Carlo based transmission growth simulations for Italy, Germany and Turkey. The probabilities of transmission at home, work and social networks and the number of initial cases have been calibrated to match
the basic reproduction number and the reported fatality curves. Parametric studies were conducted to observe the effect of social distancing, work closure, testing and quarantine of the family and colleagues of positively tested individuals. RESULTS: It is
observed that estimates of the number of initial cases in Italy compared to Turkey and Germany are higher. Turkey will probably experience about 30% less number of fatalities than Germany due its smaller elderly population. If social distancing and work contacts
are limited to 25% of daily routines, Germany and Turkey may limit the number of fatalities to a few thousands as the reproduction number decreases to about 1.3 from 2.8. Random testing may reduce the number of fatalities by 10% upon testing least 5/1000 of
the population. Quarantining of family and workmates of positively tested individuals may reduce the total number of fatalities by about 50%. CONCLUSIONS: The fatality rate of Covid-19 is estimated to be about 1.5% based on the simulation results. This may
further be reduced by limiting the number of non-family contacts to two, conducting tests more than 0.5% of the population and immediate quarantine of the contacts for positively tested individuals. Copyright (c) 2020 Serdar Gul, Kagan Tuncay, Baris Binici,
Beyazit Bestami Aydin. |
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Guo, L, Wu, et al |
Eur Eat Disord Rev |
Public Health response| Interventions de santé publique |
The goals were twofold: To estimate the depression and anxiety levels among caregivers of patients with eating disorders
(ED) in China during the COVID-19 pandemic when compared with a control group, and to assess whether an online education program was effective in decreasing the anxiety and depression of the caregivers of patients with ED, and associated factors. Caregivers
of patients with ED showed significantly higher levels of depression and anxiety than the comparison group of non-ED caregivers. The online education program showed no significant effect on decreasing depression and anxiety levels. |
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Fangcang shelter hospital in wuhan: A radiographic report on a cohort of 98 COVID-19 patients |
Guo, T, Liu, et al |
International Journal of Medical Sciences |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Objectives: To present the temporal changes of CT manifestations in COVID-19 patients from a single fangcang shelter
hospital and to facilitate the understanding of the disease course. This retrospective study included 98 patients. Ground-glass opacity (GGO) (58%, 41/71) was the earliest and most frequent finding in week 1. Consolidation (26%, 14/53) and mixed pattern (40%,
21/53) were predominant patterns in 2nd week. GGO and reticular were the main patterns of later phase CT scans in patients with relatively advanced diseases who had longer illness duration (≥4 weeks). Among the 94 CT abnormalities obtained within 3 days from
the twice RT-PCR test turned negative, the mixed pattern was mainly presented in patients with disease duration of 2-3 weeks, for GGO and reticular were common during the whole course. |
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Gupta, AK, Khan, et al |
Frontiers in Microbiology |
Coronavirology| Coronavirologie |
In this study, we have performed comprehensive meta-analyses and developed an integrative resource, “CoronaVR” (http://bioinfo.imtech.res.in/manojk/coronavr/).
Predominantly, we identified potential epitope-based vaccine candidates, siRNA-based therapeutic regimens, and diagnostic primers. The resource is categorized into the main sections “Genomes,” “Epitopes,” “Therapeutics,” and Primers.” Our study provided a
set of shortlisted B-cell and T-cell (CD4+ and CD8+) epitopes that can be experimentally tested for their incorporation in vaccine formulations. The list of selected primers can be used in testing kits to identify SARS-CoV-2, while the recommended siRNAs,
sgRNAs, and miRNAs can be used in therapeutic regimens. We foresee that this resource will help in advancing the research against coronaviruses. |
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Hafiz, M, Icksan, et al |
Journal of infection in developing countries |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
INTRODUCTION: The numbers of people infected with SARS-CoV-2 in Indonesia especially in Jakarta as the epicenter continue
to rise. Limited published clinical data, scarcity and long turn over time of diagnostic testing put clinician in dilemma to make diagnosis. METHODOLOGY: This is an observational case series study from confirmed COVID-19 patient in our hospital from first
case admission on 17 March 30 April, 2020. We collected patient's demography, symptoms, comorbidities, therapy, laboratory, chest x-ray and ECG consecutively. RESULTS: Between 17 March 2020 and 30 April 2020, there were 30 confirmed COVID-19 cases, 16 (53.3%)
were male. Clinical symptoms were dyspnea in 22 (73.3%) and dry cough 16 (53.3%). Comorbidities were diabetes in 14 (46.6%), hypertension 10 (33.3%) and Coronary Artery Disease (CAD) in 10 (33.3%) patients respectively. Laboratory findings showed lymphopenia
in 21 (70%) patients, increased inflammation marker in Erythrocyte Sedimentation Rate (ESR), C-Reactive Protein (CRP) and Lactate Dehydrogenase (LDH) 21 (70%), 23 (76.6%) and 12 (40%) patients respectively. Twenty-seven (90%) cases had abnormal Chest X-Ray
(CXR) and mostly severe 18 (60%). Descriptive finding for images included consolidation 16 (53.3%) and Ground Glass Opacities (GGO) in 10 (33.3%) patients. CONCLUSIONS: Based on our findings, most cases of COVID-19 admitted in secondary referral hospital were
already in moderate to severe stages. This is most likely due to late referral from primary care and unspecific clinical features resemblance of other infectious diseases. Inflammation marker and CXR are cost effective findings and can be used as marker to
determine further referral. Copyright (c) 2020 Muhammad Hafiz, Aziza Ghanie Icksan, Annisa Dian Harlivasari, Rizky Aulia, Febrina Susanti, Lourisa Eldinia. |
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Halberthal, M, Nachman, et al |
American journal of disaster medicine |
Healthcare Response | Réponse des soins de santé |
No abstract available |
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Assessing the recent impact of COVID-19 on carbon emissions from China using
domestic economic data |
Han, P, Cai, et al |
Science of the Total Environment |
Epidemiology| Épidémiologie |
Here, we used national and provincial GDP data and the China Emission Accounts and Datasets (CEADs) inventory to estimate
the emission reductions in the first quarter (Q1) of 2020. We find a reduction of 257.7 Mt. CO2 (11.0%) over Q1 2019. The secondary industry contributed 186.8 Mt. CO2 (72.5%) to the total reduction, largely due to lower coal consumption and cement production.
At the provincial level, Hubei contributed the most to the reductions (40.6 Mt) due to a notable decrease of 48.2% in the secondary industry. Moreover, transportation significantly contributed (65.1 Mt), with a change of −22.3% in freight transport and −59.1%
in passenger transport compared with Q1 2019. We used a point, line and area sources (PLAS) method to test the GDP method, producing a close estimate (reduction of 10.6%). One policy implication is a change in people's working style and communication methods,
realized by working from home and holding teleconferences, to reduce traffic emissions. Moreover, GDP is found to have potential merit in estimating emission changes when detailed energy activity data are unavailable. We provide provincial data that can serve
as spatial disaggregation constraints for modeling studies and further support for both the carbon cycle community and policy makers. |
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Haselmann, V, Özçürümez, et al |
Clin Chem Lab Med |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
As immunoassays for detection of anti-SARS-CoV-2 immunoreactivity are gaining growing attention, the number of commercially
available SARS-CoV-2 antibody tests is rapidly increasing. The diversity of these immunoassays using different viral components as ligand-specific binding reagents already implies a certain variability of results. In order to meet this demand, we conducted
the first pilot external quality assessment (EQA) scheme for detection of anti-SARS-CoV-2–specific antibodies in characterized serum samples. |
|
|
Hashemi, SA, Safamanesh, et al |
Journal of medical virology |
Clinical data| Données cliniques |
Case reports of 3 pediatric COVID-19 cases co-infected with human metapneumovirus, with fatal outcome. |
|
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A unique view of SARS-CoV-2 through the lens of ORF8
protein |
Hassan, Sk Sarif, Ghosh, et al |
bioRxiv |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
To understand the immune perspective of the host with respect to the ORF8 protein, a comprehensive study of the ORF8
protein of SARS-CoV-2 as well as mutations possessed by it, is performed. Chemical and structural properties of ORF8 proteins from different hosts, that is human, bat and pangolin, suggests that the ORF8 of SARS-CoV-2 and Bat RaTG13-CoV are very much closer
related than that of Pangolin-CoV. Based on geo- locations and timescale of collection, a possible flow of mutations was built. |
|
Missense mutations in SARS-CoV2 genomes from Indian patients |
Hassan, SS, Choudhury, et al |
Genomics |
Coronavirology| Coronavirologie |
In this present study, variations in terms of missense mutations among the SARS-CoV2 genomes from 128 Indian patients,
as of May 2020, are accounted and thereby some key findings with some hypotheses were made. These mutations across various genes of these genomes show wide genetic variations in sequence and rapid evolution of SARS-CoV2 virus. The presence of unique mutations
in the studied SARS-CoV2 genomes may led to their attenuation. Few Genes such as ORF6, ORF10 are free from any mutations in the Indian context of 339 genomes observed as of 14th July 2020. Further, E protein contains only one mutation. This may suggest that
designing a therapeutic approach against ORF6, ORF10 and E genes may have a beneficial effect in controlling COVID-19 pandemic especially in India. |
|
COVID-19 Among American Indian and Alaska Native Persons - 23 States, January 31-July
3, 2020 |
Hatcher, SM, Agnew-Brune, et al |
MMWR Morb Mortal Wkly Rep |
Epidemiology| Épidémiologie Clinical data| Données cliniques Public Health Priorities|
Priorités de santé publique |
In 23 states with adequate race/ethnicity data, the cumulative incidence of laboratory-confirmed COVID-19 among AI/AN
persons was 3.5 times that among non-Hispanic white persons. |
|
Hautz, WE, Sauter, et al |
Swiss medical weekly |
Healthcare Response | Réponse des soins de santé |
AIMS OF THE STUDY: While COVID-19 significantly overburdens emergency rooms (ERs) and hospitals in affected areas,
ERs elsewhere report a marked decrease in patient numbers. This study aimed to investigate the assumption that patients with urgent problems currently avoid the ER. METHODS: Electronic health records from the ER of a large Swiss university hospital were extracted
for three periods: first, the awareness phase (ap) from the publication of the national government’s initiative “How to protect ourselves” on 1 March 2020 to the lockdown of the country on 16 March; second, the mitigation phase (mp) from 16–30 March; finally,
patients presenting in March 2019 were used as a control group. We compared parameters including a critical illness as the discharge diagnosis (e.g., myocardial infarction, stroke, sepsis and ER death) using logistic and linear regression, as well as 15-day
bootstrapped means and 95% confidence intervals for the control group. RESULTS: In the three periods, a total of 7143 patients were treated. We found a 24.9% (42.5%) significant decline in the number of patients presenting during the ap (mp). Patients presenting
during the mp were more likely to be critically ill. There was an increase of 233% and 367% (ap and mp, respectively) of ER deaths (none related to COVID-19) compared with the control period. Apart from polytrauma (increase of 5% in the mp), all other critical
illnesses as discharge diagnosis showed a lower incidence in descriptive analysis. Significantly more patients died in the ER in both the ap and mp. CONCLUSIONS: Barriers to seeking emergency care during COVID-19 pandemic may lead to higher morbidity and mortality.
Healthcare authorities and hospitals must ensure low barriers to treatment and business as usual for all patients. |
|
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Histopathology of Third Trimester Placenta from SARS-CoV-2-Positive Women |
He, Mai, Skaria, et al |
arXiv |
Clinical data| Données cliniques |
This retrospective case-control study aims to investigate whether maternal SARS-CoV-2 status affect placental pathology.
There were no significant differences in individual or group gross or microscopic pathological features between cases and controls. Within the SARS-CoV-2+ group, there are no differences between symptomatic and asymptomatic women. |
|
Hervochon, R, Atallah, et al |
European Annals of Otorhinolaryngology, Head and Neck Diseases |
Healthcare Response | Réponse des soins de santé |
The purpose of this study was to assess the impact of the COVID-19 pandemic on the surgical volume of three ENT departments
in Ile-de-France. The number and nature of surgeries was collected from three university hospital ENT departments from 17/03/2020 to 17/04/2020 and from 18/03/2019 to 18/04/2019. Comparative analysis of the decreased surgical volume was conducted between 2019
and 2020. The three centres operated on 540 patients in 2019, versus 89 in 2020, i.e. an 84% decrease. Otological surgery decreased by 97%, endonasal surgery decreased by 91%, head and neck surgery decreased by 54%, plastic surgery decreased by 82%, and
transoral surgery decreased by 85%. The number of surgical operations for skin cancer decreased (24 vs. 9), while the total number of head and neck cancer surgeries remained stable (18 vs. 22). The number of planned tracheostomies increased from 8 to 22. |
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|
Hidvégi, M, Nichelatti, et al |
The Israel Medical Association journal : IMAJ |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
BACKGROUND: The 2019 severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic continued into 2020, and
the coronavirus disease-2019 (COVID-19) associated death toll increased. OBJECTIVES: To analyze COVID-19 death rates in European countries or regions to determine whether there was a significant association between bacillus Calmette-Guérin (BCG) vaccination
policy and lower rates of COVID-19 related deaths. METHODS: Certain Northern European countries or regions had low death rates regardless of BCG policy. The authors assumed the consumption of foods containing salmiak (NH4Cl) was a common and peculiar cause
of the reduced COVID-19 related death rates in these countries, because NH4Cl is a known lysosomotropic agent, which has been indicated to inhibit or prevent SARS-CoV infection. To check the possible effectiveness of salmiak consumption against COVID-19 related
death, the authors used a linear regression model with the death rate as the dependent variable and BCG-policy and salmiak consumption score as independent variables. RESULTS: Using least squares regression and a robust standard error algorithm, the authors
found a significant effect exerted by the independent variables (P < 0.0005 for BCG and P = 0.001 for salmiak). Salmiak score alone was significant (P = 0.016) when using least squares regression with robust error algorithm. CONCLUSIONS: The results seem to
confirm an association between BCG-positive vaccination policy and salmiak consumption, and lower death rates from COVID-19. Implementing BCG vaccination policy and fortification of foods with salmiak (NH4Cl) may have a significant impact on the control of
SARS-CoV epidemic. |
|
|
Hierro, LA, Cantarero, et al |
PLoS One |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique Public Health Priorities| Priorités de santé publique |
This paper seeks to determine which workers affected by lockdown measures can return to work when a government decides
to apply lockdown exit strategies. The proposed system makes it possible to accurately identify the target population for serological IgG antibody tests in the work field, as well as those affected by special income replacement measures due to lockdown being
maintained over a longer period. |
|
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COVID-19 Affected Mental Health of At-risk Groups of Psychiatric Patients: Two Case
Reports |
Hodžić, N, Hasanović, et al |
Psychiatria Danubina |
Public Health response| Interventions de santé publique |
Two cases of psychiatric patients who suddenly deteriorated and burned in a severe psychiatric condition due to the
circumstances they faced due to the COVID-19 pandemic, which required urgent admission and intensive psychiatric treatment. |
|
Assessment of SARS-CoV-2 Transmission on an International Flight and Among
a Tourist Group |
Hoehl, S, Karaca, et al |
JAMA network open |
Epidemiology| Épidémiologie Transmission Clinical data| Données cliniques |
This case series assessed a commercial airline flight from Tel Aviv, Israel, to Frankfurt, Germany, that occurred on
March 9th, 2020. We conducted a medical evaluation of the tourist group, including testing for severe acute respiratory syndrome coronavirus (SARS-CoV-2) in a throat swab specimen. In addition, we contacted all passengers 4 to 5 weeks later by phone and conducted
structured interviews. Of the 24 members of the tourist group, 7 tested positive for SARS-CoV-2 RNA in a throat swab sample on arrival. Four of the 7 were symptomatic during the flight, 2 were presymptomatic, and 1 remained asymptomatic. Seven other passengers
reported having had symptoms suggestive of COVID-19 within 14 days after the flight. |
|
Development and evaluation of a rapid CRISPR-based diagnostic for COVID-19 |
Hou, T, Zeng, et al |
PLoS Pathog |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Our study aimed to provide more insights into the molecular detection of SARS-CoV-2, and also to present a novel diagnostic
option for this new emerging virus. We developed an isothermal, CRISPR-based diagnostic for COVID-19 with near single-copy sensitivity |
|
Hua, F, Wang, et al |
Zhonghua wei zhong bing ji jiu yi xue |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
OBJECTIVE: To make a new simple respirator and observe the oxygen therapy effect of the respirator on patients with
severe and critical coronavirus disease 2019 (COVID-19). METHODS: Based on the infectivity and hospital requirements of COVID-19, a new simple respirator was designed by the medical staff of the Department of Anesthesiology of the Second Affiliated Hospital
of Nanchang University, which was applied on the 22 patients with severe and critical COVID-19 who needed oxygen therapy admitted to the Cancer Center of Tongji Medical College of Huazhong University of Science and Technology from February 15th to March 15th
in 2020. CONCLUSIONS: The new simple respirator can significantly improve the oxygen therapy effect of patients with severe and critical COVID-19. At the same time, 2019 novel coronavirus (2019-nCoV) can be filtered through the filter to reduce the formation
of aerosol and protect the medical staff and patients. |
|
|
Huang, Qimin, Mondal, et al |
SSRN- Lancet prepublication |
Modelling/ prediction| Modélisation/prédiction Infection Prevention and Control/ Prévention
et contrôle des infections (IPAC/PCI) Healthcare Response | Réponse des soins de santé |
We developed an individual-based model for COVID-19 transmission among healthcare workers (HCWs) in a hospital setting.
The calibrated model was used to simulate different intervention scenarios and estimate the impact of different interventions on outbreak size and workday loss. Among other results, we showed that the use of high efficacy face masks was most effective for
infection cases and workday loss. The impact of social distancing through reduced contacts alone had a marginal effect on mitigating the outbreak in the long run, however, its impact increased when combined with face masks. . Our findings demonstrate that
quarantine policy should be coupled with other interventions to achieve its effect. |
|
|
Structural analysis of experimental drugs binding to the SARS-CoV-2 target TMPRSS2 |
Huggins, DJ |
Journal of Molecular Graphics and Modelling |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This paper focuses on the human protein TMPRSS2, which supports coronavirus life cycles by cleaving viral spike proteins.
The three-dimensional structure of TMPRSS2 is not known and so we have generated models of the TMPRSS2 in the apo state as well as in complex with a peptide substrate and putative inhibitors to aid future work. We highlight 376 approved, investigational or
experimental drugs targeting S1A serine proteases that may also inhibit TMPRSS2. Whilst the presence of a relatively uncommon lysine residue in the S2/S3 subsites means that some serine protease inhibitors will not inhibit TMPRSS2, this residue is likely to
provide a handle for selective targeting in a focused drug discovery project. We discuss how experimental drugs targeting related serine proteases might be repurposed as TMPRSS2 inhibitors to treat coronaviruses. |
|
Hui, JYC, Yuan, et al |
Am J Clin Oncol |
Healthcare Response | Réponse des soins de santé |
Participants were recruited to an anonymous cross-sectional online survey of oncology physicians (surgeons, medical
oncologists, and radiation oncologists) using social media from March 27 to April 10, 2020. Physician demographics, practice characteristics, and cancer treatment decisions were collected. The COVID-19 pandemic has caused a majority of oncologists to alter
their treatment plans, but the primary motivators for changes differed by oncologic specialty. |
|
|
Hui, TCH, Khoo, et al |
Quantitative Imaging in Medicine and Surgery |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
This study aims to assess the diagnostic performance of CXR, with emphasis on its predictive value, for severe COVID-19
disease. Methods: A retrospective cohort study was conducted, 358 chest radiographs were performed on 109 COVID-19 patients (median age 44.4 years, 58 males and 30 with comorbidities) admitted between 22 January 2020 and 15 March 2020. Each CXR was reviewed
and scored by three radiologists in consensus using a 72-point COVID-19 Radiographic Score (CRS). Conclusions: Adjusting for key confounders of age and baseline Hb, CRSmax performed comparable to or better than laboratory markers in the diagnosis of severe
disease. CXR performed between the 6th and 10th days from symptom onset was a better predictor of severe disease than CXR performed earlier at presentation. A benign clinical course was seen in CXR that were normal or had very mild abnormalities. |
|
|
Ikenberg, B, Hemmer, et al |
Journal of Stroke and Cerebrovascular Diseases |
Healthcare Response | Réponse des soins de santé |
We analyzed if the public lockdown altered the referral pattern of Code Stroke patients by Emergency Medical Services
(EMS) to our Comprehensive Stroke Center. In total 241 patients were referred to our center during the study period, i.e. 171 before and 70 during the lockdown. The absolute daily number of Code Stroke referrals and the portion of patients with stroke mimics
remained stable. The portion of female stroke patients decreased (55% to 33%; p = 0.03), and stroke severity as measured by the National Institutes of Health Stroke Scale (median 3 (IQR 0-7) versus 6 (IQR 1-15.5) points; p = 0.04) increased during the lockdown.
There was no difference of daily numbers of patients receiving thrombolysis and thrombectomy. |
|
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Telegram as a tool to supplement online medical education during covid-19 crisis |
Iqbal, MZ, Alradhi, et al |
Acta Informatica Medica |
Public Health response| Interventions de santé publique |
. Aim: This study explores the potential benefits and disadvantages of integrating Telegram into undergraduate medical
education during the COVID-19 pandemic. Methods: An exploratory study was conducted between March and May 2020, with 203 undergraduate medical students recruited through purposive sampling. Results: Most students participating in this study reported multiple
utilities of the application, including easy access to educational resources and the ability to add unlimited members, as well as files in all formats and sizes. Additionally, the application assisted students to engage with collaborative learning, maintain
their wellbeing, and ensure their security. |
|
Jaffe, E, Sonkin, et al |
The Israel Medical Association journal : IMAJ |
Healthcare Response | Réponse des soins de santé |
BACKGROUND: The potential excess flow of patients into emergency departments and community clinics for testing and
examination during a pandemic poses a major issue. These additional patients may lead to the risk of viral transmission to other patients and medical teams. To contain the spread of coronavirus disease-2019 (COVID-19), the Israeli Ministry of Health initiated
a plan spearheaded by Magen David Adom (MDA), Israel's national emergency medical services (EMS) organization. OBJECTIVES: To describe outbreak containment actions initiated by MDA, including a COVID-19 tele-triage center and home testing by paramedics. METHODS:
Retrospective analysis was conducted of de-identified data from the call management and command and control systems during the first period of the COVID-19 outbreak in Israel (23 February 2020-15 March 2020). RESULTS: During the study period, the total number
of calls to the dispatch centers was 477,321 with a daily average of 21,696, compared to 6000-6500 during routine times. The total number of COVID-19 related calls was 334,230 (daily average 15,194). There were 28,454 calls (8.51% of all COVID-19 related calls,
average 1293/day) transferred to the COVID-19 call center. Of the COVID-19 call center inquiries, 8390 resulted in the dispatch of a dedicated vehicle, including a paramedic wearing personal protective equipment, to collect samples for testing (daily average
381). CONCLUSIONS: Maximizing EMS during a pandemic using phone triage, in addition to dispatching paramedics to perform home testing, may significantly distance infected patients from the public and health care system. These steps can further minimize the
spread of disease. |
|
|
Jamjoom, Roaa |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this research we are looking into the demographics, common presentation of pediatric COVID-19 patients in the Emergency
Department(ED), their contact with positive COVID-19 cases, return visits and disposition from Emergency Department. Males are more commonly affected than females. 85% were discharged from emergency department. 8 patients(15%) required admission. 3 of them
were admitted to Pediatric Intensive Care Unit (PICU). Two died which makes for a mortality rate of (3.8%). The most frequent presentations were fever (85%), cough (48%) and diarrhea patients (23%) |
|
|
Critical Illness Due to Covid-19: A Description of the Surge in a Single Center
in Sioux Falls |
Jamous, F, Meyer, et al |
South Dakota medicine : the journal of the South Dakota State Medical Association |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
BACKGROUND: We aim to describe the basic demographics, clinical course and outcomes of critically ill patients with
Covid-19 admitted to Avera McKennan Hospital and University Health Center Intensive Care Unit (ICU) between March 20 and May 4, 2020. METHODS: In this single centered, retrospective, observational study, we enrolled 37 critically ill adults with COVID-19 pneumonia
admitted to the (ICU) between March 20 and May 4, 2020. Demographic data, admitting symptoms, laboratory values, co-morbidities, treatments and clinical outcomes were collected. Data was compared between survivors and non-survivors. We aim to describe our
data and report the 28-day mortality as of June 1, 2020. CONCLUSION: Mortality of critically ill patients with COVID-19 is high. Multi-organ, advanced and prolonged critical care resources are needed. Interpretation of our data is limited by a higher mortality
of the earlier members of the cohort, a change in therapeutic practice over time and institution of social distancing. |
|
Prevalence of Surface Contamination With SARS-CoV-2 in a Radiation Oncology Clinic |
Jan, I, Chen, et al |
JAMA Oncol |
Epidemiology| Épidémiologie |
Patients who have cancer and become infected with SARS-CoV-2 may have greater morbidity and mortality compared with
the general public. Therefore, assessing the presence or absence of SARS-CoV-2 may provide important information for health care practitioners, patients, and their families, who must weigh the benefit of cancer treatment vs the risk of infection with SARS-CoV-2. |
|
Jeon, WH, Seon, et al |
International Journal of Environmental Research and Public Health |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this study, 7590 confirmed coronavirus disease (COVID-19) patients were defined as a target for analysis using nationwide
medical claims data. The demographic characteristics, underlying diseases, and the use of medical resources were used to examine the association with readmission through the chi-square test and then logistic regression analysis was performed to analyze factors
affecting readmission. The readmission rates of men, older age and patients with medical benefits showed a high risk of readmission. Concerning requiring medical attention, there was a higher risk of readmission for the patients with chest radiographs, computed
tomography scans taken and lopinavir/ritonavir at the time of their first admission. |
|
|
The effect of covid-19
on interventional pain management practices: A physician burnout survey |
Jha, S, Shah, et al |
Pain Physician |
Healthcare Response | Réponse des soins de santé |
Objective: To assess the presence of burnout specific to COVID-19 pandemic among practicing interventional pain physicians.
Methods: American Society of Interventional Pain Physicians (ASIPP) administered a 32 question survey to their members by contacting them via commercially available online marketing company platform. The survey was completed on www.constantcontact.com. Results:
Of 179 surveys sent, 100 responses were obtained. The data from the survey demonstrated that 98% of physician practices were affected by COVID and 91% of physicians felt it had a significant financial impact. Sixty seven percent of the physicians responded
that inhouse billing was responsible for their increased level of burnout, whereas 73% responded that electronic medical records (EMRs) were one of the causes. Overall, 78% were very concerned. |
|
Ji, P |
Social Semiotics |
Public Health response| Interventions de santé publique |
We explore how anti-epidemic promotional videos released by Chinese authorities build facemask-related narratives in
the Covid-19 epidemic. Findings reveal that “facemask in use” links people’s “smaller love” for family to a “bigger love” for Chinese people in general; transforms an individual to member of a large group of commoner-turned-protectors; or marks the military’s
loyalty and obedience to the Party-State, which makes possible the “Chinese speed” in saving lives. We add to extant literature by unraveling an entanglement between the moralization of facemask-wearing and China’s traditional values, social institutions and
media newsroom culture about disaster coverage. This scrutiny into the “face-masking morality in the making” implies that the power to frame the cultural significance of facemask induces an alternative mode of techno-moral change, which may outlast the epidemic
itself. |
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Political polarization drives online conversations about COVID-19 in the United States |
Jiang, J, Chen, et al |
Human Behavior and Emerging Technologies |
Public Health response| Interventions de santé publique |
Since the outbreak in China in late 2019, the novel coronavirus (COVID-19) has spread around the world and has come
to dominate online conversations. By linking 2.3 million Twitter users to locations within the United States, we study in aggregate how political characteristics of the locations affect the evolution of online discussions about COVID-19. We show that COVID-19
chatter in the United States is largely shaped by political polarization. Partisanship correlates with sentiment toward government measures and the tendency to share health and prevention messaging. Cross-ideological interactions are modulated by user segregation
and polarized network structure. We also observe a correlation between user engagement with topics related to public health and the varying impact of the disease outbreak in different U.S. states. These findings may help inform policies both online and offline.
Decision-makers may calibrate their use of online platforms to measure the effectiveness of public health campaigns, and to monitor the reception of national and state-level policies, by tracking in real-time discussions in a highly polarized social media
ecosystem. © 2020 Wiley Periodicals LLC. |
|
Jindal, MK, Sar, et al |
International journal of environmental analytical chemistry |
Public health interventions*| Interventions de santé publique |
Coronavirus Disease 2019 (COVID-19) has been declared officially as the pandemic worldwide. This novel coronavirus
affects almost the whole world and it can quickly spread among the population in several ways. This has initially come from China and within a few months, covers the overall world. Therefore, many countries have decided to restrict the movement through lockdown
to control the spreading of COVID-19 novel virus among the population. During this lockdown condition, almost all except few essential people stay at home means staying inside of houses 24 × 7 hours. The study aims to calculate the impact of this lockdown
condition on the annual natural gamma radiation dose. The values of indoor gamma radiation are not the same as the outdoor gamma dose rate; the ration between indoor and outdoor gamma dose rates varies based on country to country. In this study, we have used
indoor-outdoor gamma dose rate ratio which was reported by UNSCEAR (United Nations Scientific Commission on Effects of Atomic Radiation) and calculated the variation of annual dose rate during this pandemic condition that will be helpful for estimation of gamma
expose scale for this year of various countries. The higher ratio of indoor and outdoor gamma dose rates showed a high variation in annual dose rate. It was found that the change in annual dose rate continuously increases with respect to the number of days
of lockdown. This will also affect much more at high background radiation areas as compared to the low background area. © 2020 Informa UK Limited, trading as Taylor & Francis Group. |
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Jin-Yang, L, Ping, et al |
Academic Journal of Second Military Medical University |
Public Health response| Interventions de santé publique |
Objective To understand the sleep quality and psychological status of officers and soldiers in naval force stationed
in Hubei, China during the coronavirus disease 2019 (COVID-19) epidemic, and to explore the influencing factors, so as to maintain the physical and mental health of officers and soldiers during the epidemic. A total of 238 questionnaires were sent out, and
232 valid questionnaires were collected, with an effective rate of 97.5%. Poor and very poor sleep qualities accounted for 5.6% (13/232) and 0.9% (2/232), respectively. Mild, moderate and severe depression accounted for 12.1% (28/232), 0.9% (2/232) and 0.4%
(1/232), respectively. Mild and moderate psychological stress accounted for 12.5% (29/232) and 1.3% (3/232), respectively. |
|
|
Johnson, BryanA, Xie, et al |
bioRxiv |
Coronavirology| Coronavirologie Animal model | Modèle animal |
We generated a SARS-CoV-2 mutant lacking the furin cleavage site (ΔPRRA) in the spike protein. Using in vitro methods
and a hamster pathogenesis model, we demonstrate a critical role for the furin cleavage site insertion in SARS-CoV-2 replication and pathogenesis. In addition, these findings illustrate the importance of this insertion in evaluating neutralization and other
downstream SARS-CoV-2 . |
|
|
Quality of Novel Coronavirus Related Health Information over the Internet: An Evaluation
Study |
Joshi, A, Kajal, et al |
TheScientificWorldJournal |
Public Health response| Interventions de santé publique Healthcare Response | Réponse
des soins de santé |
Background: The novel coronavirus disease (COVID-19) has spread globally from its epicenter in Hubei, China, and was
declared a pandemic by the World Health Organization (WHO) on March 11, 2020. The most popular search engine worldwide is Google, and since March 2020, COVID-19 has been a global trending search term. Misinformation related to COVID-19 from these searches
is a problem, and hence, it is of high importance to assess the quality of health information over the internet related to COVID-19. The objective of our study is to examine the quality of COVID-19 related health information over the internet using the DISCERN
tool. Methods: The keywords included in assessment of COVID-19 related information using Google's search engine were "Coronavirus," "Coronavirus causes," "Coronavirus diagnosis," "Coronavirus prevention," and "Coronavirus management". The first 20 websites
from each search term were gathered to generate a list of 100 URLs. Duplicate sites were excluded from this search, allowing analysis of unique sites only. Additional exclusion criteria included scientific journals, nonoperational links, nonfunctional websites
(where the page was not loading, was not found, or was inactive), and websites in languages other than English. This resulted in a unique list of 48 websites. Four independent raters evaluated the websites using a 16-item DISCERN tool to assess the quality
of novel coronavirus related information available on the internet. The interrater reliability agreement was calculated using the intracluster correlation coefficient. Results: Results showed variation in how the raters assigned scores to different website
categories. The .com websites received the lowest scores. Results showed that .edu and .org website category sites were excellent in communicating coronavirus related health information; however, they received lower scores for treatment effect and treatment
choices. Conclusion: This study highlights the gaps in the quality of information that is available on the websites related to COVID-19 and study emphasizes the need for verified websites that provide evidence-based health information related to the novel
coronavirus pandemic. Copyright © 2020 Ashish Joshi et al. |
|
Changes in air pollution levels after COVID-19 outbreak in Korea |
Ju, MJ, Oh, et al |
Science of the Total Environment |
Public health interventions*| Interventions de santé publique |
This study investigated changes in air pollution during the social distancing after the COVID-19 outbreak in Korea.
Ambient PM2.5, PM10, NO2, and CO that are particularly related to industrial activities and traffic were reduced during the social distancing in response to the COVID-19 outbreak. In March 2020, immediately after social distancing, mean levels of PM2.5, PM10,
NO2, and CO decreased nationwide from last year's mean levels by 16.98 μg/m3, 21.61 μg/m3, 4.16 ppb, and 0.09 ppm, respectively (p-value for the year-to-year difference <0.001, =0.001, =0.008, <0.001), a decrease by 45.45%, 35.56%, 20.41%, and 17.33%, respectively.
Changes in ambient O3 or SO2 were not observed to be attributable to social distancing. Our findings, that such effort for a short period of time resulted in a significant reduction in air pollution, may point toward reducing air pollution as a public health
problem in a more sustainable post-COVID-19 world. |
|
Towards an ontology proposal model in data lake for real-time COVID-19 cases prevention |
Kachaoui, J, Larioui, et al |
International journal of online and biomedical engineering |
Public Health response| Interventions de santé publique |
Globally, the coronavirus epidemic has now hit lives of millions and thousands of people around the world. The growing
threat of this virus continues rising as new cases appear every day. Yet, affected countries by coronavirus are currently taking important measures to remedy it by using Artificial Intelligence (AI) and Big Data technologies. According to the World Health
Organization (WHO), AI and Big Data have performed an important role in China's response to COVID-19, the genetic mutation name for coronavirus. Predicting an epidemic emergence, from the coronavirus appearance to a person's predisposition to develop it, is
fundamental to combating it. In this battle, Big Data is on the front line. However, Big Data cannot provide all of the expected insights and derive value from manipulated data. This is why we propose a semantic approach to facilitate the use of these data.
In this paper, we present a novel approach that combines between the Semantic Web Services (SWS) and the Big Data characteristics in order to extract a significant information from multiple data sources that can be exploitable for generating real-time statistics
and reports. © 2020 Kassel University Press GmbH. |
|
Kaim, A, Jaffe, et al |
International Journal of Environmental Research and Public Health |
Public Health response| Interventions de santé publique |
In this cross-sectional study, a pre-post questionnaire was used to investigate the impact of a brief educational intervention
on knowledge, perceived knowledge, perceived safety, and the individual resilience of the population relating to the COVID-19 outbreak. The results of the study display the benefits of the educational intervention to include a significant overall increase
in all examined variables. The study also reviewed the overall trust of the public concerning the main responding authorities, as well as practices concerning protective measures for COVID-19. This study demonstrates that educational interventions, such as
the brief video, provide an easily implementable design and effective means for educating and empowering the public and should, thus, be considered as a component of future outbreak responses |
|
|
Kajdy, A, Feduniw, et al |
Medicine |
Public Health response| Interventions de santé publique |
INTRODUCTION: The article presents a protocol of a cross-sectional study of mental health of pregnant women in relation
to the coronavirus disease 19 (COVID-19) pandemic. The primary aim is to compare differences in anxiety and depression scores of pregnant women between countries affected by the COVID-19 pandemic. The secondary aim is to assess demographic, economic, and social
aspects affecting maternal anxiety and depression scores among pregnant women worldwide in the time of the COVID-19 pandemic. Finally, we will be able to compare differences in perception of the different aspects of the COVID-19 pandemic (social distancing,
restrictions related to delivery) between countries and according to the epidemic status (number of infected patients, number of reported deaths). The comparisons will also be done according to the COVID-19 status of the participants. METHODS AND ANALYSIS:
It is a web-based anonymous survey of pregnant women living in countries affected by the COVID-19 pandemic. The survey is comprised of 3 sections:Web-based recruitment for health research has proven to be cost-effective and efficient. At current times with
the COVID-19 pandemic, limited resources and social distancing restrictions, performing a mental health study involving pregnant women on a large international scale cannot be safely conducted without involving social-media.The fears of pregnant women fall
into 3 categories: the medical condition, the economic status and the organization of daily activity.The study has received approval of the medical ethics committee and has been registered on Clinicaltrials.gov. Results will be published in peer-reviewed journals
and made public through all available media. |
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Kakakhel, MA, Wu, et al |
New Microbes and New Infections |
Epidemiology| Épidémiologie |
We sought to investigate COVID-19's prevalence and epidemiologic trends in Pakistan. Research for COVID-19 is still
in its early stages, so data were collected from official websites and research journals, then analyzed for the disease's prevalence, epidemiology, mortality and recoveries. The results indicated that a rapid increase had indeed occurred in the number of COVID-19
infections in Pakistan, with the first case reported on 25 February, 2020. From 25 February 25 to April, 2020, COVID-19 infected 11,155 people in Pakistan, with 237 deaths (2.12%) and 2527 recoveries (19.96%). We found a statistically significant positive
correlation between the prevalence of COVID-19 and the mortality ratio (r = 0.983, r2 = 0.966; p ≤ 0.05). We concluded that proper management must be undertaken to improve the quarantine system, and the World Health Organization guidelines must be closely
followed to cope with COVID-19. |
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Nursing experiences of COVID-19 outbreak in Iran: A qualitative study |
Kalateh Sadati, A, Zarei, et al |
Nursing Open |
Healthcare Response | Réponse des soins de santé |
This study aimed to investigate nurses’ perceptions and experiences of COVID-19 outbreak in Iran. Semi-structured interviews
were conducted with 24 nurses in Qazvin, Arak, Shiraz and Kashan cities of Iran. It was found out that all the participants had faced a mysterious world created by the virus. No one had clear understanding of the new virus and knew how to tackle with such
a virus. In this case, the main experiences were related to defected preparedness, the worst perceived risk, family protection, social stigma and sacrificial commitment. |
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Hydroxychloroquine use in hospitalised patients with COVID-19: An observational
matched cohort study |
Kalligeros, M, Shehadeh, et al |
Journal of Global Antimicrobial Resistance |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
This study aimed to assess the efficacy and safety of hydroxychloroquine with or without azithromycin) in hospitalized
adult patients with COVID-19. 36 patients received hydroxychloroquine and were age- and sex-matched to 72 patients with COVID-19 who received supportive care. Compared to supportive care, the use of HCQ did not shorten the time to clinical improvement (+0.23
days; 95% CI: −1.8–2.3 days) nor did it shorten the duration of hospital stay (+0.91 days; 95% CI: −1.1–2.9 days). Additionally, HCQ did not decrease the risk of COVID-19 in-hospital death (aHR 1.67; 95% CI: 0.29–9.36). Finally, we observed a slight QTc prolongation
from a baseline of 444 ± 26 ms to 464 ± 32 ms (mean±SD) among patients receiving hydroxychloroquine with or without azithromycin. |
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Multiscale Dynamic Human Mobility Flow Dataset in the U.S. during the COVID-19 Epidemic |
Kang, Yuhao, Gao, et al |
arXiv |
Public Health response| Interventions de santé publique |
In this data descriptor, we introduce a multiscale dynamic human mobility flow dataset across the United States, with
data starting from March 1st, 2020. By analysing millions of anonymous mobile phone users' visit trajectories to various places, the daily and weekly dynamic origin-to-destination (O-D) population flows are computed, aggregated, and inferred at three geographic
scales: census tract, county, and state. There is high correlation between our mobility flow dataset and openly available data sources, which shows the reliability of the produced data. |
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Karakas, M, Jarczak, et al |
Biomolecules |
Clinical data| Données cliniques |
Case series of eight shock patients with life-threatening COVID-19 and ARDS, they were treated with administration
of Adrecizumab was followed by a favorable outcome. |
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Psychological Resilience and Depression during the Covid-19 Pandemic in Turkey |
Karaşar, B, Canli, et al |
Psychiatria Danubina |
Public Health response| Interventions de santé publique |
BACKGROUND: Turkey is one of the countries affected during the period of COVID-19 outbreak. The purpose of the current
study is to investigate psychological resilience and depression in individuals during the period of COVID-19 outbreak in Turkey in relation to different variables. The study also aims to explore the relationship between psychological resilience and depression.
SUBJECTS AND METHODS: The current study was conducted on a total of 518 people over the social media through the Google e-forms. In the study, the "Short Psychological Resilience Scale" and the "Beck Depression Scale" were used to collect data. In the analysis
of the collected data, t-test, One Way Anova, Mann-Whitney U Test, Kruskal Wallis-H Test, Pearson Correlation Coefficient were used. RESULTS: In the current study, psychological resilience and depression were investigated in relation to different variables.
Psychological resilience was found to be higher male participants, educators,university graduates and groups with not mental health problems. Depression was found to be higher females, university students, high school and lower graduates,with mental health
problems. When the relationship between psychological resilience and depression was investigated, it was found that there is a medium and negative correlation between them. Moreover, the cut-off point for the depression score was set to be 17 and the rate
of the people having 17 points or higher scores was found to be 16.6%. CONCLUSION: In light of the findings of the current study, it can be suggested to offer more mental health care services to those having higher levels of depression. Studies can be conducted
to improve online psychological support services. A medium and negative correlation was found between psychological resilience and depression in the current study, which shows that more importance should be attached to activities to improve psychological resilience. |
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Karhadkar, TejasR, Pilling, et al |
bioRxiv |
Therapeutics| Thérapeutique Animal model | Modèle animal |
In this report, we show that aspiration of the GU-rich ssRNA oligonucleotide ORN06 into mouse lungs induces COVID-19-like
symptoms. Results suggest that aspiration of ORN06 is a simple model for both COVID-19 as well as cytokine storm in general, and that serum amyloid P is a potential therapeutic for diseases with COVID-19-like symptoms as well as diseases that generate a cytokine
storm. |
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Kaspar, K |
J Med Internet Res |
Public Health response| Interventions de santé publique |
The aim of this study was to examine central cognitive variables that may constitute people’s motivations for social
distancing, using an app, and providing health-related data requested by two apps that differ in their direct utility for the individual user. Multiple regression analyses showed that the present model could explain 55% of the interindividual variance in the
participants’ motivation for social distancing, 46% for using a contact tracing app, 42% for providing their own infection status to a contact tracing app, and 34% for using a data donation app. |
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Keil, EJ, Navarro, et al |
JCO global oncology |
Public Health response| Interventions de santé publique |
PURPOSE: The rapid dissemination of information through social media renders a profound lens to evaluate perceptions
of emerging topics, especially in the context of a global pandemic. The primary objective of this cross-sectional study was to elucidate trends on social media in the setting of surgical cancer care affected by the COVID-19 pandemic across the globe. METHODS:
A public search of Twitter from April 1 to 30, 2020, was conducted, which yielded 996 posts related to COVID-19 and cancer. Two authors (E.J.K. and H.S.) individually reviewed all posts and recorded the post category, engagement, author category, and geographic
location. Data were then analyzed through descriptive analyses. Only English-language posts were included, and any noncancer- or non-COVID-related posts were excluded from the analysis. RESULTS: A total of 734 unique authors from 26 different countries wrote
996 relevant posts that averaged 12.0 likes, 4.7 retweets, and 0.5 hashtags per post. Only 2.3% (23 of 996) of posts included a video. Authors of the included tweets most frequently were friends and families of patients (183; 18.4%), academic institutions
or organizations (182; 18.3%), and physicians (138; 13.9%). Topics of importance were cancellations of surgeries (299; 40.1%), COVID-19 education (211; 121.2%), and research studies (93; 9.3%). The United Kingdom and the United States made up 81.5% of the
cohort, followed by Canada (6.6%) and India (2.4%). Of posts where a specific type of surgery was identified (196), the most common type mentioned was breast cancer (50; 25.5%), followed by lung cancer (37; 18.9%) and urologic cancer (22; 11.2%). CONCLUSION:
This analysis provides insight into the resulting impacts of COVID-19 on the global discussion of surgical cancer care. |
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African Americans and COVID-19: Beliefs, behaviors and vulnerability to infection |
Kemp, E, Price, et al |
International Journal of Healthcare Management |
Public Health response| Interventions de santé publique |
In the United States, during the early outbreak of the coronavirus (COVID-19) pandemic, African Americans experienced
disproportionately high rates of infection and mortality relative to their share of the United States population. New Orleans, Louisiana was one of the places most heavily affected by the coronavirus during its early outbreak. The study that follows explores
the attitudes of African Americans in New Orleans toward the virus, social and normative conditions which affected individual behaviors, as well as access to healthcare services and COVID-19 testing. In part one of the study, qualitative responses were collected
from a sample of African Americans in the New Orleans area to garner perspective about their attitudes and behaviors related to the coronavirus outbreak. Part two of the study builds on findings from Study 1 with parameter estimates from a Logit regression
to examine how social, economic and physical conditions determine vulnerability to COVID-19 infection among African Americans. Implications for how healthcare organizations can address the needs of vulnerable populations during a health-related crisis are
discussed. © 2020 Informa UK Limited, trading as Taylor & Francis Group. |
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Khalafallah, AM, Lam, et al |
Journal of Clinical Neuroscience |
Healthcare Response | Réponse des soins de santé |
We investigated the impact of the COVID-19 pandemic on U.S. neurosurgery resident workflow, burnout, and career satisfaction.
In 2020, a survey evaluating factors related to career satisfaction and burnout was emailed to 1,374 American Association of Neurological Surgeons (AANS) residents. 167 survey responses were received, with a response rate (12.2%) comparable to that of similar
studies. Exclusion of incomplete responses yielded 111 complete responses. Most respondents were male (65.8%) and White (75.7%). Residents reported fewer work hours (67.6%) and concern that COVID-19 would impair their achievement of surgical milestones (65.8%).
Burnout was identified in 29 (26.1%) respondents and career satisfaction in 82 (73.9%) respondents. In multivariate analysis, burnout was significantly associated with alterations in elective rotation/vacation schedules (p = .013) and the decision to not pursue
neurosurgery again if given the choice (p < .001). Higher post-graduate year was associated with less burnout (p = .011). Residents displayed greater career satisfaction when focusing their clinical work upon neurosurgical care (p = .065). Factors related
to COVID-19 have contributed to workflow changes among U.S. neurosurgery residents. |
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Kilaru, AS, Lee, et al |
Acad Emerg Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We describe the incidence of return hospital admission within 72 hours for patients with COVID-19 who were discharged
from the ED upon initial presentation. We also evaluate patient characteristics associated with return hospital admission. |
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Kilduff, CL, Thomas, et al |
BMJ health & care informatics |
Healthcare Response | Réponse des soins de santé |
BACKGROUND: The COVID-19 crisis forced hospitals in the UK dramatically to reduce outpatient activity. To provide continuity
of care and to assist patients reluctant or unable to leave their homes, video consultations were rapidly implemented across routine and emergency ophthalmology services. OBJECTIVE: To describe the deployment and scaling to a large volume of teleophthalmology
using a video consultation platform 'Attend Anywhere' in Moorfields Eye Hospital's accident and emergency (A&E) department (London, UK). METHOD: Patient satisfaction, waiting time, consultation duration, outcome and management were audited following the launch
of the new virtual A&E service. RESULTS: In the 12 days following the service launch, 331 patients were seen by video consultation. 78.6% of patients (n=260) were determined not to need hospital A&E review and were managed with advice (n=126), remote prescription
(n=57), general practitioner referral (n=27), direct referral to hospital subspecialty services (n=26) or diversion to a local eye unit (n=24). Mean patient satisfaction was 4.9 of 5.0 (n=62). The mean consultation duration was 12 min (range 5-31 min) and
the wait time was 6 min (range 0-37 min). CONCLUSION: Video consultations showed greater than expected usefulness in the remote management of eye disease and supported a substantial reduction in the number of people visiting the hospital. © Author(s) (or their
employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
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Trends in suicidal ideation over the first three months of COVID-19 lockdowns |
Killgore, WDS, Cloonan, et al |
Psychiatry research |
Public Health response| Interventions de santé publique |
To determine the effect of stay-at-home restrictions or lockdowns that limited social interaction and movement outside
the home on suicidal ideation, a total of 3,120 individuals completed the Patient Health Questionnaire (PHQ-9) at one of three time points from April through June 2020. The percentage of respondents endorsing suicidal ideation was greater with each passing
month for those under lockdown or shelter-in-place restrictions due to the novel coronavirus, but remained relatively stable and unchanged for those who reported no such restrictions. Public health policy and routine clinical care need to address the potential
for increased suicidal thinking among those experiencing prolonged restrictions of normal social contact. |
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Killgore, WDS, Cloonan, et al |
Psychiatry research |
Public Health response| Interventions de santé publique |
The majority of the U.S. population has been under stay-at-home restrictions to reduce the spread of COVID-19 since
March 2020. Over the first three months of restrictions, 3,121 U.S. adults completed the UCLA Loneliness Scale-3 and Patient Health Questionnaire-9 (PHQ-9). Despite relaxation of lockdowns and shelter-in-place orders over that time, loneliness scores increased
significantly, particularly from April to May 2020, and appear to have plateaued by June. Loneliness was correlated with depression and suicidal ideation at all time points and was most prevalent among individuals who reported that they were still under community
restrictions to socially isolate due to the novel coronavirus. Loneliness remains elevated despite the reopening of many communities. |
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Genomic Investigation of the Coronavirus Disease-2019 Outbreak in the Republic
of Korea |
Kim, Jeong-Min, Park, et al |
Research Square prepub |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
We conducted SARS-CoV-2 whole genome sequencing of 66 cases to investigate connections among the initial South Korean
cases and the Shincheonji outbreak. Five transmission clusters were estimated among the 15 initial cases. The six close-contact cases and two potential exposure pairs identified by contact tracing showed two or fewer nucleotide base differences. Additionally,
we identified two transmission clusters from the Shincheonji outbreak that were phylogenetically distinct from the initial clusters. |
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Kinoshita, M, Tanaka, et al |
Journal of Infection |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
Objectives: In Japan, the first case of coronavirus disease 2019 (COVID-19) was diagnosed on January 15, 2020 and subsequent
infections rapidly increased. The Bacillus Calmette-Guérin (BCG) vaccination program is the principal element of tuberculosis control in Japan. We investigated the impact of routine infant BCG vaccination on prevention of local COVID-19 spread. Methods: Data
on the prevalence of SARS-CoV-2 infection, annual routine infant BCG vaccine coverage (represented by the number of BCG vaccinations per live births), and other candidate factors in each prefecture were obtained from the official notifications database in
Japan. We analysed the association of vaccine coverage with the prevalence of SARS-CoV-2 infection. Results: The BCG vaccine coverage in 1999–2002, 2004, and 2012 in five prefectures with no COVID-19 infections was significantly higher than that in five prefectures
with a high prevalence of infections (Mann-Whitney U test, p<0.05). The prevalence of SARS-CoV-2 infection was significantly negatively correlated with BCG vaccine coverage in 2004 and was significantly positively correlated with age groups 20–34 and 40–54
years (Spearman's rank correlation, p<0.01). Conclusions: Our findings suggest that routine infant BCG vaccination coverage in young generation had a significant impact on prevention of local COVID-19 spread in Japan. © 2020 The British Infection Association |
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Kintscher, U, Slagman, et al |
Hypertension |
Clinical data| Données cliniques Therapeutics| Thérapeutique Immunology | Immunologie |
We analyzed distinct RAS components in plasma from COVID-19 patients ± ACEi/ARB therapy using LC-MS/MS. However, we
provide for the first time a snapshot |
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Kong, E, Prinz, et al |
Journal of Public Economics |
Public Health response| Interventions de santé publique |
We use high-frequency Google search data, combined with data on the announcement dates of non-pharmaceutical interventions
(NPIs) during the COVID-19 pandemic in U.S. states, to disentangle the short-run direct impacts of multiple different state-level NPIs in an event study framework. Exploiting differential timing in the announcements of restaurant and bar limitations, non-essential
business closures, stay-at-home orders, large-gatherings bans, school closures, and emergency declarations, we leverage the high-frequency search data to separately identify the effects of multiple NPIs that were introduced around the same time. We then describe
a set of assumptions under which proxy outcomes can be used to estimate a causal parameter of interest when data on the outcome of interest are limited. Using this method, we quantify the share of overall growth in unemployment during the COVID-19 pandemic
that was directly due to each of these state-level NPIs. We find that between March 14 and 28, restaurant and bar limitations and non-essential business closures can explain 6.0% and 6.4% of UI claims respectively, while the other NPIs did not directly increase
own-state UI claims. This suggests that most of the short-run increase in UI claims during the pandemic was likely due to other factors, including declines in consumer demand, local policies, and policies implemented by private firms and institutions. © 2020
Elsevier B.V. |
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Kozlovskaya, L, Piniaeva, et al |
International Journal of Infectious Diseases |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
The objective of this study was to determine the molecular epidemiology of the COVID-19 outbreak in Russia. In this
study, two SARS-CoV-2 strains were isolated and genetically characterized. A phylogenetic analysis of all available Russian sequences was then performed and these were compared to the epidemiological data on COVID-19 incidence to evaluate the molecular epidemiology
and pattern of virus spread in the territory of Russia. Whole genome analysis of the isolates obtained in this study and 216 others isolated in Russia revealed a set of seven common mutations when compared to the original Wuhan virus, including amino acid
substitutions in spike protein S and nucleoprotein N, possibly affecting their properties. Phylogenetic analysis of all Russian sequences and 8717 sequences from other countries showed multiple importations of the virus into Russia, local circulation, and
several patterns of virus spread. |
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Experience from a covid-19 first-line referral clinic in greater Copenhagen |
Kronborg, TM, Kimer, et al |
Danish Medical Journal |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
INTRODUCTION: Due to the coronavirus disease 2019 (COVID-19) exposure in Denmark, first-line referral centres were
established to handle all patients suspected of COVID-19 or other upper respiratory tract infection. Here we report the first experiences from a first-line referral centre from Amager-Hvidovre Hospital, situated on the outskirts of Copenhagen. METHODS: A retrospective
quality assessment was performed with collection of symptom patterns and COVID-19 status. RESULTS: During the first 24 days, a total of 3,551 patients were referred for assessment of symptoms of upper respiratory tract infection and COVID-19. A total of 2,048
patients were assessed as having mild symptoms and referred for COVID-19 testing alone, whereas 337 patients were assessed clinically by a physician. Thirty-seven were positive for COVID-19 infection, 286 were negative. The most common symptoms reported were
fever, coughing and dyspnoea. Fever was an independent predictor of COVID-19 infection (odds ratio (OR) = 2.25 (95% confidence interval (CI): 1.08-5.04); p = 0.037); whereas sore throat was not (OR = 0.40 (95% CI: 0.15-0.92); p = 0.045). Only a small number
of patients reported loss of taste or anosmia. In total, 113 patients were admitted to hospital, the majority of patients were discharged within 24 hours with mild symptoms of upper respiratory tract infections. Three of the COVID-19-positive patients developed
a severe infection and two had a fatal outcome. CONCLUSIONS: The present study is the first to report the experiences and symptom patterns of a COVID-19 first-line referral centre with efficient triage of patients in need of hospitalisation. © 2020, Danish
Medical Association. All rights reserved. |
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Kuba, M, Kraus, et al |
Chemistry - A European Journal |
Coronavirology| Coronavirologie |
Thymidine triphosphate bearing benzylidene-tetrahydroxanthylium near-IR fluorophore linked to the 5-methyl group via
triazole was synthesized through the CuAAC reaction and was used for polymerase synthesis of labelled DNA probes. The fluorophore lights up upon incorporation to DNA (up to 348-times) presumably due to interactions in major groove and the fluorescence further
increases in the single-stranded oligonucleotide. The labelled dsDNA senses binding of small molecules and proteins by a strong decrease of fluorescence. The nucleotide was used as a light-up building block in real-time PCR for detection of SARS-CoV-2 virus.
© 2020 Wiley-VCH GmbH |
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Impact of COVID-19 on Elective Colorectal Resections in a District
General Hospital |
Kudchadkar, Shantata, Cirocchi, et al |
SSRN- Lancet prepublication |
Healthcare Response | Réponse des soins de santé |
A single-center, retrospective study of prospectively collected data was conducted, aimed to identify the impact of
COVID-19 pandemic on clinical outcome of elective time critical colorectal resections and analyse the mitigating strategies to reduce the adverse clinical outcome. Total 25 elective colorectal resections were performed. Of 25, only two patients (8%) developed
Covid-19 infection post-operatively, which was managed conservatively without any morbidity/mortality. Mean hospital stay was 5.7 days. 30-day mortality was zero in 17/25 patients (68%). |
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Kumar Swain, R, Minz, et al |
Biological Rhythm Research |
Public Health response| Interventions de santé publique |
The Government of India imposed the strictest lockdown from 25 March 2020 till 31 May 2020 to control the spread of
coronavirus outbreak. Consequently, about 1.38 billion people were under home confinement. Before the COVID-19 pandemic, we studied circadian rhythm (CR) in the usages of Facebook Messenger (FBM), as a group phenomenon, and published the findings in this journal.
We thought it would be worthwhile to carry out a sequel study to assess if there are any changes in the CR in the patterns of digital activity of the FBM users during the COVID-19-triggered lockdown. All the authors of this paper harvested real-time data from
their FBM account for over 16 consecutive days between 26 March and 17 April 2020. A statistically significant CR in the digital activity pattern of FBM friends of all the authors was validated. Results of one-way repeated measures ANOVA revealed a statistically
significant higher Mesor and amplitude of the rhythm in FBM activity patterns during the lockdown; however, acrophase remained unchanged. We concluded that the COVID-19-triggered lockdown did not affect the location of the peaks and the persistence of CR in
the online activity patterns of FBM users. © 2020 Informa UK Limited, trading as Taylor & Francis Group. |
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Kumar, S, Kumar, et al |
Journal of Clinical Orthopaedics and Trauma |
Healthcare Response | Réponse des soins de santé |
The aim of this study is to analyze the effectiveness of proactive telemedicine in maintaining follow-up of orthopedic
patients, and their satisfaction with telemedicine as an alternative mode of treatment delivery. The response rate to telemedicine was 88.67%. Among the patients availing telemedicine, 71.43% were managed without needing physical visits to the outpatient-department.
The need for physical examination and failed patient-doctor communication were the most common reasons for advising physical outpatient visits. The overall satisfaction-rate to telemedicine was 92%, and only 7.2% of patients had difficulty in understanding
or following telemedicine-based advice. |
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Kumbhar, Farooque Hassan, Hassan, et al |
arXiv |
Public Health response| Interventions de santé publique |
The purpose of this study is to introduce a connected smart paradigm that not only detects the possible spread of viruses
but also helps to restart businesses/economies, and resume social life. We are proposing a connected Internet of Things ( IoT) based paradigm that makes use of object detection based on convolution neural networks (CNN), smart wearable and connected e-health
to avoid current and future outbreaks. We evaluated the proposed scheme for social distancing violation detection using YOLO (you only look once) v2 and v3, and for infection spread tracing using Python simulation. |
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Evaluation of the effect of the state of emergency for the first wave of COVID-19
in Japan |
Kuniya, T |
Infectious Disease Modelling |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
In this paper, we evaluate the effect of the state of emergency for the first wave of COVID-19 in Japan, 2020 from
the viewpoint of mathematical modelling. In Japan, it was announced during the period of the state of emergency from April 7 to May 25, 2020 that the 80% reduction of the contact rate is needed to control the outbreak. By numerical simulation, we show that
the reduction rate seems to have reached up to 86%. Moreover, we estimate the control reproduction number Rc during the period of the state of emergency as Rc=0.36 (95%CI, 0.34–0.39), and show that the effective reproduction number Re after the lifting of
the state of emergency could be greater than 1. This result suggests us that the second wave of COVID-19 in Japan could possibly occur if any effective intervention will not be taken again. © 2020 The Author |
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Hydroxychloroquine-related Rash in COVID-19
Infected Patient |
Kurd, R, Zuckerman, et al |
The Israel Medical Association journal : IMAJ |
Clinical data| Données cliniques |
Case report of a 77 year old male who developed a rash post HCQ administration. |
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Labrague, LJ, De los Santos, et al |
Journal of nursing management |
Healthcare Response | Réponse des soins de santé |
Aim: This study examines the relative influence of personal resilience, social support and organisational support in
reducing COVID-19 anxiety in front-line nurses. Background: Anxiety related to the COVID-19 pandemic is prevalent in the nursing workforce, potentially affecting nurses’ well-being and work performance. Identifying factors that could help maintain mental health
and reduce coronavirus-related anxiety among front-line nurses is imperative. Currently, no studies have been conducted examining the influence of personal resilience, social support and organisational support in reducing COVID-19 anxiety among nurses. Methods:
This cross-sectional study involved 325 registered nurses from the Philippines using four standardized scales. Results: Of the 325 nurses in the study, 123 (37.8%) were found to have dysfunctional levels of anxiety. Using multiple linear regression analyses,
social support (β = −0.142, p =.011), personal resilience (β = −0.151, p =.008) and organisational support (β = −0.127, p =.023) predicted COVID-19 anxiety. Nurse characteristics were not associated with COVID-19 anxiety. Conclusions: Resilient nurses and
those who perceived higher organisational and social support were more likely to report lower anxiety related to COVID-19. Implication for Nursing Management: COVID-19 anxiety may be addressed through organisational interventions, including increasing social
support, assuring adequate organisational support, providing psychological and mental support services and providing resilience-promoting and stress management interventions. © 2020 John Wiley & Sons Ltd |
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Lachant, DJ, Lachant, et al |
Journal of Thrombosis and Haemostasis |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
Background: Thrombotic disease complicates severe SARS-CoV-2 infection and is associated with increased morbidity and
mortality. Various anticoagulation strategies have been evaluated in hospitalized patients to prevent complications. The impact of chronic anticoagulation before SARS-CoV-2 infection on the risk for subsequent thrombosis has not been systematically studied.
Methods: This was a retrospective single-center study. All patients with positive SARS-CoV-2 PCR testing from March 13, 2020, through May 6, 2020, at the University of Rochester Medical Center were identified. We included all patients receiving therapeutic
anticoagulation for at least 1 month before COVID diagnosis. We documented the rate of thrombotic complications, type of anticoagulation, bleeding complications, and mortality. Results: A total of 107 SARS-CoV2-infected patients were chronically anticoagulated
before SARS-CoV-2 testing with a median age of 78. Of those, 42 required hospital admission, with 17 requiring intensive care. No patients, inpatient or outpatient, were diagnosed with a new symptomatic thrombotic complication. Three patients had minor bleeding
in the hospital. Thirteen (12%) patients died (69% male). Conclusion: Our uncontrolled findings suggest that chronic anticoagulation at the time of infection may protect against thrombotic complications and decrease disease severity. © 2020 International Society
on Thrombosis and Haemostasis |
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Association of Environmental Parameters with COVID-19 in Delhi, India |
Ladha, N, Bhardwaj, et al |
Indian Journal of Clinical Biochemistry |
Epidemiology| Épidémiologie |
The present study explores the association between weather and COVID-19 pandemic in Delhi, India. The study used the
data from daily newspaper releases from the Ministry of Health and Family Welfare, Government of India. Linear regression was run to understand the effect of the number of tests, temperature, and relative humidity on the number of COVID-19 cases in Delhi.
The model was significantly able to predict number of COVID-19 cases, F (4,56) = 1213.61, p < 0.05, accounting for 99.4% of the variation in COVID-19 cases with adjusted R2 = 98.8%. Maximum Temperature, average temperature and average relative humidity did
not show statistical significance. The only number of tests was significantly associated with COVID-19 cases. © 2020, Association of Clinical Biochemists of India. |
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Ladhani, ShamezN, Jeffery-Smith, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Immunology | Immunologie |
We investigated six London care homes experiencing a COVID-19 outbreak and found very high rates of SARS-CoV-2 infection
among residents and staff. Here we report follow-up investigations including antibody testing in the same care homes five weeks later. Almost all SARS-CoV-2 RT-PCR positive residents and staff were also antibody positive five weeks later, whether symptomatic
(100% & 100%) or asymptomatic (97.0% & 95.1%). Symptomatic but SARS-CoV-2 RT-PCR negative residents and staff also had high seropositivity rates as did asymptomatic RT-PCR negative individuals. Neutralising antibody was present in 89.4% seropositive individuals
and was not associated with age or symptoms. |
|
|
Transforming Positive Pressure IR Suites to Treat COVID-19
Patients |
Lamparello, NA, Choi, et al |
Journal of Vascular and Interventional Radiology |
Healthcare Response | Réponse des soins de santé |
The authors describe an experience with a positive-pressure IR suite to create a safe, optimized environment for health
care workers and patients. Strategies can be adopted in a traditional IR practice to safely and successfully perform procedures on patients with COVID-19, including but not limited to optimizing inpatient and outpatient workflow to minimize contact time and
transit time, using appropriate PPE for essential staff, and following appropriate wait times and cleaning protocols between cases. These low-cost alterations require no permanent structural changes and can transform an existing positive-pressure IR suite
into a safe environment for patients and health care workers. |
|
Lang, M, Yeung, et al |
Academic Radiology |
Healthcare Response | Réponse des soins de santé |
Our goal was to investigate imaging volume trends during the pandemic at our large academic hospital compared to the
affiliated imaging centers. Imaging volume began to decrease on March 11, 2020, after hospital policy to delay nonessential studies. The average weekly imaging volume during the post-state of emergency period declined by 54% at the main hospital campus and
64% at the affiliated imaging centers. The rate of imaging volume recovery was slower for affiliated imaging centers compared to main hospital campus. CT, radiography, and ultrasound exhibited the lowest volume loss, with weekly volume decrease of 41%, 49%,
and 53%, respectively, at the main hospital campus, and 43%, 61%, and 60%, respectively, at affiliated imaging centers. Mammography had the greatest volume loss of 92% at both the main hospital campus and affiliated imaging centers. |
|
|
Lara-Reyna, J, Yaeger, et al |
World Neurosurgery |
Public Health response| Interventions de santé publique Healthcare Response | Réponse
des soins de santé |
Objective: New York City is the epicenter of the novel coronavirus disease 2019 (COVID-19) pandemic in the United States.
Traumatic brain injury accounts for a significant proportion of admissions to our trauma center. We sought to characterize the effect of the pandemic on neurotraumas, given the cancellation of nonessential activities during the crisis. Methods: Retrospective
and prospective reviews were performed from November 2019 to April 2020. General demographics, clinical status, mechanism of trauma, diagnosis, and treatment instituted were recorded. We dichotomized the data between pre−COVID-19 (before 1 March) and COVID-19
periods and compared the differences between the 2 groups. We present the timeline of events since the beginning of the crisis in relation to the number of neurotraumas. Results: A total of 150 patients composed our cohort with a mean age of 66.2 years (standard
deviation ±18.9), and 66% were male. More males sustained neurotrauma in the COVID-19 period compared with the pre−COVID-19 (60.4% vs. 77.6%, P = 0.03). The most common mechanism of trauma was mechanical fall, but it was observed less frequently compared with
the pre−COVID-19 period (61.4% vs. 40.8; P = 0.03). Subdural hematoma, traumatic subarachnoid hemorrhage, and intracerebral contusion accounted for the most common pathologies in both periods. Nonoperative management was selected for most patients (79.2 vs.
87.8%, P = 0.201) in both periods. Conclusions: A decrease in the frequency of neurotraumas was observed during the COVID-19 crisis concomitant with the increase in COVID-19 patients in the city. This trend began after the cancellation of nonessential activities
and implementation of social distancing recommendations. © 2020 Elsevier Inc. |
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Lázaro-Pérez, C, Martínez-López, et al |
International Journal of Environmental Research and Public Health |
Healthcare Response | Réponse des soins de santé |
In Spain, in a short period of time, health professionals went from a situation of stability to living with a working
environment characterized by overcrowded hospitals, lack of individual protection equipment, non-existent or contradictory work protocols, as well as an unknown increase in mortality. Although in their professional activity health workers are closely linked
to death processes, in recent months, working conditions and health emergencies have drawn an unheard of working scenario, with the stress and anxiety they may suffer when faced with the death of their patients. The present quantitative research was carried
out in different hospitals in Spain on health professionals during the month of April 2020. Through the subscale of anxiety in the face of the death of others, developed by Collett–Lester, it has been verified that health professionals have had to develop
their work in a context of precariousness, putting at risk both their individual and collective health, notably increasing anxiety in the face of the death of their patients. The predictive variables of this anxiety have been the absence of individual protection
equipment, as well as high levels in the burnout subscales of emotional exhaustion and depersonalization. |
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Psychiatry during COVID-19 Pandemic: A Case Report of Attempted Mercy Killing |
Lazzari, C, Nusair, et al |
Psychiatria Danubina |
Public Health response| Interventions de santé publique |
Case of 50 year old male admitted to the psychiatric hospital for fears about COVID-19 |
|
Estimation of the number of working population at high-risk of COVID-19 infection in
Korea |
Lee, J, Kim, et al |
Epidemiology and health |
Epidemiology| Épidémiologie |
We aimed to identify occupational groups at high-risk of coronavirus disease 2019 (COVID-19) infection in Korea, to
estimate the number of such workers, and to examine the prevalence of protective resources by employment status. A total of 30 occupational groups, including 7 occupations from the healthcare and welfare sectors and 23 from other sectors, were classified as
high-risk occupational groups involving frequent contact with people other than fellow employees in the workplace (more than half of the working hours). Approximately 1.4 million (women, 79.1%) and 10.7 million workers (46.3%) are employed in high-risk occupations.
Occupations with a larger proportion of women are more likely to be at a high-risk of infection and are paid less. For wage-earners in high-risk occupations, protective resources to deal with COVID-19 (e.g., trade unions and health and safety committees) are
less prevalent among temporary or daily workers than among those with permanent employment. |
|
4,4′-diaminodiphenyl sulfone (Dds) as an inflammasome competitor |
Lee, JH, An, et al |
International Journal of Molecular Sciences |
Therapeutics| Thérapeutique |
The aim of this study is to examine the use of an inflammasome competitor as a preventative agent. Coronaviruses have
zoonotic potential due to the adaptability of their S protein to bind receptors of other species, most notably demonstrated by SARS-CoV. The binding of SARS-CoV-2 to TLR (Toll-like receptor) causes the release of pro-IL-1β, which is cleaved by caspase-1, followed
by the formation and activation of the inflammasome, which is a mediator of lung inflammation, fever, and fibrosis. By examining the use of 4,4′-diaminodiphenyl sulfone (DDS) in the treatment of patients with Hansen’s disease, also diagnosed as Alzheimer’s
disease, this study demonstrates the diverse mechanisms involved in the activation of inflammasomes. TLRs, due to genetic polymorphisms, can alter the immune response to a wide variety of microbial ligands, including viruses. In particular, TLR2Arg677Trp was
reported to be exclusively present in Korean patients with lepromatous leprosy (LL). Previously, mutation of the intracellular domain of TLR2 has demonstrated its role in determining the susceptibility to LL, though LL was successfully treated using a combination
of DDS with rifampicin and clofazimine. Of the three tested antibiotics, DDS was effective in the molecular regulation of NLRP3 inflammasome activators that are important in mild cognitive impairment (MCI), Parkinson’s disease (PD), and AD. The specific targeting
of NLRP3 itself or up-/downstream factors of the NLRP3 inflammasome by DDS may be responsible for its observed preventive effects, functioning as a competitor. |
|
Characteristics
and early outcomes of patients hospitalised for covid-19 in North Zealand, Denmark |
Lendorf, ME, Boisen, et al |
Danish Medical Journal |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
INTRODUCTION: Coronavirus disease 2019 (COVID-19) is an ongoing pandemic associated with significant morbidity and
mortality worldwide. Limited data are available describing the clinical presentation and outcomes of hospitalised COVID-19 patients in Europe. METHODS:This was a single-centre retrospective chart review of all patients with COVID-19 admitted to the North Zealand
Hospital in Denmark between 1 March and 4 May 2020. Main outcomes include major therapeutic interventions during hospitalisation, such as invasive mechanical ventilation, as well as death. RESULTS: A total of 115 patients were included, including four infants.
The median age of adults was 68 years and 40% were female. At admission, 55 (50%) patients had a fever, 29 (26%) had a respiratory rate exceeding 24 breaths/minute, and 78 (70%) received supplemental oxygen. The prevalence of co-infection was 13%. Twenty patients
(18%) (median age: 64 years; 15% female) were treated in the intensive care unit. Twelve (10.4%) received invasive mechanical ventilation and three (2.6%) renal replacement therapy. Nine patients (8%) developed pulmonary embolism. Sixteen patients (14%) died.
Among patients requiring mechanical ventilation (n = 12), seven (6.1%) were discharged alive, four (3.4%) died and one (0.9%) was still hospitalised. CONCLUSION: In this cohort of hospitalised COVID-19 patients, mortality was lower than in other Danish and
European case series. © 2020, Danish Medical Association. All rights reserved. |
|
Leng, Anli, Maitland, et al |
SSRN- Lancet prepublication |
Public Health response| Interventions de santé publique |
In this study, we aimed to determine individual preferences for COVID-19 vaccinations in China, and to assess the factors
influencing vaccination decision-making to facilitate vaccination coverage. Vaccine effectiveness, side-effects and proportion of acquaintances vaccinated were the most important attributes found to significantly influence respondants' vaccination decision.
We also found a higher probability of vaccinating when the vaccine was more effective; risks of serious side effects were small; vaccinations were free and voluntary; the fewer the number of doses; the longer the protection duration; and the higher the proportion
of acquaintances vaccinated. The predicted vaccination uptake of the optimal vaccination scenario in our study was 84.77%. Preference heterogeneity was substantial. |
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|
Lep, Ž, Babnik, et al |
Frontiers in Psychology |
Public Health response| Interventions de santé publique |
We thus explored how people search for information, how they perceive its credibility, and how all this relates to
their engagement in self-protective behaviors in the crucial period right after the onset of COVID-19 epidemic. The online questionnaire was circulated within 48 h after the first case of COVID-19 was confirmed in Slovenia. Conversely, medical professionals
and scientists were deemed the most credible. The perceived credibility of received information was linked not only with lower levels of negative emotional responses but also with higher adherence to much needed self-protective measures, which aim to contain
the spread of the disease |
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|
Emergency Department Triage in the Era of COVID-19: The Sheba Medical Center Experience |
Levy, Y, Frenkel Nir, et al |
The Israel Medical Association journal : IMAJ |
Healthcare Response | Réponse des soins de santé |
BACKGROUND: Sheba Medical Center, Tel Hashomer, is a tertiary hospital located in the center of Israel. It is the largest
hospital in Israel and was the first to face coronavirus disease-2019 (COVID-19) patients in the country at the beginning of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic. OBJECTIVES: To describe our experience with the COVID-19
pandemic, focusing on our triage method in the emergency department (ED). Our goal was to keep the main hospitalization buildings clean of infection by separating COVID-19 positive patients from COVID-19 negative patients. METHODS: We divided our ED into two
separate sections: a regular non-COVID-19 ED and an advanced biological ED. We created clear protocols of triage for suspected and confirmed COVID-19 patients. We reviewed the data of patients admitted to our ED during the month of March and analyzed the results
of our triage method in separating COVID-19 positive from negative patients. RESULTS: During the month of March 2020, 7957 patients were referred to our ED. Among them 2004 were referred to the biological ED and 5953 were referred to the regular ED. Of the
2004 patients referred to the biological ED, 1641 (81.8%) were sampled for SARS-CoV-2 polymerase chain reaction of whom 143 (8.7%) were positive. Only two COVID-19 positive patients unintentionally entered the main clean hospital, making our triage almost
full proof. CONCLUSIONS: Our triage method was successful in separating COVID-19 positive from negative patients and maintained the regular hospital clean of COVID-19 allowing treatment continuation of regular non-COVID-19 patients. |
|
Leyendecker, P, Ritter, et al |
Eur Radiol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
To retrospectively investigate the incidence of acute adrenal infarction (AAI) in patients who underwent chest CT for
severe SARS-CoV-2 infection and to correlate findings with prognosis. Acute adrenal infarction on initial chest evaluation of severe COVID-19 is frequent (51/219, 23%) and might be a sign of poorer prognosis. |
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|
Li, Fanghua, Zhang, et al |
Research Square prepub |
Public Health response| Interventions de santé publique |
This study aimed to assess the cognition level and attitude of the public towards the disposal of discarded face masks
during the COVID-19 pandemic, to provide a reference for a standardized disposal of discarded face masks. The results showed that 47% of individuals had a low level of relevant knowledge about the disposal of discarded face masks, but more than 95% showed
a positive attitude towards the cooperation with it. In addition, the participants had limited understanding of related regulations, and expected that the relevant departments should increase publicity and training to propagate the related information. |
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|
Li, Jiacheng, Ma, et al |
arXiv |
Coronavirology| Coronavirologie |
Considering the mechanisms of hydrophobic interaction, hydration shell, surface tension, and the shielding effect of
water molecules, this study reveals a hydrophobic-interaction-based mechanism by means of which SARS-CoV-2 S and ACE2 bind together in an aqueous environment. We propose a method to design live attenuated viruses by mutating several key amino acid residues
of the spike protein to decrease the hydrophobic surface areas at the docking site. Mutation of a small amount of residues can greatly reduce the hydrophobic binding of the coronavirus to the receptor, which may be significant reduce infectivity and transmissibility
of the virus. |
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Li, Q, Miao, et al |
Journal of affective disorders |
Public Health response| Interventions de santé publique |
This study aimed to assess the prevalence of anxiety and explore its factors during the COVID-19 epidemic among the
teachers in China. We involved 88611 teachers (response rate: 94.75%) from three cities of Henan Province, China, during February 4-12, 2020. The overall prevalence of anxiety was 13.67%. The prevalence was higher for women than men (13.89% vs. 12.93%). The
highest prevalence of anxiety was 14.06% (SE 2.51%) with age of 60 to 100 years in men, and 14.70% (SE 0.56%) with age of 50 to 60 years in women. Participants located in country-level city school had the lowest prevalence of anxiety across all age categories
(12.01% for age of 18–30 years; 12.50% for age of 30–40 years; 12.13% for age of 40–50 years; 9.52% for age of 60–100 years). After adjusting for potential confounders, age, sex, education status, type of teachers, school location, information source, worried
level, fear level, and behavior status were found to be associated with anxiety. |
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Anxiety and related factors in frontline clinical nurses fighting COVID-19 in
Wuhan |
Li, R, Chen, et al |
Medicine |
Healthcare Response | Réponse des soins de santé |
The aim of this study was to examine the anxiety status of the frontline clinical nurses in the designated hospitals
for the treatment of coronavirus disease 2019 (COVID-19) in Wuhan and to analyze the influencing factors, to provide data for psychologic nursing.This study used a cross-sectional survey design and convenience sampling. The questionnaires were completed by
176 frontline clinical nurses. Among the 176 frontline nurses, 77.3% (136/176) had anxiety. Anxiety symptoms, mild to moderate anxiety symptoms, and severe anxiety symptoms were found in 27.3%, 25%, and 25% of the nurses, respectively. Sex, age, marital status,
length of service, and clinical working time against COVID-19 were associated with anxiety (P < .05). |
|
Lim, A, Singhal, et al |
Journal of Stroke and Cerebrovascular Diseases |
Healthcare Response | Réponse des soins de santé |
This report aims to describe changes that centres providing transient ischaemic attack (TIA) pathway services have
made to stay operational in response to the SARS-CoV-2 pandemic. An international cross-sectional description of the adaptions of TIA pathways between 30th March and 6th May 2020. Experience was reported from 18 centres with rapid TIA pathways in seven countries
(Australia, France, UK, Canada, USA, New Zealand, Italy, Canada) from three continents. All pathways remained active (n = 18). Sixteen (89%) had TIA clinics. Six of these clinics (38%) continued to provide in-person assessment while the majority (63%) used
telehealth exclusively. Of these, three reported PPE use and three did not. Five centres with clinics (31%) had adopted a different vascular imaging strategy. |
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|
Lin, DD, Meghal, et al |
JCO global oncology |
Healthcare Response | Réponse des soins de santé |
As a result of their immunocompromised status associated with disease and treatment, patients with cancer face a profound
threat for higher rates of complications and mortality if they contract the coronavirus disease 2019 infection. METHODS: We systemically examined our community cancer center database to display patterns of change and to unveil factors that have been considered
with each decision. We studied a cohort of 282 patients receiving treatment and found that 159 patients (56.4%) had treatment modifications. CONCLUSION: Our observation and analysis suggested that the primary goal of treatment modification was to decrease
potential exposure. The pattern also reflected the negative impact of the pandemic on health care providers who initiated these changes. |
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Online topic detection and tracking system and its application on stock market
in china |
Lin, Y, Miao, et al |
|
Economics | Économie |
Financial markets are very sensitive to emerging news related to stock because investors need to continuously monitor
financial events when deciding buying and selling stocks. Tracking important events has done mostly using rule-based methods in the past, which is time-consuming in the face of huge online news data. To track this issue, in this paper, a novel document embedding
technology based on TF-IDF and BERT incorporating online text cluster algorithm to form an automated event detection system is proposed. Embedding technology is first used to encode text to vectors and then an online text cluster algorithm - SinglePass is
implemented to accomplish topic tracking. Experiment results show that the proposed algorithms can effectively detect and track online topics. In addition, both domestic and international events such as the outbreak of novel coronavirus (COVID-19) and Sino-U.S.
trade war and their impact on capital market in China are analyzed, which demonstrate the practical and economic value of proposed system. © Springer Nature Switzerland AG 2020. |
|
Ling, M |
|
Public Health response| Interventions de santé publique Economics | Économie |
This paper selected 14 indicators from 1999 to 2018, screened out 5 indicators with high correlation degree through
lasso regression, implemented intelligent gray BP neural network algorithm through computer technology such as matlab and stata, formed a combination of prediction models, and obtained more accurate prediction results from 2020 to 2025. The results reveal
that China’s petroleum demand was less affected by the epidemic as well as the oil price war in 2020, while the imports of the petroleum demand increased from 2020 to 2025. Comparatively speaking, the demand increased slowly, while the imports increased sharply
with an average external dependence of 75.5%, which was far more than the warning line of 50%. In this case, there are sharp contradictions in China’s oil security. In this case, this paper puts forward some targeted suggestions. |
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Link-Gelles, R, DellaGrotta, et al |
MMWR Morb Mortal Wkly Rep |
Epidemiology| Épidémiologie Transmission Public health interventions*| Interventions
de santé publique |
Upon reopening of childcare centers in Rhode Island, a total of 101 possible child care–associated COVID-19 cases were
reported during June 1–July 31. Among them, 49 (49%) symptomatic persons were excluded after receiving negative laboratory test results, 33 persons (33%) had confirmed cases, and 19 (19%) were classified as having probable cases. Secondary transmission in
four child care programs after July 15 could not be ruled out. |
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|
Lisa, A, Battistini, et al |
Plastic and Reconstructive Surgery - Global Open |
Healthcare Response | Réponse des soins de santé |
Background: The coronavirus disease 2019 (COVID-19) pandemic presented a dramatic challenge to healthcare systems.
Humanitas Clinical and Research Hospital (Rozzano, MI, Italy) was declared a regional hub for the treatment of COVID-19 patients. Our plastic surgery team, in consultation with our breast surgery colleagues, decided to perform immediate implant-based breast
reconstruction for patients undergoing mastectomy for cancer. In this report, we present our experience performing breast reconstruction with a new protocol in the first month following the COVID-19 pandemic in the most affected region in Italy. Methods: We
adopted a new protocol to treat patients with breast cancer during the COVID-19 pandemic. The main goals of our protocol were to reduce the risk of COVID-19 spread for both patients and clinicians, postpone nononcologic and more advanced surgery, develop rapid
recovery for early patient discharge (within 24 hours from surgery) through pain management, and finally reduce postoperative consultations. Results: The protocol was applied to 51 patients between early March and early April 2020. After 1 month, we decided
to retrospectively review our experience. We found no significant differences in terms of postoperative pain and complication rate compared with our data in the pre-COVID period. Conclusion: Our new protocol is safe and effective, enabling tumor resection
and immediate implant-based breast reconstruction, without increasing risks to the patient or staff. © 2020 BMJ Publishing Group. All rights reserved. |
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Liu, F, Liu, et al |
Infection and Drug Resistance |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
To investigate the clinico-radiological findings and outcomes in pregnant women with COVID-19 pneumonia compared to
age-matched non-pregnant women. A retrospective case-controlled study was conducted to review clinical and CT data of 21 pregnant and 19 age-matched non-pregnant women with COVID-19 pneumonia. Compared with age-matched non-pregnant women, initial absence of
fever (13/21, 62%) and normal lymphocyte count (11/21, 52%) were more frequent in pregnant group. The predominant patterns of lung lesions were pure ground-glass opacity (GGO), GGO with consolidation or reticulation, and pure consolidation in both groups.
Pure consolidation on chest CT was more common at presentation in pregnant cases. Pregnant women progressed with a higher consolidation frequency compared with non-pregnant group in stage 2 (95% vs 82%).Most patients (38/40, 95%) were grouped as mild or common
type. The length of hospitalization between the two groups was similar. |
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|
Predicting and analyzing the COVID-19 epidemic in China: Based on SEIRD, LSTM
and GWR models |
Liu, F, Wang, et al |
PLoS One |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
In this study, three models were used to fit and predict the epidemic situation in China: a modified SEIRD (Susceptible-Exposed-Infected-Recovered-Dead)
dynamic model, a neural network method LSTM (Long Short-Term Memory), and a GWR (Geographically Weighted Regression) model reflecting spatial heterogeneity. |
|
Surgical treatment of hip fracture complicated with suspected COVID-19:
a case report |
Liu, J, Liu, et al |
Chinese Journal of Orthopaedic Trauma |
Clinical data| Données cliniques |
Case report of 50 year old female with COVID=19 |
|
The dynamical model for COVID-19 with asymptotic analysis and numerical implementations |
Liu, J, Wang, et al |
Applied Mathematical Modelling |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
The 2019 novel coronavirus (COVID-19) emerged at the end of 2019 has a great impact on China and all over the world.
The transmission mechanism of COVID-19 is still unclear. Except for the initial status and the imported cases, the isolation measures and the medical treatments of the infected patients have essential influences on the spread of COVID-19. In this paper, we
establish a mathematical model for COVID-19 transmission involving the interactive effect of various factors for the infected people, including imported cases, isolating rate, diagnostic rate, recovery rate and also the mortality rate. Under the assumption
that the random incubation period, the cure period and the diagnosis period are subject to the Weibull distribution, the quantity of daily existing infected people is finally governed by a linear integral-differential equation with convolution kernel. Based
on the asymptotic behavior and the quantitative analysis on the model, we rigorously prove that, for limited external input patients, both the quantity of infected patients and its variation ratio will finally tend to zero, if the infected patients are sufficiently
isolated or the infection rate is small enough. Finally, numerical performances for the proposed model as well as the comparisons between our simulations and the clinical data of the city Wuhan and Italy are demonstrated, showing the validity of our model
with suitably specified model parameters. © 2020 |
|
Surgery for a case of femoral fracture complicated with suspected
COVID-19 |
Liu, M, Liu, et al |
Chinese Journal of Orthopaedic Trauma |
Clinical data| Données cliniques |
Case of 41 year old male with suspected COVID-19 infection. |
|
Liu, Y, Finch, et al |
American Journal of Preventive Medicine |
Public Health response| Interventions de santé publique |
Introduction: This study examines COVID-19–associated discrimination regardless of infection status. It evaluates the
contribution of various risk factors (e.g., race/ethnicity and wearing a face mask) and the relationship with mental distress among U.S. adults in March and April 2020, when the pandemic escalated across the country. Methods: Participants consisted of a probability-based,
nationally representative sample of U.S. residents aged ≥18 years who completed COVID-19–related surveys online in March and April (n=3,665). Multivariable logistic regression was used to predict the probability of a person perceiving COVID-19–associated discrimination.
Linear regression was used to analyze the association between discrimination and mental distress. Analyses were conducted in May 2020. Results: Perception of COVID-19–associated discrimination increased from March (4%) to April (10%). Black, non-Hispanics
(absolute risk from 0.09 to 0.15 across months) and Asians (absolute risk from 0.11 to 0.17) were more likely to perceive discrimination than other racial/ethnic groups (absolute risk from 0.03 to 0.11). Individuals who wore face masks (absolute risk from
0.11 to 0.14) also perceived more discrimination than those who did not (absolute risk from 0.04 to 0.11). Perceiving discrimination was subsequently associated with increased mental distress (from 0.77 to 1.01 points on the 4-item Patient Health Questionnaire
score). Conclusions: Perception of COVID-19–associated discrimination was relatively low but increased with time. Perceived discrimination was associated with race/ethnicity and wearing face masks and may contribute to greater mental distress during early
stages of the pandemic. The long-term implications of this novel form of discrimination should be monitored. © 2020 American Journal of Preventive Medicine |
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Liu, Z, Li, et al |
International Journal of Environmental Research and Public Health |
Modelling/ prediction| Modélisation/prédiction Healthcare Response | Réponse des soins
de santé |
In view of the selection of temporary storage stations and realistic transportation demand, an efficiency-of-transport
model of medical waste between hospitals and temporary storage stations is established by using an ant colony–tabu hybrid algorithm. In order to specify such status, Wuhan city in Hubei Province, China—considered the first city to suffer from COVID-19—was
chosen as an example of verification; the two-level model and the immune algorithm–ant colony optimization–tabu search (IA–ACO–TS) algorithm were used for simulation and testing, which achieved good verification. To a certain extent, the model and the algorithm
are proposed to solve the problem of medical waste disposal, based on transit temporary storage stations, which we are convinced will have far-reaching significance for China and other countries to dispatch medical waste in response to such public health emergencies. |
|
|
Loo, RL, Lodge, et al |
J Proteome Res |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
we describe systematically, the impact of variations in sample collection and preparation on information recovery from
quantitative proton (1H) NMR spectroscopy of human blood plasma and serum. We also present several simple blood sample handling recommendations for optimal NMR-based biomarker discovery investigations in SARS CoV-2 studies and general clinical biomarker research. |
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López-Otero, D, López-Pais, et al |
Revista espanola de cardiologia |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
Introduction and objectives: Coronavirus disease (COVID-19) has been designated a global pandemic by the World Health
Organization. It is unclear whether previous treatment with angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) affects the prognosis of COVID-19 patients. The aim of this study was to evaluate the clinical implications
of previous treatment with ACEI/ARB on the prognosis of patients with COVID-19 infection. Methods: Single-center, retrospective, observational cohort study based on all the inhabitants of our health area. Analyses of main outcomes (mortality, heart failure,
hospitalization, intensive care unit ICU] admission, and major acute cardiovascular events a composite of mortality and heart failure]) were adjusted by multivariate logistic regression and propensity score matching models. Results: Of the total population,
447 979 inhabitants, 965 patients (0.22%) were diagnosed with COVID-19 infection, and 210 (21.8%) were under ACEI or ARB treatment at the time of diagnosis. Treatment with ACEI/ARB (combined and individually) had no effect on mortality (OR, 0.62; 95%CI, 0.17-2.26;
P = .486), heart failure (OR, 1.37; 95%CI, 0.39-4.77; P = .622), hospitalization rate (OR, 0.85; 95%CI, 0.45-1.64; P = .638), ICU admission (OR, 0.87; 95%CI, 0.30-2.50; P = .798), or major acute cardiovascular events (OR, 1.06; 95%CI, 0.39-2.83; P = .915).
This neutral effect remained in a subgroup analysis of patients requiring hospitalization. Conclusions: Previous treatment with ACEI/ARB in patients with COVID-19 had no effect on mortality, heart failure, requirement for hospitalization, or ICU admission.
Withdrawal of ACEI/ARB in patients testing positive for COVID-19 would not be justified, in line with current recommendations of scientific societies and government agencies. © 2020 Sociedad Española de Cardiología |
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|
Lorentzen, HF, Schmidt, et al |
Danish Medical Journal |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
INTRODUCTION: As the coronavirus disease 2019 (COVID-19) epidemic evolves and test strategies change, understanding
the concepts of testing (gold standard and test performance measures) becomes essential. The challenge of any novel disease is that the gold standard has yet to be defined. METHODS: We reanalysed published data on real-time reverse transcription quantitative
polymerase chain reaction (RT-qPCR) of severe acute respiratory syndrome coronavirus-2 to illustrate how predictive values vary with disease prevalence, sensitivity (set to values between 30% and 95%) and specificity (set to 99% or 99.98%). We used published
data on chest CT and RT-qPCR to examine the potential of latent class analysis to estimate the sensitivity and specificity of RT-qPCR when no single gold standard exists. RESULTS: For the various sensitivity values, the negative predictive value of a RT-qPCR
test remained above 92% until a COVID-19 prevalence of > 10%. The positive predictive value (PPV) was more variable. For a sensitivity of 95% and a specificity of 99%, the PPV was < 10% at a prevalence of 0.1%, increasing to about 90% at a prevalence of 10%.
This improved to a PPV of 85% and almost 100%, respectively, when specificity increased to 99.98%. In a restricted latent class analysis, the sensitivity was 97.1% and the specificity was 99.9%, which is similar to figures from the Danish Health Authority.
However, derived predictive values depended on model specification. CONCLUSIONS: A high risk of false-positives should be considered when extending the testing strategy, whereas false-negatives may occur during local outbreaks. This may have consequences for,
e.g., containment strategies and research. A confirmatory test (e.g., demonstrating seroconversion or repeated RT-qPCR) may be warranted. © 2020, Danish Medical Association. All rights reserved. |
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Losee, S, Hanson, et al |
South Dakota medicine : the journal of the South Dakota State Medical Association |
Clinical data| Données cliniques |
case report describes a patient with no past psychiatric history who developed psychotic symptoms in the context of
acute COVID-19 delirium. |
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|
Lotfi, B, Lotfi, et al |
Epidemiologic Methods |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
The main objective is to predict the evolution of the COVID-19 pandemic in Morocco and to estimate the time needed
for its disappearance. ion chain of this virus as well as its future evolution. Then we used the SIR epidemiological model, which proves to be well suited to address this issue. It shows that identification of the key parameters of this pandemic, such as
the probability of transmission, should help to adequately explain its behaviour and make it easier to predict its progress. As a result, the measures and actions taken by the public authorities in Morocco allowed to record lower number of virus reproduction
than many countries. So, in the case of Morocco, we were able to predict that the Covid-19 pandemic should disappear in a shorter time and without registering a larger number of infected individuals compared to other countries. |
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Using rapid online survey to assess public perceptions
of COVID-19 in Gambia |
Lowe, M |
Pan African Medical Journal |
Public Health response| Interventions de santé publique |
This letter to the editors is a report of a rapid online crosssectional survey that was conducted to assess the perceived
severity of Covid-19 among adult population in the Gambia. The survey was conducted from April 4-8, 2020. A total of 206 respondents participated in the survey. Of these, (56%) were males and (43.5%) were females. Their ages ranged from 20 to 64 years old
and more than half (69%) have university education. Drawing from the data presented in, (62.6%) of respondents reported being very worried for themselves and their family members of contracting coronavirus. (68.5%) were also very worried that there will be
many cases of coronavirus in the Gambia and (70%) were not too confident that the healthcare system will be able to handle many cases of coronavirus. Most respondents (98%) believed that Covid-19 is a disease that could be spread very easily and (54%) regarded
death as their biggest fear towards the Covid-19 pandemic. |
|
The immunodominant and neutralization linear epitopes
for SARS-CoV-2 |
Lu, Shuai, Xie, et al |
bioRxiv |
Coronavirology| Coronavirologie Immunology | Immunologie Animal model | Modèle animal |
Here, we simulated the three-dimensional structures of SARS-CoV-2 proteins with high performance computer, predicted
the B cell epitopes on spike (S), envelope (E), membrane (M), and nucleocapsid (N) proteins of SARS-CoV-2 using structure-based approaches, and then validated the epitope immunogenicity by immunizing mice. Almost all 33 predicted epitopes effectively induced
antibody production. |
|
The Impact of COVID-19 on Systemic Anti-Cancer Treatment Delivery in Scotland |
MA, Baxter, J, et al |
Research Square prepub |
Healthcare Response | Réponse des soins de santé |
In this article we report real-time national systemic anti-cancer therapy (SACT) delivery data from NHS Scotland during
COVID-19. We demonstrate an initial rapid reduction in patient attendance for SACT of 28.7% with a subsequent rapid and full recovery following service re-design. |
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Electrical storm in a febrile patient with Brugada syndrome and COVID-19 infection |
Maglione, TJ, Aboyme, et al |
HeartRhythm Case Reports |
Clinical data| Données cliniques |
We present a case of electrical storm in the setting of acute febrile illness in a patient with Brugada syndrome and
COVID-19 infection. |
|
Mahmood, I, Arabnejad, et al |
Journal of Simulation |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Here we introduce the Flu And Coronavirus Simulator (FACS), a simulation tool that models the viral spread at the sub-national
level, incorporating geospatial data sources to extract buildings and residential areas in a region. Using FACS, we can model Covid-19 spread at the local level, and provide estimates of the spread of infections and hospital arrivals for different scenarios.
We validate the simulation results with the ICU admissions obtained from the local hospitals in the UK. |
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Majoko, T, Dudu, et al |
International Journal of Developmental Disabilities |
Public Health response| Interventions de santé publique |
This study explored parents’ strategies for home educating their children with Autism Spectrum Disorder (ASD) during
the COVID-19 period in Harare Urban District in Zimbabwe. Embedded within international research findings on the subject, this qualitative study drew on a purposive sample of eight parents. Telephonic individual interviews, information sheets, and field notes
were used to collect data. A constant comparative approach of data organization with continuous adjustment was used throughout the analysis in order to guarantee that codes captured the range of ideas of the parents. Parents committedly home educated children
with ASD in collaboration and discourse with their family members and peer parents. Complementary and supplementary roles of parents and family members in the home education of their children with ASD facilitated the transition of these children from school
to home routine activities. Parents of children with ASD fostered in these children an awareness of the new social reality of the COVID-19 period and the safety precautions. This study offers insights regarding parents’ strategies for home educating their
children with ASD during the COVID-19 period. © The British Society of Developmental Disabilities 2020. |
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Impact of SARS-COV-2 pandemic on elective and emergency surgery in a university
hospital |
Maldonado-Marcos, E, Caula-Freixa, et al |
Cirugia Espanola |
Healthcare Response | Réponse des soins de santé |
Introduction: SARS-CoV-2 pandemic has caused an important impact in our country and elective surgery has been postponed
in most cases. There's not known information about the decreasing and impact on surgery. Mortality of surgical patients with SARS-CoV-2 infection is estimated to be around 20%. Methods: We conducted prospective data recruitment of people inpatient in our Digestive
and General Surgery section of Girona's University Hospital Dr. Josep Trueta from 03/14 to 05/11. Our objective is to analyze the impact that SARS-CoV-2 pandemic over elective and urgent surgery. Results: During the peak occupation of our center Intensive
Care Unit (303.8%) there was a reduction on elective (93.8%) and urgent (72.7%) surgery. Mortality of patients with SARS-CoV-2 infection who underwent surgery (n = 10) is estimated to be a 10%. An 80% of these patients suffer complications (sever complications
in 30%). Conclusions: The actual study shows a global reduction of the surgical activity (elective and urgent) during de SARS-CoV-2 pandemic. Global mortality of patients with SARS-CoV-2 infection are low, but the severe complications have been over the usual.
© 2020 AEC |
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Malhotra, Dr Sumit, Rahi, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We have conducted one of the largest cohort studies and analysed clinico-epidemiological attributes of >22,000 COVID-19
patients from India. Amongst the 22,684 tested, 2158 (9.5%) were positive for COVID-19. We show that women and symptomatic individuals had higher odds of testing positive as compared to men and asymptomatic individuals respectively. Of 1729 cases prospectively
followed, 74% remained asymptomatic. The age group of 50-59 years, intra-familial positivity, alcohol intake, smoking and comorbidities were associated with clinical symptom positivity. |
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Mamishi, S, Heydari, et al |
Journal of Microbiology, Immunology and Infection |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Background: During the coronavirus disease 2019 (COVID-19) pandemic, Iran reported its first confirmed cases of syndrome
coronavirus 2 (SARS-CoV-2) infections on 19 February 2020 in Qom. Although the numbers of cases are increasing, no report about clinical manifestations, laboratory results, and imaging findings of the children infected with COVID-19 in Iran has been published.
The aim of this study was to evaluate the epidemiological, clinical, and radiological and laboratory findings of 24 children who had proven SARS-CoV-2 infection and performed chest computed tomographic (CT) in Qom, Iran. Methods: Demographic information and
clinical characteristics of the patients including signs and symptoms, chest CT scan manifestation, laboratory findings and clinical outcomes were collected. Diagnosing of the confirmed case was based on positive real-time reverse-transcriptase-polymerase-chain-reaction
test for SARS-CoV-2. Findings: During the first 3 months of the epidemic in Qom, Iran, 24 children with confirmed diagnosis of COVID-19 were included. The median age of the cases was 6 years inter-quartile range 3.5–9.5 years]. The most common presenting symptoms
were fever (100%), dry cough (62.5%), tachypnea (29%), abdominal pain (21%), and vomiting (21%). Three cases (12.5%) presented with a history of diarrhea in addition to fever and cough. According to the chest CT findings, 2 cases (8%) showed no abnormality.
Typical CT findings were found in 6 patients (25%), 2 patients showed indeterminate appearance, and 14 patients (58%) showed atypical findings. Two children with SARS-CoV-2 infection manifested as a hyperinflammatory syndrome with multi-organ involvement similar
to Kawasaki disease shock syndrome. Seventy-one percent of the patients showed severe SARS-CoV-2 infection and the mortality of 12.5% (3 cases) were reported. Interpretation: High frequency of atypical chest CT finding in children should raise concern for
pediatricians. Early recognition of patients with SARS-CoV-2 infection is of crucial importance in controlling of the outbreak and atypical imaging features should be interpreted with caution. © 2020 |
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Manenti, R, Mori, et al |
Biological Conservation |
Public Health response| Interventions de santé publique |
We addressed the impacts of the COVID-19 lockdown on wildlife in Italy, the first European country that performed a
countrywide lockdown, and identified potentially beneficial and negative consequences for wildlife conservation and management. We combined a qualitative analysis of social media information with field data from multiple taxa, data from citizen science projects,
and questionnaires addressed to managers of protected areas. Both social media information and field data suggest that a reduction of human disturbance allowed wildlife to exploit new habitats and increase daily activity. Results from questionnaires addressed
to managers of protected areas highlighted that the COVID-19 lockdown interrupted actions for the control of invasive alien species, and hampered conservation activities targeting threatened taxa. Furthermore, the reduction of enforcement could cause a surge
of illegal killing of wildlife. |
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Mantero, V, Abate, et al |
Multiple Sclerosis and Related Disorders |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to analyze the incidence of the clinical presentations suggestive for COVID-19 infection among patients
with Multiple Sclerosis in the province of Lecco, in the North Italy, the closest province capital to Bergamo. We telephonically interviewed all the 275 MS patients followed in the MS center. 15 out of 275 patients reported symptoms suggestive for COVID-19
infection, only one of them with PCR-confirmed diagnosis. No one of them presented severe symptoms or needed hospitalization. Using a multivariable logistic regression model, the only factor associated with being in the COVID-suspect group was the report of
a recent contact with a patient with a COVID-19 diagnosis. The prevalence of COVID-19 within MS patients seems to resemble the prevalence in general population. |
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Marchioni, D, Bisi, et al |
American Journal of Otolaryngology - Head and Neck Medicine and Surgery |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
The current study aims at assessing the effectiveness of the guidelines set up by our clinic for the protection of
patients and staff which enabled us to proceed with urgent and oncological surgery after the outbreak of the Covid-19 pandemic. In about a couple of months (from March 8th to May 3rd) a relevant amount of medical tests and surgical procedures were carried
out on non COVID-19 patients and a certain number of tracheostomies were performed on COVID-19 patients. Consequently, all the ENT personnel were checked and found negative. Also, all the patients in the ward were swab tested and chest X-rayed, only one had
a positive outcome and was adequately handled and treated. Our ENT guidelines regarding personal protection equipment and multiple simultaneous diagnostic procedures have proved to be an essential instrument for the management of patients with both known and
unknown COVID-19 status. |
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Martelloni, G, Martelloni, et al |
Chaos Solitons Fractals |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
We study the temporal evolution of the pandemic Sars-Cov-2 in Italy by means of dynamic population models., with data
from February 24 through March 25 in Italy. an important observation is that the virus spreads between Regions with some delay. Indeed, we suggest that a different analysis, region by region, would be more sensible than one on the whole Italy. |
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Martínez-Mateo, V, Fernández-Anguita, et al |
Journal of electrocardiology |
Clinical data| Données cliniques |
This paper reports 6 cases of patients affected by COVID-19 bilateral pneumonia with associated acute respiratory distress
associated and signs of acute right ventricular hypertrophy on electrocardiography despite the absence of acute pulmonary embolism or signs of severe pulmonary hypertension on transthoracic echocardiography. These cases suggest a possible connection between
acute elevated right ventricular afterload and acute respiratory distress in patients affected by SARS-CoV-2. |
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Impact of Famotidine Use on Clinical Outcomes of Hospitalized Patients With COVID-19 |
Mather, JF, Seip, et al |
Am J Gastroenterol |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
Retrospective, propensity-matched observational study of consecutive COVID-19-positive patients receiving famotidine
therapy and those not receiving famotidine, between February 24, 2020, and May 13, 2020. Famotidine use in hospitalized patients with COVID-19 is associated with a lower risk of mortality, lower risk of combined outcome of mortality and intubation, and lower
levels of serum markers for severe disease in hospitalized patients with COVID-19. |
|
Mazouz, S, Aissaoui, et al |
Pan African Medical Journal |
Clinical data| Données cliniques |
Case report of a 33 year old male suspected to be infected with COVID-19. |
|
|
Mazzocco, Giovanni, Niemiec, et al |
bioRxiv |
Coronavirology| Coronavirologie Vaccine Research| Recherche sur les vaccins Immunology
| Immunologie |
In this work we use a novel in silico approach (based on AI and bioinformatics methods) developed to support the design
of epitope-based vaccines. We evaluated the capabilities of our method for predicting the immunogenicity of epitopes. Next, the results of our approach were compared with other vaccine-design strategies reported in the literature. The risk of immuno-toxicity
was also assessed. The analysis of epitope conservation among other Coronaviridae was carried out in order to facilitate the selection of peptides shared across different SARS-CoV-2 strains and which might be conserved in emerging zootic coronavirus strains. |
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McBee, SM, Thomasson, et al |
MMWR Morb Mortal Wkly Rep |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
During April 21–May 8, universal testing was conducted in all 123 West Virginia nursing homes. Receiving testing was
declined by 1.3% (115 of 9,026) of residents and 1.7% (239 of 13,926) of staff members. Among the 8,911 residents and 13,687 staff members who were tested, 42 COVID-19 cases were identified in 28 (23%) nursing homes, none of which had previously experienced
an outbreak. |
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Mechessa, DF, Ejeta, et al |
International Journal of General Medicine |
Public Health response| Interventions de santé publique |
Background: Coronaviruses are a large group of viruses that are common throughout the community. They are associated
with mortality, hospitalization, substantial extra costs and lower patient’s quality of life. Thus, this study aimed to assess the community’s knowledge of COVID-19 and associated factors in Mizan-Aman town, southwest Ethiopia. Methods: Community-based cross-sectional
study design was conducted among the community of Mizan-Aman from April 14 to May 14, 2020. A systematic sampling technique was used to collect data from selected households. Data were entered into Epi data version 4.0.2.101 and then exported to SPSS version
24.0 for analysis. To identify the predictors of knowledge of COVID-19, multiple backward logistic regression analysis was used. To show the accuracy of data analysis, 95% CI was used, and statistical significance was considered at p <0.05. Results: From 423
sampled population, 393 (92.9%) of them responded to the question-naire. Of these, 233 (59.3%) were male, 225 (57.3%) were 18–34 years old, and 250 (63.6%) were married. The overall correct rate of the knowledge questionnaire was 74.75%. More than 85% of respondents
were well aware of the main clinical symptoms of COVID-19, its transmission by close contact, its prevention by not going to crowded places and isolation of infected persons. Male gender (AOR=3.74, CI: 1.87–7.49), age (35–54 years) (AOR=3.81, CI: 1.35–10.70),
age ≥55 (AOR=2.97, CI: 1.16–7.62), lack of formal education (AOR=6.0, CI: 1.54–23.40), farmer (AOR=8.72, CI: 2.08–35.53), daily laborer (AOR=7.57, CI: 2.28–-25.15), merchant (AOR=6.34, CI: 2.06–19.43), house wife (AOR=11.59, CI: 2.91–46.23) were significantly
associated with poor knowledge, whereas single marital status was less likely associated with poor knowledge of COVID-19. Conclusion: One-third of the study participants had poor knowledge regarding COVID-19. Male gender, age above thirty-five years, lack
of formal education, being farmer, daily laborer, merchant and house wife were significantly associated with poor knowledge. Therefore, awareness creation should be given. © 2020 Mechessa et al. |
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A Case Report of Isopropanol Ingestion During the SARS-CoV-2 Pandemic |
Meehan, CP, Wightman, et al |
J Addict Med |
Public Health response| Interventions de santé publique |
We present a case of intentional isopropanol ingestion used as an ethanol surrogate within the setting of the COVID-19
pandemic. |
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Mehrotra, S, Jambunathan, et al |
Medical Journal Armed Forces India |
Healthcare Response | Réponse des soins de santé |
Background: In late 2019, the world saw a viral outbreak of unprecedented scale that sent a significant fraction of
humankind into either quarantine or lockdown. Coronavirus disease 2019 (COVID-19) is a respiratory tract infection caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which was first recognized in Wuhan, China, in December 2019. Methods:
We created and administered a 17-item questionnaire for health care professionals (HCPs) to assess their level of knowledge towards this ongoing and evolving pandemic. It was disseminated through Web- and mobile-based social networks. The questions were sourced
and created from various standard national and international guidelines available at the time of writing. Results: A total of 827 medical personnel participated in the study. Among them, 65.5% scored between 60% and 79%, indicating a moderate level of knowledge.
There was no statistically significant difference in the scores of doctors, nursing officers and dental surgeons (p = 0.200). Participants had good knowledge regarding clinical symptoms, mode of transmission and preventive measures. But the study identified
some gaps in knowledge in the implementation of management protocols, handling of dead bodies and biomedical waste management of COVID-19 cases. Conclusion: With this understanding, regular training, drills and knowledge dissemination along with skill development
through learning correct practices focusing on HCP at all levels are the current needs. © 2020 |
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Mehta, B, Moezinia, et al |
J Clin Rheumatol |
Healthcare Response | Réponse des soins de santé |
We aimed to understand how rheumatologists prescribed hydroxychloroquine (HCQ) and chloroquine (CQ) to manage COVID-19
and to understand if their patients are affected by shortages. Only 6% of online survey respondents prescribed HCQ/CQ for COVID-19 prophylaxis, and only 12% for outpatient treatment of COVID-19. Compared to the United States, the likelihood of prescribing
HCQ/CQ for prophylaxis was higher in India. Further, compared to the United States and those with 1 to 5 years of experience, rheumatologists in Europe and those with 10+ years of experience had a higher likelihood of prescribing HCQ/CQ for outpatient treatment.
Of note, 71% of all rheumatologists reported that their patients were directly affected by HCQ/CQ shortages. |
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Air quality variations in Northern South America during the COVID-19 lockdown |
Mendez-Espinosa, J, Rojas, et al |
Science of the Total Environment |
Public health interventions*| Interventions de santé publique |
This study aims to analyze, for the first time in Northern South America (NSA), the behavior of selected criteria air
pollutants during the implementation of the SARS-CoV-2 lockdown in two high populated cities of the region: Bogotá and Medellín in Colombia. A set of tools including surface measurements, as well as satellite and modeled data were used. 24-hour average concentrations
of PM10, PM2.5, and NO2 were collected from air quality stations for the lockdown period ranging from February 21 to June 30, 2020. Our analysis shows short-term background NO2, PM10, and PM2.5 concentration reductions of 60%, 44%, and 40%, respectively, for
the strict lockdown; and 62%, 58%, and 69% for the relaxed lockdown. Corresponding long-term reductions were of 50%, 32%, and 9% for the strict lockdown; and 37%, 29%, and 19% for the relaxed lockdown. Regional BB increased PM2.5 concentrations by 20 μg/m3
during the strict lockdown, and the Saharan dust event increased PM10 concentrations up to 168 μg/m3 in Bogotá, and 104 μg/m3 in Medellín, bringing an additional risk of morbidity and mortality for population. |
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Hemoglobin A1C is a Predictor of COVID-19 Severity in Patients with Diabetes |
Merzon, E, Green, et al |
Diabetes Metab Res Rev |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
we report here the association between pre‐infection HemoglobinA1c (A1C) levels and COVID‐19 severity as assessed by
need for hospitalization in a cohort of 2068 patients with diabetes tested for COVID‐19 in Israel. Using pre‐infection glycemic control data we identify A1C as a clear predictor of COVID‐19 severity. |
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Metya, A, Dagupta, et al |
Aerosol and Air Quality Research |
Public health interventions*| Interventions de santé publique |
This study uses satellite retrievals and attempts to estimate the extent of the reduction of major pollutants, like
carbon monoxide (CO), nitrogen dioxide (NO2) and sulfur dioxide (SO2) in India and China during January to April, 2020. We have calculated anomalies of pollutants during the lockdown period relative to their long-term records. NO2, which has significant emissions
from the transport sector, is reduced on an average by 17% over India and 25% over China. SO2, which mainly emits from power plants, shows significant reductions (approx. 17%) especially over the Eastern sector of India. CO is found to be reduced by 6.5% over
north-central China. The differential reduction was attributed to man made versus natural activities. This study is helpful to policy makers in mitigating the air-pollution on a long-term perspective. |
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Transmission, start of symptom and morbidity among Danish COVID-19 patient s admitted
to hospital |
Meyer, CN |
Danish Medical Journal |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
INTRODUCTION: We explored transmission of the coronavirus disease 2019 (COVID-19) in severely ill patients and analysed
the relationship between co-morbidity and mortality or the need for intensive care unit (ICU) care. METHODS: Clinical data, treatment and outcome were analysed in this retrospective study of 101 consecutive patients with COVID-19 admitted to a regional Danish
hospital from 2 March 2020, based on data from electronic medical records. RESULTS: The mean age was 71.8 years, 33% were never smokers and 82% had one or more predefined chronic diseases. In-hospital mortality was 30%, and 20% of the patients were offered
ICU care. In ICU patients, we found a male preponderance (88% versus 44%, p = 0.006), but death (50% versus 25%, p = 0.053) and other pre-defined co-morbidities did not differ significantly from non-ICU patients. The source of infection was unknown in 74%
of patients, related to endemic travel in 10%, hospital acquired in 6% and related to close acquaintances in 11%. COVID-19-related symptoms were initially observed from February 21 (week 8 and week 9) in the first three patients who had no known source of
infection. We found that 7% of cases had an increased risk of in-hospital transmission, based on a 7-16 days delay in coronavirus testing. CONCLUSIONS: The frequency of co-morbidity in hospital-admitted COVID-19 patients and the correlation to death and ICU
attendance were analysed. In all, 74% of the infection cases were of unknown source during the first weeks of the epidemic, which points to considerable community transmission and possibly pre-or asymptomatic transmission, also several weeks before 21 February
2020. FUNDING: none. TRIAL REGISTRATION: not relevant after correspondence with the Ethics Committee of Region Zealand. Furthermore, permission was granted from The Danish Data Protection Agency, Region Zealand (REG-070-2020). © 2020, Danish Medical Association.
All rights reserved. |
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Impact of the COVID-19
Outbreak on Routine Obstetrical Management |
Meyer, R, Levin, et al |
The Israel Medical Association journal : IMAJ |
Healthcare Response | Réponse des soins de santé |
BACKGROUND: Channeling medical resources for coronavirus disease-2019 (COVID-19) management can potentially endanger
routine healthcare practices. As a preventive measure, a department of obstetrics and gynecology in Israel constructed a separate, designated complex for its COVID-19-exposed patients. OBJECTIVES: To evaluate the effect of the COVID-19 pandemic infection control
measures on obstetric care in the obstetrical emergency department and delivery unit. METHODS: The authors collected data retrospectively from February 2020 to March 2020 and compared it to data of a parallel period in 2019. RESULTS: From 1 February 2020 to
28 March 2020, 3897 women were referred to the emergency department (ED), compared to 4067 the previous year. Mean duration of treatment until decision and referral indications did not differ between 2020 and 2019 (207 vs. 220 minutes, P = 0.26; urgent referrals
58.8% vs. 59.2%, P = 0.83). A per-week comparison showed a significant reduction in ED referrals only in the last week of the period (337 2020] vs. 515 2019], P < 0.001). The proportion of women admitted to the delivery unit in active labor was significantly
higher in the last three weeks (39.1% vs. 28.2%, P = 0.005). During February and March 2020, 1666 women delivered, compared to 1654 during February and March 2019. The proportion of types and modes of delivery did not differ. In a per-week comparison, the
number of deliveries did not differ (mean 208 vs. 206, P = 0.88). CONCLUSIONS: With timely preparation and proper management, negative impact of COVID-19 can be reduced in obstetrical emergency departments. |
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Meza-Robles, C, Barajas-Saucedo, et al |
Journal of infection in developing countries |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
INTRODUCTION: Due to the coronavirus pandemic, identifying the infected individuals has become key to limiting its
spread. Virus nucleic acid real-time RT-PCR testing has become the current standard diagnostic method but high demand could lead to shortages. Therefore, we propose a detection strategy using a one-step nested RT-PCR. METHODOLOGY: The nucleotide region in
the ORF1ab gene that has the greatest differences between the human coronavirus and the bat coronavirus was selected. Primers were designed after that sequence. All diagnostic primers are species-specific since the 3´ end of the sequence differs from that
of other species. A primer set also creates a synthetic positive control. Amplified products were seen in a 2.5% agarose gel, as well as in an SYBR Green-Based Real-Time RT-PCR. RESULTS: Amplification was achieved for the positive control and specific regions
in both techniques. CONCLUSIONS: This new technique is flexible and easy to implement. It does not require a real-time thermocycler and can be interpreted in agarose gels, as well as adapted to quantify the viral genome. It has the advantage that if the coronavirus
mutates in one of the key amplification nucleotides, at least one pair can still amplify, thanks to the four diagnostic primers. Copyright (c) 2020 Carmen Meza-Robles, Carlos E Barajas-Saucedo, Daniel Tiburcio-Jimenez, Karen A Mokay-Ramirez, Valery Melnikov,
Iram P Rodriguez-Sanchez, Margarita L Martinez-Fierro, Idalia Garza-Veloz, Sergio A Zaizar-Fregoso, Jose Guzman-Esquivel, Mario Ramirez-Flores, Oscar A Newton-Sanchez, Francisco Espinoza-Gomez, Osiris G Delgado-Enciso, Alba SH Centeno-Ramirez, Ivan Delgado-Enciso. |
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Miao, X, Luo, et al |
mAbs |
Therapeutics| Thérapeutique |
In the absence of a proven effective vaccine preventing infection by SARS-CoV-2, or a proven drug to treat COVID-19,
the positive results of passive immune therapy using convalescent serum provide a strong lead. We have developed a new class of tetravalent, biparatopic therapy, 89C8-ACE2. It combines the specificity of a monoclonal antibody (89C8) that recognizes the relatively
conserved N-terminal domain of the viral Spike (S) glycoprotein, and the ectodomain of ACE2, which binds to the receptor-binding domain of S. This molecule shows exceptional performance in vitro, inhibiting the interaction of recombinant S1 to ACE2 and transduction
of ACE2-overexpressing cells by S-pseudotyped lentivirus with IC50s substantially below 100 pM, and with potency approximately 100-fold greater than ACE2-Fc itself. Moreover, 89C8-ACE2 was able to neutralize authentic viral infection in a standard 96-h co-incubation
assay at low nanomolar concentrations, making this class of molecule a promising lead for therapeutic applications. © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. |
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Michaud, WilliamA, Boland, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Early in the current pandemic, the D614G mutation arose in the Spike protein of SARS-CoV-2 and quickly became the dominant
variant globally. Mounting evidence suggests D614G enhances viral entry. Here we use a direct competition assay with single-cycle viruses to show that D614G outcompetes the wildtype. Our findings suggest that D614G increases infection of cells expressing a
wide range of ACE2, and informs the mechanism underlying enhanced entry. |
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Miller, AO, Kapadia, et al |
HSS Journal |
Healthcare Response | Réponse des soins de santé |
Background: COVID-19, the illness caused by the novel coronavirus, SARS-CoV-2, has sickened millions and killed hundreds
of thousands as of June 2020. New York City was affected gravely. Our hospital, a specialty orthopedic hospital unaccustomed to large volumes of patients with life-threatening respiratory infections, underwent rapid adaptation to care for COVID-19 patients
in response to emergency surge conditions at neighboring hospitals. Purposes: We sought to determine the attributes, pharmacologic and other treatments, and clinical course in the cohort of patients with COVID-19 who were admitted to our hospital at the height
of the pandemic in April 2020 in New York City. Methods: We conducted a retrospective observational cohort study of all patients admitted between April 1 and April 21, 2020, who had a diagnosis of COVID-19. Data were gathered from the electronic health record
and by manual chart abstraction. Results: Of the 148 patients admitted with COVID-19 (mean age, 62 years), ten patients died. There were no deaths among non-critically ill patients transferred from other hospitals, while 26% of those with critical illness
died. A subset of COVID-19 patients was admitted for orthopedic and medical conditions other than COVID-19, and some of these patients required intensive care and ventilatory support. Conclusion: Professional and organizational flexibility during pandemic
conditions allowed a specialty orthopedic hospital to provide excellent care in a global public health emergency. © 2020, Hospital for Special Surgery. |
|
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Decline in phytoplankton biomass along Indian coastalwaters due to COVID-19 lockdown |
Mishra, DR, Kumar, et al |
Remote Sensing |
Public health interventions*| Interventions de santé publique |
Air quality has improved in all urban centers in India, a major emitter of greenhouse gases (GHG). We present the
first evidence of an overall decline in pre-monsoon chlorophyll-a, a proxy for phytoplankton biomass, in coastal waters off urban centers during the peak of the lockdown in April. The preliminary field data and indirect evidence suggests the reduction in coastal
chlorophyll-a could be linked to a net decline in nutrient loading, particularly of bioavailable N through watershed fluxes and atmospheric deposition. |
|
Corona-like illness: Did we get it before who announcement of the disease? A cross-sectional
survey |
Mohamed-Hussein, A, Makhlouf, et al |
Electronic Journal of General Medicine |
Public Health response| Interventions de santé publique |
This study aimed to determine the frequency of people who assume they got, “Corona-like illness” before WHO announcement
of the disease. This cross-sectional web-based anonymous survey study included participants who were fulfilling online designed questionnaire. Most of the individuals that fill the questionnaire were in the age group (31-40 years old), most of them were from
Egypt 91.5%, 10.7% were smokers, 6.7% of them with cardiac – hypertension and myocardial ischemia, 47.9% of them with allergic rhinitis and 23.4% with asthma. In total, 55.2% of those who fill the questionnaire have the experience of symptoms like coronavirus
symptoms in October, November and early December. About 25.9% need to be admitted to ER. |
|
Structural analysis of ACE2 variant N720D demonstrates a higher binding affinity
to TMPRSS2 |
Mohammad, A, Marafie, et al |
Life Sciences |
Coronavirology| Coronavirologie |
This study investigates the N720D variant, positioned in the collectrin-like domain (CLD) at proximity to type II transmembrane
serine protease (TMPRSS2) cleavage site. The effect of N720D variant on ACE2 structure and thermodynamic stability was studied by DynaMut. HDOCK was utilised to model TMPRSS2 protease binding to ACE2 WT and D720 variant cleavage site. The N720D variant is
a more dynamic structure with a free energy change (ΔΔG): −0.470 kcal/mol. As such, introducing a tighter binding affinity of Kd = 3.2 × 10−10 M between TMPRSS2 and N720D variant. RMSD, RMSF calculations showed the N720D variant is less stable, however, RMSF
values of the D720-TMPRSS2 complex reflected a slower dynamic motion. The hotspot N720D variant in the CLD of ACE2 affected the stability and flexibility of ACE2 by increasing the level of motion in the loop region, resulting in a more favourable site for
TMPRSS2 binding and cleavage. Consequently, this would facilitate S-protein binding and can potentially increase viral entry highlighting the importance of variants affecting the ACE2-TMPRSS2 complex. |
|
Mohideen, AKS |
Biointerface Research in Applied Chemistry |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The sudden outbreak due to severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) is responsible for causing
acute, highly dreadful coronavirus disease (COVID‐19). The pore-forming proteins in the SARS-CoV-2 envelope protein employ amphipathic α-helix for pore formation. The pore openings are essential for the transport of ions, toxins, and viroporin activity. Moreover,
there is an insurgence to identify lead compounds to target the novel coronavirus for therapeutic purposes. Therefore in the present study, the SARS CoV-2 envelope protein sequence was analyzed, constructed the three-dimensional homology model, and screened
against the bioactive phytochemical Thymoquinone (TQ). Molecular docking was performed between the modeled E protein and TQ to study protein-ligand interactions using ArgusLab 4.0. The investigation revealed that the modeled E protein contains a single α-amphipathic
helix identified for the first time across the Amino-terminal region of the transmembrane domain may contribute to pore formation of small membrane proteins. Molecular docking results showed the promising inhibitory potential of the ligand TQ and the binding
free energy of the bound complex was found to be-9.01 kcal/mol. The in silico approach has explicitly demonstrated the significant inhibitory effects of the ligand TQ. Therefore it may be used effectively as an antagonist against the SARS-CoV-2 infection owing
to its outstanding pharmacological properties. © 2020 by the authors. |
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COVID-19 during pregnancy: non-reassuring fetal heart rate, placental pathology and coagulopathy |
Mongula, JE, Frenken, et al |
Ultrasound Obstet Gynecol |
Clinical data| Données cliniques |
A case of a pregnant woman suffering from COVID‐19 is presented. The PCR test of the vaginal swab was positive on SARS‐CoV‐2
RNA, suggesting a possibility of perinatal transmission. A cesarean delivery was done because of a non‐reassuring fetal heart rate; the placenta showed increased perivillous fibrin deposition and intervillositis. |
|
Moradi, H, Abbasi, et al |
International Medical Case Reports Journal |
Clinical data| Données cliniques |
In late 2019, the world encountered an unexpected new virus, resulting in a highly challenging new pandemic. The case
presented here involves a 73-year-old man experiencing fever and respiratory distress, who was ultimately diagnosed with COVID-19. During the course of his hospitalization, the patient developed acute respiratory distress syndrome (ARDS), followed by being
intubated due to his breathing difficulties. Because of variations in the patient’s clinical features, we decided to perform hemoperfusion to remove cytokines. Afterward, his clinical status improved significantly, and he was discharged in stable condition.
However, 26 days later, fever and respiratory distress manifested again. After evaluation, pulmonary thromboembolism was confirmed through computed tomogra-phy (ie, CT scan). © 2020 Moradi and Abbasi. |
|
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Fake news and covid-19 in Italy: Results of a quantitative observational study |
Moscadelli, A, Albora, et al |
International Journal of Environmental Research and Public Health |
Public Health response| Interventions de santé publique |
The aim of this study is to measure how much “fake news” and corresponding verified news have circulated in Italy in
the period between 31 December 2019 and 30 April 2020, and to estimate the quality of informal and formal communication. We used the BuzzSumo application to gather the most shared links on the Internet related to the pandemic in Italy, using keywords chosen
according to the most frequent “fake news” during that period. Links that contained fake news were shared 2,352,585 times, accounting for 23.1% of the total shares of all the articles reviewed. Our study throws light on the “fake news” phenomenon in the SARS-CoV-2
pandemic. |
|
Environmental contamination of SARS-CoV-2 on surfaces, air-conditioner and ventilation
systems |
Mouchtouri, VA, Koureas, et al |
International journal of hygiene and environmental health |
Epidemiology| Épidémiologie Transmission |
Environmental samples were collected from a ferryboat during a COVID-19 ongoing outbreak investigation and a nursing
home and from three COVID-19 isolation hospital wards and a long-term care facility where asymptomatic COVID-19 cases were isolated. Samples were tested by real-time reverse transcriptase–polymerase chain reaction. SARS-CoV-2 was detected on swab samples taken
from surfaces of food preparation and service areas, hospital isolation wards, an air exhaust duct screen, air-conditioning filter, sewage treatment unit and air sample during investigations conducted in response to COVID-19 outbreaks on a ferryboat, nursing
home, isolation facility and COVID-19 hospital wards. Food preparation areas and utensils can be contaminated during COVID-19 outbreaks. Respiratory droplets/nuclei from infected persons can be displaced by the air flow and deposited on surfaces. It can be
assumed that in the same manner, air flow could transfer and deposit infected respiratory droplets/nuclei from infected persons to the mucous membranes of persons standing against the air flow direction. |
|
Mykytyn, AnnaZ, Lamers, et al |
bioRxiv |
Clinical data| Données cliniques Animal model | Modèle animal |
We demonstrate the susceptibility of rabbits to SARS-CoV-2, which excrete infectious virus from the nose and throat
upon experimental inoculation. Therefore, investigations on the presence of SARS-CoV-2 in farmed rabbits should be considered. |
|
|
Nakagawara, K, Masaki, et al |
International Journal of Infectious Diseases |
Clinical data| Données cliniques |
This study investigated, using cycle threshold (Ct) qPCR values, the association between symptoms and viral clearance
in 57 patients with asymptomatic/mild SARS-CoV-2 infection. Patients with olfactory/taste disorders (OTDs) exhibited lower qPCR Ct values and longer time to negative qPCR than those without OTDs, suggesting an association between OTDs and high viral burden. |
|
|
Comparing the Spread of COVID-19 between Italy and the United
States |
Nash, Graeme, Schiffmann, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie |
When aligning two sets of outbreak data, the infection rate of COVID-19 has a statistical average of 93.5% correlation
between Italy and the United States. This indicates a reliable trend of viral spread (despite a difference in total population size and “patient zero” dates). If the matching rates continue into the end of the month, the amount of confirmed cases in the United
States may reach ≥25,000 by March 31st, 2020. |
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Fever with rash is one of the first presentations of COVID-19 in children: A case report |
Navaeifar, MR, Ghazaghi, et al |
International Medical Case Reports Journal |
Clinical data| Données cliniques |
Introduction: Clinical presentations of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vary among
patients, which make a confusing challenge for clinicians to diagnose the disease. While the disease is not rare, but the symptoms may be atypical in children. Case Presentation: A 12-month-old boy with fever and rash without respiratory com-plaints at the
onset of the disease presented to the hospital. His illness was then accompanied by severe anemia, hypoalbuminemia, hypoxemia, and pleural effusion. The nasopharyngeal swab polymerase chain reaction test was positive for the novel coronavirus. Despite primary
normal lung imaging, the second imaging was typical for the disease on the third day of admission. Discussion: Dermatologic manifestations of the novel coronavirus infection are not rare during the illness but rarely occur at the onset of the disease. Information
about the cutaneous manifestations of SARS-CoV-2 and its time interval from the onset of the disease in children are not clear yet. Severe anemia, hypoalbuminemia, and pleural effusion are not reported as classic findings of the novel SARS-CoV-2. They may
be considered as a consequence of the hyperinflammatory response or direct effect of the virus. Conclusion: As a different manifestation of SARS-CoV-2, infected children may initially present fever and rash. More studies are needed to discover the cause of
these complications. The correct answer may lead to better insight and more effective treatment. © 2020 Navaeifar et al. |
|
Nicholas, T, Mandaah, et al |
Pan African Medical Journal |
Public Health response| Interventions de santé publique |
Introduction: since December 2019, the world is experiencing, the COVID-19 pandemic caused by the Virus SARS-CoV-2.
It is feared that the pandemic maybe more devastating in conflict affected areas in the world. This study assessed the knowledge, attitudes and practices with regard to the COVID-19 in Buea municipality, Cameroon. Methods: this was a cross-sectional study
carried out in communities selected from 5 health areas of the Buea Health District. A questionnaire was administered to collect data on the knowledge, attitudes and practices on COVID-19. The knowledge was measured using a 26-points Liker scale on awareness,
mode of transmission, clinical manifestation, site of the infection and prevention. The data was analyzed in SPSS version 25. Results: of the 545 particpants who consented, 21.9% had a correct knowledge of COVID-19, 43.8% had intermediate knowledge, 34.4%
had poor knowledge and 11.93% had no knowledge. Majority of the participants (73.3%) knew they were at risk of contacting the infection. They were aware that cleaning and disinfecting the environment (78.8%), reducing contact with animals (56.3%) could help
prevent the infection. Even though participants knew about the face mask (93.5%) and hand sanitizers (88.8%), only 21.7% and 32.9% had purchased them respectively. Few participants reported that they will go to a man of God (6.0%), native doctor (3.5%) and
auto-medication (25.8%) if infected. Conclusion: There is still a knowledge gap in the Buea population with respect to COVID-19. The population is aware of the disease and preventive measures, but few have taken steps to procure essential tools for the prevention.
There is need to intensify sensitization to fill the knowledge gap the population has with regards to COVID-19. © Tendongfor Nicholas et al. |
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Nikjoo, A, Shabani, et al |
Current Issues in Tourism |
Public Health response| Interventions de santé publique |
The COVID-19 pandemic, and its consequent self-isolation, has imposed changes on various aspects of people's lifestyle.
The present study aims at exploring the effect of these lifestyle changes on the content people share on their social media pages. To do so, we analysed Instagram posts containing the hashtag #viewfromquarantine which is promoted by the ‘National Geographic’
on a global scale. Adaptation to the new lifestyle, self-expression, and social issues were identified as the main issues shared by people during this time of pandemic. © 2020 Informa UK Limited, trading as Taylor & Francis Group. |
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Short-term forecasts of the COVID-19 pandemic: a study case of Cameroon |
Nkwayep, CH, Bowong, et al |
Chaos, Solitons and Fractals |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
In this paper, an Ensemble of Kalman filter (EnKf) approach is developed to estimate unmeasurable state variables and
unknown parameters in a COVID-19 model. We first formulate a mathematical model for the dynamic transmission of COVID-19 that takes into account the circulation of free coronaviruses in the environment. We provide the basic properties of the model and compute
the basic reproduction number R0 that plays an important role in the outcome of the disease. After, assuming continuous measurement of newly COVID-19 reported cases, deceased and recovered individuals, the EnKf approach is used to estimate the unmeasured variables
and unknown COVID-19 transmission rates using real data of the current COVID-19 pandemic in Cameroon. We present the forecasts of the current pandemic in Cameroon and explore the impact of non-pharmaceutical interventions such as mass media-based sensitization,
social distancing, face-mask wearing, contact tracing and the desinfection and decontamination of infected places by using suitable products against free coronaviruses in the environment in order to reduce the spread of the disease. Through numerical simulations,
we find that at that time (i) R0≈2.9495 meaning that the disease will not die out without any control measures, (ii) the infection from COVID-19 infected cases is more important than the infection from free coronaviruses in the environment, (iii) the number
of new COVID-19 cases will still increase and there is a necessity to increase timely the surveillance by using contact tracing and sensibilisation of the population to respect social distancing, face-masks wearing through awareness programs and (iv) the eradication
of the pandemic is highly dependent on the control measures taken by governments. |
|
Noghabi, ME, Baniasad, et al |
Iranian Journal of Pediatrics |
Transmission Clinical data| Données cliniques |
The target of this report is a 35-day-old male infant with respiratory distress and cyanosis.
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Respiratory Failure in a Child With Pulmonary Metastatic Osteosarcoma and COVID-19 |
Offenbacher, R, Fabish, et al |
J Pediatr Hematol Oncol |
Clinical data| Données cliniques |
We report the case of an adolescent with pulmonary metastatic osteosarcoma who died of COVID-19 early in the course
of the pandemic in New York City in the hope that heightening awareness that pulmonary metastatic disease may predispose to a more severe outcome will increase surveillance in this vulnerable population. |
|
Ogundokun, RO, Lukman, et al |
Infectious Disease Modelling |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
The coronavirus outbreak is the most notable world crisis since the Second World War. The pandemic that originated
from Wuhan, China in late 2019 has affected all the nations of the world and triggered a global economic crisis whose impact will be felt for years to come. This necessitates the need to monitor and predict COVID-19 prevalence for adequate control. The linear
regression models are prominent tools in predicting the impact of certain factors on COVID-19 outbreak and taking the necessary measures to respond to this crisis. The data was extracted from the NCDC website and spanned from March 31, 2020 to May 29, 2020.
In this study, we adopted the ordinary least squares estimator to measure the impact of travelling history and contacts on the spread of COVID-19 in Nigeria and made a prediction. The model was conducted before and after travel restriction was enforced by
the Federal government of Nigeria. The fitted model fitted well to the dataset and was free of any violation based on the diagnostic checks conducted. The results show that the government made a right decision in enforcing travelling restriction because we
observed that travelling history and contacts made increases the chances of people being infected with COVID-19 by 85% and 88% respectively. This prediction of COVID-19 shows that the government should ensure that most travelling agency should have better
precautions and preparations in place before re-opening. © 2020 The Authors |
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|
Olding, J, Zisman, et al |
Surgeon |
Healthcare Response | Réponse des soins de santé |
Data was collected on all patients presenting with traumatic penetrating injuries during the ‘lockdown’ period of 23rd
March to 29th April 2020. Demographics and injury details were compared with the same period in the two preceding years. Overall trauma fell by 35% compared with the previous year. Over one in four penetrating injuries seen were a result of self-harm, which
was significantly higher than in previous years (11% in 2019, 2% in 2018). There were two cases of injuries due to domestic violence, while a total of 4 cases of injury arose in separate violent domestic incidents. Self-harm commonly involved penetrating injury
to the neck. |
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Ordóñez, C, Garrido-Perez, et al |
Science of the Total Environment |
Public health interventions*| Interventions de santé publique |
This paper analyses the impact of the control measures during the COVID-19 lockdown in Europe (15 March–30 April 2020)
on 1-h daily maximum nitrogen dioxide (NO2) and maximum daily 8-h running average ozone (MDA8 O3) observations obtained from the European Environment Agency's air quality database (AirBase). Daily maximum NO2 decreased consistently over the whole continent,
with relative reductions ranging from 5% to 55% with respect to the same period in 2015–2019 for 80% of the sites considered (10th – 90th percentiles). However, MDA8 O3 concentrations showed a different pattern, decreasing over Iberia and increasing elsewhere.
In particular, a large region from northwestern to central Europe experienced increases of 10–22% at urban background stations, reaching typical values of the summer season. The analysis of the expected NO2 and O3 concentrations in the absence of the lockdown,
using generalised additive models fed by reanalysis meteorological data, shows that the low NO2 concentrations were mostly attributed to the emission reductions while O3 anomalies were dominated by the meteorology. |
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Ortmann, R, Pelster, et al |
Finance Research Letters |
Public Health response| Interventions de santé publique Economics | Économie |
How do retail investors respond to the outbreak of COVID-19? We use transaction-level trading data to show that investors
significantly increase their trading activities as the COVID-19 pandemic unfolds, both at the extensive and at the intensive margin. Investors, on average, increase their brokerage deposits and open more new accounts. The average weekly trading intensity increases
by 13.9% as the number of COVID-19 cases doubles. The increase in trading is especially pronounced for male and older investors, and affects stock and index trading. Following the 9.99%-drop of the Dow Jones on March 12, investors significantly reduce the
usage of leverage. © 2020 Elsevier Inc. |
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Serum lipid profile changes and their clinical diagnostic
significance in COVID-19 Mexican Patients |
Osuna-Ramos, Juan, Rendon Aguilar, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Clinical
data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
To evaluate the clinical diagnosis utility of the lipid profile changes in Mexican COVID-19 patients, the lipid profile
of one hundred two COVID-19 positive patients from three hospitals was analyzed. Through a predictive model using ROC curves, our findings suggest that low cholesterol and LDL levels could be considered an acceptable predictor for COVID-19, and low levels
of LDL might be a risk factor for critical COVID-19 patients. |
|
Olfactory dysfunction in patients after recovering from COVID-19 |
Otte, MS, Eckel, et al |
Acta Otolaryngol |
Clinical data| Données cliniques |
80 of 91 patients had experienced sudden olfactory loss during the course of disease and at the time of testing, 33
patients subjectively still had an impaired olfactory sense. Around 8 weeks had passed since the onset of symptoms. 45.1% of the tested individuals were still hyposmic according to the olfactory test while 53.8% showed an olfactory performance within the normal
range. Patients’ self-assessment correlated poorly with the measured olfactory performance. |
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Classification of Coronavirus (COVID-19) from X-ray and CT images using shrunken features |
Öztürk, Ş, Özkaya, et al |
International Journal of Imaging Systems and Technology |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
The study is aimed to develop a machine learning method for the detection of viral epidemics by analyzing X-ray and
CT images. In this study, images belonging to six situations, including coronavirus images, are classified using a two-stage data enhancement approach. Since the number of images in the dataset is deficient and unbalanced, a shallow image augmentation approach
was used in the first phase. It is more convenient to analyze these images with hand-crafted feature extraction methods because the dataset newly created is still insufficient to train a deep architecture. Therefore, the Synthetic minority over-sampling technique
algorithm is the second data enhancement step of this study. Finally, the feature vector is reduced in size by using a stacked auto-encoder and principal component analysis methods to remove interconnected features in the feature vector. |
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Padala, SA, Medepalli, et al |
J Clin Rheumatol |
Clinical data| Données cliniques |
This case report describes severe COVID-19 infection in a 57 year old woman with pulmonary and cardiac sarcoidosis. |
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Pagano, A, Pagano, et al |
European Physical Journal Plus |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
A statistical analysis of the corona-virus (Covid-19) infective process has been performed by a cooperative action
during the period February-June 2020. A good analysis has been obtained by using an entropic model typical of phenomena where statistical entropy-negaentropy balance is expected to play a major role. A saturation value of the infected humans was observed,
and the number of people potentially (asymptomatic) involved in the process was determined with an accuracy of 15% in the Italian case, as relevant example. The saturation value represents about 16% of the total (symptomatic + asymptomatic) involved population
in the process. The stability of the observed saturation level with the time shows that the governmental lockdown prescriptions, guided by scientists (virologists) have been effective to contain the diffusion of the virus and the associated human mortality.
© 2020, Società Italiana di Fisica and Springer-Verlag GmbH Germany, part of Springer Nature. |
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Pagotto, VPF, Abbas, et al |
European Journal of Plastic Surgery |
Healthcare Response | Réponse des soins de santé |
The Division of Plastic Surgery postponed non-essential surgeries and outpatient consultations, accomplishing new guidelines
(ANG) of national and international organizations. Total number of surgeries, type of procedures, and outpatient consultations in 2020, before (pre-ANG) and after (post-ANG) ANG, were compared with the same period in 2019 (2019-pre and 2020-post). A marked
reduction in the total number of surgeries and outpatient consultations was observed in the post-ANG period. In the post-ANG period, 267 operations were performed (26.7 ± 20.3/week), while in the 2019-post period, 1036 surgeries were performed (103.6 ± 9.7/week)
(p = 0.0002). Similarly, 1571 consultations were conducted in the post-ANG period (157.1 ± 93.6/week), while in the 2019-post period, 3907 were performed (390.7 ± 43.1/week) (p = 0.0003). However, in the post-ANG period, an increase in the proportion of reconstructive
compared with aesthetic surgery was observed. The maintenance of highly complex procedures such as microsurgical transplants was also identified. |
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Paliogiannis, P, Zinellu, et al |
Journal of infection in developing countries |
Clinical data| Données cliniques |
The aim of this study was to investigate differences and prognostic potential of routine blood tests in a series of
Italian patients with COVID-19 and non-COVID-19 interstitial pneumonia. This study showed several alterations in blood cell populations and indexes in patients with COVID-19 pneumonia in comparison with patients with non COVID-19 pneumonia. |
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Palma-Ruiz, J, Castillo-Apraiz, et al |
International Journal of Financial Studies |
Economics | Économie |
This paper aims to further clarify the understanding of potentially profitable strategies for firms during a global
crisis such as a pandemic. Both primary and secondary data were gathered, and descriptive analyses were conducted. |
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Palumbo, D, Guazzarotti, et al |
Journal of Vascular and Interventional Radiology |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
This report describes 818 consecutive patients admitted to the emergency department between March 1 and April 30, 2020,
with a positive nasopharyngeal swab test for SARS-CoV-2, 16 (1.9%) experienced at least 1 severe arterial bleeding episode, defined as any imaging-proven, clinically overt sign of arterial hemorrhage coupled with a decrease in hemoglobin count ≥ 3 mg/dL and
requiring intervention. A single patient (1/16; 6.2%) was excluded owing to an iatrogenic hepatic injury, bringing the incidence of spontaneous hemorrhage to 1.8% (15/818). The median time interval between onset of COVID-19 symptoms and occurrence of hemorrhage
was 23 days (IQR: 19–35 d); all patients had severe, radiologically proven interstitial pneumonia and required ventilator support during their hospital stay. Thirteen of 15 patients (86.7%) were receiving prophylactic antithrombotic treatment (low-molecular-weight
heparin) according to current internal guidelines; at the time of bleeding onset, no patient was above the therapeutic range of anticoagulation or had deep vein thrombosis and/or pulmonary embolism. |
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Pandey, P, Khan, et al |
Biointerface Research in Applied Chemistry |
Therapeutics| Thérapeutique |
The novel coronavirus (nCoV) has emerged as a severe public health threat globally in the 21st century. Several therapies
were reported towards identifying ligand against coronavirus, including targeting specific functional proteins or enzymes that are crucial to viruses, thereby preventing the synthesis and replication of virus RNA. Our study is mainly focused on targeting the
virus's structural proteins, which could further block the binding of the virus to human cell receptors. In our study, we have selected nine Flavonoids for the inhibition of COVID-19 Spike protein, which have already been reported with their antiviral efficacies
against other virus-infected diseases. AutoDock and PatchDock were used to study the inhibitory potential of flavonoids against COVID-19. Amongst all the eleven screened compounds, baicalin has depicted the highest binding affinity against 2019-nCoV spike
glycoprotein. Additionally, we have also compared its potential with two standard HIV drugs Abacavir and hydroxychloroquine, and the docking results clearly revealed the better inhibitory potential of baicalin in comparison to recently used drug Abacavir and
hydroxychloroquine for the treatment of COVID-19. Therefore our experimental findings strongly suggested that baicalin can be used as a potential inhibitor against COVID-19 spike protein, which could inhibit the interaction of the virus with the host cell
and thus could provide a potential lead molecule for the development of a drug against COVID-19 disease. © 2020 by the authors. |
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Influence of the Pandemic Dissemination of COVID-19 on Facial Rejuvenation: A Survey of
Twitter |
Pang, R, Wei, et al |
J Cosmet Dermatol |
Public Health response| Interventions de santé publique |
The purpose of this study was to understanding the impact of pandemic on the attitude of people towards facial skin
rejuvenation. |
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Papa, A, Di Dato, et al |
Anesthesiology and Pain Medicine |
Clinical data| Données cliniques Immunology | Immunologie |
Introduction: In the last months of 2019, the advent of a new virus called SARS-CoV-2 caused the spread of a pandemic
disease, COVID-19, that has afflicted patients with chronic pain. Case Presentation: We describe a COVID-19 patient recently implanted with a spinal cord stimulator for FBSS, treated with Tocilizumab for cytokine storm complicating SARS-COV-2 infection. This
patient developed a delayed hyperimmune reaction, caus-ing an inflammatory reaction in the surgical pocket site, well treated with total remission. The total resolution of this local reaction occurred after the resolution of systemic COVID-19 infection by
Tocilizumab. Conclusions: We discuss the balance between damage-associated molecular patterns (DAMPs) and pathogen-recognition receptors (PRRs), and the putative role of polymorphism in the IL-6/174 position of the promoter region. © 2020, Author(s). |
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Papouli, E, Chatzifotiou, et al |
Social Work Education |
Public Health response| Interventions de santé publique |
This study aims to explore Greek social work students’ views on the use of digital technology during their stay at
home due to the coronavirus lockdown. To do this, an online questionnaire was voluntarily completed by 550 students (89.64% female and 9.82% male) from different university departments of social work across the country. The study was carried out by the researchers
from 21 April 2020 to 1 May 2020. The results presented here describe aspects of using digital technology and its connections to learning interactions, communication with others, self-fulfilment and well-being. Also, they describe aspects of support either
providing or receiving assistance as forms of solidarity and voluntarism during the COVID-19 confinement period. Overall, the results highlight the critical role digital technology played in numerous aspects of the daily lives of students, helping them to
discover new ways to navigate the unprecedented new reality formed due to the COVID-19 pandemic. © 2020 Informa UK Limited, trading as Taylor & Francis Group. |
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Passanisi, S, Pecoraro, et al |
Frontiers in Pediatrics |
Public Health response| Interventions de santé publique |
Authors conducted a web-based survey to investigate the behavioral responses during quarantine due to the COVID-19
outbreak in a cohort of pediatric patients with type 1 diabetes. Although quarantine was a stressful psychological condition, our results showed that most children and adolescents with type 1 diabetes developed high levels of resilience and excellent coping
skills by using technology in a proper way. |
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SARS-Cov-2 Infection and Pulmonary Thromboembolism - The Prothrombotic State in
COVID-19 |
Passos, HD, Alves, et al |
Arquivos Brasileiros de Cardiologia |
Clinical data| Données cliniques |
This report describes a case of SARS-Cov-2 Infection and pulmonary thromboembolism. |
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A case report of a pregnant woman infected with coronavirus disease 2019 pneumonia |
Peng, J, Li, et al |
Medicine |
Clinical data| Données cliniques |
Authors report a clinically confirmed COVID-19 pregnant woman.
|
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Thermal inactivation and nucleic acid amplification-based testing for SARS-CoV-2 |
Péré, H, Podglajen, et al |
Journal of Clinical Virology |
Coronavirology| Coronavirologie Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) |
In order to provide protection of our laboratory staff, and in the absence of instruction for clinical specimen inactivation
from the manufacturer, we investigated herein whether thermal inactivation could affect the results of viral detection using RealTime SARS-CoV-2 assay (Abbott Molecular). In the present series, heat-inactivation of clinical specimen did not affect significantly
the results of SARS-CoV-2 detection, despite very slight increase of Ct values and rare undetectability with few samples harboring low viral load after thermal inactivation. |
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Cytokine release syndrome-associated encephalopathy in patients with COVID-19 |
Perrin, P, Collongues, et al |
Eur J Neurol |
Clinical data| Données cliniques |
we sought to describe the neurological manifestations of patients with COVID‐19 and gain pathophysiological insights
especially with respect to cytokine release syndrome (CRS). Extensive clinical, laboratory, and imaging phenotyping was performed in five patients admitted to our renal unit. Treatment with corticosteroids and/or intravenous immunoglobulins was attempted –
resulting in rapid recovery from neurological disturbances in two cases. SARS‐CoV2 was undetectable in 88 of the 90 patients with COVID‐19 who underwent RT‐PCR testing of CSF. |
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The "Glass Lung" - A Lifelike Electromechanical Lung Simulator |
Peuscher, Heiko, Dubies, et al |
Research Square prepub |
Healthcare Response | Réponse des soins de santé |
Background: This contribution describes the hardware setup, control, and parametrization of an electromechanical test
lung intended to perform tests with clinical ventilators. Methods: We use a nonlinear model to imitate the dynamic behavior of a real lung in terms of compliance and resistance. Both passive behavior and spontaneous breathing (weaning) are supported. In automated
test sequences, the test lung mimics a variety of physiological and pathological lung conditions, including COVID-19. Results: We present the results obtained with an approved clinical ventilator in various modes including pressure-controlled and pressure
support ventilation. Conclusions: All results are clinically consistent with the values expected from ventilation of a real patient. |
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Synchronized Attachment and the Darwinian Evolution of Coronaviruses CoV-1 and CoV-2 |
Phillips, JC |
arXiv |
Coronavirology| Coronavirologie |
We identify a new first stage of infection which precedes structural rearrangements by using biomolecular evolutionary
theory to identify sequence differences enhancing viral attachment rates. We find a small cluster of mutations which show that SARS-CoV-2 has a new feature that promotes much stronger viral attachment and enhances contagiousness. |
|
Pinto, J, van Zeller, et al |
Sleep medicine |
Public Health response| Interventions de santé publique |
Our aim was to evaluate the sleep quality of respiratory patients during the COVID-19 pandemic lockdown. All patients
who underwent a telemedicine appointment from March 30 to April 30 of 2020 were asked to participate in the survey. The study population consisted of 365 patients (mean age 63.9 years, 55.6% male, 50.1% with sleep-disordered breathing SDB]). During the lockdown,
78.9% of participants were confined at home without working. Most patients (69.6%) reported at least one sleep difficulty and frequent awakenings was the most prevalent problem. Reporting at least one sleep difficulty was associated with home confinement without
working, female gender and diagnosed or suspected SDB, after adjustment for cohabitation status and use of anxiolytics. Home confinement without working was associated with difficulties falling asleep and waking up too early in the morning. Older age was a
protective factor for difficulties falling asleep, waking up too early and non-restorative sleep. Notably, SDB patients with good compliance to positive airway pressure therapy were less likely to report sleep difficulties. |
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Pivetta, E, Girard, et al |
Chest |
Healthcare Response | Réponse des soins de santé |
With the goal of safely isolating infected patients while providing advanced monitoring, we present a first report
of patient self-performed lung ultrasound in the home with a hand-held device under the guidance of a physician using a novel teleguidance platform. |
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An application of a mixture of exponential distributions for assessing hazard rates
from COVID-19 |
Polymenis, A |
Journal of Population Therapeutics and Clinical Pharmacology |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In the present study, we are interested in modeling repose time periods (the length of the time intervals between successive
deaths) caused by a new, widespread disease called covid-19. This is useful for predict-ing probabilities of new deaths that occur within pre-determined time intervals. In practical applications, the choice of the statistical model is crucial for obtaining
accurate estimates of death hazard rates. Based on an earlier research, we propose to use a mixture of exponential distributions; this model is simple to implement when hazard rates obtained from the components of the mixture are easily calculated, and it
is adequate for dealing with nonstationary time series as those appearing in the case of this disease. The model is then applied to the example of Italy, and it appears to be also useful for comparing hazard rates along time. © 2020, Codon Publications. All
rights reserved. |
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Poteat, TC, Reisner, et al |
J Acquir Immune Defic Syndr |
Epidemiology| Épidémiologie |
Transgender women with HIV may be particularly vulnerable to pandemic harms. Mitigating this harm would have positive
effects for everyone, given the highly infectious nature of this coronavirus. The 1020 participants had high rates of poverty, unemployment, food insecurity, homelessness, and sex work. Transgender women with HIV (n=273) were older, more likely to be Black,
had lower educational attainment, and were more likely to experience material hardship. Collecting gender identity in COVID-19 data is crucial to inform an effective public health response. |
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Existing data sources in clinical epidemiology: The danish covid-19 cohort |
Pottegård, A, Kristensen, et al |
Clinical Epidemiology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Background: To facilitate research on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a prospective cohort
of all Danish residents tested for SARS-CoV-2 in Denmark is established. Data Structure: All Danish residents tested by reverse transcriptase polymerase chain reactions (RT-PCR) for SARS-CoV-2 in Denmark are included. The cohort is identified using the Danish
Microbiology Database. Individual-level record linkage between administrative and health-care registries is facilitated by the Danish Civil Registration System. Information on outcomes related to SARS-CoV-2 infection includes hospital admission, intensive
care unit admission, mechanical ventilation, and death and is retrieved from the five administrative Danish regions, the Danish National Patient Registry, and the Danish Register of Causes of Death. The Patient Registry further provides a complete hospital
contact history of somatic and psychiatric conditions and procedures. Data on all prescriptions filled at community pharmacies are available from the Danish National Prescription Registry. Health-care authorization status is obtained from the Danish Register
of Healthcare Professionals. Finally, selected laboratory values are obtained from the Register of Laboratory Results for Research. The cohort is governed by a steering committee with representatives from the Danish Medicines Agency, Statens Serum Institut,
the Danish Health Authority, the Danish Health Data Authority, Danish Patients, the Faculties of Health Sciences at the Danish universities, and Danish regions. The steering committee welcomes suggestions for research studies and collaborations. Research proposals
will be prioritized based on timeliness and potential clinical and public health implications. All research protocols assessing specific hypotheses for medicines will be made publicly available using the European Union electronic Register of Post-Authorisation
Studies. Conclusion: The Danish COVID-19 cohort includes all Danish residents with an RT-PCR test for SARS-CoV-2. Through individual-level linkage with existing Danish health and administrative registries, this is a valuable data source for epidemiological
research on SARS-CoV-2. © 2020 Pottegård et al. |
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Prata-Barbosa, A, Lima-Setta, et al |
Jornal de pediatria |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This prospective, multicenter, observational study, in 19 pediatric intensive care units was conducted to describe
the clinical characteristics of children and adolescents admitted to intensive care with confirmed COVID-19. Findings show that in Brazilian pediatric intensive care units, COVID-19 had low mortality, age less than 1 year was not associated with a worse prognosis,
and patients with multisystemic inflammatory syndrome had more severe symptoms, higher inflammatory biomarkers, and a greater predominance of males, but only comorbidities and chronic diseases were independent predictors of severity. |
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Prigoff, J, Hunter, et al |
Journal of Surgical Education |
Public Health response| Interventions de santé publique |
Background: Medical student education in the era of the COVID-19 outbreak is vastly different than the standard education
we have become accustomed to. Medical student assessment is an important aspect of adjusting curriculums in the era of increased virtual learning. Methods: Students took our previously validated free response clinical skills exam (CSE) at the end of the scheduled
clerkship as an open-book exam to eliminate any concern for breaches in the honor code and then grades were adjusted based on historic norms. The National Board of Medical Examiners (NBME) shelf exam was taken with a virtual proctor. Students whose clerkship
was affected by the COVID-19 pandemic were compared to the students from a similarly timed surgery block the previous 3 years. Primary outcomes included CSE and NBME exam scores. Secondary outcomes included clinical evaluations and the percentage of students
who received grades of Honors, High Pass, and Pass. After the surgery clerkship was completed, we surveyed all students who participated in the surgery clerkship during the COVID-19 crisis. Results: There were 19 students during the COVID-interrupted clerkship
and 61 students in similarly timed clerkships between 2017 and 2019. Prior to adjustment and compared to historic scores, the COVID-interrupted clerkship group scored higher on the CSE, NBME exam, and performance evaluations (median, CSE:75.2 vs 68.7, shelf:68.0
vs 64.0, performance evaluation mean: 2.96 vs 2.78). The percentage of students with an honors was marginally higher in the group affected by COVID (42% vs 32%). Out of 19 students surveyed, 9 students responded. Seven students stated they would have preferred
a closed-book CSE, citing a few drawbacks of the open-book format such as modifying their exam preparation, being discouraged from thinking prior to searching online during the test, and second guessing their answers. Conclusions: During the initial outbreak
of COVID-19, we found that an open book exam and a virtually proctored shelf exam was a reasonable option. However, to avoid adjustments and student dissatisfaction, we would recommend virtual proctoring if available. © 2020 Association of Program Directors
in Surgery |
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Songbirds Must Sing: How Artistic Voice Users Perceive Their Voice in Times of
COVID-19 |
Primov-Fever, A, Roziner, et al |
Journal of Voice |
Public Health response| Interventions de santé publique |
A total of 110 participants volunteered for the study: 57 professional artistic voice users (34 singers and 19 actors)
and a control group of 53 nonprofessional voice users. All participants completed three questionnaires related to their self-assessment of their voice, their voice difficulties, vocal training, and current stress in the time of the COVID-19 pandemic. Compared
to the controls, artistic voice users were more concerned about their voice (P < 0.001), practiced their voice more often (P < 0.001), and experienced more anxiety and stress (P < 0.05). In addition, within the professional group, singers reported practicing
their voice in the time of the COVID-19 significantly more than actors (P < 0.01). Professional artistic voice users experience the COVID-19 pandemic as a stressful time, with negative effects on their well-being and specifically on their voice. This should
be considered in the treatment and maintenance of their voice and professional career at current and future stressful times. |
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Differences in US COVID-19 case rates and case fatality rates across the urban-rural continuum |
Pro, G, Hubach, et al |
Rural and remote health |
Epidemiology| Épidémiologie |
This study aimed to analyze the differences in US COVID-19 case rates and case fatality rates across the urban-rural
continuum. The mean IRR score was 0.47. The mean predicted case rate was 2397 (per 100 000 county residents), and the mean predicted case fatality rate was 2.7%. The predicted COVID-19 case rate decreased |
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Visualizations of Topologic Entropy on SARS-CoV-2 Genomes in Multiple Regions |
Qiao, Mu, Liu, et al |
Research Square prepub |
Coronavirology| Coronavirologie |
This paper is focused on the study to make error bars and scatter graphs with the support of the metagenetic analysis
system MAS. Using SARS-CoV-2 genomes in different countries and regions as input datasets, topological entropy values provide global characteristic quantities based on C4 module for visualization. Sample results show that the method is powerful and useful
for consistently integrating all genomes on one unique genomic index map. |
|
Qing, L, Jiu-Long, et al |
Academic Journal of Second Military Medical University |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Objective To analyze the characteristics and related risk factors of myocardial injury in severe and critical coronavirus
disease 2019 (COVID-19) patients and their relationship with the prognosis. A total of 56 patients were included, with 22 in the non-myocardial injury group and 34 in the myocardial injury group. the age of onset was significantly higher in the myocardial
injury group (78.5[ 70.8, 89.0] years vs 56.5[ 50.3, 68.3] years, P<0.01), and the proportions of patients over 65 years old and combined with coronary heart disease were significantly greater (85.3%[ 29/34] vs 31.8%[ 7/22] and 38.2% [13/34] vs 9.1%[ 2/22],
both P<0.05). In terms of symptoms, fever (87.5%, 49/56), cough (64.3%, 36/56) and fatigue (46.4%, 26/56) were the most common ones, and there were no significant differences between the two groups (all P>0.05). For the CT findings of the lungs, the proportion
of patients having patch-like/plaque-like shadows and ground-glass opacities was significantly greater in the non-myocardial injury group versus the myocardial injury group (72.7%[ 16/22] vs 38.2%[ 13/34], χ2=6.364, P<0.05), and other signs were not significantly
different between the two groups (P>0.05). Compared with the non-myocardial injury group, the levels of N-terminal pro-B-type natriuretic peptide, D-dimer, procalcitonin and IL-6 were significantly higher in the myocardial injury group (4 939.5[ 1 817.0, 9
450.3] pg/mL vs 612.5[ 301.0, 1 029.5] pg/mL, 4 386.5 [2 309.5, 9 635.3] ng/mL vs 850.5 [343.5, 2 333.8] ng/mL, 0.46 [0.23, 3.79] ng/mL vs 0.18 [0.13, 0.39] ng/mL, and 138.6 [41.9, 464.8] pg/mL vs 65.1[ 34.7, 99.3] pg/mL, respectively), and the differences
were significant (all P<0.01). Multivariate logistic regression analysis showed that age≥65 years old (odds ratio[ OR] =18.62, 95% confidence interval[ CI] 1.61-215.96, P<0.05) and D-dimer level≥3 000 ng/mL (OR=15.48, 95% CI 1.45-164.77, P<0.05) were the independent
risk factors for myocardial injury in severe and critical COVID-19 patients. There were no significant differences in the use of antiviral drugs, antibacterial drugs, or glucocorticoids between the two groups (all P>0.05). The mortality rate was significantly
higher in the myocardial injury than that in the non-myocardial injury group (58.8% [20/34] vs 9.1% [2/22], P<0.01). Patients who received tracheal intubation, extracorporeal membrane oxygenation, continuous renal replacement therapy (CRRT) and other invasive
life support measures were all in the myocardial injury group. |
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Epitopes targeted by T cells in convalescent COVID-19
patients |
Quadeer, AhmedA, Ahmed, et al |
bioRxiv |
Coronavirology| Coronavirologie Vaccine Research| Recherche sur les vaccins |
Here, we provide a unified description of emerging data of SARS-CoV-2 T cell epitopes compiled from results of 8 independent
studies of convalescent COVID-19 patients. We describe features of these epitopes relevant for vaccine design, while indicating knowledge gaps that can, in part, be augmented using prior immunological data from SARS-CoV. The landscape of SARS-CoV-2 T cell
epitopes that we describe can help guide SARS-CoV-2 vaccine development as well as future immunological studies. A web-based platform has also been developed to complement these efforts. |
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Cardiac Injury Patterns and Inpatient Outcomes Among Patients Admitted With
COVID-19 |
Raad, M, Dabbagh, et al |
American Journal of Cardiology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this large retrospective longitudinal cohort study, we analyzed the cases of 1,044 consecutively admitted patients
with COVID-19 from March 9 until April 15. The final analyzed cohort included 1,020 patients. 390 (38%) patients had cardiac injury on presentation. These patients were older (median age 70 years), had a higher cardiovascular disease burden, in addition to
higher serum concentrations of inflammatory markers. They also exhibited an increased risk for our primary and secondary outcomes, with the risk increasing with higher hs-cTnI concentrations. Peak hs-cTnI concentrations continued to be significantly associated
with mortality after a multivariate regression controlling for comorbid conditions, inflammatory markers, acute kidney injury, and acute respiratory distress syndrome. Within the same multivariate regression model, presenting hs-cTnI concentrations were not
significantly associated with outcomes, and undetectable hs-cTnI concentrations on presentation did not completely rule out the risk for mechanical ventilation or death. |
|
Rabes, C, Bläuer, et al |
Pflege |
Healthcare Response | Réponse des soins de santé |
The intrinsic retrospective case study describes the setting up of a cohort ward for patients with COVID-19 on a surgical
ward including the development of the nursing team. |
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Rahmatpour, P, Nia, et al |
International Journal of General Medicine |
Healthcare Response | Réponse des soins de santé |
The aim of this study is to evaluate the reliability and validity of the Persian version of the nurses’ intention to
care scale (NICS) by Iranian nurses who care for patients with COVID-19 in hospitals. A cross-sectional study was conducted on nurses (n= 400) at public and private Mazandaran hospitals. The findings from an exploratory factor analysis yielded six factors
that explained 53.12% of the total variance of the NICS. The confirmatory factor analysis demonstrated that the model had a good fit and the inter-item correlation values of the factors indicated good internal consistency. |
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Rakib, A, Sami, et al |
Computers in biology and medicine |
Coronavirology| Coronavirologie Vaccine Research| Recherche sur les vaccins |
Our study provides a strong basis for designing vaccine candidates against SARS-CoV-2. Our group comprehensibly analyzed
the SGP of SARS-CoV-2 through multiple sequence analysis and a phylogenetic analysis. We predicted the strongest immunogenic epitopes of the SGP for both B cells and T cells. Key findings: We focused on predicting peptides that would bind major histocompatibility
complex class I. Two optimal epitopes were identified, WTAGAAAYY and GAAAYYVGY. They interact with the HLA-B*15:01 allele, which was further validated by molecular docking simulation. This study also found that the selected epitopes are able to be recognized
in a large percentage of the world's population. Furthermore, we predicted CD4+ T-cell epitopes and B-cell epitopes. |
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Research paper: The role of anxiety and cortisol in outcomes of patients with
Covid-19 |
Ramezani, M, Simani, et al |
Basic and Clinical Neuroscience |
Clinical data| Données cliniques |
The current study enrolled patients with COVID-19 to evaluate the serum concentration of cortisol and levels of anxiety
and depression using the Hospital Anxiety and Depression Scale (HADS) to investigate a possible relationship between cortisol, depression, and anxiety levels and outcomes of patients with COVID-19.
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Pediatric multisystem inflammatory syndrome associated with sars-cov-2 |
Raúl Bustos, B |
Revista chilena de pediatria |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Article in Spanish. Full text not available online. |
|
Razif, M, Miraja, et al |
Entrepreneurship and Sustainability Issues |
Public Health response| Interventions de santé publique |
Working From Home (WFH) technologies has been used and discussed for a long time. The many positive benefits of WFH
technologies, including its potential to create a more sustainable work activity, attracted many studies to gain a better understanding of this subject. This study is interested to understand the different factors, including environmental, influencing WFH
technologies acceptance in this current shifting situation stimulated by the Covid-19 pandemic. An extended Unified Theory of Acceptance and Use of Technology (UTAUT) model, employing Environmental Concern, was used. The model was assessed by using the structural
equation model. The total of 172 respondents participated in this research. The total of 5 hypotheses was tested. The present study’s model is able to predict 57.4% of WFH Technology acceptance. Finally, discussion and recommendations to businesses that are
currently taking WFH measures during the Covid-19 pandemic were presented. © Entrepreneurship and Sustainability Center. All rights reserved. |
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COVID-19 on selective sentinel node biopsy: the unexpected guest |
Ribera-Perianes, J, Cases, et al |
Revista de Senologia y Patologia Mamaria |
Healthcare Response | Réponse des soins de santé |
This study aims to describe the measures adopted within the COVID-19 contingency plan regarding selective sentinel
lymph node biopsy (SLNB) and analyze their impact on healthcare activity in Spain. 42 interventions were performed with SLNB, 31.1% less than in 2019. The medical indication for breast cancer experienced the greatest decrease in activity (n = 18, 41.9%).
Of the total CRG, Hospital Clínic made 45.2%, Hospital Maternitat 31.0%, Hospital Plató 16.7% and Hospital Sant Joan de Déu the remaining 7.1%. Regarding human resources, the initial planning was fulfilled in 77% of the days. The total of PCR controls to patients
(n = 42) and CRG personnel (n = 9) gave negative results. |
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High body mass index and night shift work are associated with COVID-19 in health
care workers |
Rizza, S, Coppeta, et al |
J Endocrinol Invest |
Epidemiology| Épidémiologie |
We found 30 cases of COVID-19 infection in a total of 1180 HCWs (2.5%). Most COVID-19-positive hospital employees were
r-NSWs with significantly higher BMI than that of individuals who tested negative. After adjustment for covariates, night work and BMI > 30 were associated with a markedly greater risk of COVID-19 diagnosis. |
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Psychological factors associated with substance use initiation during the COVID-19
pandemic |
Rogers, AH, Shepherd, et al |
Psychiatry research |
Public Health response| Interventions de santé publique |
The results of this study suggest that COVID-19-specific psychological factors appear to be involved in substance use
behaviorResults indicated that COVID-19-related worry was associated with substance use coping motives. Additionally, compared to abstainers, pre-COVID-19 substance users and COVID-19 substance initiators demonstrated the highest levels of worry and fear.
Examination of differences suggested that the COVID-19 substance initiators had the highest COVID-19-related worry and fear for all substances except for opioids, with effect size estimates ranging from small to medium. |
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Rui-Yong, C, Yan-Chao, et al |
Academic Journal of Second Military Medical University |
Clinical data| Données cliniques |
Objective To explore the potential mechanisms underlying the prominent efficiency of hyperbaric oxygen therapy (HBOT)
in the treatment of severe coronavirus disease 2019 (COVID-19) patients. After the first HBOT, the symptoms and signs of the five patients began to improve. All the five patients had typical lung CT imaging changes of severe COVID-19 before HBOT, which were
improved after HBOT. |
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Challenges of diagnosis of COVID-19 in trauma patients: A case series |
Sabetian, G, Feiz, et al |
Trauma (United Kingdom) |
Clinical data| Données cliniques |
We present a case series of patients from February and March 2020 who were admitted to our trauma center at Rajaee
Hospital Trauma Center, in Shiraz, Iran and had positive SARS-CoV-2 PCR test or chest CT scan suggestive of COVID-19 and were admitted to the specific ICU for COVID-19. Eight COVID-19 patients (6 male) with mean age of 40 (SD = 16.3) years old, were presented.
All patients were cases of trauma injuries, with multiple injuries including chest trauma and lung contusion, admitted to our trauma center for management of their injuries, but they were diagnosed with COVID-19 as well. Two of them had coinfection of influenza
type-B and SARS-CoV-2. All patients were treated for COVID-19 and three of them died; the rest were discharged from hospital. |
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Sadioglu, RE, Aktar, et al |
Peritoneal Dialysis International |
Clinical data| Données cliniques |
Here we report a case of 62 year old COVID-19 patient in a peritoneal dialysis (PD) without any virus shedding in peritoneal
fluid. In our patient, the clinical course was favorable and all the symptoms were resolved in a week and there was no virus shedding in peritoneal fluid after a 6-h dwell time. |
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Safaee Fakhr, B, Wiegand, et al |
Obstet Gynecol |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
We treat pregnant patients meeting criteria for severe or critical COVID-19 with high-dose (160–200 ppm) nitric oxide
by mask twice daily. An improvement in cardiopulmonary function was observed after commencing nitric oxide gas, as evidenced by an increase in systemic oxygenation in each administration session among those with evidence of baseline hypoxemia and reduction
of tachypnea in all patients in each session. |
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Sahoo, S, Pattnaik, et al |
J Psychosom Obstet Gynaecol |
Public Health response| Interventions de santé publique |
We evaluate the beliefs held by the public regarding sexual health, pregnancy, and breastfeeding during COVID-19 era.
Results suggests that a significant proportion of people in India have misinformation about sexual intimacy, pregnancy, and breastfeeding in the ongoing pandemic which needs to be addressed. |
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Salman, M, Mustafa, et al |
Journal of infection in developing countries |
Healthcare Response | Réponse des soins de santé |
This cross-sectional study was conducted among the health professionals providing services at seven hospitals of Punjab
province of Pakistan to assess their knowledge, attitude and practices (KAP). |
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|
Salmon Ceron, D, Bartier, et al |
Journal of Infection |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aims to determine the frequency of SARS-CoV-2 positive samples in a subset of patients consulting for primarily
isolated acute (<7 days) loss of smell and to assess the diagnostic accuracy of olfactory/gustatory dysfunction for COVID-19 diagnosis in the overall population tested for COVID-19 in the same period. i) Among a subset of 55 patients consulting for primarily
recent loss of smell, we found that 51 (92.7%) had a COVID-19 positive test (median viral load of 28.8 cycle threshold). Loss of smell was mostly total (anosmia), rarely associated with nasal obstruction but associated with a taste disorder in 80%. Olfactory
dysfunction occurred suddenly, either as first complaint or preceded by mild symptoms occurring a median of 3 days. The majority of patients (72.9%) partially recovered the sense of smell within 15 days. ii) In a population of 1824 patients tested for COVID-19,
the positive predictive value and the specificity of loss of smell and/or taste were 78.5% and 90.3% respectively (sensitivity (40.8%), negative predictive value (63.6%)). Self-reported loss of smell had a high predictive positive value to identify COVID-19.
Making this sign well known publicly could help to adopt isolation measures and inform potential contacts. |
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Differences in Distress and Coping with the COVID-19 Stressor in Nurses and Physicians |
Salopek-Žiha, D, Hlavati, et al |
Psychiatria Danubina |
Healthcare Response | Réponse des soins de santé |
Authors explored ways to deal with the coronavirus stressor and psychological outcomes among physicians and nurses.
|
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Effect of covid-19 pandemic on the cardiac outpatients’ perception of seeking medical
advice |
Samargandy, SA, Al Garni, et al |
Journal of the Saudi Heart Association |
Healthcare Response | Réponse des soins de santé |
A quantitative descriptive cross-section survey study of 388 patients. It has been done in the cardiac outpatient department
and conducted virtually through telemedicine. Despite this pandemic and its consensuses, the majority of cardiac outpatients will still seek medical advice in case of experiencing symptoms. Nevertheless, the fear of contracting COVID-19 infection, which can
alter patient’s decisions from visiting the emergency room and the increase in stress level during these challenging times, is genuine and no more an element of guessing. |
|
Samuel, S, Friedman, et al |
Heart Rhythm |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aims to describe the electrophysiologic findings and arrhythmias associated with pediatric COVID-19 (n =
36) and its treatment. Significant arrhythmias were found in 6 (nonsustained ventricular tachycardia in 5 and sustained atrial tachycardia in 1). All were self-resolving and half prompted prophylactic antiarrhythmic therapy. Patients with significant arrhythmias
were likely to have noncardiac comorbidities (4/6), but these were not more common than in patients without arrhythmias (20/30, P = 1). The use of HCQ was associated with statistically significant QTc prolongation (413 ± 19 ms vs 425 ± 16 ms, P =.005). QTc
was not statistically different in patients with and without arrhythmias (425 ± 15 ms vs 425 ± 15 ms, P = 1). |
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Sánchez-Pérez, P, González-Calero, et al |
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia |
Healthcare Response | Réponse des soins de santé |
In this study the experience of a tertiary hospital and four hemodialysis centers in Spain attached to it during the
COVID-19 epidemic is described. COVID-19 disease in hemodialysis patients is severe in a significant percentage of cases, and high lethality is mostly caused by the infection itself. |
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Sánchez-Rovira, Pedro, Pérez-Chica, et al |
SSRN- Lancet prepublication |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
We conducted a retrospective, observational, cohort study including 50 patients affected by COVID-19 with severe pneumonia
and poor prognosis criteria, who have undergone standard treatment; 36 of these patients additionally received tocilizumab in an early stage. Treatment with tocilizumab significatively increased interleukin-6 levels, while C-reactive protein mean levels
were reduced, but no significant difference was found between cohorts. In comparison with the controls, tocilizumab reduced mortality and the number of ICU admissions. 44.1% of patients treated with tocilizumab showed a favourable radiological evolution, when
compared to 15.4% of patients from the control group. |
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Sandhaus, Y, Kushnir, et al |
The Israel Medical Association journal : IMAJ |
Public Health response| Interventions de santé publique |
The objective of this study was to explore potential implications of COVID-19 on future pre-clinical medical studies.
The high satisfaction and the positive experience with the electronic distance learning imposed by the COVID-19 epidemic implied a successful transition and might induce future changes in pre-clinical medical studies. |
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Santeusanio, AD, Zendel, et al |
Clinical transplantation |
Healthcare Response | Réponse des soins de santé |
We performed a single‐center review of all adult kidney transplants performed during the COVID‐19 pandemic in New York
City. Patients were managed with standard immunosuppression protocols, including lymphocyte depleting induction and trough‐guided tacrolimus. 30 kidney transplants were performed during the height of the COVID‐19 pandemic. After a median follow‐up of 51.5
days, 93.3% of patients were alive with 100% death‐censored allograft survival. 9 patients were readmitted to the hospital during the study period, 4 (13.3%) related to infection with COVID‐19. Infections were mild in 3/4 patients, with one patient developing
severe disease leading to respiratory failure. Patients readmitted with COVID‐19 were numerically more likely to be African American, have a BMI > 30 kg/m2, have a lymphocyte count ≤ 300 cells/mL, and be on maintenance corticosteroids. Kidney transplantation
in areas endemic to COVID‐19 using standard induction and maintenance immunosuppression appears to be associated with a modest risk for severe COVID‐19 related disease. |
|
|
Capacity Evaluation of Diagnostic Tests For COVID-19 Using Multicriteria Decision-Making
Techniques |
Sayan, M, Sarigul Yildirim, et al |
Computational and mathematical methods in medicine |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This study is aimed at comparing the confusion regarding the selection of effective diagnostic methods to make a mutual
comparison among existing SARS-CoV-2 diagnostic tests and at determining the most effective one. The results of our study with both proposed MCDM methods indicated that the most effective diagnosis method of COVID-19 was chest CT. It is interesting to note
that the methods that are consistently used in the diagnosis of viral diseases were ranked in second place for the diagnosis of COVID-19. However, each country should use appropriate diagnostic solutions according to its own resources. Our findings also show
which diagnostic systems can be used in combination. |
|
Schimmenti, A, Starcevic, et al |
Frontiers in Psychiatry |
Public Health response| Interventions de santé publique |
Authors present the development and psychometric properties of the Multidimensional Assessment of COVID-19--Related
Fears (MAC-RF). |
|
|
Schooley, RobertT, Carlin, et al |
bioRxiv |
Therapeutics| Thérapeutique |
We focused on making simple orally bioavailable lipid analogs of Remdesivir nucleoside (RVn, GS-441524) that are processed
to RVn-monophosphate, the precursor of the active RVn-triphosphate, by a single step intracellular cleavage. In addition to likely improved oral bioavailability and simpler metabolic activation, two of the three new lipid prodrugs of RVn had anti-SARS-CoV-2
activity 9 to 24 times greater than that of RDV in Vero E6 cells. |
|
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IgM and IgG antibodies against SARS-CoV-2 in neonates born to mothers with COVID-19 |
Semeshkin, AA, Vechorko, et al |
Bulletin of Russian State Medical University |
Transmission Clinical data| Données cliniques Immunology | Immunologie |
Immunity against the novel coronavirus infection in neonates born to mothers with PCR-confirmed COVID-19 is an understudied
field of research. The aim of this study was to analyze the levels of IgM and IgG antibodies against SARS-CoV-2. The study was carried out in 20 mothers aged 19 to 39 years and 21 neonates (including a pair of twins). Babies born to mothers with elevated IgM
and IgG against SARS-CoV-2 also had elevated IgG. There is a hypothesis that anti-SARSCoV-2 IgM are not passed on to the child across the placenta. In all cases studied in this work, neonates were PCR-negative for the virus, which suggests the absence of vertical
COVID-19 transmission. Further research is needed. © 2020 Pirogov Russian National Research Medical University. All rights reserved. |
|
Inhibiting coronavirus replication in cultured cells
by chemical ER stress |
Shaban, Mohammed Samer, Mueller, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Here, we provide evidence that pharmacological reprogramming of ER stress pathways can be exploited to suppress CoV
replication. We found that the ER stress inducer thapsigargin efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types, (partially) restores the virus-induced translational shut-down, and counteracts the CoV-mediated
downregulation of IRE1α and the ER chaperone BiP. Proteome-wide data sets revealed specific pathways, protein networks and components that likely mediate the thapsigargin-induced antiviral state. |
|
Shah, N, Raheem, et al |
European Journal of Obstetrics and Gynecology and Reproductive Biology |
Healthcare Response | Réponse des soins de santé |
With the threat of a second COVID-19 peak looming, now more than ever, it is vital that steps are taken to break the
stigmatisation of mental health amongst doctors, encouraging doctors to seek help when required. A total of 207 doctors completed the survey. Obstetricians and Gynaecologists reported significantly higher rates of both Major Depressive Disorder (versus, p
= 0.023) and Generalised Anxiety Disorder (versus, p = 0.044) as compared to the UK-wide estimates. Sub-group analysis showed that anxiety was more common amongst female doctors as compared to males (versus, p = 0.047). Although the prevalence of GAD was higher
amongst registrars compared to their Consultant and/or Senior House Officer counterparts, this was not statistically significant. Respondents felt that the most significant factor for work-related changes to mental health was keeping up to date with frequently
changing guidelines and protocols related to COVID-19. Only of respondents felt able to talk to colleagues about their mental health. |
|
|
Factors affecting antibody response to SARS-CoV-2 in patients with severe COVID-19 |
Shang, Y, Liu, et al |
Journal of medical virology |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
This study aimed to analyze the role of antibody response to outcomes of severe COVID‐19 and to find factors affecting
seroconversion. The median time from symptoms onset to antibodies detection was 41 days (ranging 21‐81 days), and IgG antibody response was 89.1% in severe COVID‐19 patients. IgG prevalence showed a downward trend after 70 days post symptoms onset. Patients
without IgG antibody had higher mortality than those with IgG antibody (P = .009). There was no statistical difference in antibody responses between ages or sex. Prevalence of IgG was 65.4% (95% CI, 44.4%‐82.1%) in cancer patients, and was 97.5% (95% CI, 96.0‐98.5%)
in non‐cancer patients (P = .001). By univariable analysis, cancer (P < .001), elevated hematocrit (HCT) (P = .029), and procalcitonin (PCT) (P = .006) were associated with IgG antibody responses. Multivariable analysis showed that cancer (P = .001) and elevated
PCT (P = .010) were independent risk factors affecting IgG response. |
|
What is the policy focus for tourism recovery after the outbreak of COVID-19?
A co-word analysis |
Shao, Y, Hu, et al |
Current Issues in Tourism |
Public Health response| Interventions de santé publique |
Policies for tourism recovery are highly instrumental in achieving tourism development after the outbreak of COVID-19.
To understand these policies, this study performed the co-word analysis to map the topics of 140 recovery policies for tourism in China. Four core themes are identified in these policies, namely (i) prophylactic measures, (ii) tourism recovery and development,
(iii) policy support, and (iv) departmental management. Moreover, the focus of policy measures varies by region within China. This study provides insights into further research on health-related crises and crisis recovery management in tourism, especially
for developing countries and regions. © 2020 Informa UK Limited, trading as Taylor & Francis Group. |
|
Computational guided drug repurposing for targeting 2′-O-ribose methyltransferase
of SARS-CoV-2 |
Sharma, K, Morla, et al |
Life Sciences |
Therapeutics| Thérapeutique |
The results suggested that these drugs may be used as potential inhibitors for 2′OMTase for combating the SARS-CoV-2
infection. The modeled structure displayed the conserved characteristic fold of class I MTase family. The quality assessment analysis by SAVES server reveals that the modeled structure follows protein folding rules and of excellent quality. The docking analysis
displayed that the active site of 2′OMTase accommodates an array of drugs, which includes alkaloids, antivirals, cardiac glycosides, anticancer, steroids, and other drugs. The redocking and MD simulation analysis of the best 5 FDA approved drugs reveals that
these drugs form a stable conformation with the 2′OMTase. |
|
Shawky, E, Nada, et al |
RSC Advances |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In this work, the potential use of medicinal plants and more than 16 500 of their constituents was investigated within
two suggested therapeutic strategies in the fight against SARS-CoV-2 including prevention of SARS-CoV-2 RNA synthesis and replication, through targeting vital proteins and enzymes as well as modulation of the host's immunity through production of virulence
factors. This study identified natural compounds targeting SARS-CoV-2 for further in vitro and in vivo studies and emphasizes the potential role of medicinal plants in the mitigation of SARS-CoV-2. |
|
|
Impact of early pandemic stage mutations on molecular dynamics of SARS-CoV-2 M(pro) |
Sheik Amamuddy, O, Verkhivker, et al |
J Chem Inf Model |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Our results showed that SARS-CoV-2 Mpro essentially behaves in a similar manner to its SAR-CoV homolog. Our entire
approach combining database preparation, variant retrieval, homology modelling, Dynamic Residue Network (DRN), relevant conformation retrieval from 1-D kernel density estimates from reaction coordinates, to other existing approaches of structural analysis
and data visualisation within the coronaviral Mpro is also novel and is applicable to other coronaviral proteins. |
|
Shih, WJ, Shen, et al |
Open Access Journal of Clinical Trials |
Clinical data| Données cliniques Therapeutics| Thérapeutique RCT |
The first clinical trial on remdesivir for treatment of severe COVID-19 conducted in China was terminated prematurely
due to limited patient enrollment, which rendered the findings inconclusive. We re-analyzed the efficacy with a statistically more powerful and clinically meaningful method based on published data using the 6-point ordinal scale of patient’s disease severity.
Eighty-two percent (82%) of the patients were in the disease severity point=3 (hospitalized, required supplemental oxygen (but not NIV/HFNC)) – the moderately severe category. The response rate was 85% for remdesivir-treated patients with baseline disease
point=3 versus 70% response rate for likewise placebo-treated patients on Day 28 (OR=2.38, P=0.0012). On Day 14, the response rate for these patients was 43% for remdesivir versus 33% for placebo (OR=1.53, P=0.0022). For patients with baseline disease point=4
(critically severe category), no similar comparisons were statistically significant. This result supports the preliminary findings of ACTT that remdesivir is effective for patients who were not critically severe. This result also suggests that remdesivir
should be given to hospitalized COVID-19 patients as soon as possible. There is no race difference in the treatment effect. |
|
|
Shorer, M, Leibovich, et al |
Early Child Development and Care |
Public Health response| Interventions de santé publique |
The present study explored young children’s emotional adjustment during the COVID19 outbreak as it relates to their
exposure to stress, and their parents’ emotion regulation and playfulness. A sample of 351 Israeli parents of children aged 2–7 years completed online questionnaires. The most frequent stress symptoms in children were nervousness, agitation, and aggression,
separation fears and clinging. Parental difficulties in emotion regulation, and the level of exposure to stressogenic situations were both significantly associated with children’s stress reactions. Parental emotion regulation fully mediated the relationship
between exposure to stress and children’s stress reactions. Parental playfulness was only inversely related to children’s stress reaction in fathers. |
|
|
Shree, P, Mishra, et al |
J Biomol Struct Dyn |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Here, an attempt was made to recognize natural phytochemicals from medicinal plants, in order to reutilize them against
COVID-19 by the virtue of molecular docking and molecular dynamics (MD) simulation study. Molecular docking study showed six probable inhibitors against SARS-CoV-2 Mpro (Main protease). Hence from present study it could be suggested that active phytochemicals
from medicinal plants could potentially inhibit Mpro of SARS-CoV-2 and further equip the management strategy against COVID-19. |
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|
Cotrimoxazole in the Domiciliary Management of Clinically Diagnosed
Severe COVID-19: A Case Series |
Siddiqui, Khawer, Das, et al |
SSRN- Lancet prepublication |
Clinical data| Données cliniques |
This case series is a retrospective analysis of clinical data of successive patients presenting to a telemedicine clinic
between May and August 2020 with severe COVID 19 and receiving domiciliary treatment with oral cotrimoxazole in addition to standard therapy. 14 patients received cotrimoxazole in addition to standard therapy. Following start of the treatment regimen, all
of the patients showed marked improvement in their clinical parameters including fever and oxygen requirements, following which all of them made complete recoveries. Only one patient required hospital admission. |
|
Sustaining education in the age of COVID-19: A survey of synchronous web-based
platforms |
Sidpra, J, Gaier, et al |
Quantitative Imaging in Medicine and Surgery |
Public Health response| Interventions de santé publique |
Authors discuss the efficacy of techniques being used for the control of communicable diseases . |
|
Potential impact of earthquakes during the 2020 COVID-19 pandemic |
Silva, V, Paul, et al |
Earthquake Spectra |
Epidemiology| Épidémiologie |
The occurrence of earthquakes coincident with the pandemic may prevent the effective practice of such measures, and
consequently cause an increase in the virus spread. This study analyzes the potential impact that seismic events may have on the infection rate within regions afflicted by both epidemics and earthquakes and explores open software packages that can be employed
to simulate the impact of future destructive earthquakes on the spread of an emerging virus. Recent data on the number of confirmed cases at the national or subnational level were combined with a global seismic hazard and risk map to produce a combined index.
This index highlights regions where preparedness and contingency plans should be developed to account for the possibility of COVID-19 outbreaks due to the earthquake impact |
|
The impact of COVID-19 control measures on air quality in China |
Silver, B, He, et al |
Environmental Research Letters |
Public health interventions*| Interventions de santé publique |
We use a 5 year dataset from China's air quality monitoring network to assess the impact of control measures on air
pollution. Over 2015-2019, there were significant negative trends in particulate matter (PM2.5, -6% yr-1) and sulphur dioxide (SO2, -12% yr-1) and nitrogen dioxide (NO2, -2.2% yr-1) whereas there were positive trends in ozone (O3, + 2.8% yr-1). We quantify
the change in air quality during the LNY holiday week, during which pollutant concentrations increase on LNY's day, followed by reduced concentrations in the rest of the week. After accounting for interannual trends and LNY we find NO2 and PM concentrations
were significantly lower during the lockdown period than would be expected, but there were no significant impacts on O3. Largest reductions occurred in NO2, with concentrations 27.0% lower on average across China, during the lockdown. Average concentrations
of PM2.5 and PM10 across China were respectively 10.5% and 21.4% lower during the lockdown period. The largest reductions were in Hubei province, where NO2 concentrations were 50.5% lower than expected during the lockdown. Concentrations of affected pollutants
returned to expected levels during April, after control measures were relaxed. |
|
Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from
Mild COVID-19 |
Silvin, A, Chapuis, et al |
Cell |
Clinical data| Données cliniques Immunology | Immunologie |
We performed high-dimensional flow cytometry and single-cell RNA sequencing of COVID-19 patient peripheral blood cells
and detected disappearance of non-classical CD14LowCD16High monocytes, accumulation of HLA-DRLow classical monocytes (Human Leukocyte Antigen - DR isotype), and release of massive amounts of calprotectin (S100A8/S100A9) in severe cases. Immature CD10LowCD101−CXCR4+/−
neutrophils with an immunosuppressive profile accumulated in the blood and lungs, suggesting emergency myelopoiesis. Finally, we show that calprotectin plasma level and a routine flow cytometry assay detecting decreased frequencies of non-classical monocytes
could discriminate patients who develop a severe form of COVID-19, suggesting a predictive value that deserves prospective evaluation. |
|
Singanayagam, A, Patel, et al |
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin |
Clinical data| Données cliniques |
Severe acute respiratory syndrome coronavirus 2 viral load in the upper respiratory tract peaks around symptom onset
and infectious virus persists for 10 days in mild-to-moderate coronavirus disease (n = 324 samples analysed). RT-PCR cycle threshold (Ct) values correlate strongly with cultivable virus. Probability of culturing virus declines to 8% in samples with Ct > 35
and to 6% 10 days after onset; it is similar in asymptomatic and symptomatic persons. Asymptomatic persons represent a source of transmissible virus. |
|
|
Preparedness among dental professionals towards COVID-19 in India |
Singh, KT, Mishra, et al |
Pan African Medical Journal |
Healthcare Response | Réponse des soins de santé |
This study was carried out for evaluating knowledge, attitude and practices (KAP) along with perceived barriers to
practice dentistry during pandemic. |
|
Singh, V, Singh, et al |
Environmental Pollution |
Public health interventions*| Interventions de santé publique |
India: Delhi's air quality has improved with a significant reduction in primary pollutants, however, an increase in
O3 was observed. The changes reported during the lockdown are combined effect of changes in the emissions, meteorology, and atmospheric chemistry that requires detailed investigations. |
|
|
Sinha, M, Pande, et al |
Journal of Public Health Research |
Public Health response| Interventions de santé publique |
An online questionnaire-based survey was conducted to assess the impact of lockdown on the sleepwake pattern, meal
timings and digital media exposure time on the Indian population during lockdown. Responses of 1511 participants (age ≥18 years) were analyzed to assess the effect of gender and age on these parameters before and during lockdown. The sleep onset-wakeup times
and meals’ time was significantly delayed during lockdown, which was more pronounced in younger subjects. However, young individuals reported increased sleep duration at this time. Increased digital media duration was evident in all age groups, mainly in males.
However, females reported more delay in sleep onset-waking time and first meal timing with longer sleep duration during lockdown. |
|
|
Sinha, P, Mostaghim, et al |
International Journal of Infectious Diseases |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
IL6ri administration prior to >45% FiO2 requirement was associated with improved COVID-19 outcomes. A total of 255
COVID-19 patients were treated with IL6ri (149 stage IIB and 106 stage III). Patients treated in stage IIB had lower mortality than those treated in stage III (adjusted hazard ratio (aHR) 0.24, 95% confidence interval (CI) 0.08–0.74). Overall, 218 (85.5%)
patients were discharged alive. Patients treated in stage IIB were more likely to be discharged (aHR 1.43, 95% CI 1.06–1.93) and were less likely to be intubated (aHR 0.43, 95% CI 0.24–0.79). |
|
|
Erythema nodosum-like rash in a COVID-19 patient: A case report |
Sipfle Do, N, Bridwell Md, et al |
American Journal of Emergency Medicine |
Clinical data| Données cliniques |
We describe a case of a female patient who presented with an Erythema Nodosum-like exanthema likely secondary to COVID-19.
The patient described tested positive for COVID-19 three days prior to presentation for the rash with minimal other symptoms of COVID-19. Given the high infectivity rate as well as multisystem presentation, it is important to continue to report on novel presentations
of the virus for early identification and treatment of complications. |
|
Siqueira, Juliana, Goes, et al |
bioRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques Coronavirology| Coronavirologie |
We have determined the full-length SARS-CoV-2 genomic sequences of cancer patients and healthcare workers (HCW; non-cancer
controls) by deep sequencing and investigated the within-host viral quasispecies of each infection, quantifying intrahost genetic diversity. Cancer patients displayed a significantly higher intrahost viral genetic diversity compared to HCW. Intrahost genetic
diversity in cancer patients was independent of SARS-CoV-2 Ct values, and was not associated with disease severity, use of corticosteroids, or use of antivirals, characteristics that could influence viral diversity. Such a feature may explain, at least in
part, the more adverse outcomes to which cancer/COVID-19 patients experience. |
|
|
Si-Yuan, W, Han-Lin, et al |
Academic Journal of Second Military Medical University |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This study aims to study the effect of predicting the development of the COVID-19 epidemic based on the dynamic SEIR
model of infectious diseases, and to provide guidance for effective response to the epidemic. Findings show that the peak of the COVID-19 epidemic in Hubei Province predicted by the model was on February 21, 2020. The current number of confirmed cases is about
50,000 (February 19), and the epidemic is expected to fall to less than 30,000 on March 4, and will end around May 10. According to actual data released by the National Health Commission of the People's Republic of China, the peak number of confirmed cases
is 53,371. The peak of the epidemic in South Korea predicted by the model will be on March 7 and will end at the end of April. |
|
|
Skulmowski, A, Rey, et al |
Human Behavior and Emerging Technologies |
Public Health response| Interventions de santé publique |
In this article, authors present the case study of Chemnitz University of Technology (Germany), where digital classes
were introduced in a matter of weeks. |
|
|
Šljivo, A, Kačamaković, et al |
Psychiatria Danubina |
Public Health response| Interventions de santé publique |
The aim of this study was to examine levels of fear and depressive symptoms in association with COVID-19 outbreak and
to assess other contributing factors in the population of Bosnia and Herzegovina.
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|
|
Telehealth uptake in general practice as a result of the coronavirus (COVID-19) pandemic |
Snoswell, CL, Caffery, et al |
Aust Health Rev |
Healthcare Response | Réponse des soins de santé |
In March 2020, the Australian Government added new temporary telehealth services to the Medicare Benefits Schedule
(MBS) to reduce the risk of patient-patient and patient-clinician transmission of the 2019 coronavirus (COVID-19). Here, the MBS statistics for general practitioner activity and the associated costs are described; a small increase in both activity and costs
for the new MBS telehealth items were observed. The opportunities for future research and policy implications are also discussed. |
|
Soltani, Kamran, Rezazadeh, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
We have established a novel mathematical model that considers various aspects of the spreading of the virus. The efficiency
of the proposed model has been shown for Iran and Italy. The model has shown that the reopening plans and governmental measures directly affect the number of active cases of the disease. Control strategies including strict implementation of mitigation (reducing
the transmission rates) and re-quarantine of some portion of population have been investigated and their efficiency has been shown. |
|
|
SARS CoV 2 infection in chronic myelogenous leukemia: Severe hematological presentation |
Sorà, F, Chiusolo, et al |
Transfusion and Apheresis Science |
Clinical data| Données cliniques |
This case highlights the novel and multifaceted hematological findings during sever COVID 19 infection. COVID 19-related
pneumonia is mediated by hyper activation of effector T cells and excessive production of inflammatory cytokines, such as IL-6, IL-1, interferon-gamma, and TNF. This inflammatory process called "cytokine storm" is a life-threatening complication of COVID 19
infection. In this case severe immunohematological consequences are reported for the first time and recognition of this complications are probably underestimated. |
|
Souza, Anacleto Silva de, Rivera, et al |
bioRxiv |
Coronavirology| Coronavirologie |
As initial steps leading to virus entry involves significant changes in protein conformation as well as in the electrostatic
environment in the vicinity of the spike-hACE-2 complex, we explored the sensitivity of the interaction to changes in ionic strength through computational simulations and surface plasmon resonance. We identified two regions in the receptor-binding domain (RBD),
E1 and E2, which interact differently with hACE-2. At high salt concentration, E2-mediated interactions are weakened but are compensated by strengthening E1-mediated hydrophobic interactions. |
|
|
Low risk of serological cross-reactivity between dengue and COVID-19 |
Spinicci, M, Bartoloni, et al |
Memorias do Instituto Oswaldo Cruz |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
In the near future, the overlap of Coronavirus disease 2019 (COVID-19) and dengue epidemics is a concrete threat in
tropical regions. Co-epidemics of COVID-19 and dengue could be an overwhelming challenge for health systems in low- and middle-income countries. In this work, we investigated potential serological cross-reactions between COVID-19 and dengue patients. Among
32 COVID-19 positive sera, no positive Dengue virus (DENV) IgG/IgM results were observed. On the other hand, one false-positive result was observed among 44 DENV-positive sera tested for COVID-19 antibodies with each of the two rapid tests used. Further data
on accuracy of COVID-19 diagnostic test are urgently warranted. |
|
Stangvaltaite-Mouhat, L, Uhlen, et al |
International Journal of Environmental Research and Public Health |
Healthcare Response | Réponse des soins de santé |
Authors aimed to investigate the management of urgent dental care, the perception of risk and workplace preparedness
among dental staff in Norway during the COVID-19 pandemic. Urgent dental health care was managed relatively well in Norway. |
|
|
Steuwe, A, Rademacher, et al |
Journal of Radiological Protection |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
The purpose of this study was to evaluate protocol settings, associated radiation exposure, image quality and diagnostic
performance of a low-dose CT protocol in a university hospital setting. The mean effective dose was 1.3 ± 0.4 mSv (0.7-2.9 mSv) for the patient cohort (mean age 66.6 ± 16.7 years (19-94 years), mean body mass index (BMI) 26.6 ± 5.3 kg m-2 (16-46 kg/m2)). A
sensitivity of 100 [95% CI: 82-100]%, a specificity of 78 [95% CI: 68-86]%, a positive predictive value of 50 [95% CI: 33-67]% and a negative predictive value of 100 [95% CI: 95-100]% were obtained. No COVID-19 diagnoses were missed by CT. Image noise did
not strongly correlate with BMI or patient diameter and was rated as average. |
|
|
Strang, P, Bergström, et al |
Journal of pain and symptom management |
Public Health response| Interventions de santé publique |
The aim was to study whether end of life (EOL) discussions were offered and to what degree patients were alone at time
of death when dying from coronavirus disease 2019 (COVID-19), comparing deaths in nursing homes and hospitals. Findings show that fewer EOL discussions with patients were held compared with deaths in 2019 (74% vs. 79%, P < 0.001), and dying with someone present
was much more uncommon (59% vs. 83%, P < 0.0001). In comparisons between nursing homes and hospital deaths, more patients dying in nursing homes were women (56% vs. 37%, P < 0.0001), and significantly fewer had a retained ability to express their will during
the last week of life (54% vs. 89%, P < 0.0001). Relatives were present at time of death in only 13% and 24% of the cases in nursing homes and hospitals, respectively (P < 0.001). The corresponding figures for staff were 52% and 38% (P < 0.0001). Dying from
COVID-19 negatively affects the possibility of holding an EOL discussion and the chances of dying with someone present. This has considerable social and existential consequences for both patients and families. |
|
|
Su, L, Tu, et al |
Biomedicine and Pharmacotherapy |
Therapeutics| Thérapeutique |
Collectively, we proposed that entecavir and imipenem might be candidates for the treatment of CSS. Entecavir and imipenem
efficiently suppressed the release of inflammatory cytokines by partly intervention of NF-κB activity. The acute lung injury was also alleviated and the survival time was prolonged in mice. In addition, entecavir and imipenem inhibited the release of TNF-α
and IL-10 in human peripheral blood mononuclear cells (hPBMCs). |
|
|
Su, Z, Min, et al |
Academic Journal of Second Military Medical University |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Objective To sum up the clinical characteristics and chest computed tomography (CT) findings of severe and critical
coronavirus disease 2019 (COVID-19) patients, and to explore the factors affecting the outcomes, so as to provide experience for the clinical diagnosis and treatment of severe and critical COVID-19. The data of 25 severe and critical COVID-19 patients, who
were treated in our hospital from Jan. 23, 2020 to Mar. 5, 2020, were collected. Twenty-two patients had a clear epidemiological history. Fever (22 cases) and cough (14 cases) were the most common first symptoms, and 18 patients had underlying diseases. Twelve
patients were cured and discharged (median hospital stay was 25.5 d), and 13 patients were not cured, including three deaths and 10 cases with hospital stay>25 d with no remission. Multivariate logistic regression analysis showed that high CD4+T lymphocyte
count was an independent protective factor for the cure and discharge of severe and critical COVID-19 patients (P=0.031). Twenty-one patients received chest CT examination in the progressive stage; and all of them had multiple ground-glass opacities and consolidation
shadows of the multiple-lobe lateral band and the dorsal side of bilateral lungs, 20 cases had pleural thickening, 9 cases had a small amount of bilateral pleural effusion, and 8 cases had mediastinal lymphadenopathy. |
|
|
Prediction of covid-19 outbreak in India by employing epidemiological models |
Sudheer Reddy, K, Anji Reddy, et al |
Journal of Computer Science |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
The objective is to study the impact of lockdown and to compare its effects from an epidemiological standpoint. Authors
employed Exponential and SIR (Susceptible, Infected and Removed) epidemiological models for study and analysis. The study reveals that India will enter equilibrium by the end of June with a prediction of 135,000 cases approximately. |
|
Sun, Z, Yang, et al |
International Journal of Environmental Research and Public Health |
Public Health response| Interventions de santé publique |
In this study, to understand the influencing factors of COVID-19-related risks and coping behaviors of elderly individuals
with respect to COVID-19 and to provide a basis for taking corresponding protective measures, a questionnaire survey was applied to an elderly population.
|
|
|
SARS-CoV-2 Nucleocapsid protein is decorated with multiple
N- and O-glycans |
Supekar, NitinT, Shajahan, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Recent studies have indicated that the N protein can serve as an important diagnostic marker for coronavirus disease
and a major immunogen by priming protective immune responses. Our comprehensive glycomics and glycoproteomics experiments confirm that the N protein is highly O glycosylated and also contains significant levels of N glycosylation. We were able to confirm the
presence of O glycans on seven sites with substantial glycan occupancy, in addition to less abundant O glycans on four sites. We also detected N glycans on two out of five potential N glycosylation sites. Moreover, we were able to confirm one phosphorylation
site. |
|
Sussmann, R, Rettinger, et al |
Remote Sensing |
Epidemiology| Épidémiologie |
Authors present a mathematical framework to derive annual growth rates from observed column-averaged carbon dioxide
(XCO2) including uncertainties. |
|
|
Pulmonary Function in Early Follow-up of patients with COVID-19 Pneumonia |
Tabernero Huguet, E, Urrutia Gajarte, et al |
Archivos de Bronconeumologia |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
With the aim of knowing the functional repercussion of COVID-19 pneumonia in patients who did not require invasive
mechanical ventilation or ICU, we organized a follow-up at 4-6 weeks after hospital discharge of all patients with SARS-CoV- 2 diagnosed by polymerase chain reaction (PCR) admitted to our department with confirmed pneumonia in plain radiology. In conclusion,
our data suggest that in patients with COVID-19 pneumonia who do not require invasive mechanical ventilation, functional sequelae after one month are not frequent, and in any case they are mild. Moderate functional impairment in this population has been exceptional
and has been related to the severity of pneumonia. |
|
Tamai, M, Maekawa, et al |
Journal of Dermatology |
Clinical data| Données cliniques |
The authors encountered three patients with COVID‐19 who presented with erythema and suspected viral rash. In all cases,
erythema appeared after the onset of the initial symptoms of COVID‐19. Erythema was considered to be caused by COVID‐19 and not a drug‐induced eruption because, in all cases, erythema was relieved merely by external medicine and oral antihistamines, without
discontinuing the original medication. |
|
|
Tansey, RJ, Patel, et al |
Surgeon |
Healthcare Response | Réponse des soins de santé |
Through a trainee research collaborative, we have studied the changes in practice of 12 T&O departments across the
East of England over the first four weeks of the UK lockdown and COVID-19 pandemic, comparing to activity levels with the corresponding period in 2019. We focused on changes in T&O practice, training and redeployment of Trainees. Units differ considerably
in several aspects of practice. We found a 97% reduction in elective operating, 64% reduction in elective outpatient activity and 37% reduction in operative trauma. 58% of trainees continued working in T&O clinics, with an average of 6 operative cases over
this period. Our modelling suggests that the impact on training will persist; counter-measures must be incorporated into central recovery planning. © 2020 |
|
|
Tao, PY, Leng, et al |
International Journal of Medical Sciences |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The purpose of this study is to investigate the risk factors of symptoms onset and clinical features in asymptomatic
COVID-19 infected patients. A retrospective study was performed in 70 asymptomatic COVID-2019 infected patients confirmed by nucleic acid tests in Hunan province, China between 28 January 2020 and 18 February, 2020. The study included 36 males and 34 females
with a mean age of 33.24±20.40 years (range, 0.5-84 years). There were 22 asymptomatic carriers developed symptoms during hospitalization isolated observation, and diagnosed as confirmed cases, while 48 cases remained asymptomatic throughout the course of
disease. Of 70 asymptomatic patients, 14 (14/70, 20%) had underlying diseases, 3 (3/70, 4.3%) had drinking history, and 11 (11/70, 15.7%) had smoking history. 22 patients developed symptoms onset of fever (4/22, 18.2%), cough (13/22, 59.1%), chest discomfort
(2/22, 9.1%), fatigue (1/22, 4.5%), pharyngalgia (1/22, 4.5%) during hospitalization; only one (1/22, 4.5%) patient developed signs of both cough and pharyngalgia. Abnormalities on chest CT were detected among 35 of the 69 patients (50.7%) after admission,
except for one pregnant woman had not been examined. 4 (4/70, 5.7%) and 8 (8/70, 11.4%) cases showed leucopenia and lymphopenia. With the effective antiviral treatment, all the 70 asymptomatic infections had been discharged, none cases developed severe pneumonia,
admission to intensive care unit, or died. The mean time from nucleic acid positive to negative was 13.2±6.84 days. Cox regression analysis showed that smoking history (P=0.028, hazard ratio=4.49, 95% CI 1.18-17.08) and existence of pulmonary disease (P=0.038,
hazard ratio=7.09, 95% CI 1.12-44.90) were risk factors of the onset of symptoms in asymptomatic carries. |
|
|
Tariq, R, Hamid, et al |
Journal of Oral Research |
Healthcare Response | Réponse des soins de santé |
This study aimed to find out the level of misconceptions among healthcare professionals (HCPs) worldwide about the
ensuing COVID-19 pandemic. A total of 652 participants from 35 different countries across the world responded to the global online survey. Among all HCPs, general physicians (61.2%) were the most common respondents. The responses from females (63.3%) almost
doubled those of men, and nearly half of the participants were working in private institutes (49.2%). Additionally, the major source of information used by HCPs about COVID-19 was social media (55.4%). Regarding misconception assessment, 71.6% of participants
had correct concepts regarding COVID-19. However, 28.4% had incorrect information. Female HCPs were 1.49 times more likely to have correct concepts compared to males (OR=1.49, 95% CI=1.04-2.14). |
|
|
Melkersson-Rosenthal syndrome induced by COVID-19: A case report |
Taşlıdere, B, Mehmetaj, et al |
American Journal of Emergency Medicine |
Clinical data| Données cliniques |
We present a case of a female patient presenting with edema. Her examination revealed edema in the right lower lip,
right facial paralysis, and fissured tongue. COVID-19 may be associated with which was not previously included in the etiology of the disease. Melkersson–Rosenthal syndrome is a rare condition characterized by a triad of orofacial edema, facial paralysis,
and fissured tongue. Histopathological examination of the disease has demonstrated areas of inflammation involving mast cells. Activated mast cells also play a part in the pathogenesis of COVID-19 infection, as they release cytokines in the lungs. |
|
Epidemiologic and clinical features of patients with COVID-19 in Brazil |
Teich, VD, Klajner, et al |
Einstein (Sao Paulo, Brazil) |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this retrospective, single-center study, we included all laboratory confirmed COVID-19 cases at Hospital Israelita
Albert Einstein , São Paulo, Brazil, from February until March 2020. Demographic, clinical, laboratory and radiological data were analyzed. A history of a close contact with a positive/suspected case was reported by 61.1% of patients and 34.4% had a history
of recent international travel. The most common symptoms upon presentation were fever (67.5%), nasal congestion (42.4%), cough (41.6%) and myalgia/arthralgia (36.3%). Chest computed tomography was performed in 78 (15.3%) patients, and 93.6% of those showed
abnormal results. Hospitalization was required for 72 (14%) patients and 20 (27.8%) were admitted to the Intensive Care Unit. Regarding clinical treatment, the most often used medicines were intravenous antibiotics (84.7%), chloroquine (45.8%) and oseltamivir
(31.9%). Invasive mechanical ventilation was required by 65% of Intensive Care Unit patients. The mean length of stay was 9 days for all patients (22 and 7 days for patients requiring or not intensive care, respectively). Only one patient (1.38%) died during
follow-up. |
|
Thomas, P |
Nanotechnology Perceptions |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
An epidemic model has been developed to explore the range of possible actions open to the UK and other nations to combat
the virus. The challenge for the UK Government (and other governments around the world) will be to manage its interventions so that the recession that is now inevitable is not significantly worse than that following the 2007–9 financial crash. |
|
|
Management of sleep apnea in New York City during the COVID-19 pandemic |
Thorpy, M, Figuera-Losada, et al |
Sleep medicine |
Healthcare Response | Réponse des soins de santé |
Sleep center changes: A telephone questionnaire survey of 112 OSA patients determined the occurrence of COVID-19 in
the sleep apnea population and the patients' perspective on sleep apnea Positive Airway Pressure (PAP) management during the COVID-19 outbreak. The three main objectives of the survey were as follows: (1) To discover how patients were coping with COVID-19
pandemic in terms of their sleep apnea and PAP use, (2) To determine whether PAP usage changed after the onset of the outbreak in terms of adherence, and (3) To find out if patients were concerned about whether they were at greater risk of contracting COVID-19
because of their sleep apnea and, if they became infected, whether COVID-19 might result in greater complications because of the presence of sleep apnea. |
|
Tirolien, JA, Garnier, et al |
Praticien en Anesthesie Reanimation |
Clinical data| Données cliniques |
Hypoxaemia is the key symptom of the disease but other features are different such as pulmonary compliance that is
most of the time initially normal. The mechanisms of the pulmonary damage are not completely understood. A new ventilation strategy has been set up to prevent ventilator induced lung injury (VILI). |
|
|
Correlation of ambient temperature and COVID-19 incidence in Canada |
To, T, Zhang, et al |
Science of the Total Environment |
Epidemiology| Épidémiologie |
Canada: We sought to determine the relationship between ambient temperature and COVID-19 incidence in Canada. We
analyzed over 77,700 COVID-19 cases from four Canadian provinces (Alberta, British Columbia, Ontario, and Quebec) from January to May 2020. After adjusting for precipitation, wind gust speed, and province in multiple linear regression models, we found a positive,
but not statistically significant, association between cumulative incidence and ambient temperature (14.2 per 100,000 people; 95% CI: −0.60–29.0). We also did not find a statistically significant association between total cases or effective reproductive number
of COVID-19 and ambient temperature. Our findings do not support the hypothesis that higher temperatures will reduce transmission of COVID-19 and warns the public not to lose vigilance and to continue practicing safety measures such as hand washing, social
distancing, and use of facial masks despite the warming climates. |
|
Setting the criteria for SARS-CoV-2 reinfection – six possible cases |
Tomassini, S, Kotecha, et al |
Journal of Infection |
Clinical data| Données cliniques |
We present 6 cases of hospitalised patients or staff with likely SARS-CoV-2 reinfection based on objective laboratory-based
criteria and rationales. All 6 cases had at least one SARS-CoV2 IgG antibody test. Our small case series here indicates that symptomatic and asymptomatic SARS-CoV-2 reinfection can occur in the presence of SARS-CoV-2 IgG antibodies. |
|
The psychological impact of the COVID-19 pandemic on medical students in Turkey |
Torun, F, Torun, et al |
Pakistan Journal of Medical Sciences |
Public Health response| Interventions de santé publique |
We aimed to investigate the knowledge of medical students (Istanbul, Turkey) about COVID-19, the effects of the traumatic
situation they experienced, the stress they perceived and the factors affecting them. In addition, we aimed to learn the thoughts of the students about the virus due to the uncertainties. The presence of chronic disease in the participants was found to be
a factor that increased anxiety (p = 0.01). Majority of participants (60.40%) stated that they agree with COVID-19 is a biological weapon. The mean scores of women ‘s total PSS and IES-R were higher than men. It was found that the families of the students
had a lower monthly income than the minimum monthly wage is increasing the anxiety about getting COVID-19 infection and perceived stress. One-third of the students reported that sleep and appetite were impaired than the before pandemic. The announcements and
website of Ministry of Health and the social media was the main source of information of the participants. |
|
Touati, J, Rico, et al |
Journal of Hospital Infection |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Healthcare
Response | Réponse des soins de santé |
Pre-op Screening: The aim of this study was to assess the use of APMs (the study hospital implemented pre-operative
screening as part of the active preventive measures (APMs) during the peak of the epidemic.) to diminish nosocomial transmission rates. The study hospital employs 3142 healthcare workers and has 862 beds. During the outbreak in the Provence region of France
(from 17th March to 19th April 2020), Pre-operative ld-CT was part of the APMs and led to a 7.5% change in the way that patients were handled. Unfortunately, it is not possible to estimate the weight of each individual APM |
|
|
Trifirò, G, Massari, et al |
Drug Saf |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
The aim of this large-scale, retrospective cohort study was to investigate whether prior exposure to ACEIs and/or ARBs
was associated with all-cause mortality among over 40,000 hospitalised COVID-19 patients compared with calcium channel blockers (CCBs), a potential therapeutic alternative. ACEI/ARB use is not associated with either an increased or decreased risk of all-cause
mortality, compared with CCB use, in the largest cohort of hospitalised COVID-19 patients exposed to these drugs studied to date. |
|
|
Tull, MT, Barbano, et al |
Journal of anxiety disorders |
Public Health response| Interventions de santé publique |
Results speak to the relevance of different risk factors for health anxiety during the COVID-19 pandemic and highlight
targets for reducing health anxiety risk. A U.S. community sample of 364 participants completed online self-report measures at a baseline assessment (Time 1) and one month later (Time 2). Time 1 intolerance of uncertainty was uniquely associated with the
Time 2 health anxiety dimension of body vigilance. |
|
|
Tung, HYL, Limtung, et al |
Biochemical and biophysical research communications |
Coronavirology| Coronavirologie |
Mutations in the phosphorylation sites of SARS-CoV-2 encoded nucleocapsid protein isolated from various populations
and locations, are described. Mutations occurred in the phosphorylation sites, all located within a stretch which forms a phosphorylation dependent interaction site, including C-TAK1 phosphorylation sites for 14-3-3. The consequences of these mutations are
discussed and a structure-based model for the role of protein 14-3-3 in the sequestration and inhibition of SARS-CoV-2 nucleocapsid protein’s function is presented. It is proposed that the phosphorylation of SARS-CoV-2 nucleocapsid protein and its sequestration
by Protein 14-3-3 is a cellular response mechanism for the control and inhibition of the replication, transcription and packaging of the SARS-CoV-2 genome. |
|
|
Turgut, A, Arlı, et al |
Acta Orthopaedica et Traumatologica Turcica |
Healthcare Response | Réponse des soins de santé |
The purpose of this study was to evaluate the types and the frequency of fractures, both in the pediatric and adult
population during the COVID-19 pandemic and to find out the differences in comparison to the non-pandemic period. We observed that the frequency of fractures decreased by approximately one-third during the pandemic period compared with that in the non-pandemic
period. |
|
|
Laser irradiated phenothiazines: New potential treatment for COVID-19 explored
by molecular docking |
Udrea, AM, Avram, et al |
Journal of Photochemistry and Photobiology B: Biology |
Therapeutics| Thérapeutique |
In this study we predict, using molecular docking, the binding affinity of 15 phenothiazines (antihistaminic and antipsychotic
drugs) when interacting with the main protease (Mpro) of SARS-CoV-2. Additionally, we tested the binding affinity of photoproducts identified after irradiation of phenothiazines with Nd:YAG laser beam at 266 nm respectively 355 nm. Our results reveal that
thioridazine and its identified photoproducts (mesoridazine and sulforidazine) have high biological activity on the virus Mpro. This shows that thioridazine and its two photoproducts might represent new potent medicines to be used for treatment in this outbreak.
Such results recommend these medicines for further tests on cell cultures infected with SARS-CoV-2 or animal model. The transition to human subjects of the suggested treatment will be smooth due to the fact that the drugs are already available on the market |
|
Usman, AA, Han, et al |
Journal of cardiothoracic and vascular anesthesia |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
This report was created to describe the authors’ single institutional experience, with emphasis on the high rate of
intracranial hemorrhage for the first 10 patients with COVID-19 placed on venovenous extracorporeal membrane oxygenation (VV ECMO). Four of 10 patients had hemorrhagic strokes, 3 of which resulted in death. At 30 days after initiation of VV ECMO, a total of
7 survivors included 6 patients discharged from the hospital and 1 patient who remained in the intensive care unit. The authors urge caution in the anticoagulation management of VV ECMO for patients with severe ARDS and COVID-19 patients. Close monitoring
of all hematologic parameters is recommended during ECMO support while awaiting larger, multicenter studies to examine the best practice. |
|
|
Self-isolation or borders closing: What prevents the spread of the epidemic better? |
Valba, O, Avetisov, et al |
Physical review.E |
Public health interventions*| Interventions de santé publique |
Pandemic propagation of COVID-19 motivated us to discuss the impact of the human network clustering on epidemic spreading.
Today, there are two clustering mechanisms which prevent of uncontrolled disease propagation in a connected network: an "internal" clustering, which mimics self-isolation (SI) in local naturally arranged communities, and an "external" clustering, which looks
like a sharp frontiers closing (FC) between cities and countries, and which does not care about the natural connections of network agents. SI networks are "evolutionarily grown" under the condition of maximization of small cliques in the entire network, while
FC networks are instantly created. Running the standard SIR model on clustered SI and FC networks, we demonstrate that the evolutionary grown clustered network prevents the spread of an epidemic better than the instantly clustered network with similar parameters.
We find that SI networks have the scale-free property for the degree distribution P(k)∼k^{η},
with a small critical exponent -2<η<-1. We argue that the scale-free behavior emerges as a result of the randomness in the initial degree distributions. |
|
Valga, F, Vega-Díaz, et al |
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia |
Clinical data| Données cliniques |
In this letter to the editor, authors present the case of a 68-year-old man with a history of high blood pressure,
type 2 diabetes mellitus, congestive heart failure, sleep apnea-hypopnea syndrome, ischemic heart disease and chronic kidney disease G3a A3 according to KDIGO 2012 of probable diabetic etiology with baseline serum creatinine figures of 1.3-1,5 mg/dl. |
|
|
Outcomes Associated With Use of a Kinin B2 Receptor Antagonist
Among Patients With COVID-19 |
van de Veerdonk, FL, Kouijzer, et al |
JAMA network open |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
Authors investigated whether treatment with the bradykinin 2 receptor antagonist icatibant in patients with COVID-19
could be used as a treatment strategy. |
|
Vanaerschot, Manu, Mann, et al |
bioRxiv |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie Diagnostics / Pathogen
detection| Diagnostics / Détection d'agents pathogènes |
We identify a mutation in the N gene of SARS-CoV-2 that adversely affects annealing of a commonly used RT-PCR primer;
epidemiologic evidence suggests the virus retains pathogenicity and competence for spread. This reinforces the importance of using multiple targets for robust SARS-CoV-2 detection. |
|
|
Varela, K, Scott, et al |
MMWR Morb Mortal Wkly Rep |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
Kentucky’s indicator monitoring report (IMR) is a useful tool that combines multiple data elements to generate a daily
COVID-19 status score that allows systematic assessment of the state’s mitigation, response, and reopening efforts. The Kentucky Department for Public Health analyzes publicly available data sources and compiles the IMR using standardized methods. |
|
|
Vepa, A, Saleem, et al |
British Journal of Medical Practitioners |
Clinical data| Données cliniques |
Authors describe a rare case of COVID-19 presenting with acute psychosis which was also complicated by a false negative
RT-PCR nasopharyngeal swab upon hospital admission. False negative rate with RT-PCR COVID-19 nasopharyngeal swabs is high and this identifies a crucial diagnostic role for CT Thorax in swab-negative, symptomatic patients with suspected COVID-19. |
|
|
Vilela-Estrada, M, Benites-Flores, et al |
Medwave |
Clinical data| Données cliniques |
The objective of this study was to characterize the clinical manifestations and course of the first cases of contagion
by SARS-CoV-2 in doctors of Peru. Despite a small number of cases, this is the first report detailing the evolution of symptoms day by day, which can help for occupational health and even for case surveillance and monitoring. |
|
|
Volpato, Fabiana, Lima-Morales, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This study has aimed to evaluate the use pool of samples as a strategy to optimize the diagnostic of SARS-CoV-2 by
RT-qPCR in a general population. A total of 220 naso/orofaryngeal swab samples were collected and tested using two different protocols of sample pooling. In the first protocol (Protocol A); 10 clinical samples were pooled before RNA extraction. The second
protocol (Protocol B) consisted of pooling the already extracted RNAs from 10 individual samples. Results from Protocol A were identical (100% agreement) with the individual results. However, for results from Protocol B, reduced agreement (91%) was observed
in relation to results obtained by individual testing. |
|
|
Immune Modulation to Improve Survival of Viral Pneumonia in Mice |
Wali, S, Flores, et al |
Am J Respir Cell Mol Biol |
Therapeutics| Thérapeutique Immunology | Immunologie Animal model | Modèle animal |
We aim to validate strategies for immune modulation in a preclinical model of viral pneumonia and determine their mechanisms.
Mice were challenged with the Sendai paramyxovirus in the presence or absence of Pam2-ODN treatment. Virus burden and host immune responses were assessed. The data reveal opportunities for targeted immunomodulation to protect susceptible human subjects. |
|
Impacts on the U.S. macroeconomy of mandatory business closures in response
to the COVID-19 Pandemic |
Walmsley, TL, Rose, et al |
Applied Economics Letters |
Economics | Économie |
We estimate the macroeconomic impacts of mandatory business closures in the U.S. and many other countries in order
to control the spread of the COVID-19. For the three-month scenario, we estimate a 20.3% decline of U.S. GDP on an annual basis, or $4.3 trillion. The employment decline of 22.4% in the U.S. for the three-month closure represents 35.2 million workers for
that period. If the mandatory closures are extended to six months because of a second wave, these negative impacts would slightly more than double. |
|
Wang, Luyun, Chen, et al |
Research Square prepub |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this study was to provide insights into the mortality, intensive care unit (ICU) management, risk factors
for mortality, 180-day short term prognosis of the COVID-19 related severe ARDS patients receiving ECMO treatment. The all-cause 180-day mortality was 56.3% (9/16) in ECMO group and 33 (89.2%, 33/37) in non-ECMO group. Up to 180-day follow up after disease
onset, the ECMO-treated survivors maintained good quality of life without severe complications or disabilities. Hypercapnia, thrombopenia, myocardial injury and elevation of IL-8 and IL-10 during ECMO treatment were strongly associated with death. |
|
|
COVID-19 Sensing: Negative Sentiment Analysis on Social Media in China via BERT
Model |
Wang, T, Lu, et al |
IEEE Access |
Public Health response| Interventions de santé publique |
we observed that people concern four aspects regarding COVID-19, the virus Origin (Gamey Food, 3.08%; Bat, 2.70%; Conspiracy
Theory, 1.43%), Symptom (Fever, 2.13%; Cough, 1.19%), Production Activity (Go to Work, 1.94%; Resume Work, 1.12%; School New Semester Beginning, 1.06%) and Public Health Control (Temperature Taking, 1.39%; Coronavirus Cover-up, 1.26%; City Shutdown, 1.09%).
Results from Weibo posts provide constructive instructions on public health responses, that transparent information sharing and scientific guidance might help alleviate public concerns |
|
Wang, Xia, Yin, et al |
SSRN- Lancet prepublication |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Transmission
Public health interventions*| Interventions de santé publique |
In this work, global COVID-19 data were used to examine the dynamical variations from the perspectives of immunity
and contact over five climate regions: tropical, arid, temperate, cold, and polar. Our modelling results suggest that the COVID-19 pandemic will persist over a long period of time or enter into regular circulation in multiple periods of 1-2 years. Reducing
contact rates based on non-pharmaceutical interventions is an effective method to reduce COVID-19 transmission together with growing herd immunity. Moreover, it is found that the temperate and cold climate regions have higher infection rates than the tropical
and arid climate regions, which indicates that climate may modulate the transmission of COVID-19. |
|
|
Wańkowicz, P, Szylińska, et al |
International Journal of Environmental Research and Public Health |
Healthcare Response | Réponse des soins de santé |
The aim of this study was to assess the mental health factors among healthcare workers by quantifying the severity
of anxiety, depression, and sleep disorders during the current SARS-CoV-2 pandemic, while taking into account coexisting diseases.
|
|
|
Multi-species ELISA for the detection of antibodies
against SARS-CoV-2 in animals |
Wernike, Kerstin, Aebischer, et al |
bioRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Here, we developed an indirect multi-species ELISA based on the receptor-binding domain (RBD) of SARS-CoV 2. The newly
established ELISA was validated using 59 sera of infected or vaccinated animals including ferrets, raccoon dogs, hamsters, rabbits, chickens, cattle and a cat, and a total of 220 antibody-negative sera of the same animal species. Overall, a diagnostic specificity
of 100.0% and sensitivity of 98.31% was achieved, and the functionality with every species included in this study could be demonstrated. |
|
Wolff, F, Dahma, et al |
Diagnostic microbiology and infectious disease |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Immunology
| Immunologie |
The Elecsys and the VIDAS methods with a combination of IgG/IgM measurement demonstrated a high sensitivity with no
false positive. The antibody response against SARS-CoV-2 was examined in 111 patients with a positive qRT-PCR. Seroconversion was assessed using the Elecsys from Roche, the Liaison S1/S2 IgG from Diasorin, the IgG and IgA from Euroimmun, as well as the VIDAS
IgG and IgM. Specificity was estimated based on the measurement of SARS-CoV-2 antibodies in 96 residual samples collected during a non-pandemic period. Results: The highest overall sensitivity for detecting seroconversion was obtained using the Elecsys (81.1%),
the Euroimmun with a combined detection of IgG/IgA (86.5%), and the VIDAS with a simultaneous measurement of IgG/IgM (78.4%).The Elecsys and the VIDAS IgG/IgM demonstrated a specificity as well as a positive predictive value of 100%. |
|
|
Abrupt Subsidence of Seasonal Influenza after Coronavirus Disease Outbreak, Hong Kong,
China |
Wong, NS, Leung, et al |
Emerg Infect Dis |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
The onset of the 2019-20 winter influenza season in Hong Kong coincided with the emergence of the coronavirus disease
epidemic in neighboring mainland China. After widespread adoption of large-scale social distancing interventions in response to the impending coronavirus disease outbreak, the influenza season ended abruptly with a decrease to a low trough. |
|
Wong, RCW, Wong, et al |
Journal of Clinical Virology |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Xpert Xpress SARS-CoV-2 assay has satisfactory performance when compared with reference method. The positive percent
agreement (PPA) of DTS and LRT specimens were 98.86 % & 100 % respectively while the negative percent agreement (NPA) was 100 % for both DTS and LRT specimens. Conclusions: This study demonstrated with appropriate sample pre-treatment, Xpert Xpress SARS-CoV-2
assay can be used to test on non-validated specimen types including DTS & LRT specimens. (Specimen types such as deep throat saliva (DTS), also known as posterior oropharyngeal saliva and lower-respiratory tract specimens (LRT) including sputum, tracheal
aspirate and bronchoalveolar lavage.) |
|
|
Wu, R, Guan, et al |
Quantitative Imaging in Medicine and Surgery |
Clinical data| Données cliniques |
The objective of this study was to investigate the distribution of CT features and also to introduce a novel described
CT feature of coronavirus disease-19 (COVID-19) pneumonia. |
|
|
Xi, L, Yu, et al |
Medical Journal of Chinese People's Liberation Army |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective of this study was to provide a basis for further optimizing the diagnosis and treatment strategies of
severe and critical corona virus disease 2019 (COVID-19) by investigating and analyzing the epidemiological and clinical characteristics of the death cases. |
|
|
Clinical features and imaging findings in six coronavirus disease 2019 patients |
Xia-Hui, G, Jing, et al |
Academic Journal of Second Military Medical University |
Clinical data| Données cliniques |
This study summarizes the clinical characteristics and imaging findings of 6 patients with novel coronavirus pneumonia,
so as to provide evidence for the early diagnosis and clinical intervention of COVID-19. 6 patients had a clear history of travel or residence in Wuhan, 4 patients had fever, 3 had cough, 2 had upper respiratory tract symptoms such as runny nose and sore
throat, and 2 had systemic symptoms such as headache and muscle aches. The chest CT examinations of 6 patients showed abnormal lung manifestations. The lesions were all bilaterally distributed. There were more lesions in the lower lung than the upper lung.
The main manifestations were multiple ground glass shadows, consolidation shadows, and "paving stone" signs in the bilateral lung fields. And different degrees of fibrosis. Chest CT examination was performed later after the onset of the disease, showing lung
consolidation and obvious fibrosis. COVID-19 imaging has certain characteristic manifestations, combined with the patient's epidemiological history, clinical manifestations and SARS-CoV-2 nucleic acid detection can make early diagnosis. |
|
Xiao, M, Tian, et al |
Pharmacological Research |
Clinical data| Données cliniques Therapeutics| Thérapeutique RCT |
This randomized controlled clinical trial evaluated the clinical efficacy and prognosis of Huoxiang Zhengqi dropping
pills and Lianhua Qingwen granules in patients with COVID-19. After 14 days of treatment, there was no significant difference in the improvement rate of clinical symptoms among the three groups (P > 0.05). Huoxiang Zhengqi dropping pills combined with Lianhua
Qingwen granules has advantages in the treatment of nausea, vomiting and limb soreness. During treatment, all participants were treated with western medicine, and there was a significant difference in the use of macrolides among the three groups (P 0.05).
However, the proportion of patients who progressed to severe disease in the Huoxiang + Lianhua group was the lowest, suggesting that the combination of TCM with western medicine has a potential advantage in improving the prognosis of patients with COVID-19. |
|
|
Clinical characteristics of diarrhea in 90 cases with COVID-19: A descriptive study |
Xiao, Y, Huang, et al |
International Emergency Nursing |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
912 patients with COVID-19 were admitted to hospital, in which, 90 cases (9.87%) presented with diarrhea. Among the
90 cases, 8 cases (9%) presented with diarrhea as the initial symptom, and 24%, 17%, and 24% of the patients complained of nausea, vomiting, and poor appetite, respectively. The most common fecal characteristics on admission were watery stool (64%) and mushy
stool (28%). For the defecation frequency, 37% of the cases defecated over three times a day. The median time from illness onset to diarrhea was 3.0 days (IQR 0.0–5.0) and the median duration of diarrhea was 5.0 days (IQR 2.0–9.3). |
|
Xiao-Ling, Z, Rui-Yong, et al |
Academic Journal of Second Military Medical University |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
This paper reports the experience of hyperbaric oxygen therapy (HBOT) in an elderly critically ill patient (87-years-old)
with new coronavirus pneumonia (COVID-19) endotracheal intubation, and to provide a reference for expanding the application of HBOT in the treatment of COVID-19. Findings show that HBOT is beneficial to alleviate CO 2 retention in critically ill patients
with COVID-19 , and has a positive effect on reducing the body's hypoxia injury and protecting the function of important organs. The overall HBOT infection control program is feasible, and the safety of medical staff can be guaranteed through reasonable design. |
|
|
Xiong, Y, Zhang, et al |
Medicine |
Clinical data| Données cliniques |
Authors aimed to investigate the clinical and chest computed tomography (CT) characteristics of healthcare workers
who became infected with COVID-19. |
|
|
Computed tomography in coronavirus disease 2019: diagnosis and clinical
significance |
Xu, F, Yun, et al |
Academic Journal of Second Military Medical University |
Clinical data| Données cliniques |
Objective To investigate the computed tomography (CT) features of the coronavirus disease 2019 (COVID-19) and the clinical
significance, so as to improve our understanding of CT imaging of this disease. The chest CT features of seven COVID-19 patients, who were diagnosed by virus nucleic acid test from Jan. 25 to Feb. 15, 2020 in Changhai Hospital of Naval Medical University,
were analyzed retrospectively.The average time from onset of symptoms to CT examination was 3.6 d (range 1-9 d) in the seven COVID-19 patients. The lesions were distributed in single lung in one case and bilateral lungs in six cases. The lesions involved middle
and lateral fields of lungs in five cases and the whole field of lungs in two cases. The lesions showed ground-glass opacity in four cases and mixed shadow in three cases. The lesions involved two or less lobes in four cases and five lobes in three cases.
One case had air bronchogram. No mediastinal lymphadenopathy or pleural effusion were found. |
|
Yamada, Z, Nanki, et al |
J Clin Rheumatol |
Clinical data| Données cliniques |
This case report describes a 51 year old woman with rheumatoid arthritis receiving tocilizumab and COVID-19 in early
April 2020. As symptoms were mild we was observed at home without specific treatment. Tocilizumab was temporarily withdrawn. Her arthralgia recurred on April 20th. On May 13th her symptoms had improved and SARS-CoV-2 was no longer detected. Tocilizumab was
resumed and arthritis improved. |
|
|
Yang, YG, Hu, et al |
Fudan University Journal of Medical Sciences |
Clinical data| Données cliniques |
The objective of this study was to retrospectively analyze patients diagnosed with COVID-19 in Anqing area on their
clinical characteristics, curative effect and outcome. |
|
|
Yan-Xin, C, Ming-Lin, et al |
Academic Journal of Second Military Medical University |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This retrospective study investigates the false negative rate of throat swab nucleic acid detection method for SARS-CoV-2,
and analyze the reasons, in order to stabilize the prevention and control of COVID-19 pneumonia in China for reference. There were 592 males (40.77%) and 860 females (59.23%) of 1452 COVID-19 patients. 212 cases (14.60%) had false negative results in throat
swab nucleic acid test. A total of 28 patients (1.93%) with reyang after discharge from the hospital were followed up. Among the 918 patients with negative nucleic acid tests for two consecutive times, 24 (2.61%) had reyang, which was higher than that of patients
with negative nucleic acid tests for 3 consecutive times or more. Rate (0.75%, 4/534), the difference was statistically significant (χ~2=6.21, P=0.0127). The SARS-CoV-2 throat swab nucleic acid detection method has a certain proportion of false negatives,
which is one of the reasons for the recovery of nucleic acid after discharge from the hospital. It is recommended that different testers perform multiple and continuous tests before discharge, and meeting the discharge standard of negative nucleic acid tests
for 3 times or more in a row can reduce the recovery rate. |
|
|
Yawney, J, Gadsden, et al |
IEEE Access |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
In this paper, the baseline SIR model is introduced with its close counterpart, the SEIR model. Social distancing is
modelled through the isolation of a subset of the susceptible population and comparative studies are performed considering a range in the proportion of individuals isolated. Robust and accurate numerical approximation techniques are used to simulate the pessimistic
base case for which no preventative measures are taken and for various social distancing regimes. The results of social distancing are consolidated into two groups - those that flatten the curve and those that completely halt the disease spread. Mathematical
formulations show that the turning point between these two regimes is when the effective reproductive rate, denoted Re, is equal to 1. |
|
|
Yehia, BR, Winegar, et al |
JAMA network open |
Epidemiology| Épidémiologie |
The objective of this study was to evaluate the association of race, adjusting for sociodemographic and clinical factors,
on all-cause, in-hospital mortality for patients with COVID-19. |
|
|
Youssef, A, Brunelli, et al |
J Ultrasound Med |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
This was a prospective cohort pilot study on asymptomatic pregnant women undergoing an oropharyngeal swab for SARS‐CoV‐2
by quantitative reverse transcription polymerase chain reaction (RT‐PCR). Although LUS is likely to be useful in symptomatic pregnant women with COVID‐19, in this pilot study, despite the relatively small population, LUS did not seem to be useful in the screening
for COVID‐19 in pregnancy. |
|
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Yu, BYM, Yeung, et al |
Sleep medicine |
Public Health response| Interventions de santé publique |
Adequate and stable supply of masks may play an important role to maintain the sleep health in the Hong Kong general
population during a pandemic outbreak. The weighted prevalence of worsened sleep quality, difficulty in sleep initiation, and shortened sleep duration since the outbreak were 38.3%, 29.8%, and 29.1%, respectively. The prevalence of current insomnia (ISI score
of ≥10) was 29.9%. Insufficient stock of masks was significantly associated with worsened sleep quality, impaired sleep initiation, shortened sleep duration, and current insomnia in multivariate logistic regression (adjusted OR = 1.57, 1.72, 1.99, and 1.96
respectively, all p < 0.05). |
|
|
Surgical treatment of a case of lumbar burst fracture complicated
with 2019-nCoV infection |
Yu, S, Zhang, et al |
Chinese Journal of Orthopaedic Trauma |
Clinical data| Données cliniques |
This case report describes the surgical treatment of a new type of coronavirus infection with a burst fracture of the
lumbar spine. |
|
Financial literacy in the covid-19 pandemic: Pressure conditions in indonesia |
Yuesti, A, Rustiarini, et al |
Entrepreneurship and Sustainability Issues |
Public Health response| Interventions de santé publique |
This study aims to analyse how financial literacy helps in the depression condition of the COVID-19 pandemic. This
study takes a sample of 396 household heads. This study uses partial least square (PLS) analysis to analyse the data. Results show that all financial attitudes, behaviour and literacy variables positively affect financial literacy and wellbeing. The implication
of this research is that financial literacy, which is reflected by financial attitudes and behaviour plays a key role in public financial welfare. |
|
Zaplotnik, Ž, Gavrić, et al |
PLoS One |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique Public Health Priorities| Priorités de santé publique |
A virus transmission model is constructed on a simplified social network. The social network consists of more than
2 million nodes, each representing an inhabitant of Slovenia. The presented ongoing forecasts of COVID-19 epidemic in Slovenia are compared with the collected Slovenian data. Results show that at the end of the first epidemic wave, the infection was twice
more likely to transmit within households/elderly care centers than outside them. Virus transmission models with accurate social network models are thus essential for improving epidemics forecasting. |
|
|
Zhan, B, Lan, et al |
Journal of International Medical Research |
Clinical data| Données cliniques |
Authors study chest CT findings in family clusters of COVID-19. On chest CT, 14 patients with family clustered COVID-19
had bilateral lung lesions. By contrast, 7 patients with no history of familial gatherings showed single lung exudative lesions or consolidation. Seven patients with family clustered COVID-19 had bilateral multiple exudative lesions. Four patients with no
history of familial gathering had unilateral lesions. Not all patients with COVID-19 have direct epidemiological links to an infected case. They may become infected because of poor protection. In patients with family clustered COVID-19, chest CT often showed
multiple exudative lesions in both lungs. In some patients, symptoms may be complicated by influenza virus infection. |
|
|
Zhan, C, Zheng, et al |
Neural Computing and Applications |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
At the end of 2019, a new coronavirus (COVID-19) epidemic has triggered global public health concern. Here, a model
integrating the daily intercity migration network, which constructed from real-world migration records and the Susceptible–Exposed–Infected–Removed model, is utilized to predict the epidemic spreading of the COVID-19 in more than 300 cities in China. However,
the model has more than 1800 unknown parameters, which is a challenging task to estimate all unknown parameters from historical data within a reasonable computation time. In this article, we proposed a pseudocoevolutionary simulated annealing (SA) algorithm
for identifying these unknown parameters. The large volume of unknown parameters of this model is optimized through three procedures co-adapted SA-based optimization processes, respectively. Our results confirm that the proposed method is both efficient and
robust. Then, we use the identified model to predict the trends of the epidemic spreading of the COVID-19 in these cities. We find that the number of infections in most cities in China has reached their peak from February 29, 2020, to March 15, 2020. For most
cities outside Hubei province, the total number of infected individuals would be less than 100, while for most cities in Hubei province (exclude Wuhan), the total number of infected individuals would be less than 3000. © 2020, Springer-Verlag London Ltd.,
part of Springer Nature. |
|
|
Zhan, J, Li, et al |
Eur Radiol |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
We elucidate the CT manifestations and patterns of evolution in 110 patients with COVID-19 pneumonia. Predominant findings
at initial CT scans were bilateral multifocal subpleural GGO. The most commonly shown evolution pattern was type 2: progression of disease with increased extent and density of opacities on first follow-up CT followed by improvement on second follow-up CT. |
|
|
Zhang, H, Quek, et al |
Journal of Cancer |
Coronavirology| Coronavirologie |
In this study, by exploring the TCGA and GTEx public databases, we investigated ACE2 expression and its association
with prognosis in non-small cell lung cancer (NSCLC), the most susceptible caner type. We found that lung was one of the major organs with highly expressed ACE2. Furthermore, ACE2 expression was significantly elevated in lung adenocarcioma (LUAD) and lung
squamous cell carcinoma (LUSC) compared to normal tissues. DNA methylation might be one possible mechanism leading to ACE2 upregulation. Despite that, the AEC2 expression was not statistically associated with disease-free survival (DFS) and overall survival
(OS) for LUAD patients, and higher ACE2 expression was associated with prolonged DFS in LUSC patients. Taken together, we observed ACE2 was highly expressed in LUAD and LUSC despite the controversial role of ACE2 expression in predicting prognosis in these
two common lung cancer types. |
|
|
Analysis of Olfactory and Gustatory Dysfunction of COVID-19 Cases
in Wuhan, China |
Zhang, Lu, Wu, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective of this study was to describe the olfactory and gustatory dysfunctions in 101 COVID-19 patients from
China and analyze the association with systemic symptoms. 30 cases (29.70%) had olfactory dysfunction and 37 cases (36.63%) reported gustatory dysfunction, respectively. The females were more likely to suffer from gustatory disorder (P=0.012). Notably, cases
with bilateral lung infection were more likely to have olfactory and gustatory dysfunction (P=0.041 and P=0.038). In systemic symptoms, nasal obstruction, diarrhea, and abdominal pain remained significantly associated with olfactory dysfunction after confounding
factors adjusted; anorexia, nasal obstruction and vomiting remained significant for gustatory dysfunction. |
|
Zhang, S, Yu, et al |
Journal of Jilin University Medicine Edition |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
The objective of this study was to investigate the effect of modified fecal drainage device on avoiding the occupational
exposure infection of the medical staffs in the treatment of corona virus disease 2019 (COVID-19), and to provide the reference for the clinical treatment of COVID-19 and avoiding the occupational exposure infection of the medical staffs. The modified fecal
drainage device has better stability, which can effectively prevent IAD and the spread of COVID-19 and reduce the risk of occupational exposure infection of medical staffs, and it is suitable for clinical promotion application. |
|
|
The characteristics and predictive role of lymphocyte subsets in COVID-19 patients |
Zhang, W, Li, et al |
International Journal of Infectious Diseases |
Clinical data| Données cliniques |
We evaluated lymphocyte subsets and other clinical features of COVID-19 patients, and analyzed their potential impacts
on COVID-19 outcomes. 1. Lymphocyte subset counts in the peripheral blood of patients with COVID-19 were significantly reduced, especially in patients with severe disease. 2. In patients with non-severe disease, the time from symptom onset to hospital admission
was positively correlated with total T cell counts. 3. Among COVID-19 patients who did not reach the composite endpoint, lymphocyte subset counts were higher than in patients who had reached the composite endpoint. 4. The Kaplan-Meier survival curves showed
significant differences in COVID-19 patients, classified by the levels of total, CD8+, and CD4+ T cells at admission. |
|
Correlation between hyponatremia and the severity of coronavirus disease
2019 |
Zhang, W, Lu, et al |
Zhonghua wei zhong bing ji jiu yi xue |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective of this study was to investigate the correlation between hyponatremia and the severity of coronavirus
disease 2019 (COVID-19) Shantou Central Hospital, in China. Serum Na+ showed decreasing tendency during the development of COVID-19, and hyponatremia was closely related to the severity of COVID-19. |
|
COVID-19 outbreak prevention by early containment in Shantou, China |
Zhang, X, Zhang, et al |
Journal of infection in developing countries |
Epidemiology| Épidémiologie Clinical data| Données cliniques Public health interventions*|
Interventions de santé publique |
The objective of this study was to report about the successful outbreak containment of COVID-19 in Shantou, one of
the prefectural cities of Guangdong province in the mainland China. All patients confirmed as having COVID-19 between 23 January and 25 March 2020 by RT-PCR assay in the clinical lab of Shantou CDC were included and divided into three groups based on the
source of identification: hospital diagnosis, contact tracing, and community screening. Collected data was analyzed and compared among these three groups. The early containment measures applied in Shantou, a city with insufficient healthcare resources for
COVID-19, seems to be appropriate for cities or areas with similar profiles. |
|
Lung Ultrasound Score in Evaluating the Severity of Coronavirus Disease
2019 (COVID-19) Pneumonia |
Zhao, L, Yu, et al |
Ultrasound in Medicine and Biology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The purpose of this study is to observe the potential of lung ultrasound in evaluating the severity of coronavirus
disease 2019 (COVID-19) pneumonia. In total, 7 patients were enrolled in the refractory group and 28 in the non-refractory group. Patients in the refractory group had significantly more ground-glass signs (median 6 [interquartile range {IQR}, 2.5–6.5] vs.
median 0 [IQR, 0–3]), consolidation signs (median 1 [IQR, 1–1.5] vs. median 0 [IQR, 0–3]) and pleural effusions (median 5 [IQR, 1.5–6] vs. median 0 [IQR, 0–0.25]). The LUS was significantly higher in the refractory group (33.00 [IQR 27.50–34.00] vs. 25.50
[IQR 22.75–30.00]). The ROC of the LUS showed a cutoff score of 32 with a specificity of 0.893 and a sensitivity of 0.571 in diagnosing refractory respiratory failure among patients. |
|
Zhao, S |
Infectious Disease Modelling |
Epidemiology| Épidémiologie |
In this study, we developed a simple likelihood-based framework to estimate the instantaneous CFR of infectious diseases.
We used the publicly available COVID-19 surveillance data in Canada for demonstration. We estimated the mean fatality ratio of reported COVID-19 cases (rCFR) in Canada was estimated at 6.9% (95%CI: 4.5–10.6). We emphasize the extensive implementation of the
constructed instantaneous CFR that is to identify the key determinants affecting the mortality risk. |
|
|
Zhao, X, Zhang, et al |
Sleep medicine |
Healthcare Response | Réponse des soins de santé |
All healthcare workers temporarily scheduled to screen the 2019-nCoV patients were asked to complete a self-administered
questionnaire that included questions on demographics, job-related factors, and sleep quality as assessed using the Pittsburgh Sleep Quality Index (PSQI). Sleep quality was assessed over a one-month follow-up period. A total of 116 doctors and 99 nurses were
recruited for this study. The total scheduled work time was 14.78 ± 6.69 days during follow-up. Healthcare workers involved in screening for 2019-nCoV experienced reduced sleep quality, and a reasonable work schedule may help with maintaining sleep quality.
In addition, interventions for healthcare workers should target self-help sleep assistance. |
|
|
Zheng, C, Huang, et al |
International Journal of Environmental Research and Public Health |
Public Health response| Interventions de santé publique |
The results of this study demonstrated a sedentary lifestyle in young adults during the COVID-19 pandemic, which will
assist health policymakers and practitioners in the development of population specific health education and behavior interventions during this pandemic and for other future events. A total of 631 young adults (38.8% males) aged between 18 and 35 participated
in the cross-sectional study and completed a one-off online survey relating to general information, 1) physical activity (PA) levels, sedentary behavior (SB), and sleep in young adults during the COVID-19 epidemic, and 2) the change in these behaviors before
and during the pandemic. |
|
|
Zheng, F, Zhou, et al |
International Journal of Infectious Diseases |
Therapeutics| Thérapeutique RCT |
The antiviral effects of Novaferon, a potent antiviral protein drug, on COVID-19 was evaluated in the laboratory, and
in a randomized, open-label, parallel-group trial. Novaferon inhibited viral replication (EC50 = 1.02 ng/ml), and prevented viral infection (EC50 = 0.10 ng/ml). Results from the 89 enrolled COVID-19 patients showed that both Novaferon and Novaferon plus Lopinavir/Ritonavir
groups had significantly higher viral clearance rates on day six than Lopinavir/Ritonavir group (50.0% vs. 24.1%, p = 0.0400, and 60.0% vs. 24.1%, p = 0.0053). The median time to viral clearance was six days, six days, and nine days for three groups, respectively,
a 3-day reduction in both the Novaferon and Novaferon plus Lopinavir/Ritonavir groups compared with the Lopinavir/Ritonavir group. |
|
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Recovery of pneumonia in 27 discharged COVID-19 patients with positive
virus detection |
Zheng, J, Chen, et al |
Quantitative Imaging in Medicine and Surgery |
Clinical data| Données cliniques |
To give a detailed description on the clinical course of post-discharged redetectable as positive (RP) patients and
thus further confirm the recovery of RP patients, authors studied 285 adult patients with COVID-19 and acquired their clinical outcome during post-discharge surveillance with PCR results. The results further confirm that RP patients are more likely to have
false negative RT-PCR tests before discharging and the positive re-tests unlikely reflect reinfection (7). Since most RP patients can have pulmonary inflammations further absorbed spontaneously, it may not be necessary to offer additional treatment for these
patients. |
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Zhiming, N, Song, et al |
|
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
This paper uses the digital platform Rhino & Grasshopper to simulate the possible traces of urbanites' activities,
and visually combines the most widely used virus transmission model such as SEIR, and proposes a new M-SEIR model to control transmission of urban pandemics. By exploring the relationship between the morphology of urbanites' activities flow and the development
of the pandemic, this study will generate fresh insight into the design of public transportation, prevention and control of urban pandemics. |
|
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Sleep problems among Chinese adolescents and young adults during the coronavirus-2019
pandemic |
Zhou, SJ, Wang, et al |
Sleep medicine |
Public Health response| Interventions de santé publique |
To assess the prevalence and sociodemographic correlates of insomnia symptoms among Chinese adolescents and young adults
affected by the outbreak of coronavirus disease-2019 (COVID-19). Among 11,835 adolescents and young adults included in the study, the prevalence of insomnia symptoms during part of the COVID-19 epidemic period was 23.2%. Results of this study revealed a
high prevalence of sleep problems among adolescents and young adults during the COVID-19 epidemic, especially senior high school and college students, which were negatively associated with students’ projections of trends in COVID-19. The adverse impact of
COVID-19 was a risk factor for insomnia symptoms; as such, the government must devote more attention to sleep disorders in this patient population while combating COVID-19. |
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Aggarwal, M, Dass, et al |
Indian Journal of Hematology and Blood Transfusion |
Review Literature| Revue de littérature |
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Al-Bayaty, F |
Journal of Oral Research |
Review Literature| Revue de littérature |
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Ali, MJ, Hanif, et al |
Frontiers in Medicine |
Review Literature| Revue de littérature |
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Mapping COVID-19 related research from Saudi Arabia, a scoping review. Between reality
and dreams |
Almaghlouth, I, Islam, et al |
Saudi medical journal |
Review Literature| Revue de littérature |
ScR: Medline and Cochrane databases were searched between March and May 2020. Most of the research production from
Saudi Arabia was opinion and narrative reviews related to the clinicopathological features of COVID-19 as well as control and prevention of virus spread. |
|
Neurological manifestations of coronavirus infections - a systematic review |
Almqvist, J, Granberg, et al |
Ann Clin Transl Neurol |
Review Literature| Revue de littérature |
SR: identified relevant publications (until 26 July 2020) using systematic searches in PubMed, Web of Science, and
Ovid EMBASE with predefined search strings. |
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Australia's COVID-19 public budgeting response: the straitjacket of neoliberalism |
Andrew, J, Baker, et al |
Journal of Public Budgeting, Accounting and Financial Management |
Review Literature| Revue de littérature |
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COVID-19 Pandemic: A Serious Threat for Public Mental Health Globally |
Anjum, S, Ullah, et al |
Psychiatria Danubina |
Review Literature| Revue de littérature |
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Artika, IM, Dewantari, et al |
Heliyon |
Review Literature| Revue de littérature |
|
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Atluri, S, Manocha, et al |
Pain Physician |
Review Literature| Revue de littérature |
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Aucoin, M, Cooley, et al |
Advances in Integrative Medicine |
Review Literature| Revue de littérature |
Rapid Review: Medline (Ovid), AMED (Ovid), CINAHL (EBSCO), EMBASE (Ovid) were searched. Current evidence on the efficacy
of quercetin supplementation in the treatment and prevention of COVID-19 is insufficient for its clinical recommendation at this time. Quercetin exhibits both immunomodulatory and antimicrobial effects in preclinical studies; however, only three human clinical
trials, each with a low risk of bias rating. |
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Aucoin, M, Cooley, et al |
Advances in Integrative Medicine |
Review Literature| Revue de littérature |
Rapid Review: Medline (Ovid), AMED (Ovid), CINAHL (EBSCO), EMBASE (Ovid) were searched. When assessing all human trials
which reported changes in cytokine levels in response to Echinacea supplementation, the results were largely consistent with a decrease in the pro-inflammatory cytokines that play a role in the progression of cytokine storm and Acute Respiratory Distress Syndrome
(ARDS), factors that play a significant role in the death of COVID-19 patients. |
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OUTBREAK of novel corona virus disease (COVID-19): Antecedence and aftermath |
Awasthi, A, Vishwas, et al |
European journal of pharmacology |
Review Literature| Revue de littérature |
|
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Melatonin potentials against viral infections including COVID-19: Current evidence
and new findings |
Bahrampour Juybari, K, Pourhanifeh, et al |
Virus research |
Review Literature| Revue de littérature |
|
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Neurocovid: Pharmacological Recommendations for Delirium Associated With COVID-19 |
Baller, EB, Hogan, et al |
Psychosomatics |
Review Literature| Revue de littérature |
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Banerjee, D, Viswanath, et al |
Asian Journal of Psychiatry |
Review Literature| Revue de littérature |
|
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Bao, L, Zhang, et al |
Frontiers in Microbiology |
Review Literature| Revue de littérature |
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Bashash, D, Abolghasemi, et al |
Iranian Journal of Blood and Cancer |
Review Literature| Revue de littérature |
MA |
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Hesperidin and SARS-CoV-2: New light on the healthy function of citrus fruits |
Bellavite, P, Donzelli, et al |
Antioxidants |
Review Literature| Revue de littérature |
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Brikman, S, Bieber, et al |
The Israel Medical Association journal : IMAJ |
Review Literature| Revue de littérature |
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Chen, Y, Shen, et al |
Frontiers in Pharmacology |
Review Literature| Revue de littérature |
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Cardiovascular Imaging and Interventional Procedures in Patients with Novel Coronavirus
Infection |
Costa, IBSDS, Rochitte, et al |
Arquivos Brasileiros de Cardiologia |
Review Literature| Revue de littérature |
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Craft, AR |
Serials Review |
Review Literature| Revue de littérature |
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Crimi, E, Benincasa, et al |
British journal of anaesthesia |
Review Literature| Revue de littérature |
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da Silva, PG, Mesquita, et al |
Science of the Total Environment |
Review Literature| Revue de littérature |
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An overview of key potential therapeutic strategies for combat in the COVID-19 battle |
Das, G, Ghosh, et al |
RSC Advances |
Review Literature| Revue de littérature |
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Allattamento e infezione da sars-cov-2 indicazioni ad interim della società italiana
di neonatologia |
Davanzo, R, Mosca, et al |
Medico e Bambino |
Review Literature| Revue de littérature |
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Davidson, AM, Wysocki, et al |
Hypertension |
Review Literature| Revue de littérature |
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Desai, A, Durham, et al |
Psychology, Public Policy, and Law |
Review Literature| Revue de littérature |
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Is covid-19 sibling of sars and mers? A review on: Novel covid-19 |
Devi, S, Singh, et al |
Indian Journal of Pharmaceutical Education and Research |
Review Literature| Revue de littérature |
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Douma, MJ, MacKenzie, et al |
Resuscitation |
Review Literature| Revue de littérature |
ScR: databases searched were MEDLINE, Embase, CINAHL, Cochrane CENTRAL, Cochrane Database of Systematic Reviews, Scopus
and Google Scholar on April 25, 2020. It remains reasonable to initiate resuscitation in the prone position if turning the patient supine would lead to delays or risk to providers or patients. Prone resuscitation quality can be judged using end-tidal CO2,
and arterial pressure tracing, with patients turned supine if insufficient. |
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COVID-19 (Coronavirus disease 2019): A new coronavirus disease |
Dousari, AS, Moghadam, et al |
Infection and Drug Resistance |
Review Literature| Revue de littérature |
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Echeverría-Esnal, D, Martin-Ontiyuelo, et al |
Expert Rev Anti Infect Ther |
Review Literature| Revue de littérature |
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Fischer, F, Raiber, et al |
Pflege |
Review Literature| Revue de littérature |
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Key guidelines in developing a pre-emptive COVID-19 vaccination uptake promotion strategy |
French, J, Deshpande, et al |
International Journal of Environmental Research and Public Health |
Review Literature| Revue de littérature |
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Gao, Z, Xu, et al |
Infection, Genetics and Evolution |
Review Literature| Revue de littérature |
SR |
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Garg, P, Arora, et al |
J Med Virol |
Review Literature| Revue de littérature |
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Endothelial Dysfunction in COVID-19: Lessons Learned from Coronaviruses |
Gavriilaki, E, Anyfanti, et al |
Curr Hypertens Rep |
Review Literature| Revue de littérature |
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Ghanim, SM, Alaasam, et al |
Iranian Journal of Pediatrics |
Review Literature| Revue de littérature |
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Covid-19 pandemic: Implications on interventional
pain practice—a narrative review |
Gharaei, H, Diwan, et al |
Pain Physician |
Review Literature| Revue de littérature |
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Risk management model, the contribution of phi value in the business continuity plan |
Gómez Betancourt, G, Morón Vásquez, et al |
Revista Venezolana de Gerencia |
Review Literature| Revue de littérature |
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Effect of Covid-19 in Otorhinolaryngology Practice: A Review |
Grag, K, Kumar, et al |
Indian Journal of Otolaryngology and Head and Neck Surgery |
Review Literature| Revue de littérature |
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Groban, L, Wang, et al |
Curr Hypertens Rep |
Review Literature| Revue de littérature |
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Hanfi, SH, Lalani, et al |
J Thorac Imaging |
Review Literature| Revue de littérature |
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Haq, W, Raza, et al |
Journal of infection in developing countries |
Review Literature| Revue de littérature |
SR: The literature on Pakistan has shown the evidence of human-to-human and animal-to-human transmission of viruses,
the presence of antibodies of MERS-CoV in camels, and careless attitude towards preventive measures of such respiratory diseases.
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He, Y, Tang, et al |
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics |
Review Literature| Revue de littérature |
SR: PubMed, Embase, Web of Science, The Cochrane Library, CNKI, Weipu Database, and Wanfang Database were searched
for clinical studies on COVID-19 in children published up to May 21, 2020. Children with COVID-19 have similar symptoms to those with SARS or MERS, mainly fever and cough. Asymptomatic infection is observed in all three diseases. Children with COVID-19 or
SARS have milder disease conditions than those with MERS. |
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Hu, SL |
Fudan University Journal of Medical Sciences |
Review Literature| Revue de littérature |
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Covid-19 pandemic research opportunity: Is the Middle East & North Africa (MENA)
missing out? |
Ibrahim, H, Kamour, et al |
Contemporary Clinical Trials |
Review Literature| Revue de littérature |
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Clinical and Prodromal Ocular Symptoms in Coronavirus Disease: A Systematic Review and
Meta-Analysis |
Inomata, T, Kitazawa, et al |
Investigative ophthalmology & visual science |
Review Literature| Revue de littérature |
SR-MA: An online article search was performed in PubMed and EMBASE to retrieve all articles published from April 2,
2020, to May 7, 2020. Ocular symptoms may occur in the presymptomatic phase as a prodromal symptom (12.5%, 13/104 cases), suggesting the possibility of viral transmission from the conjunctiva. |
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Jones, DL, Baluja, et al |
Science of the Total Environment |
Review Literature| Revue de littérature |
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Joonaki, E, Hassanpouryouzband, et al |
Chem |
Review Literature| Revue de littérature |
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Kaur, G, Mohan, et al |
Indian Journal of Otolaryngology and Head and Neck Surgery |
Review Literature| Revue de littérature |
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Kaur, S, Bansal, et al |
Blood reviews |
Review Literature| Revue de littérature |
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Overview of stem cell therapy for acute respiratory
distress syndrome with focus on covid 19 |
Kaye, RJ |
Pain Physician |
Review Literature| Revue de littérature |
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Virtual croi 2020: Tuberculosis
and coinfections in hiv infection |
Kerkhoff, AD, Havlir, et al |
Topics in Antiviral Medicine |
Review Literature| Revue de littérature |
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Chest ct imaging spectrum of coronavirus disease 2019 (Covid-19) pneumonia: A pictorial
essay |
Khazaei, M, Mahdavi, et al |
Iranian Journal of Radiology |
Review Literature| Revue de littérature |
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Things Are Looking Up: Using Cloud-Based Technology Tools in Collection Management
Workflows |
Kipps, KL, Jones, et al |
Serials Review |
Review Literature| Revue de littérature |
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Kirtipal, N, Bharadwaj, et al |
Infection, Genetics and Evolution |
Review Literature| Revue de littérature |
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Klaus, ‘ P, Manthiou, et al |
Journal of Service Management |
Review Literature| Revue de littérature |
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Kofod, LM, Jeschke, et al |
Ugeskrift for laeger |
Review Literature| Revue de littérature |
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Pathogenesis, clinical manifestations and complications of coronavirus disease 2019
(COVID-19) |
Kordzadeh-Kermani, E, Khalili, et al |
Future Microbiol |
Review Literature| Revue de littérature |
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Körner, RW, Majjouti, et al |
Viruses |
Review Literature| Revue de littérature |
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The effectiveness of global systems for monitoring sociopolitical instability:
A systematic analysis |
Korotayev, A, Medvedev, et al |
Sotsiologicheskoe Obozrenie |
Review Literature| Revue de littérature |
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Krishnamoorthy, Y, Nagarajan, et al |
Psychiatry research |
Review Literature| Revue de littérature |
SR-MA: MEDLINE, Chinese National Knowledge Infrastructure (CNKI), Cochrane library, ScienceDirect and Google Scholar
were searched from inception to 22 April 2020. Pooled prevalence rate of psychological morbidities with respect to impact of event due to COVID-19 pandemic was 44% (95%CI-42% to 47%). The burden of these psychological morbidities was highest among the COVID-19
patients followed by healthcare workers and general population. |
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Krishnamurthy, G, Sahni, et al |
Seminars in perinatology |
Review Literature| Revue de littérature |
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Potential diagnostics and therapeutic approaches in COVID-19 |
Kumari, P, Singh, et al |
Clinica Chimica Acta |
Review Literature| Revue de littérature |
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Kunutsor, SK, Laukkanen, et al |
Thrombosis research |
Review Literature| Revue de littérature |
SR-MA: searched MEDLINE and Embase from January 2020 to 6 August 2020. Aggregate analysis of the available literature
suggests a high incidence of thromboembolic complications in patients hospitalised with COVID-19, particularly in those with severe disease. The incidence is higher for venous thromboembolic events compared to arterial thromboembolic complications. |
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Kyle, MH, Glassman, et al |
Seminars in perinatology |
Review Literature| Revue de littérature |
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Testicular pain as an unusual presentation of COVID-19: a brief review of SARS-CoV-2
and the testis |
La Marca, A, Busani, et al |
Reproductive BioMedicine Online |
Review Literature| Revue de littérature |
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Lazzari, C, Shoka, et al |
Psychiatria Danubina |
Review Literature| Revue de littérature |
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Li, LC, Zhang, et al |
Biomedicine and Pharmacotherapy |
Review Literature| Revue de littérature |
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Progress in developing inhibitors of sars-cov-2 3c-like protease |
Li, Q, Kang, et al |
Microorganisms |
Review Literature| Revue de littérature |
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Mahajan, A, Manchikanti, et al |
Pain Physician |
Review Literature| Revue de littérature |
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Mahmud-Al-Rafat, A, Muzammal Haque Asim, et al |
Cytokine |
Review Literature| Revue de littérature |
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Mahooti, M, Miri, et al |
Microbial pathogenesis |
Review Literature| Revue de littérature |
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Malik, S, Gupta, et al |
Pharmaceuticals |
Review Literature| Revue de littérature |
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Addictions in the COVID-19 era: Current evidence, future perspectives a comprehensive
review |
Mallet, J, Dubertret, et al |
Progress in Neuro-Psychopharmacology and Biological Psychiatry |
Review Literature| Revue de littérature |
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Massalska, M, Maslinski, et al |
Cells |
Review Literature| Revue de littérature |
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Matuschek, C, Moll, et al |
European journal of medical research |
Review Literature| Revue de littérature |
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Recent progress in plasmonic biosensing schemes for virus detection |
Mauriz, E |
Sensors (Switzerland) |
Review Literature| Revue de littérature |
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Meireles, D, Gomes, et al |
Advances in Traditional Medicine |
Review Literature| Revue de littérature |
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A checklist to improve health system resilience to infectious disease outbreaks
and natural hazards |
Meyer, D, Bishai, et al |
BMJ Global Health |
Review Literature| Revue de littérature |
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Understanding covid-19: From origin to potential therapeutics |
Moazzam, M, Sajid, et al |
International Journal of Environmental Research and Public Health |
Review Literature| Revue de littérature |
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Sars‐cov‐2 orf8 and sars‐cov orf8ab: Genomic divergence and functional convergence |
Mohammad, S, Bouchama, et al |
Pathogens |
Review Literature| Revue de littérature |
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Mohan, AT, Vyas, et al |
Plastic and Reconstructive Surgery - Global Open |
Review Literature| Revue de littérature |
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Moores, LK, Tritschler, et al |
Chest |
Review Literature| Revue de littérature |
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Vascular medicine in the COVID-19 era: The Vanderbilt experience |
Moran, A, Kim, et al |
Journal of Vascular Nursing |
Review Literature| Revue de littérature |
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ACE2 as drug target of COVID-19 virus treatment, simplified updated review |
Mostafa-Hedeab, G |
Reports of Biochemistry and Molecular Biology |
Review Literature| Revue de littérature |
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Mudatsir, M, Yufika, et al |
Scientia Pharmaceutica |
Review Literature| Revue de littérature |
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Genome evolution of SARS-CoV-2 and its virological characteristics |
Nakagawa, S, Miyazawa, et al |
Inflammation and Regeneration |
Review Literature| Revue de littérature |
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Nepal, R, Rogerson, et al |
Education Sciences |
Review Literature| Revue de littérature |
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Nieto, Ines, Navas, et al |
SSRN- Lancet prepublication |
Review Literature| Revue de littérature |
SR: PubMed and Scopus databases on the 13th of May. Empirical studies, published in peer-reviewed journals in English,
between February and May 2020, were included. Twenty-eight studies were identified. More than 75% met the requirements related to reporting key methodological and statistical information. However, 89.3% used convenience samples and 92.86% lacked of a priori
power analysis. |
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The Application of Single-Cell RNA Sequencing in Vaccinology |
Noé, A, Cargill, et al |
Journal of immunology research |
Review Literature| Revue de littérature |
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Nokhostin, F, Malamir, et al |
Journal of Advances in Medical and Biomedical Research |
Review Literature| Revue de littérature |
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SARS-CoV-2, COVID-19, skin and immunology – What do we know so far? |
Novak, N, Peng, et al |
Allergy: European Journal of Allergy and Clinical Immunology |
Review Literature| Revue de littérature |
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Containment of COVID-19: the unprecedented response of Saudi Arabia |
Obied, DA, Alhamlan, et al |
Journal of infection in developing countries |
Review Literature| Revue de littérature |
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Coronavirus Disease 2019: Hematological Anomalies and Antithrombotic Therapy |
Ornelas-Ricardo, D, Jaloma-Cruz, et al |
The Tohoku journal of experimental medicine |
Review Literature| Revue de littérature |
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Telemedicine, COVID-19, and disparities: Policy implications |
Ortega, G, Rodriguez, et al |
Health Policy and Technology |
Review Literature| Revue de littérature |
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Pal, R, Banerjee, et al |
Diabetes and Metabolic Syndrome: Clinical Research and Reviews |
Review Literature| Revue de littérature |
SR: PubMed, Scopus, Embase, and Google Scholar databases were systematically searched till August 3, 2020. DKA in
COVID-19 patients portends a poor prognosis with a mortality rate approaching 50%. Differentiating isolated DKA from combined DKA/HHS is essential as the latter represents nearly one-fifth of the DKA cases and tends to have higher mortality than DKA alone.
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Panday, US, Pratihast, et al |
Drones |
Review Literature| Revue de littérature |
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Papadopoulos, N, Vasileiadi, et al |
Annals of Gastroenterology |
Review Literature| Revue de littérature |
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Utilizing drug repurposing against COVID-19 – Efficacy, limitations, and challenges |
Parvathaneni, V, Gupta, et al |
Life Sciences |
Review Literature| Revue de littérature |
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A review of the current state of management and post-recovery rehabilitation
of covid-19 |
Patel, DJ, Patel, et al |
Critical Reviews in Physical and Rehabilitation Medicine |
Review Literature| Revue de littérature |
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Increased plastic pollution due to COVID-19 pandemic: Challenges and recommendations |
Patrício Silva, AL, Prata, et al |
Chemical Engineering Journal |
Review Literature| Revue de littérature |
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Paul, Aneesh Mathews, Thomas, et al |
arXiv |
Review Literature| Revue de littérature |
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Salivary glands, saliva and oral findings in COVID-19 infection |
Pedrosa, MDS, Sipert, et al |
Pesquisa Brasileira em Odontopediatria e Clinica Integrada |
Review Literature| Revue de littérature |
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Pham, QV, Nguyen, et al |
IEEE Access |
Review Literature| Revue de littérature |
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Piepoli, S, Shamloo, et al |
Turkish Journal of Immunology |
Review Literature| Revue de littérature |
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The recent outbreaks of human coronaviruses: A medicinal chemistry perspective |
Pillaiyar, T, Wendt, et al |
Med Res Rev |
Review Literature| Revue de littérature |
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Pourbagheri-Sigaroodi, A, Bashash, et al |
Clinica Chimica Acta |
Review Literature| Revue de littérature |
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Pranata, R, Huang, et al |
Indian Pacing and Electrophysiology Journal |
Review Literature| Revue de littérature |
SR-MA: y searched PubMed, SCOPUS, Europe PMC, Cochrane Central Databases, and Google Scholar + Preprint Serverson April
14, 2020. Cardiac arrhythmias were significantly associated with an increased risk of poor outcome in COVID-19. Arrhythmias were observed in 19% of patients with COVID-19 and in 48% of patients with COVID-19 and poor outcomes. |
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Knowledge, attitude, and practice during the COVID-19 pandemic: A review |
Puspitasari, IM, Yusuf, et al |
Journal of Multidisciplinary Healthcare |
Review Literature| Revue de littérature |
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Radwan, GN |
Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit |
Review Literature| Revue de littérature |
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Attachment Theory and Psychological Responses to the COVID-19 Pandemic: A Narrative
Review |
Rajkumar, RP |
Psychiatria Danubina |
Review Literature| Revue de littérature |
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Razavi, A, Davoodi, et al |
Open Access Macedonian Journal of Medical Sciences |
Review Literature| Revue de littérature |
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Reddy, GB, Greif, et al |
HSS Journal |
Review Literature| Revue de littérature |
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Psychological Aid to COVID-19 Pandemic: A Mental Health Response to Crises Management |
Rehman, S, Lela, et al |
Psychiatria Danubina |
Review Literature| Revue de littérature |
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Reuter, H, Jenkins, et al |
African journal of primary health care & family medicine |
Review Literature| Revue de littérature |
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Rowan, NJ, Galanakis, et al |
Science of the Total Environment |
Review Literature| Revue de littérature |
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Role of social media during the COVID-19 pandemic: Beneficial, destructive, or reconstructive? |
Sahni, H, Sharma, et al |
International Journal of Academic Medicine |
Review Literature| Revue de littérature |
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SanJuan-Reyes, S, Gómez-Oliván, et al |
Chemosphere |
Review Literature| Revue de littérature |
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Santhanam, M, Algov, et al |
Sensors (Switzerland) |
Review Literature| Revue de littérature |
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Review of Geospatial Technology for Infectious Disease Surveillance: Use Case on
COVID-19 |
Saran, S, Singh, et al |
Journal of the Indian Society of Remote Sensing |
Review Literature| Revue de littérature |
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COVID-19: dealing with a potential risk factor for chronic neurological disorders |
Schirinzi, T, Landi, et al |
J Neurol |
Review Literature| Revue de littérature |
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Schloss, J, Lauche, et al |
Advances in Integrative Medicine |
Review Literature| Revue de littérature |
Rapid Review: Medline (Ovid), Embase (Ovid), AMED (Ovid), CINAHL (EBSCO) were searched. Oral vitamin C may assist with
the symptoms of acute respiratory viral infections (ARI) and common cold-induced asthma but no studies have been identified justifying oral vitamin C for the prevention or treatment of coronavirus infections including COVID-19. |
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Nanomaterials based superhydrophobic and antimi-crobial coatings |
Seth, M, Jana, et al |
NanoWorld Journal |
Review Literature| Revue de littérature |
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Shang, L, Shao, et al |
Archives of Medical Research |
Review Literature| Revue de littérature |
SR-MA: systematically searched the PubMed, Web of Science, MedRxiv and COVID-19 academic research communication platform
for studies reporting clinical severity and/or overall mortality data on DM in patients with COVID-19 published up to July 10, 2020. DM is associated with increased risk of severe infection and higher mortality in patients with COVID-19. Our study suggests
that clinicians should pay more attention to the monitoring and treatment of COVID-19 patients with DM. |
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Sharma, H, Verma, et al |
International Journal of Academic Medicine |
Review Literature| Revue de littérature |
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Shorey, S, Chan, et al |
Midwifery |
Review Literature| Revue de littérature |
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Ohio response to covid-19 and its impact on interventional
pain management practices |
Soin, A, Vuppala, et al |
Pain Physician |
Review Literature| Revue de littérature |
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Somashekhar, SP, Inamdar, et al |
Indian Journal of Gynecologic Oncology |
Review Literature| Revue de littérature |
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Souza, VGC, Lopes, et al |
Pesquisa Brasileira em Odontopediatria e Clinica Integrada |
Review Literature| Revue de littérature |
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Soysal, F, İşler, et al |
Klimik Dergisi |
Review Literature| Revue de littérature |
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Starke, KR, Petereit-Haack, et al |
International Journal of Environmental Research and Public Health |
Review Literature| Revue de littérature |
RR-MA: searched Pubmed to find relevant studies published in 2020. The indication of a rather weak influence of age
on COVID-19 disease severity after adjustment for important age-dependent risk factors should be taken in consideration when implementing age-related preventative measures. |
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Delaying Cancer Cases in Urology during COVID-19: Review of the Literature |
Tachibana, I, Ferguson, et al |
J Urol |
Review Literature| Revue de littérature |
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Takahashi, T, Luzum, et al |
npj Genomic Medicine |
Review Literature| Revue de littérature |
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Aerosol transmission of SARS-CoV-2? Evidence, prevention and control |
Tang, S, Mao, et al |
Environment international |
Review Literature| Revue de littérature |
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Tannous, C, Booz, et al |
Acta Physiol (Oxf) |
Review Literature| Revue de littérature |
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Tariku, M, Hajure, et al |
Psychology Research and Behavior Management |
Review Literature| Revue de littérature |
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Toro, SV, Sotta, et al |
Revista chilena de pediatria |
Review Literature| Revue de littérature |
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Triantafyllou, T, Olson, et al |
Annals of Gastroenterology |
Review Literature| Revue de littérature |
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van Doorn, AS, Meijer, et al |
Aliment Pharmacol Ther |
Review Literature| Revue de littérature |
SR-MA: Embase database, Google scholar, MEDLINE databases through PubMed and The Cochrane Library were searched, including
articles from December 2019 until July 7 2020. Viral shedding of SARS-CoV-2 in stool samples occurs in a substantial portion of patients, making faecal-oral transmission plausible. Furthermore, detection in stool sample or anal swab can persist long after
negative respiratory testing. |
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Vernuccio, F, Lombardo, et al |
Clinical radiology |
Review Literature| Revue de littérature |
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Volpe, M, Battistoni, et al |
International journal of cardiology |
Review Literature| Revue de littérature |
SR: We searched clinical papers investigating the effects of RAAS inhibitors on SARS-Cov2 infection and Covid-19 published
during the last 90 days. We conclude that at this time, the overall available evidence fails to support a pathogenetic speaks against any harmful role for of renin-angiotensin-aldosterone-system inhibitors in COronaVIrus Disease-19. |
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Wang, CC, Chao, et al |
Journal of Stroke and Cerebrovascular Diseases |
Review Literature| Revue de littérature |
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Proning Patients With COVID-19: A Review of Equipment and Methods |
Wiggermann, N, Zhou, et al |
Human factors |
Review Literature| Revue de littérature |
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Yam, C, Jokubaitis, et al |
Multiple Sclerosis Journal |
Review Literature| Revue de littérature |
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Yang, J, Liu, et al |
Risk Management and Healthcare Policy |
Review Literature| Revue de littérature |
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Yu, JN, Wu, et al |
Biol Res Nurs |
Review Literature| Revue de littérature |
SR-MA: collected studies from PubMed, Wed of Science and CNKI (Chinese) to July 25. This meta-analysis showed that
cardio-cerebrovascular disease has a significant relation with severe and death outcomes of COVID-19. Nurses should pay special attention to COVID-19 patients with the cardio-cerebrovascular disease. |
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Zhou, Y, Yang, et al |
International Journal of Infectious Diseases |
Review Literature| Revue de littérature |
SR-MA: PubMed, Embase, and Cochrane Library databases were searched from inception to April 25, 2020. Chronic comorbidities,
including obesity, hypertension, diabetes, cardiovascular disease, cerebrovascular disease, respiratory disease, kidney disease, and malignancy are clinical risk factors for a severe or fatal outcome associated with COVID-19, with obesity being the most prevalent
and respiratory disease being the most strongly predictive. |
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Government aid as relief for the COVID-19 emergency: Some accounting considerations |
I, De La Hoz Suárez, A, et al |
Revista Venezolana de Gerencia |
Commentary/Editorial| Commentaire/Éditorial |
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Presidential Address* and record of the Royal Geographical Society (with IBG) AGM 2020 |
the Baroness Chalker of TheRtHon, Wallasey |
Geographical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19
Emergency and mental health: Intensive and coordinated step-up interventions |
Abbracciavento, G, Cognigni, et al |
Medico e Bambino |
Commentary/Editorial| Commentaire/Éditorial |
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Neglecting the effect of COVID-19 on neglected tropical diseases: the Ethiopian perspective |
Abdela, SG, van Griensven, et al |
Trans R Soc Trop Med Hyg |
Commentary/Editorial| Commentaire/Éditorial |
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Abdullahi, IN, Emeribe, et al |
Journal of infection in developing countries |
Commentary/Editorial| Commentaire/Éditorial |
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Adaway, JE, Hawley, et al |
J Appl Lab Med |
Commentary/Editorial| Commentaire/Éditorial |
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Adhanom, T |
Appropriate Technology |
Commentary/Editorial| Commentaire/Éditorial |
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Three months of COVID-19 in a pediatric setting in the center of Milan |
Agostoni, C, Bertolozzi, et al |
Pediatr Res |
Commentary/Editorial| Commentaire/Éditorial |
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Mental health problems related to COVID-19: A call for psychosocial interventions in Uganda |
Ainamani, HE, Gumisiriza, et al |
Psychol Trauma |
Commentary/Editorial| Commentaire/Éditorial |
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Akacha, M, Branson, et al |
Statistics in Biopharmaceutical Research |
Commentary/Editorial| Commentaire/Éditorial |
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Al Hashmi, AM, Ozdemir, et al |
Journal of Stroke and Cerebrovascular Diseases |
Commentary/Editorial| Commentaire/Éditorial |
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Alavi, M, Moghanibashi-Mansourieh, et al |
International Journal of Drug Policy |
Commentary/Editorial| Commentaire/Éditorial |
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Alexander, BK |
Qualitative Inquiry |
Commentary/Editorial| Commentaire/Éditorial |
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Fragile Endothelium and Brain Dysregulated Neurochemical Activity in COVID-19 |
Alharthy, A, Faqihi, et al |
ACS Chemical Neuroscience |
Commentary/Editorial| Commentaire/Éditorial |
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Inhibition of viral infection by using of natural herbal remedies as alternative treatment |
Ali Al-Garawyi, AM, Hussein, et al |
Systematic Reviews in Pharmacy |
Commentary/Editorial| Commentaire/Éditorial |
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Ali, MH |
Journal of the Indian Medical Association |
Commentary/Editorial| Commentaire/Éditorial |
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Coronavirus is still talking…. you! humankind, first know the universe, evolution and
thyself! |
Alkan, ŞŞ |
Turkish Journal of Immunology |
Commentary/Editorial| Commentaire/Éditorial |
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Alomari, SO, Abou-Mrad, et al |
Clinical neurology and neurosurgery |
Commentary/Editorial| Commentaire/Éditorial |
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Altal, O, Bani Hani, et al |
Adv Ther |
Commentary/Editorial| Commentaire/Éditorial |
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From nut-2 to covid 19: What it teaches us?. the
triple therapy for covid 19 |
Altman, R, Muntaner, et al |
Revista de la Federacion Argentina de Cardiologia |
Commentary/Editorial| Commentaire/Éditorial |
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Andellini, M, De Santis, et al |
Health and Technology |
Commentary/Editorial| Commentaire/Éditorial |
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Physical and Digital Educational Escape Room for Teaching Chemical Bonding |
Ang, JWJ, Ng, et al |
Journal of chemical education |
Commentary/Editorial| Commentaire/Éditorial |
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Antúnez-Montes, OY |
J Ultrasound Med |
Commentary/Editorial| Commentaire/Éditorial |
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Anzovino, ME, Mallia, et al |
Journal of chemical education |
Commentary/Editorial| Commentaire/Éditorial |
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Myocardial Injury in COVID-19: a Challenge for Clinical Cardiologists |
Aragão, RCA, Alves, et al |
Arquivos Brasileiros de Cardiologia |
Commentary/Editorial| Commentaire/Éditorial |
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Protection of nephrology health professionals during the COVID-19 pandemic |
Arenas, MD, Villar, et al |
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia |
Commentary/Editorial| Commentaire/Éditorial |
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COVID 19 pandemic unveiling the opportunities and challenges in orthodontic
training |
Artese, F |
Dental Press Journal of Orthodontics |
Commentary/Editorial| Commentaire/Éditorial |
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Atkinson, JG |
International Journal of Infectious Diseases |
Commentary/Editorial| Commentaire/Éditorial |
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Aubey, J, Zork, et al |
Seminars in perinatology |
Commentary/Editorial| Commentaire/Éditorial |
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Infection-iron interaction during COVID-19 pandemic: Time to re-design iron supplementation
programs |
Augustine, LF, Mullapudi, et al |
Medical hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
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Recommendations for a good sleep during quarantine
by COVID-19. April 2020 |
Avendaño, L, Cerda, et al |
Revista chilena de pediatria |
Commentary/Editorial| Commentaire/Éditorial |
|
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Leisure and SCUBA diving safety tips during and after COVID-19 |
Aygün, Y, Tüfekçi, et al |
Cogent Social Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Acute endodontic and dental trauma provision during the COVID-19 crisis |
Ayub, K, Alani, et al |
British dental journal |
Commentary/Editorial| Commentaire/Éditorial |
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Baay, M, Neels, et al |
Biologicals |
Commentary/Editorial| Commentaire/Éditorial |
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Bai, GH |
Multilingua |
Commentary/Editorial| Commentaire/Éditorial |
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The academic as activist: managing tension and creating impact |
Baird, M |
Community, Work and Family |
Commentary/Editorial| Commentaire/Éditorial |
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Baker, SA, Wade, et al |
Media International Australia |
Commentary/Editorial| Commentaire/Éditorial |
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Balogh, S, Diós, et al |
Orvosi hetilap |
Commentary/Editorial| Commentaire/Éditorial |
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Practising ethically during COVID-19: Social work challenges and responses |
Banks, S, Cai, et al |
International Social Work |
Commentary/Editorial| Commentaire/Éditorial |
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Baptista, FVD, Aguiar, et al |
Clinics |
Commentary/Editorial| Commentaire/Éditorial |
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Bara, GA, de Ridder, et al |
Medical hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
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Bara, GA, de Ridder, et al |
Pain Physician |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 clinical implications: The significance of nanomedicine |
Barar, J |
BioImpacts |
Commentary/Editorial| Commentaire/Éditorial |
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Barros, D, Borges-Machado, et al |
American Journal of Alzheimer's Disease and Other Dementias |
Commentary/Editorial| Commentaire/Éditorial |
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Bautista-Molano, W, Ferreyra Garrot, et al |
J Clin Rheumatol |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 Research: Navigating the European General Data Protection Regulation |
Becker, R, Thorogood, et al |
J Med Internet Res |
Commentary/Editorial| Commentaire/Éditorial |
|
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Beech, HH, Sutton, et al |
International Social Work |
Commentary/Editorial| Commentaire/Éditorial |
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Bender, S, Florentine, et al |
Journal of Loss and Trauma |
Commentary/Editorial| Commentaire/Éditorial |
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Berbari, EF, Williams, et al |
Mayo Clinic proceedings |
Commentary/Editorial| Commentaire/Éditorial |
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Berghel, H, Charette, et al |
Computer |
Commentary/Editorial| Commentaire/Éditorial |
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Hospital response plan for the city of Porto Alegre, Brazil, during the pandemic of
COVID-19 |
Bertuzzi, B, Dal Ponte, et al |
International Journal of Academic Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Lopinavir-Ritonavir Treatment for COVID-19 Infection in Intensive Care Unit: Risk
of Bradycardia |
Beyls, C, Martin, et al |
Circulation.Arrhythmia and electrophysiology |
Commentary/Editorial| Commentaire/Éditorial |
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Bhargava, S, Rathod, et al |
Skinmed |
Commentary/Editorial| Commentaire/Éditorial |
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Bischof, E, Broek, et al |
International Journal for Multiscale Computational Engineering |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19: Gesundheitliche Ungleichheit und Pflegebedürftigkeit |
Blättner, B |
Pflege |
Commentary/Editorial| Commentaire/Éditorial |
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Bloem, C, Butts, et al |
International Journal of Academic Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Bloomer, MJ, Bouchoucha, et al |
Australian Critical Care |
Commentary/Editorial| Commentaire/Éditorial |
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Rethinking wastewater risks and monitoring in light of the COVID-19 pandemic |
Bogler, A, Packman, et al |
Nature Sustainability |
Commentary/Editorial| Commentaire/Éditorial |
|
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Race Disparities in the COVID-19 Pandemic-Solutions Lie in Policy, Not
Biology |
Boulware, LE |
JAMA network open |
Commentary/Editorial| Commentaire/Éditorial |
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Bowen, L |
Journal of Perioperative Nursing |
Commentary/Editorial| Commentaire/Éditorial |
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Bowman, B |
South African Journal of Psychology |
Commentary/Editorial| Commentaire/Éditorial |
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Mayo Clinic Strategies for COVID-19: Revisiting the Safety of Health Care Workers |
Breeher, LE, Sampathkumar, et al |
Mayo Clinic proceedings |
Commentary/Editorial| Commentaire/Éditorial |
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Brest, P, Refae, et al |
Trends in Genetics |
Commentary/Editorial| Commentaire/Éditorial |
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Brown, DR, Hennecke, et al |
American journal of disaster medicine |
Commentary/Editorial| Commentaire/Éditorial |
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How Partisanship Affected Public Reaction to Potential Treatments for COVID-19 |
Brunell, TL, Maxwell, et al |
World Medical and Health Policy |
Commentary/Editorial| Commentaire/Éditorial |
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Bryson, JR, Andres, et al |
Journal of Geography in Higher Education |
Commentary/Editorial| Commentaire/Éditorial |
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Mayo Clinic Strategies for COVID-19: Research Response to SARS-CoV-2/COVID-19 |
Burger, CD, Mikhail, et al |
Mayo Clinic proceedings |
Commentary/Editorial| Commentaire/Éditorial |
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Dengue Fever and COVID-19 Co-Infection; A Threat to Public Health for Co-epidemic in Pakistan |
Butt, MH, Ahmad, et al |
J Med Virol |
Commentary/Editorial| Commentaire/Éditorial |
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Cardiac magnetic resonance characterization of COVID-19 myocarditis |
Caballeros Lam, M, de la Fuente Villena, et al |
Revista espanola de cardiologia |
Commentary/Editorial| Commentaire/Éditorial |
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Post Covid-19 stimulus and bailouts need to be compatible with the Paris Agreement |
Caldecott, B |
Journal of Sustainable Finance and Investment |
Commentary/Editorial| Commentaire/Éditorial |
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Cankay, TU, Besenek, et al |
Psychiatria Danubina |
Commentary/Editorial| Commentaire/Éditorial |
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Could nasal irrigation and oral rinse reduce the risk for COVID-19 infection? |
Casale, M, Rinaldi, et al |
International Journal of Immunopathology and Pharmacology |
Commentary/Editorial| Commentaire/Éditorial |
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Administrative and economic university management in times of COVID-19 pandemic |
Castillo Cabeza, SN |
Revista Venezolana de Gerencia |
Commentary/Editorial| Commentaire/Éditorial |
|
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Sex hormones and hormone therapy during covid-19 pandemic: Implications for patients
with cancer |
Cattrini, C, Bersanelli, et al |
Cancers |
Commentary/Editorial| Commentaire/Éditorial |
|
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Dental clinical recommendations against COVID-19, according
to scientific evidence |
Cayo-Rojas, C, Baltazar-Sánchez, et al |
Revista Habanera de Ciencias Medicas |
Commentary/Editorial| Commentaire/Éditorial |
|
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Empathy in medical education: An opportunity after the
COVID-19 crisis |
Cayo-Rojas, C, Miranda-Dávila, et al |
Revista Habanera de Ciencias Medicas |
Commentary/Editorial| Commentaire/Éditorial |
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Chan, JCX, Kwok, et al |
Hong Kong Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Chan, LL, Tan, et al |
Quantitative Imaging in Medicine and Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Chang, WT, Hughes, et al |
Journal of the Formosan Medical Association |
Commentary/Editorial| Commentaire/Éditorial |
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Neurological involvement associated with COVID-19 infection in children |
Chen, TH |
Journal of the neurological sciences |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 Lockdowns: a Public Mental Health Ethics Perspective |
Cheung, D, Ip, et al |
Asian Bioethics Review |
Commentary/Editorial| Commentaire/Éditorial |
|
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Chevillotte, J |
Revue de l'infirmiere |
Commentary/Editorial| Commentaire/Éditorial |
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Leveraging best practices: Protecting sub-saharan african prison detainees
amid COVID-19 |
Chireh, B, Essien, et al |
Pan African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
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Caring for Patients With Cancer in the Face of Self-Vulnerability During the COVID-19
Pandemic |
Choi, JI, Simone, et al |
JAMA Oncol |
Commentary/Editorial| Commentaire/Éditorial |
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Managing the post-COVID-19 pediatric surgical surge – Opportunities and challenges |
Christensen, R, Haydar, et al |
Journal of clinical anesthesia |
Commentary/Editorial| Commentaire/Éditorial |
|
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Cioffi, A |
Psychiatria Danubina |
Commentary/Editorial| Commentaire/Éditorial |
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Clark, M |
Media International Australia |
Commentary/Editorial| Commentaire/Éditorial |
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Coban, C |
Current opinion in immunology |
Commentary/Editorial| Commentaire/Éditorial |
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Improving care in care homes: what can Primary Care Networks learn from the Vanguards? |
Coleman, A, Croke, et al |
Journal of Integrated Care |
Commentary/Editorial| Commentaire/Éditorial |
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Telepsychiatry in the Post-COVID-19 Era: Moving Backwards or Forwards? |
Colle, R, Ait Tayeb, et al |
Psychother Psychosom |
Commentary/Editorial| Commentaire/Éditorial |
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Coloma, E, Nicolás, et al |
Eur J Clin Invest |
Commentary/Editorial| Commentaire/Éditorial |
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Comite Asesor en Vacunas y Estrategias de, Vacunacion |
Revista chilena de pediatria |
Commentary/Editorial| Commentaire/Éditorial |
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Courtney, A, Howell, et al |
International Journal of Surgery Protocols |
Commentary/Editorial| Commentaire/Éditorial |
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Cousins, Sophie |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Dysphagia services in the era of COVID-19: Are speech-language therapists essential? |
Coutts, KA |
The South African journal of communication disorders = Die Suid-Afrikaanse tydskrif vir Kommunikasieafwykings |
Commentary/Editorial| Commentaire/Éditorial |
|
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Recommendations for future university pandemic responses: What the first COVID-19
shutdown taught us |
Coyne, C, Ballard, et al |
PLoS Biol |
Commentary/Editorial| Commentaire/Éditorial |
|
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Croton, B, Brocius, et al |
Lancet Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Alpha-lipoic acid may protect patients with diabetes against COVID-19 infection |
Cure, E, Cumhur Cure, et al |
Medical hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
|
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Curtis, V, Dreibelbis, et al |
BMJ Global Health |
Commentary/Editorial| Commentaire/Éditorial |
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Cuthbertson, DJ, Alam, et al |
Therapeutic Advances in Endocrinology and Metabolism |
Commentary/Editorial| Commentaire/Éditorial |
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Cuttler, JM, Bevelacqua, et al |
Dose-Response |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 Crisis and the Opportunities
to Advance Telemedicine |
Czerninski, R |
The Israel Medical Association journal : IMAJ |
Commentary/Editorial| Commentaire/Éditorial |
|
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The impact of the COVID-19 pandemic on oral biopsies in the Brazilian National Health System |
da Cunha, AR, Antunes, et al |
Oral Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Dall’Olio, R, Blacquiere, et al |
Journal of Apicultural Research |
Commentary/Editorial| Commentaire/Éditorial |
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Effectiveness of hydroxychloroquine in COVID-19 disease: A done and dusted deal? |
d'Arminio Monforte, A, Tavelli, et al |
International Journal of Infectious Diseases |
Commentary/Editorial| Commentaire/Éditorial |
|
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Bacillus Calmette-Guerin (BCG) as a Protective Factor for COVID-19? |
David, P, Shoenfeld, et al |
The Israel Medical Association journal : IMAJ |
Commentary/Editorial| Commentaire/Éditorial |
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Phase 2 of coronavirus disease (COVID-19) and head and neck cancer: An action plan |
De Felice, F, Valentini, et al |
Oral diseases |
Commentary/Editorial| Commentaire/Éditorial |
|
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De Franceschi, L, Costa, et al |
European journal of internal medicine |
Commentary/Editorial| Commentaire/Éditorial |
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De Guttry, A |
Global Jurist |
Commentary/Editorial| Commentaire/Éditorial |
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Deng, C, Chen, et al |
JAMA Ophthalmol |
Commentary/Editorial| Commentaire/Éditorial |
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Dequin, PF, Gouge, et al |
Statistics in Biopharmaceutical Research |
Commentary/Editorial| Commentaire/Éditorial |
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Preventing influenza and influenza like illness during Covid-19 pandemic:
A call for action |
d'Ettorre, G, Ceccarelli, et al |
Early human development |
Commentary/Editorial| Commentaire/Éditorial |
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Di Giacomo, D |
Mediterranean Journal of Clinical Psychology |
Commentary/Editorial| Commentaire/Éditorial |
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Diamond, R, Byrd, et al |
Journal of affective disorders |
Commentary/Editorial| Commentaire/Éditorial |
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Use of simulation to develop a COVID-19 resuscitation process in a pediatric emergency
department |
Diaz, MCG, Dawson, et al |
American Journal of Infection Control |
Commentary/Editorial| Commentaire/Éditorial |
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Didehban, R, Caine, et al |
Mayo Clinic proceedings |
Commentary/Editorial| Commentaire/Éditorial |
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Dinoto, A, Cheli, et al |
Seizure |
Commentary/Editorial| Commentaire/Éditorial |
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Divocha, VA, Gozhenko, et al |
Pharmacologyonline |
Commentary/Editorial| Commentaire/Éditorial |
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Dixit, A, Yadav, et al |
Malaysian Journal of Medical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Dobler, CC |
Breathe |
Commentary/Editorial| Commentaire/Éditorial |
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Aerosols in meat plants as possible cause of Covid-19 spread |
Donaldson, AI |
Veterinary Record |
Commentary/Editorial| Commentaire/Éditorial |
|
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Racism and media: a response from Australia during the global pandemic |
Dreher, T |
Ethnic and Racial Studies |
Commentary/Editorial| Commentaire/Éditorial |
|
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Public Opinion, Crisis, and Vulnerable Populations: The Case of Title IX and COVID-19 |
Druckman, JN, Sharrow, et al |
Politics and Gender |
Commentary/Editorial| Commentaire/Éditorial |
|
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Dubbels, VW |
Pharmazeutische Zeitung |
Commentary/Editorial| Commentaire/Éditorial |
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Duman, M, Bloom, et al |
Journal of Communication in Healthcare |
Commentary/Editorial| Commentaire/Éditorial |
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Dunavan, CP |
Am J Trop Med Hyg |
Commentary/Editorial| Commentaire/Éditorial |
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Dunnagan, CL, Gallardo-Williams, et al |
Journal of chemical education |
Commentary/Editorial| Commentaire/Éditorial |
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Duszak, R, J, et al |
Journal of the American College of Radiology |
Commentary/Editorial| Commentaire/Éditorial |
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Dyer, C |
BMJ (Clinical research ed.) |
Commentary/Editorial| Commentaire/Éditorial |
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Emmert, S |
JDDG - Journal of the German Society of Dermatology |
Commentary/Editorial| Commentaire/Éditorial |
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Safe Villages during the 1918-1919 influenza pandemic in Spain and Portugal |
Erkoreka, A |
Journal of preventive medicine and hygiene |
Commentary/Editorial| Commentaire/Éditorial |
|
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Eryilmaz, D, Patria, et al |
Electricity Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Essa, MM, Hamdan, et al |
International Journal of Tryptophan Research |
Commentary/Editorial| Commentaire/Éditorial |
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Impact of periodontal condition for individuals with covid-19 |
Esteves-Lima, R, Pereira, et al |
Journal of Oral Research |
Commentary/Editorial| Commentaire/Éditorial |
|
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Pregnant women in the context of the COVID-19 pandemic: Reflections and challenges |
Estrela, FM, da Silva, et al |
Physis |
Commentary/Editorial| Commentaire/Éditorial |
|
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Faddoul, A, de la Jonquière, et al |
Praticien en Anesthesie Reanimation |
Commentary/Editorial| Commentaire/Éditorial |
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Treatment of COVID-19: Perspective on Convalescent Plasma Transfusion |
Farhat, RM, Mousa, et al |
Frontiers in Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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Social workers of the world unite! A call to unionize the social work profession |
Farr, P |
International Social Work |
Commentary/Editorial| Commentaire/Éditorial |
|
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Faust, JS, Lin, et al |
JAMA network open |
Commentary/Editorial| Commentaire/Éditorial |
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Psychological impact of the Pandemic COVID-19 Outbreak Among Medical Residents in
Tunisia |
Fekih-Romdhane, F, Snene, et al |
Asian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
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Management of urology during COVID-19 pandemic: A perspective from Sichuan Province,
China |
Feng, D, Liu, et al |
International Journal of Surgery |
Commentary/Editorial| Commentaire/Éditorial |
|
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Ferreira, LLG, Andricopulo, et al |
Current Topics in Medicinal Chemistry |
Commentary/Editorial| Commentaire/Éditorial |
|
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World chagas disease day and the new road map for neglected tropical diseases |
Ferreira, LLG, Andricopulo, et al |
Current Topics in Medicinal Chemistry |
Commentary/Editorial| Commentaire/Éditorial |
|
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Finsterer, J, Scorza, et al |
Journal of medical virology |
Commentary/Editorial| Commentaire/Éditorial |
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Fitzgerald, DA, Maclean, et al |
Paediatric Respiratory Reviews |
Commentary/Editorial| Commentaire/Éditorial |
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Floyd, E, Garg, et al |
International Journal of Academic Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Fonseka, T, Ellis, et al |
Journal of Clinical Urology |
Commentary/Editorial| Commentaire/Éditorial |
|
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A Call for a National Agenda for a Healthy, Equitable, and Sustainable Food System |
Freudenberg, N, Nestle, et al |
Am J Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
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Friedman, DN, Blackler, et al |
JCO Oncol Pract |
Commentary/Editorial| Commentaire/Éditorial |
|
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Home working and cyber security – an outbreak of unpreparedness? |
Furnell, S, Shah, et al |
Computer Fraud and Security |
Commentary/Editorial| Commentaire/Éditorial |
|
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Mixed Distribution of Relief Materials with the Consideration of Demand Matching
Degree |
Gai, L, Jin, et al |
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Commentary/Editorial| Commentaire/Éditorial |
|
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International student experiences in Queensland during COVID-19 |
Gallagher, HL, Doherty, et al |
International Social Work |
Commentary/Editorial| Commentaire/Éditorial |
|
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Gallego, P, Ruperti-Repilado, et al |
Revista espanola de cardiologia |
Commentary/Editorial| Commentaire/Éditorial |
|
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All That Glitters Isn't Gold: Critical Care in the Time of Coronavirus Disease
2019 |
Gallo de Moraes, A, Carroll, et al |
Chest |
Commentary/Editorial| Commentaire/Éditorial |
|
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Gamus, A, Chodick, et al |
The Israel Medical Association journal : IMAJ |
Commentary/Editorial| Commentaire/Éditorial |
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Research progress on coronavirus prevention and control in animal-source foods |
Gan, Y, Tan, et al |
Journal of Multidisciplinary Healthcare |
Commentary/Editorial| Commentaire/Éditorial |
|
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Gao, Y |
EClinicalMedicine |
Commentary/Editorial| Commentaire/Éditorial |
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Changes in orthodontics during the COVID-19 pandemic that have come to stay |
García-Camba, P, Marcianes, et al |
American Journal of Orthodontics and Dentofacial Orthopedics |
Commentary/Editorial| Commentaire/Éditorial |
|
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Gates, TG, Beazley, et al |
International Social Work |
Commentary/Editorial| Commentaire/Éditorial |
|
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Headache relevance in outpatient activity during Covid-19 pandemic |
Gatti, F, Manneschi, et al |
Neurol Sci |
Commentary/Editorial| Commentaire/Éditorial |
|
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COVID-19, fever and dressings used for pressure ulcer prevention: monthly update |
Gefen, A, Ousey, et al |
Journal of wound care |
Commentary/Editorial| Commentaire/Éditorial |
|
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What is efficacy of BCG vaccination in protection from COVID-19 in European countries? |
Ghazvini, K, Keikha, et al |
Pharmacien Hospitalier et Clinicien |
Commentary/Editorial| Commentaire/Éditorial |
|
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SARS-CoV-2 and extended lockdown: A new lesson for India’s alcohol policy? |
Ghosh, A, Choudhury, et al |
Journal of Studies on Alcohol and Drugs |
Commentary/Editorial| Commentaire/Éditorial |
|
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Combating covid-19: Lessons learnt particularly among developing countries and the
implications |
Godman, B |
Bangladesh Journal of Medical Science |
Commentary/Editorial| Commentaire/Éditorial |
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Goel, A, Gupta, et al |
J Clin Rheumatol |
Commentary/Editorial| Commentaire/Éditorial |
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Goodbred, A |
International Journal of Academic Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Goon, DT, Okafor, et al |
Open Public Health Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Gopalan, PD, Joubert, et al |
South African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Infringement of preventive health measure misdemeanor in pandemic
times |
Gordilho, H, Gondim, et al |
Revista Juridica |
Commentary/Editorial| Commentaire/Éditorial |
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So much at stake: Ethical tradeoffs in accelerating SARSCoV-2 vaccine development |
Grady, C, Shah, et al |
Vaccine |
Commentary/Editorial| Commentaire/Éditorial |
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Gräfe, VKA |
Pharmazeutische Zeitung |
Commentary/Editorial| Commentaire/Éditorial |
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Graham, C, Mizen, et al |
British Journal of Oral and Maxillofacial Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Graz, B, Houriet, et al |
Rev Med Suisse |
Commentary/Editorial| Commentaire/Éditorial |
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Grimaldi, PW, , et al |
HSS Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Guideline for medical certification of death in the COVID-19 era |
Groenewald, P, Awotiwon, et al |
South African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Gu, Y, Wang, et al |
Fudan University Journal of Medical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Guerriaud, M |
Medecine et Droit |
Commentary/Editorial| Commentaire/Éditorial |
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Gulati, RR, Reid, et al |
Education for Primary Care |
Commentary/Editorial| Commentaire/Éditorial |
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Guo, T, Chen, et al |
Statistics in Biopharmaceutical Research |
Commentary/Editorial| Commentaire/Éditorial |
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Gutierrez Fernandez, PJ, III |
Risk Management and Insurance Review |
Commentary/Editorial| Commentaire/Éditorial |
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Hadjiyiannakis, D, Dimitroyannis, et al |
Clinical oncology |
Commentary/Editorial| Commentaire/Éditorial |
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Hansen, DS |
Trends in parasitology |
Commentary/Editorial| Commentaire/Éditorial |
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From Zero to a National Data Set in 2 Weeks: Reflections on a COVID-19 Collaborative
Survey Project |
Hargittai, E, Nguyen, et al |
Social Media and Society |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19, bar crowding, and the Wisconsin Supreme Court: A non-linear tale of
two counties |
Harris, JE |
Research in International Business and Finance |
Commentary/Editorial| Commentaire/Éditorial |
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Hascalovici, J, Shaparin, et al |
Pain Physician |
Commentary/Editorial| Commentaire/Éditorial |
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Hasoon, J, Al-Jumah, et al |
Pain Physician |
Commentary/Editorial| Commentaire/Éditorial |
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Hasoon, J, Burroughs, et al |
Pain Physician |
Commentary/Editorial| Commentaire/Éditorial |
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The “New” Problem of Humanity: New Coronavirus (2019-nCoV / COVID-19) Disease |
Hatipoğlu, N |
Medical Journal of Bakirkoy |
Commentary/Editorial| Commentaire/Éditorial |
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Can a gluten-free diet be partly protective for covid-19 infection? |
Haupt-Jorgensen, M, Buschard, et al |
APMIS |
Commentary/Editorial| Commentaire/Éditorial |
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Haussner, W, Garg, et al |
International Journal of Academic Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Heffron, RJ, Sheehan, et al |
Journal of Energy and Natural Resources Law |
Commentary/Editorial| Commentaire/Éditorial |
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Helding, L, Carroll, et al |
Journal of Voice |
Commentary/Editorial| Commentaire/Éditorial |
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The COVID-19 Outbreak: A Game-Changer in Reinforcing the Use of Telemedicine in
Dermatology? |
Hemdani, R, Rathod, et al |
Skinmed |
Commentary/Editorial| Commentaire/Éditorial |
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Hervé, C |
Ethics, Medicine and Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Lean in or out: How to balance when the world turns upside down? |
Hickman, AW, Rosman, et al |
International Journal of Women's Dermatology |
Commentary/Editorial| Commentaire/Éditorial |
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Hinchliffe, N, Bullen, et al |
Practical Diabetes |
Commentary/Editorial| Commentaire/Éditorial |
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Graduate medical education: A walk in our shoes during the COVID-19 pandemic |
Hoey, A, Stewart, et al |
International Journal of Academic Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Hoffman, JA, Miller, et al |
World Medical and Health Policy |
Commentary/Editorial| Commentaire/Éditorial |
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Hoffman, WW |
South Dakota medicine : the journal of the South Dakota State Medical Association |
Commentary/Editorial| Commentaire/Éditorial |
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Hohmann-Jeddi, V |
Pharmazeutische Zeitung |
Commentary/Editorial| Commentaire/Éditorial |
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Holton, AJ |
Journal of chemical education |
Commentary/Editorial| Commentaire/Éditorial |
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Hopkins, C, Alanin, et al |
Clin Otolaryngol |
Commentary/Editorial| Commentaire/Éditorial |
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Hosomi, R, Lefor, et al |
International Journal of Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Hower, KI, Pfaff, et al |
Pflege |
Commentary/Editorial| Commentaire/Éditorial |
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Gesundheitsverhalten und Bedürfnisse von Menschen mit COPD während der COVID-19-Pandemie |
Hübsch, C, Clarenbach, et al |
Pflege |
Commentary/Editorial| Commentaire/Éditorial |
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Capitalism in Australia: New histories for a reimagined future |
Huf, B, Rees, et al |
Thesis Eleven |
Commentary/Editorial| Commentaire/Éditorial |
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Hughes, J |
Life Writing |
Commentary/Editorial| Commentaire/Éditorial |
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Information frictions and access to the Paycheck Protection Program |
Humphries, JE, Neilson, et al |
Journal of Public Economics |
Commentary/Editorial| Commentaire/Éditorial |
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Hussain, K, Patel, et al |
Clin Exp Dermatol |
Commentary/Editorial| Commentaire/Éditorial |
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Identification of Exertional Hypoxia and Its Implications in SARS-CoV-2 Pneumonia |
Hussain, T, Saman, et al |
Am J Trop Med Hyg |
Commentary/Editorial| Commentaire/Éditorial |
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Hüttemann, VD |
Pharmazeutische Zeitung |
Commentary/Editorial| Commentaire/Éditorial |
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Hüttemann, VD |
Pharmazeutische Zeitung |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19: APPROACHES, OUTLOOKS, AND POWER DYNAMICS IN CENTRAL ASIA |
Ibbotson, S |
Asian Affairs |
Commentary/Editorial| Commentaire/Éditorial |
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The contagion of sentiments during the covid-19 pandemic crisis: The case of isolation
in spain |
Iglesias-Sánchez, PP, Witt, et al |
International Journal of Environmental Research and Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Insalaco, G, Dal Farra, et al |
Respiration |
Commentary/Editorial| Commentaire/Éditorial |
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The net worth trap: Investment and output dynamics in the presence of financing constraints |
Isohätälä, J, Milne, et al |
Mathematics |
Commentary/Editorial| Commentaire/Éditorial |
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Jakovljevic, M, Jakovljevic, et al |
Psychiatria Danubina |
Commentary/Editorial| Commentaire/Éditorial |
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Current ethical challenges in intensive care in the face of the corona pandemic |
Janssens, U |
Deutsche medizinische Wochenschrift (1946) |
Commentary/Editorial| Commentaire/Éditorial |
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Jaskuła, E, Lange, et al |
Pol Arch Intern Med |
Commentary/Editorial| Commentaire/Éditorial |
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Jassi, A, Shahriyarmolki, et al |
Cognitive Behaviour Therapist |
Commentary/Editorial| Commentaire/Éditorial |
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Jia, H, Han, et al |
Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Jieru, D, Canjun, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Collateral damage: How COVID-19 is adversely impacting women physicians |
Jones, Y, Durand, et al |
Journal of Hospital Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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School Closures and Mental Health Concerns for Children and Adolescents during the
COVID-19 Pandemic |
Joseph, SJ, Bhandari, et al |
Psychiatria Danubina |
Commentary/Editorial| Commentaire/Éditorial |
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Valorization of disposable COVID-19 mask through the thermo-chemical process |
Jung, S, Lee, et al |
Chemical Engineering Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
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Kahana, E |
International Journal of Intelligence and CounterIntelligence |
Commentary/Editorial| Commentaire/Éditorial |
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Strategies and key points of perioperative management of coronavirus disease
2019 patients |
Kai-Min, Z, Guo-Lin, et al |
Academic Journal of Second Military Medical University |
Commentary/Editorial| Commentaire/Éditorial |
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Kalcev, G, Preti, et al |
Open Public Health Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Kalra, S, Mittal, et al |
JPMA.The Journal of the Pakistan Medical Association |
Commentary/Editorial| Commentaire/Éditorial |
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Occupational therapy: The key to unlocking locked-up occupations during the
COVID-19 pandemic |
Kamalakannan, S, Chakraborty, et al |
Wellcome Open Research |
Commentary/Editorial| Commentaire/Éditorial |
|
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Kamran, A, Naeim, et al |
Archives of Psychiatric Nursing |
Commentary/Editorial| Commentaire/Éditorial |
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Mobile Cardiac Monitoring During the COVID-19 Pandemic: Necessity is the Mother of Invention |
Kancharla, K, Mark Estes, et al |
J Cardiovasc Electrophysiol |
Commentary/Editorial| Commentaire/Éditorial |
|
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Farmers Distress During the COVID-19 Lock Down: Psychosocial Response |
Kapse, Praful |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
|
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Taking care of vascular access in patients with cancer following the prevalence of covid-19 |
Karimian, M, Solaimanizadeh, et al |
International Journal of Cancer Management |
Commentary/Editorial| Commentaire/Éditorial |
|
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Karuppiah, A, Bharadwaj, et al |
American journal of disaster medicine |
Commentary/Editorial| Commentaire/Éditorial |
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It is time to drop hydroxychloroquine from our COVID-19 armamentarium |
Kashour, T, Tleyjeh, et al |
Medical hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
|
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The role of COVID-19 in shaping the experiences
of pain medicine fellowship training |
Kassem, H, Urits, et al |
Pain Physician |
Commentary/Editorial| Commentaire/Éditorial |
|
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Kaunda, CJ |
Expository Times |
Commentary/Editorial| Commentaire/Éditorial |
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Keric, D, Stafford, et al |
Drug Alcohol Rev |
Commentary/Editorial| Commentaire/Éditorial |
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Khadka, S, Shrestha, et al |
Clinical Pharmacology: Advances and Applications |
Commentary/Editorial| Commentaire/Éditorial |
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Managing mental health in pandemic covid-19 and movement control order |
Khaiyom, JHA |
Malaysian Journal of Medical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
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Khitan, ZJ, Khawaja, et al |
Medical hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
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Catching our breath: reshaping rehabilitation services for COVID-19 |
Khoo, TC, Jesudason, et al |
Disabil Rehabil |
Commentary/Editorial| Commentaire/Éditorial |
|
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Flattening the anxiety curve: Obstetricians’ response to the COVID-19 pandemic in Victoria |
Khot, N, Kumar, et al |
Australian and New Zealand Journal of Obstetrics and Gynaecology |
Commentary/Editorial| Commentaire/Éditorial |
|
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What Stone-formers Should Know About Vitamin C and D Supplementation in the COVID-19
Era |
Khusid, JA, Atallah, et al |
European Urology Open Science |
Commentary/Editorial| Commentaire/Éditorial |
|
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Kilvert, A, Wilmot, et al |
Practical Diabetes |
Commentary/Editorial| Commentaire/Éditorial |
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Effects of COVID-19 on preferences for private dining facilities in restaurants |
Kim, J, Lee, et al |
Journal of Hospitality and Tourism Management |
Commentary/Editorial| Commentaire/Éditorial |
|
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Kitara, DL, Ikoona, et al |
Pan African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Ethics of Digital Contact Tracing and COVID-19: Who Is (Not) Free
to Go? |
Klenk, Michael, Duijf, et al |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
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König, J, Jäger-Biela, et al |
European Journal of Teacher Education |
Commentary/Editorial| Commentaire/Éditorial |
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Nursing fundamentals – supporting clinical competency online during the COVID-19
pandemic |
Konrad, S, Fitzgerald, et al |
Teaching and Learning in Nursing |
Commentary/Editorial| Commentaire/Éditorial |
|
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Kow, CS, Hasan, et al |
Drugs and Therapy Perspectives |
Commentary/Editorial| Commentaire/Éditorial |
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Aerosol and surface persistence: Novel SARS-CoV-2 versus other coronaviruses |
Krishan, K, Kanchan, et al |
Journal of infection in developing countries |
Commentary/Editorial| Commentaire/Éditorial |
|
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Kristoufek, L |
Frontiers in Physics |
Commentary/Editorial| Commentaire/Éditorial |
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Kusotera, T, Nhengu, et al |
African journal of primary health care & family medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Lahmiri, S, Bekiros, et al |
Entropy |
Commentary/Editorial| Commentaire/Éditorial |
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Contactless u: Higher education in the postcoronavirus world |
Laplante, P |
Computer |
Commentary/Editorial| Commentaire/Éditorial |
|
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Lauer, JK, Acker, et al |
Seminars in perinatology |
Commentary/Editorial| Commentaire/Éditorial |
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Leacock, CJ, Warrican, et al |
Journal of Education for Teaching |
Commentary/Editorial| Commentaire/Éditorial |
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Lee, JJ, Chu, et al |
Clinical Colorectal Cancer |
Commentary/Editorial| Commentaire/Éditorial |
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Academics in Absentia: An Opportunity to Rethink Conferences in the Age of Coronavirus
Cancellations |
Lessing, JN, Anderson, et al |
Acad Med |
Commentary/Editorial| Commentaire/Éditorial |
|
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Levine, DT, Morton, et al |
Child Abuse and Neglect |
Commentary/Editorial| Commentaire/Éditorial |
|
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Ley, C |
Appropriate Technology |
Commentary/Editorial| Commentaire/Éditorial |
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Ley, C |
Appropriate Technology |
Commentary/Editorial| Commentaire/Éditorial |
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Leys, D |
European Journal of Neurology |
Commentary/Editorial| Commentaire/Éditorial |
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Practical research of intelligence in epidemic prevention product design |
Li, M, Pan, et al |
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Commentary/Editorial| Commentaire/Éditorial |
|
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Li, S, Li, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Li, Y, Bi, et al |
Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Liang, F, Dong, et al |
Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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Midsemester Transition to Remote Instruction in a Flipped College-Level Organic
Chemistry Course |
Liberman-Martin, A, Ogba, et al |
Journal of chemical education |
Commentary/Editorial| Commentaire/Éditorial |
|
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The effect of novel coronavirus pandemic on tourism share prices |
Liew, VKS |
Journal of Tourism Futures |
Commentary/Editorial| Commentaire/Éditorial |
|
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Social distancing and isolation during COVID-19 in Brazil: Impacts on mental
health |
Lima, RC |
Physis |
Commentary/Editorial| Commentaire/Éditorial |
|
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5G Communication Technology and Coronavirus Disease [Health Matters] |
Lin, JC |
IEEE Microwave Magazine |
Commentary/Editorial| Commentaire/Éditorial |
|
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Linz, W, Andrzejewski, et al |
Journal of clinical apheresis |
Commentary/Editorial| Commentaire/Éditorial |
|
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Recovery from the pandemic: evidence-based public policy to safeguard health |
Lo, SN, Skarbek, et al |
Med J Aust |
Commentary/Editorial| Commentaire/Éditorial |
|
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Scrutinising COVIDSafe: Frameworks for evaluating digital contact tracing technologies |
Lodders, A, Paterson, et al |
Alternative Law Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
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Recommendations for return to sport during the SARS-CoV-2 pandemic |
Löllgen, H, Bachl, et al |
BMJ Open Sport and Exercise Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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Social policy responses to the COVID-19 crisis in China in 2020 |
Lu, Q, Cai, et al |
International Journal of Environmental Research and Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
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Lucchinetti, CF, von Bormann, et al |
Mayo Clinic proceedings |
Commentary/Editorial| Commentaire/Éditorial |
|
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Editorial of Special Column “Research on Emerging COVID-19 (Target, Mechanism,
and Therapeutics)” |
Luo, HB, Chen, et al |
Acta Pharmaceutica Sinica B |
Commentary/Editorial| Commentaire/Éditorial |
|
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Luttrell, A, Petty, et al |
Social Psychological and Personality Science |
Commentary/Editorial| Commentaire/Éditorial |
|
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Management of oral medicine emergencies during COVID-19: A study to develop practise
guidelines |
Lv, N, Sun, et al |
Journal of Dental Sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
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Lyons, A, McDonald, et al |
British Journal of Oral and Maxillofacial Surgery |
Commentary/Editorial| Commentaire/Éditorial |
|
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Proposing “healing tourism” as a post-COVID-19 tourism product |
Ma, S, Zhao, et al |
Anatolia |
Commentary/Editorial| Commentaire/Éditorial |
|
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Madzimbamuto, FD |
African journal of primary health care & family medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Maffettone, P, Oldani, et al |
Global Policy |
Commentary/Editorial| Commentaire/Éditorial |
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Maher, R, Murphet, et al |
Media International Australia |
Commentary/Editorial| Commentaire/Éditorial |
|
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Benchmarks for INGOs’ effective responses during COVID-19 pandemic |
Mahmoud Saleh, FI, Karia, et al |
Benchmarking |
Commentary/Editorial| Commentaire/Éditorial |
|
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Mahmoudi, M, Keashly, et al |
BioImpacts |
Commentary/Editorial| Commentaire/Éditorial |
|
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State support for the russian economy affected by covid-19 consequences (legal
aspects) |
Malinovsky, AA, Osina, et al |
Lecture Notes in Networks and Systems |
Commentary/Editorial| Commentaire/Éditorial |
|
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(Dis)embodied encounters between art and academic writing amid a pandemic |
Mandalaki, E, Daou, et al |
Gender, Work and Organization |
Commentary/Editorial| Commentaire/Éditorial |
|
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Preventive
care in india-86 years ago: Resemblance with covid-19 prevention |
Mankad, V |
Journal of the Indian Medical Association |
Commentary/Editorial| Commentaire/Éditorial |
|
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Mankad, V |
Journal of the Indian Medical Association |
Commentary/Editorial| Commentaire/Éditorial |
|
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Marchetti, F, Guiducci, et al |
Medico e Bambino |
Commentary/Editorial| Commentaire/Éditorial |
|
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Reduction of contagion risks by sarscov-2 (Covid-19)
in air-conditioned work environments |
Marcone, V |
Pain Physician |
Commentary/Editorial| Commentaire/Éditorial |
|
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Martin, A, Lang, et al |
JDDG - Journal of the German Society of Dermatology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Martinez, R, Masron, et al |
Cities |
Commentary/Editorial| Commentaire/Éditorial |
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Martínez-Infante, A, Quintero-Pérez, et al |
Revista Cubana de Investigaciones Biomedicas |
Commentary/Editorial| Commentaire/Éditorial |
|
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COVID-19 & an NGO and university developed interactive portal: a perspective from
Iran |
Maserat, E, Jafari, et al |
Health and Technology |
Commentary/Editorial| Commentaire/Éditorial |
|
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On Occasion of the COVID-19 Pandemic - One of the Most Important Dilemma: Vaccinate
or Not? |
Masic, I, Gerc, et al |
Medical archives (Sarajevo, Bosnia and Herzegovina) |
Commentary/Editorial| Commentaire/Éditorial |
|
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Masoudi-Sobhanzadeh, Y |
BioImpacts |
Commentary/Editorial| Commentaire/Éditorial |
|
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How we accelerated clinical trials in the age of coronavirus |
Mather, N |
Nature |
Commentary/Editorial| Commentaire/Éditorial |
|
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Immigrant physicians fill a critical need in COVID-19 response |
Mathews, BK, Malik, et al |
Journal of Hospital Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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Mathian, A, Amoura, et al |
Annals of the Rheumatic Diseases |
Commentary/Editorial| Commentaire/Éditorial |
|
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Mathian, A, Amoura, et al |
Annals of the Rheumatic Diseases |
Commentary/Editorial| Commentaire/Éditorial |
|
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Roadmap to strengthen global mental health systems to tackle the impact of the
COVID-19 pandemic |
Maulik, PK, Thornicroft, et al |
International Journal of Mental Health Systems |
Commentary/Editorial| Commentaire/Éditorial |
|
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Mc Crory, PV |
British dental journal |
Commentary/Editorial| Commentaire/Éditorial |
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McCulley, L, Cheng, et al |
Clin Toxicol (Phila) |
Commentary/Editorial| Commentaire/Éditorial |
|
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McLennan, AmyK, Hansen, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
|
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McMahon, M, Nadigel, et al |
Healthcare policy = Politiques de sante |
Commentary/Editorial| Commentaire/Éditorial |
|
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Medina, MG, Giovanella, et al |
Cadernos de saude publica |
Commentary/Editorial| Commentaire/Éditorial |
|
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Meiler, S, Hamer, et al |
Journal of Vascular and Interventional Radiology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Mende, VA |
Pharmazeutische Zeitung |
Commentary/Editorial| Commentaire/Éditorial |
|
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Mertz, L |
IEEE pulse |
Commentary/Editorial| Commentaire/Éditorial |
|
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Responding to COVID-19: Community volunteerism and coproduction in China |
Miao, Q, Schwarz, et al |
World Development |
Commentary/Editorial| Commentaire/Éditorial |
|
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The covid-19 pandemic as a reflection opportunity in health sciencies education |
Millán, T, Heresi, et al |
Revista chilena de pediatria |
Commentary/Editorial| Commentaire/Éditorial |
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The COVID-19 Pandemic Crisis: The Loss and Trauma Event of Our Time |
Miller, ED |
Journal of Loss and Trauma |
Commentary/Editorial| Commentaire/Éditorial |
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Disruption and dislocation in post-COVID futures for digital health |
Milne, R, Costa, et al |
Big Data and Society |
Commentary/Editorial| Commentaire/Éditorial |
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Mir, N, D'Amico, et al |
Blood reviews |
Commentary/Editorial| Commentaire/Éditorial |
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Mishra, V, Dexter, et al |
JAMA network open |
Commentary/Editorial| Commentaire/Éditorial |
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The coronavirus crisis as tipping point: communicating the environment in a time
of pandemic |
Mocatta, G, Hawley, et al |
Media International Australia |
Commentary/Editorial| Commentaire/Éditorial |
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The ICU medical director leadership during Covid-19 pandemic |
Modrykamien, AM |
American journal of disaster medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Pulmonary Limited ANCA-Associated Vasculitis Mimicking COVID-19 |
Moezinia, CJ, Ji-Xu, et al |
J Clin Rheumatol |
Commentary/Editorial| Commentaire/Éditorial |
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Mollenkopf, DA, Ozanne, et al |
Journal of Service Management |
Commentary/Editorial| Commentaire/Éditorial |
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Montgomery, J, Stokes-Lampard, et al |
Journal of the Intensive Care Society |
Commentary/Editorial| Commentaire/Éditorial |
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Moorhouse, BL, Beaumont, et al |
TESOL Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Morris, ZA, Dragone, et al |
Social Work Education |
Commentary/Editorial| Commentaire/Éditorial |
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Muhammad, F |
Open Public Health Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Mukherjee, S, Bhattacharyya, et al |
Biophysical chemistry |
Commentary/Editorial| Commentaire/Éditorial |
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Mukumbang, FC, Kriel, et al |
South African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Online doctoral mentoring in a pandemic: help or hindrance to academic progress
on dissertations? |
Mullen, CA |
International Journal of Mentoring and Coaching in Education |
Commentary/Editorial| Commentaire/Éditorial |
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Muse, IO, Montilla, et al |
Journal of clinical anesthesia |
Commentary/Editorial| Commentaire/Éditorial |
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Teacher education and Covid-19: responses and opportunities for new pedagogical
initiatives |
Mutton, T |
Journal of Education for Teaching |
Commentary/Editorial| Commentaire/Éditorial |
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Nadeem, T, Siddiqui, et al |
Psychol Trauma |
Commentary/Editorial| Commentaire/Éditorial |
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Patient-centric research in the time of COVID-19: Conducting ethical COVID-19 research
in Africa |
Nembaware, V, Munung, et al |
BMJ Global Health |
Commentary/Editorial| Commentaire/Éditorial |
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The Art of Surgery: Balancing Compassionate With Virtual Care |
Nemetz, ETA, Urbach, et al |
J Med Internet Res |
Commentary/Editorial| Commentaire/Éditorial |
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Ng, SM |
Practical Diabetes |
Commentary/Editorial| Commentaire/Éditorial |
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Letter to the Editor: New onset psychosis and mania following COVID-19 infection |
Noone, R, Cabassa, et al |
Journal of psychiatric research |
Commentary/Editorial| Commentaire/Éditorial |
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Norbash, AM, Moore, et al |
Journal of the American College of Radiology |
Commentary/Editorial| Commentaire/Éditorial |
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The preventive strategies of COVID-19 pandemic in Saudi Arabia |
Nurunnabi, M |
Journal of Microbiology, Immunology and Infection |
Commentary/Editorial| Commentaire/Éditorial |
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The looming dangers of explosion in community transmissions of covid-19 in nigeria |
Nwozor, A, Okolie, et al |
Annals of Global Health |
Commentary/Editorial| Commentaire/Éditorial |
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Nyasulu, J, Pandya, et al |
African Journal of Primary Health Care and Family Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Dishonesty during a pandemic: The concealment of COVID-19 information |
O’Connor, AM, Evans, et al |
Journal of Health Psychology |
Commentary/Editorial| Commentaire/Éditorial |
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Oborn, EM, Barrett, et al |
BMJ Leader |
Commentary/Editorial| Commentaire/Éditorial |
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Olabumuyi, AA, Ali-Gombe, et al |
Pan African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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The homeless, inmates and refugees in africa in the face of covid-19 outbreak |
Oladimeji, O, Atiba, et al |
Open Public Health Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Caring for Patients With Cancer in the Face of Self-Vulnerability During the COVID-19
Pandemic-Reply |
Olazagasti, C, Seetharamu, et al |
JAMA Oncol |
Commentary/Editorial| Commentaire/Éditorial |
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Oncel, MY, Akın, et al |
European journal of pediatrics |
Commentary/Editorial| Commentaire/Éditorial |
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Virtual Medical Spanish Education at the Corazón of Hispanic/Latinx Health During
COVID-19 |
Ortega, P, Shin, et al |
Medical Science Educator |
Commentary/Editorial| Commentaire/Éditorial |
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Digitalization of higher legal education in russia in the age of covid-19 |
Osina, DM, Tolstopyatenko, et al |
Lecture Notes in Networks and Systems |
Commentary/Editorial| Commentaire/Éditorial |
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Osman, ME |
Journal of Education for Teaching |
Commentary/Editorial| Commentaire/Éditorial |
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The COVID-19 Pandemic and Its Impact on Children in Domestic Violence Refuges |
Øverlien, C |
Child Abuse Review |
Commentary/Editorial| Commentaire/Éditorial |
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Fumigation of Schools for COVID-19 Prevention in Nigeria: The Need for a Rethink |
Oyeyemi, A, Adesina, et al |
Am J Trop Med Hyg |
Commentary/Editorial| Commentaire/Éditorial |
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Vehicle routing for the urgent delivery of face shields during the COVID-19 pandemic |
Pacheco, J, Laguna, et al |
Journal of Heuristics |
Commentary/Editorial| Commentaire/Éditorial |
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Social representations of COVID-19 (Representaciones sociales del COVID-19) |
Páez, D, Pérez, et al |
Revista de Psicologia Social |
Commentary/Editorial| Commentaire/Éditorial |
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Pallanti, S, Grassi, et al |
Journal of psychiatric research |
Commentary/Editorial| Commentaire/Éditorial |
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E-commerce and its importance in times of covid-19 in Northern Peru |
Palomino Pita, AF, Carolina, et al |
Revista Venezolana de Gerencia |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19,
Serendipity, and Strange Interlude: Gloria in Absurdicum with an Apology to Ovid |
Parish, LC, Lambert, et al |
Skinmed |
Commentary/Editorial| Commentaire/Éditorial |
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Parivudhiphongs, A |
Journal of Urban Culture Research |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 Era Impacts on the American Academy of Ophthalmology |
Parke, DW, , et al |
Ophthalmology |
Commentary/Editorial| Commentaire/Éditorial |
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How does sars-cov-2 manipulates the immune system? Critical role of th1, th2, th17
responses |
Pat, Y, Alkan, et al |
Turkish Journal of Immunology |
Commentary/Editorial| Commentaire/Éditorial |
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Patel, T, Wong, et al |
British dental journal |
Commentary/Editorial| Commentaire/Éditorial |
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Recasting social workers as frontline in a socially accountable COVID-19 response |
Paul, TJ, de Bruin, et al |
International Social Work |
Commentary/Editorial| Commentaire/Éditorial |
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Researching with the Sturm und Drang of COVID-19: telling tales of teachers' teaching |
Pelosi, L, Vicars, et al |
Qualitative Research Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Perlman, S |
Nature |
Commentary/Editorial| Commentaire/Éditorial |
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Phyu Khin, P, Cha, et al |
Medical hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
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Poletti, M |
Trends in Neuroscience and Education |
Commentary/Editorial| Commentaire/Éditorial |
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Response to: 'Rational use of tocilizumab in COVID-19' by Jain and Sharma |
Potere, N, Di Nisio, et al |
Annals of the Rheumatic Diseases |
Commentary/Editorial| Commentaire/Éditorial |
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Hygiene resource practitioners’ experience, at a time of health challenges |
Pougnet, L, Raposo, et al |
Revue de l'infirmiere |
Commentary/Editorial| Commentaire/Éditorial |
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Present and future impact of COVID-19 in the renewable energy sector: a case
study on India |
Pradhan, S, Ghose, et al |
Energy Sources, Part A: Recovery, Utilization and Environmental Effects |
Commentary/Editorial| Commentaire/Éditorial |
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Prayag, G |
Tourism Review International |
Commentary/Editorial| Commentaire/Éditorial |
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Prem, A, Anand, et al |
Pain Physician |
Commentary/Editorial| Commentaire/Éditorial |
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Prentice, C, Chen, et al |
Journal of Retailing and Consumer Services |
Commentary/Editorial| Commentaire/Éditorial |
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Quaranta, L, Micheletti, et al |
J Glaucoma |
Commentary/Editorial| Commentaire/Éditorial |
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Safety and Impact of Nasal Lavages During Viral Infections Such as SARS-CoV-2 |
Radulesco, T, Lechien, et al |
Ear Nose Throat J |
Commentary/Editorial| Commentaire/Éditorial |
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Rafa, N, Uddin, et al |
Water International |
Commentary/Editorial| Commentaire/Éditorial |
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Ralph Edwards, I, Lindquist, et al |
The International journal of risk & safety in medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Impact of COVID-19 lockdown on self-managed weight loss journeys |
Ramachandran, D, Gill, et al |
Obesity Research and Clinical Practice |
Commentary/Editorial| Commentaire/Éditorial |
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Ramachandran, P, Swamy, et al |
Chest |
Commentary/Editorial| Commentaire/Éditorial |
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Rampini, SK, Wolfensberger, et al |
South African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Ramsay, S |
International Social Work |
Commentary/Editorial| Commentaire/Éditorial |
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Razonable, RR, Carmona, et al |
Mayo Clinic proceedings |
Commentary/Editorial| Commentaire/Éditorial |
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Ren, FF, Guo, et al |
Psychiatria Danubina |
Commentary/Editorial| Commentaire/Éditorial |
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Fruitful Neutralizing Antibody Pipeline Brings Hope To Defeat SARS-Cov-2 |
Renn, A, Fu, et al |
Trends in pharmacological sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Reynolds, P |
IEEE pulse |
Commentary/Editorial| Commentaire/Éditorial |
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Drive-Through Model for Anticoagulation Clinics During the COVID-19 Pandemic |
Rezaei Bookani, K, Minga, et al |
Clinical and Applied Thrombosis/Hemostasis |
Commentary/Editorial| Commentaire/Éditorial |
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Rieder, HL |
Indian Journal of Tuberculosis |
Commentary/Editorial| Commentaire/Éditorial |
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Obesity and COVID-19: Molecular Mechanisms Linking Both Pandemics |
Ritter, A, Kreis, et al |
International journal of molecular sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Robinson, LA, Pierce, et al |
Journal of the Royal Society of Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Robledo, AR, Borroto, et al |
Revista Cubana de Investigaciones Biomedicas |
Commentary/Editorial| Commentaire/Éditorial |
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Robson, B |
Computers in biology and medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Nourishing and protecting our urban ‘green’ space in a post-pandemic world |
Rodgers, C |
Environmental Law Review |
Commentary/Editorial| Commentaire/Éditorial |
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Regulation of COVID-19 fake news infodemic in China and India |
Rodrigues, UM, Xu, et al |
Media International Australia |
Commentary/Editorial| Commentaire/Éditorial |
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SARS-CoV-2 Coronavirus Pandemic: Now Is the Right Time to Stop Smoking |
Rojnić Palavra, I, Bodor, et al |
Psychiatria Danubina |
Commentary/Editorial| Commentaire/Éditorial |
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Rollands, JS |
Family process |
Commentary/Editorial| Commentaire/Éditorial |
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Impact of Coronavirus Disease 2019 (COVID-19) on the Practice of Clinical Radiology |
Rosen, MP, Norbash, et al |
Journal of the American College of Radiology |
Commentary/Editorial| Commentaire/Éditorial |
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Clarifying the record on hydroxychloroquine for the treatment of patients hospitalized
with COVID-19 |
Rosenberg, ES, Holtgrave, et al |
International Journal of Infectious Diseases |
Commentary/Editorial| Commentaire/Éditorial |
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Dental care and the COVID-19 pandemic: The precautionary principle and the best available
evidence |
Rösing, CK, Cavagni, et al |
Pesquisa Brasileira em Odontopediatria e Clinica Integrada |
Commentary/Editorial| Commentaire/Éditorial |
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The COVID-19 Crisis and Its Impact on the Future of Healthcare |
Rosser, JB, J |
JSLS : Journal of the Society of Laparoendoscopic Surgeons |
Commentary/Editorial| Commentaire/Éditorial |
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Roth, C, Berat, et al |
Rev Med Suisse |
Commentary/Editorial| Commentaire/Éditorial |
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Rui, W, Hong-Yong, et al |
Medical Journal of Chinese People's Liberation Army |
Commentary/Editorial| Commentaire/Éditorial |
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Ruscitti, P, Giacomelli, et al |
The Israel Medical Association journal : IMAJ |
Commentary/Editorial| Commentaire/Éditorial |
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Russo, A, Cirella, et al |
Agriculture (Switzerland) |
Commentary/Editorial| Commentaire/Éditorial |
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Sabahat, M, Naeem, et al |
Pakistan Journal of Medical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Sabando Vélez, BE, Plaza Meneses, et al |
Journal of infection in developing countries |
Commentary/Editorial| Commentaire/Éditorial |
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Sandy-Hodgetts, K |
Journal of wound care |
Commentary/Editorial| Commentaire/Éditorial |
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Santos, LMD |
International Journal of Environmental Research and Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Criteria for establishing an association between Covid-19 and hearing loss |
Satar, B |
American Journal of Otolaryngology - Head and Neck Medicine and Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Savastano, D |
Ink World |
Commentary/Editorial| Commentaire/Éditorial |
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Savastano, D |
Ink World |
Commentary/Editorial| Commentaire/Éditorial |
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It's Time to Resolve the Direct Care Workforce Crisis in Long-Term Care |
Scales, K |
Gerontologist |
Commentary/Editorial| Commentaire/Éditorial |
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Scemama, P, Farah, et al |
Pain Physician |
Commentary/Editorial| Commentaire/Éditorial |
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Schindler, F |
IEEE Microwave Magazine |
Commentary/Editorial| Commentaire/Éditorial |
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Schlenger, R |
Deutsche Apotheker Zeitung |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 bei Neugeborenen, Kindern und Jugendlichen: Fakten, Zahlen und Risiken |
Schlüer, AB |
Pflege |
Commentary/Editorial| Commentaire/Éditorial |
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Incorporating telemedicine into interventional
pain practices during the covid 19 pandemic |
Schwartz, R, Urits, et al |
Pain Physician |
Commentary/Editorial| Commentaire/Éditorial |
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Secara, IA |
Network Security |
Commentary/Editorial| Commentaire/Éditorial |
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Seoudy, H, Frey, et al |
Deutsche medizinische Wochenschrift (1946) |
Commentary/Editorial| Commentaire/Éditorial |
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Serón, P, Oliveros, et al |
Medwave |
Commentary/Editorial| Commentaire/Éditorial |
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Settineri, S |
Mediterranean Journal of Clinical Psychology |
Commentary/Editorial| Commentaire/Éditorial |
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Shah, AS, Tande, et al |
Mayo Clinic proceedings |
Commentary/Editorial| Commentaire/Éditorial |
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The technological impact of COVID-19 on the future
of education and health care delivery |
Shah, S, Diwan, et al |
Pain Physician |
Commentary/Editorial| Commentaire/Éditorial |
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Shakoor, H, Feehan, et al |
Maturitas |
Commentary/Editorial| Commentaire/Éditorial |
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Shanley, A |
BioPharm International |
Commentary/Editorial| Commentaire/Éditorial |
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Urban resilience assessment: Mapping knowledge structure and trends |
Sharifi, A |
Sustainability (Switzerland) |
Commentary/Editorial| Commentaire/Éditorial |
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Drugs Repositioned for COVID-19 Are Routinely Prescribed by Dermatologists |
Sharma, A, Mhatre, et al |
Skinmed |
Commentary/Editorial| Commentaire/Éditorial |
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Sharma, D |
Combinatorial Chemistry and High Throughput Screening |
Commentary/Editorial| Commentaire/Éditorial |
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Sheehy, AM, Locke, et al |
Journal of hospital medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Unemployment in Switzerland in the wake of the Covid-19 pandemic: an intertemporal
perspective |
Sheldon, G |
Swiss Journal of Economics and Statistics |
Commentary/Editorial| Commentaire/Éditorial |
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Prevention and control of COVID-19 in public transportation: Experience from
China |
Shen, J, Duan, et al |
Environmental Pollution |
Commentary/Editorial| Commentaire/Éditorial |
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Shinwari, K, Liu, et al |
Acta Medica Iranica |
Commentary/Editorial| Commentaire/Éditorial |
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Is Religious
Behavior Harbinger for COVID-19 - Indian Perspective? |
Shoib, S, Joseph, et al |
Psychiatria Danubina |
Commentary/Editorial| Commentaire/Éditorial |
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Siddique, SM, Sultan, et al |
Gastroenterology |
Commentary/Editorial| Commentaire/Éditorial |
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Benefits and limitations of serological assays in COVID-19 infection |
Sidiq, Z, Hanif, et al |
Indian Journal of Tuberculosis |
Commentary/Editorial| Commentaire/Éditorial |
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Siebenand, VS |
Pharmazeutische Zeitung |
Commentary/Editorial| Commentaire/Éditorial |
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Siegal, DS, Wessman, et al |
Journal of the American College of Radiology |
Commentary/Editorial| Commentaire/Éditorial |
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Siegler, JE, Cardona, et al |
Int J Stroke |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 Pandemia: Neuropsychiatric Comorbidity and Consequences |
Sinanović, O, Muftić, et al |
Psychiatria Danubina |
Commentary/Editorial| Commentaire/Éditorial |
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Singh, A |
Finance Research Letters |
Commentary/Editorial| Commentaire/Éditorial |
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Novel coronavirus infection and periodontal clinic: Are we prepared? |
Singh, M |
International Journal of Academic Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Reply to Jakovac and to Rocha et al.: Can vitamin D prevent or manage COVID-19
illness? |
Slominski, AT, Slominski, et al |
American journal of physiology.Endocrinology and metabolism |
Commentary/Editorial| Commentaire/Éditorial |
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Smiley, SL, Agbemor, et al |
African Geographical Review |
Commentary/Editorial| Commentaire/Éditorial |
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Trends in upper gastrointestinal bleeding during the covid-19 pandemic |
Sobani, ZA, Paleti, et al |
Annals of Gastroenterology |
Commentary/Editorial| Commentaire/Éditorial |
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Soldati, G, Smargiassi, et al |
J Ultrasound Med |
Commentary/Editorial| Commentaire/Éditorial |
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Telehealth approaches to care coordination in autism spectrum disorder |
Solomon, D, Soares, et al |
Interprofessional Care Coordination for Pediatric Autism Spectrum Disorder: Translating Research into Practice |
Commentary/Editorial| Commentaire/Éditorial |
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Song, Z, Bai, et al |
Chinese Journal of Orthopaedics |
Commentary/Editorial| Commentaire/Éditorial |
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Cancer pain treatment during the covid-19 pan-demic: Institutional recommendations |
Sousa, AM, Grigio, et al |
Clinics |
Commentary/Editorial| Commentaire/Éditorial |
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Does Existence of Prior Circulatory System Diseases Accelerate Mortality Due to COVID-19? |
Souza, CDF, Leal, et al |
Arquivos Brasileiros de Cardiologia |
Commentary/Editorial| Commentaire/Éditorial |
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Nurse Leaders Advocate for Nurses Across a Health Care System: COVID-19 |
Stamps, DC, Foley, et al |
Nurse Leader |
Commentary/Editorial| Commentaire/Éditorial |
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Stark, C |
IPPR Progressive Review |
Commentary/Editorial| Commentaire/Éditorial |
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Stewart, MW |
Journal of Perianesthesia Nursing |
Commentary/Editorial| Commentaire/Éditorial |
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Recovering from a
covid-19 shutdown: Tips and tricks for starting up, part ii |
Stoll, DR, Taylor, et al |
LC-GC North America |
Commentary/Editorial| Commentaire/Éditorial |
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Mayo Clinic Strategies for COVID-19: Revamping Outpatient Care for Patients Without
COVID-19 |
Storino, CB, Watson, et al |
Mayo Clinic proceedings |
Commentary/Editorial| Commentaire/Éditorial |
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Su, Y |
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Commentary/Editorial| Commentaire/Éditorial |
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Mayo Clinic Strategies for COVID-19: Avoiding a Medical Education Quarantine
During the Pandemic |
Suh, GA, Shah, et al |
Mayo Clinic proceedings |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 and possible links with Parkinson’s disease and parkinsonism: from bench
to bedside |
Sulzer, D, Antonini, et al |
npj Parkinson's Disease |
Commentary/Editorial| Commentaire/Éditorial |
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Sun, Q |
Chinese Journal of Radiological Medicine and Protection |
Commentary/Editorial| Commentaire/Éditorial |
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Sun, Z, Ostrikov, et al |
Sustainable Materials and Technologies |
Commentary/Editorial| Commentaire/Éditorial |
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Sunasee, R |
Journal of chemical education |
Commentary/Editorial| Commentaire/Éditorial |
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Management strategy of pregnant women during COVID-19 pandemic |
Suzumori, N, Goto, et al |
Australian and New Zealand Journal of Obstetrics and Gynaecology |
Commentary/Editorial| Commentaire/Éditorial |
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Swannell, C |
Medical Journal of Australia |
Commentary/Editorial| Commentaire/Éditorial |
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Swanson, R, Smith, et al |
Sport in Society |
Commentary/Editorial| Commentaire/Éditorial |
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Considerations for colorectal cancer surgery in Greece during covid-19 pandemic |
Syllaios, A, Davakis, et al |
Pan African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Ta, SHS, Hong, et al |
Journal of Foot and Ankle Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Tagaev, T, Mamatov, et al |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Tamara Velásquez, C, María Adela Godoy, et al |
Revista chilena de pediatria |
Commentary/Editorial| Commentaire/Éditorial |
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Mayo Clinic Strategies for COVID-19: Community-Based Drive-Through and Walk-Through
Testing Centers |
Tande, AJ, Challener, et al |
Mayo Clinic proceedings |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Tanrıvermiş, H |
Journal of Urban Management |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Bone biology and COVID-19 infection: Is ACE2 a potential influence factor? |
Tao, H, Bai, et al |
Medical hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Tarkang, EE |
Pan African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Guidelines for conducting medico legal autopsy during COVID-19 pandemic |
Tayal, I, Garg, et al |
Journal of Punjab Academy of Forensic Medicine and Toxicology |
Commentary/Editorial| Commentaire/Éditorial |
|
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COVID-19
and the New Zealand institute of medical laboratory science -a view from the bottom up |
Taylor, T |
New Zealand Journal of Medical Laboratory Science |
Commentary/Editorial| Commentaire/Éditorial |
|
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Tebroke, VE |
Pharmazeutische Zeitung |
Commentary/Editorial| Commentaire/Éditorial |
|
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The, Lancet |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
|
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Letter: role of probiotics in the COVID-19 pandemic—authors' reply |
Tian, Y, Rong, et al |
Alimentary Pharmacology and Therapeutics |
Commentary/Editorial| Commentaire/Éditorial |
|
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An International Perspective: Teaching Chemistry and Engaging Students during
the COVID-19 Pandemic |
Tigaa, RA, Sonawane, et al |
Journal of chemical education |
Commentary/Editorial| Commentaire/Éditorial |
|
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Mayo Clinic Strategies for COVID-19: Elements of an Effective Incident Command
Center |
Tosh, PK, Bucks, et al |
Mayo Clinic proceedings |
Commentary/Editorial| Commentaire/Éditorial |
|
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L'expertise des infirmières au cœur de la pandémie de Covid-19 |
Trochet, C |
Revue de l'infirmiere |
Commentary/Editorial| Commentaire/Éditorial |
|
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Tsolaki, V, Zakynthinos, et al |
Thrombosis research |
Commentary/Editorial| Commentaire/Éditorial |
|
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COVID-19: new challenges for medical science and practical health |
Tutelyan, VA, Nikityuk, et al |
Voprosy pitaniia |
Commentary/Editorial| Commentaire/Éditorial |
|
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Contribution of nanotechnology in the fight against covid-19 |
Tyagi, PK, Tyagi, et al |
Biointerface Research in Applied Chemistry |
Commentary/Editorial| Commentaire/Éditorial |
|
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Mental Health Crisis of Pakistanis Population during COVID-19 Pandemic |
Ullah, R, Rana, et al |
Psychiatria Danubina |
Commentary/Editorial| Commentaire/Éditorial |
|
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Recommendations for the prevention and management of the newborn. COVID-19 pandemic |
Urzúa, S, Cifuentes, et al |
Revista chilena de pediatria |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Valentino, M, Bravo, et al |
Revista de la Federacion Argentina de Cardiologia |
Commentary/Editorial| Commentaire/Éditorial |
|
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Latent organizing for responding to emergencies: foundations for research |
van Fenema, PC, Romme, et al |
Journal of Organization Design |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Van Heuvelen, KM, Daub, et al |
Journal of chemical education |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Challenges and strategies for effective plastic waste management during and
post COVID-19 pandemic |
Vanapalli, KR, Sharma, et al |
Science of the Total Environment |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Spontaneous pneumothorax and pneumomediastinum in bilateral pneumonia due to COVID-19 |
Vela Colmenero, RM, Pola Gallego de Guzmán, et al |
Medicina Intensiva |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Vicente Quiroz, S, Claudia Amarales, et al |
Revista chilena de pediatria |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The neglected role of Faith-based Organizations in prevention and control of COVID-19
in Africa |
Vilakati, PN, Villa, et al |
Trans R Soc Trop Med Hyg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Vinson, V |
Science |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
Volpi, S, Naviglio, et al |
Medico e Bambino |
Commentary/Editorial| Commentaire/Éditorial |
|
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White paper on Ivermectin as a potential therapy for COVID-19 |
Vora, A, Arora, et al |
Indian Journal of Tuberculosis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Voulgaris, A, Ferini-Strambi, et al |
Sleep medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
Walker, G, Booker, et al |
Environment and Planning C: Politics and Space |
Commentary/Editorial| Commentaire/Éditorial |
|
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Waller, HD, McCarthy, et al |
Journal of wound care |
Commentary/Editorial| Commentaire/Éditorial |
|
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Covid-19 and perioperative nursing – inside the NSW state emergency operation
centre |
Waller, SJ |
Journal of Perioperative Nursing |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Wang, L, Wang, et al |
International journal of antimicrobial agents |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
Wang, X, Xie, et al |
Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
Warkentin, TE, Kaatz, et al |
Thrombosis research |
Commentary/Editorial| Commentaire/Éditorial |
|
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Warnet, S |
Revue de l'infirmiere |
Commentary/Editorial| Commentaire/Éditorial |
|
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Treating Social Anxiety Disorder Remotely with Cognitive Therapy |
Warnock-Parkes, E, Wild, et al |
Cognitive Behaviour Therapist |
Commentary/Editorial| Commentaire/Éditorial |
|
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Wathore, R, Gupta, et al |
Science of the Total Environment |
Commentary/Editorial| Commentaire/Éditorial |
|
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Wayne, DB, Green, et al |
Science advances |
Commentary/Editorial| Commentaire/Éditorial |
|
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Webber, R |
International Journal of Market Research |
Commentary/Editorial| Commentaire/Éditorial |
|
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Wellenreuther, C |
Wirtschaftsdienst |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
Wen, D, Wu, et al |
Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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Mayo Clinic Strategies for COVID-19: Community Engagement With Vulnerable Populations |
Wieland, ML, Doubeni, et al |
Mayo Clinic proceedings |
Commentary/Editorial| Commentaire/Éditorial |
|
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Wielogórska, NL, Ekwobi, et al |
Current problems in surgery |
Commentary/Editorial| Commentaire/Éditorial |
|
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The COVID-19 experiment: Pandemic planning and preparedness lessons we must remember |
Wilkens, EP, Klein, et al |
American journal of disaster medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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Williams, J |
Photonics Spectra |
Commentary/Editorial| Commentaire/Éditorial |
|
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Wittert, G, McLachlan, et al |
Obesity Research and Clinical Practice |
Commentary/Editorial| Commentaire/Éditorial |
|
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COVID-19 and beyond: Social work interventions for supporting homeless populations |
Wu, H, Karabanow, et al |
International Social Work |
Commentary/Editorial| Commentaire/Éditorial |
|
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Xiang, F, Dong, et al |
Chin Med J (Engl) |
Commentary/Editorial| Commentaire/Éditorial |
|
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Xiao, N, Gordon, et al |
Journal of Vascular and Interventional Radiology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Xiao, Y, Cao, et al |
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
Our experiences of resuming services in ENT departments in Wuhan, once a COVID-19
epicenter |
Xu, K, Lu, et al |
American Journal of Otolaryngology - Head and Neck Medicine and Surgery |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Xu, X, Sun, et al |
Nature medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
Yang, L, Yu, et al |
Resources, Conservation and Recycling |
Commentary/Editorial| Commentaire/Éditorial |
|
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Yang, S |
Urological Science |
Commentary/Editorial| Commentaire/Éditorial |
|
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Yang, XH, Hu, et al |
Chin Med J (Engl) |
Commentary/Editorial| Commentaire/Éditorial |
|
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Yi-Fan, F, Qiang, et al |
Academic Journal of Second Military Medical University |
Commentary/Editorial| Commentaire/Éditorial |
|
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Acute ischemic stroke
- an extrapulmonary COVID-19 presentation |
Yousuf, B, Alsarraf, et al |
Critical Care and Shock |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Zaidi, S, Garg, et al |
International Journal of Academic Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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Zame, WR, Bica, et al |
Statistics in Biopharmaceutical Research |
Commentary/Editorial| Commentaire/Éditorial |
|
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An insight into weighing the impact of draconian measures in the battle against COVID-19
[letter] |
Zehra, SS, Rizvi, et al |
Journal of Multidisciplinary Healthcare |
Commentary/Editorial| Commentaire/Éditorial |
|
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Zhang, MY, Wang, et al |
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi |
Commentary/Editorial| Commentaire/Éditorial |
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Zhang, Q, Cao, et al |
Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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Zhang, X, Cao, et al |
Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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Comparison between two types of control strategies for the coronavirus disease 2019 pandemic |
Zhang, X, Wang, et al |
Journal of infection in developing countries |
Commentary/Editorial| Commentaire/Éditorial |
|
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Principles of diagnosis and treatment for traumatic fractures in
the epidemic of COVID-19 |
Zhang, Y |
Chinese Journal of Orthopaedic Trauma |
Commentary/Editorial| Commentaire/Éditorial |
|
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Zheng, J, Zhang, et al |
Quantitative Imaging in Medicine and Surgery |
Commentary/Editorial| Commentaire/Éditorial |
|
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Zhou, X |
Management and Organization Review |
Commentary/Editorial| Commentaire/Éditorial |
|
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Redesigning (virtual) learning with a “love ethic” in the wake of COVID-19 |
Zimmett, J |
Education for Information |
Commentary/Editorial| Commentaire/Éditorial |
|
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Zingone, F, D'Odorico, et al |
Autoimmunity Reviews |
Commentary/Editorial| Commentaire/Éditorial |
|
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Zukin, S |
Theory and Society |
Commentary/Editorial| Commentaire/Éditorial |
|
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Zumla, A, Azhar, et al |
International Journal of Infectious Diseases |
Commentary/Editorial| Commentaire/Éditorial |
|
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Exam 2: Endoscopic Findings in Patients Infected With 2019 Novel Coronavirus in
Lombardy, Italy |
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Clinical Gastroenterology and Hepatology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Nature |
Commentary/Editorial| Commentaire/Éditorial |
|
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COVID-19 immunity, scorching temperatures and telescope accident |
|
Nature |
Commentary/Editorial| Commentaire/Éditorial |
|
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EBioMedicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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Lungenultraschall bei COVID-19-Patienten ist auf Intensivstation das Mittel der Wahl |
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Ultraschall in der Medizin |
Commentary/Editorial| Commentaire/Éditorial |
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Gastroenterology |
Commentary/Editorial| Commentaire/Éditorial |
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Veterinary Record |
Commentary/Editorial| Commentaire/Éditorial |
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Acta Pharmaceutica Sinica B |
Commentary/Editorial| Commentaire/Éditorial |
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Aci update
aviation industry restart and recovery post COVID-19 |
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Journal of Airport Management |
Commentary/Editorial| Commentaire/Éditorial |
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80 million
children face disease risks as covid-19 disrupts vaccinations |
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Appropriate Technology |
Commentary/Editorial| Commentaire/Éditorial |
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Research progress in psychological stress response and prevention and control
strategies of COVID-19 |
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Journal of Jilin University Medicine Edition |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19: Information of the Thoracic Imaging Section of the German Radiological Society |
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RoFo Fortschritte auf dem Gebiet der Rontgenstrahlen und der Bildgebenden Verfahren |
Commentary/Editorial| Commentaire/Éditorial |
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Expert consensus on management principles for orthopaedic emergency
in the epidemic of COVID-19 |
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Chinese Journal of Orthopaedic Trauma |
Commentary/Editorial| Commentaire/Éditorial |
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Chinese Journal of Orthopaedic Trauma |
Commentary/Editorial| Commentaire/Éditorial |
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JAMA - Journal of the American Medical Association |
Commentary/Editorial| Commentaire/Éditorial |
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Coronavirus research updates: Why infected primary-school pupils could be hard
to spot |
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Nature |
Commentary/Editorial| Commentaire/Éditorial |
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Appendix: Process and definitions.
A daily search for new publications is conducted in PubMed, Scopus,
BioRxiv and MedRxiv, SSRN,
Research Square,
arXiv for all publications related to COVID-19 disease or SARS-CoV-2 using the search terms (COVID-19 OR SARS-CoV-2
OR "novel CoV" OR "novel coronavirus" OR nCoV) adapted to each database. The capture is cross-referenced with publication announcements on the COVID-19 dashboards set up by a number of publishers and google. Publishers include
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ, Wiley,
Springer Nature, ChinaCDCweekly.
Additionally the database is cross-referenced with other literature scans e.g.
WHO publication list and activities by collaborators. Members of the Emerging Sciences group develop 1 -2 point summaries of each publication. Please email Lisa Waddell for additional information:
Lisa.Waddell@canada.ca.
References are compiled in a reworks database that has citations since the beginning of the outbreak. All references can be accessed at this
link and by the categories listed below. The daily scan has also been compiled in an excel sheet and copies can be provided upon request or
accessed
here.
Category Definitions:
Modelling/ prediction: Predictive modeling is a process that uses data mining and probability
to forecast outcomes. Each model is made up of a number of predictors, which are variables that are likely to influence future results.
Epidemiology:
the branch of medicine which deals with the incidence, distribution, and possible control of diseases and other factors relating to health. Includes Ro, attack rates, case number doubling time, case fatality
rate, serial interval, clinical attack rate, asymptomatic fraction, proportion of asymptomatic and infective*
Transmission: The passage of a pathogen causing communicable disease from an infected host
to an uninfected host via direct or indirect routes.
Clinical data
of cases: Includes clinical parameters such as incubation period, latent period, period of communicability, duration of illness, duration of hospitalization, host risk factors, as well as clinical profiles of patients; presenting symptoms, symptoms over
course of illness, sequelae, comorbidities.*
Surveillance: Public health surveillance is the continuous, systematic collection, analysis and
interpretation of health-related data. Surveillance data will likely be number of cases suspected/confirmed, number of deaths, number recovered. *
Coronavirology: All research relating to the virus; its characteristics, genetic make-up, phylogenetic
analyses
Diagnostics / Pathogen detection:
All studies on identification of the virus; culture, PCR, antibody/antigen tests etc.
Therapeutics:
Studies of substances that may be used to treat infected hosts including passive immunization products.
Vaccine Research:
Studies of vaccine candidates to prevent infection with 2019-nCoV including clinical trials.
Public Health Priorities:
These citations will focus on what the current research priorities are and/or where knowledge gaps exist.
Public Health interventions*:
Any study evaluating how effective a public health intervention is or maybe (in the case of a predictive model).
Public Health response:
These papers are typically overviews of past and current activities, they often also identify knowledge gaps and suggest future activities or objectives.
Infection Prevention and Control/
Prévention et contrôle des infections (IPAC/PCI): Any research on the effectiveness of IPC interventions should also be tagged as IPC
Health care Response:
This foci would include a description of activities to deal with 2019-nCoV cases including, but not limited to: set up of a special emergency multi-disciplinary intensive care team; Bed and medical equipment preparation/ stock piling supplies; Education
and training of staff; Early case recognition and classification of disease severity.
Economics: papers discussing/ forecasting the economics of COVID-19 pandemic.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Review Literature:
All articles that summarize the published literature can be tagged as a review. This includes systematic review, meta-analysis, scoping review, overviews, umbrella reviews*
Commentary/Editorial:
For commentaries, editorials, letters to the editor, other types of opinion pieces where there is no new data collected by the author or analysis conducted by the author, please tag these within the commentary category.
News articles that have not scientific information.
*Lists are not exhaustive
Annexe: Processus et définitions.
Une recherche quotidienne des nouvelles publications est effectuée dans PubMed, Scopus,
BioRxiv and MedRxiv,
SSRN,
Research Square,
arXiv
pour toutes les publications relatives à la maladie COVID-19 ou au SRAS-CoV-2 en utilisant les termes de recherche (COVID-19 OU SARS-CoV-2 OU « novel CoV » OU « novel coronavirus » OU nCoV). La saisie renvoie à des annonces de publication
sur les tableaux de bord du nCoV mis en place par un certain nombre d'éditeurs et par Google. Parmi les éditeurs figurent
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ,
Wiley,
Springer Nature,
ChinaCDCweekly. En outre, la base de données renvoie à d'autres survols de publications, e.g.
la liste des publications de l'OMS,
et à des activités des collaborateurs. Les membres du groupe scientifique émergent préparent des résumés en 1 ou 2 points de chaque publication. Pour en savoir plus, veuillez envoyer un courriel à Lisa Waddell au :
Lisa.Waddell@canada.ca.
Les références sont compilées dans une base de données Refworks qui contient des citations depuis le début de l'épidémie. Toutes les références sont accessibles à partir de ce
lien et par les catégories énumérées ci-dessous. L'analyse quotidienne a également été compilée
dans une feuille Excel et des copies peuvent être fournies sur demande ou consultées
ici.
Définitions des catégories :
Modélisation / prédiction :
La modélisation prédictive est un processus qui utilise l'exploration de données et la probabilité pour prévoir les résultats. Chaque modèle est composé de plusieurs prédicteurs, qui sont des variables susceptibles d'influencer les résultats futurs.
Épidémiologie :
Branche de la médecine qui traite de l'incidence, de la répartition et du contrôle éventuel des maladies et d'autres facteurs liés à la santé. Comprend le taux de reproduction de base (Ro),
les taux d'attaque, le temps de doublement du nombre de cas, le taux de létalité, l'intervalle sériel, le taux d'attaque clinique, la fraction asymptomatique, la proportion de cas asymptomatiques et infectieux*.
Transmission :
Passage d'un agent pathogène causant une maladie transmissible d'un hôte infecté à un hôte non infecté par des voies directes ou indirectes.
Données cliniques
des cas : Comprend les paramètres cliniques tels que la période d'incubation, la période de latence, la période de contagiosité, la durée de la maladie, la durée de l'hospitalisation, les facteurs de risque de l'hôte, ainsi que les profils
cliniques des patients; les symptômes présentés, les symptômes au cours de la maladie, les séquelles, les comorbidités.*
Surveillance : La surveillance
de la santé publique est la collecte, l'analyse et l'interprétation continues et systématiques de données relatives à la santé. Les données de surveillance concerneront probablement le nombre de cas suspects / confirmés, le nombre de décès, le nombre de personnes
guéries. *
Coronavirologie : Toutes les recherches relatives
au virus, ses caractéristiques, sa constitution génétique et les analyses phylogénétiques.
Diagnostics / Détection d'agents pathogènes :
Toutes les études sur l'identification du virus : culture, PCR, tests de dépistage d'anticorps ou d’antigènes, etc.
Thérapeutique :
Étude des substances pouvant être utilisées pour traiter les hôtes infectés, y compris les produits d'immunisation passive.
Recherche sur les vaccins : Études des candidats à la
vaccination pour prévenir l'infection par le 2019-nCoV, y compris des essais cliniques.
Priorités de santé publique :
Ces citations porteront sur les priorités actuelles de recherche et/ou sur les lacunes dans les connaissances.
Interventions de santé publique* :
Toute étude évaluant l'efficacité (réelle ou possible) d'une intervention de santé publique (dans le cas d'un modèle prédictif).
Réponse de la santé publique :
Ces articles sont généralement des aperçus des activités passées et actuelles, qui identifient souvent les lacunes dans les connaissances et suggèrent des activités ou des objectifs futurs.
Prévention et contrôle des infections/Infection Prevention and Control (PCI/IPAC) :
Les recherches sur l'efficacité des interventions en PCI doivent également être marquées comme PCI.
Réponse des soins de santé :
Ce point comprendrait une description des activités pour traiter les cas de 2019-nCoV, notamment : mise en place d'une équipe multidisciplinaire spéciale de soins intensifs d'urgence; préparation des lits et des équipements médicaux
/ stockage des fournitures; sensibilisation et formation du personnel; reconnaissance précoce des cas et classification de la gravité de la maladie.
Modèle animal:
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Économie: documents discutant / prévoyant l'économie de la pandémie de COVID-19
Revue de la documentation :
Tous les articles qui résument les documents publiés peuvent être marqués comme une revue. Cela comprend les revues systématiques, les méta-analyses, les études de la portée, les aperçus, les examens généraux*.
Commentaires/Éditorial :
Pour les commentaires, éditoriaux, lettres à la rédaction, autres types d'articles d'opinion pour lesquels aucune nouvelle donnée n'est collectée ou aucune analyse n'est effectuée par l'auteur, veuillez les marquer dans la catégorie des
commentaires.
journaux
Articles de presse qui n'ont pas d'informations scientifiques.
* Les listes ne sont pas exhaustives